Click here to switch to the map view.

The map label for this gene is metG

Identifier: 108762836

GI number: 108762836

Start: 3272136

End: 3274247

Strand: Direct

Name: metG

Synonym: MXAN_2804

Alternate gene names: 108762836

Gene position: 3272136-3274247 (Clockwise)

Preceding gene: 108761368

Following gene: 108763671

Centisome position: 35.8

GC content: 67.66

Gene sequence:

>2112_bases
ATGGCTGAGAGAACCCTCGTCACCAGCGCGCTGCCCTACGCGAACGGCCCGCTCCACATCGGCCACGCCGTCGAGTACGT
GCAGACCGACATCTACGTTCGTTTCCTCCGCTCGTGCGGCAGGGACGTCGTCTACTTCTGTGCCGATGACACCCACGGCA
CGCCCATCGAGCTGAACGCGGCGAAGCAGGGCCTCAAGCCCGAGGAATTCATCGCCCGCTTCCACGAGGAGCACCAGCGG
GACTTCCACGACCTCGATGTCCGCTTCGACTACTTCCACTCCACCAACTCGCCGGAGAACCGCCAGTACGCGGAGCTCAT
CTACGGGCGGCTGAAGGAGAAGGGCGACATCGAGCGCCGGAACATCGAGCAGACCTACTGCGAGAACGACCGCCGCTTCC
TTCCGGACCGCTTCATCAAGGGGACCTGCCCCAACTGCAAGGCTTCCGACCAGTACGGCGACGCCTGTGAGAAGTGCGGC
AAGGCCTACGACCCCACGGACCTCATCGACGCGCGCTGTGCCCTGTGTGGCACGCCTCCGGTCCGCAAGCACTCCGAACA
CCTGTTCTTCAAGCTGTCGCGGCACGAGGACTTCCTCCAGGACGTGCTGCGCAAGCCAGGCTTCATCCATCCGGGCCTGG
CGACCCAACTCCAGGGCTTCTTCGAGAAGGGCCTGTCGGACTGGGACATCAGCCGCGACGGGCCGTACTTCGGCTTCGCC
ATTCCGGGTGAGACGGACAAGTACTTCTACGTCTGGTTGGACGCGCCCATCGGGTACATCGCCACCACGGAGAAGTGGGC
GAAGGAGACGGGCAAGGCGAAGAGCGCGCTGGACTACTGGAGCGCGGACGCGGACACCCGCATCATCCACTTCATCGGCA
AGGACATCGTCTACTTCCACGCGCTGTTCTGGCCGGCCGTGCTCAACGTCGCGGGCTTCCACATCCCCAGCGAAATCAAG
GTCCACGGCCACCTGATGTTGAACGGCGAGAAGATGTCGAAGACTCGCGGCACCATGGTGCCAGTGCGCGACTACCTGGA
CCAGTTGGACCCCAGCTACTTGCGCTACTTCTACGCGGCCAACCTGGGCCCGGGGGTGGAGGACCTGGACCTCAACCTCA
AGGACTTCCGCCAGCGCGTGAATGGCGAGCTGGTCAACAACGTGGGCAACCTGGCCAACCGCGCCCTGTCGCTGCTGGCC
GGTCCGCTGGAGAAGCGTCTCGCGCCCGGCCGTGCCGAGGGCCCGGGCCGCGAGTTGGTGGAGGCCGCGCTCGCCCGCGT
GCCGGAGGTTCGCGACGCGTTCGACAAGCTGGAGTACCGGTCCGCCATCCGCGTCATCACCGAGATTGCGTCGGCCGCGA
ACGGCTTCCTCCAGACGGCCGCGCCGTGGGCCCAGGTGAAGAAGGACGCGGAGGTCGCTCGCGCGGACCTGTCCGACGCC
GCGGACGTGGCCTACCTCCTGGGCGCGCTGCTCGCCCCGGTGACACCGCGCCTGTCCGAGAAGCTCTTCGCTCAGCTCGG
CGCCGAGCCGCTGACGTTCCAGGCCCTGGAGGGCGCGAAGTACCCGCTGTTGGATCGCAGCCGTCCCATCGGCACGCCCG
AGCCGCTGCTGCCGCGGCTGGAGGAGGAGCGCGTCAACGCCATCATCAAGCTACCGGAAGGCGCCGCTGCGCCGCAGGCC
GCGGAGGCCAGGCCGGCCAAGGGCGCCAAGACGGAGAAGAAGCCCGCCGAGGCTCCCGCCGCGACGCAGGCGGCGGCTCC
GAGCGCTGGCGCGGCCGAGTCGCCGGGTGAAATCGAGTACGACGACTTCGCCAAGGTGGTGCTGAAGGCGGGCAAGGTGC
TGGCCGCGGAGAAGGTGCAGAAGGCAGACAAGCTGCTCAAGCTCACGGTGGACGTGGGCGAGGGGAGCCCGCGCACCATC
GTCTCCGGCATCGCGGAGGCCTTCGCTCCCGAGGCGCTCACCGGGCGCAACGTGGTGGTGGTGGCCAACCTCAAGCCGCG
CAAGCTCAAGGGCATCGAGTCGCGCGGCATGCTCCTGACGGCGGGGCCGGGCGGCAAGGAGCTGTCGCTGCTCGACCCGG
GCGATGTGGCCCCTGGCAGCGAGGTGAAGTGA

Upstream 100 bases:

>100_bases
AACATCTCCGGCTCCGCGGCGCATTCGGGCCCGCGGACTTCACGCCGTCGATGACCTCGGCCATCCGAGCGGCTAAGGTC
CGCCGCCCTCAGGAGAGTCC

Downstream 100 bases:

>100_bases
CGTGACGGACTGGCGCGCCGACCGGGACCGGGCCCTCCTGACGCTGGAGCGCGAGAAGCGCCCGGCGTTCAGGACGGAAG
CCGCGCTCCAGCTCTATCAC

Product: methionyl-tRNA synthetase

Products: NA

Alternate protein names: Methionine--tRNA ligase; MetRS

Number of amino acids: Translated: 703; Mature: 702

Protein sequence:

>703_residues
MAERTLVTSALPYANGPLHIGHAVEYVQTDIYVRFLRSCGRDVVYFCADDTHGTPIELNAAKQGLKPEEFIARFHEEHQR
DFHDLDVRFDYFHSTNSPENRQYAELIYGRLKEKGDIERRNIEQTYCENDRRFLPDRFIKGTCPNCKASDQYGDACEKCG
KAYDPTDLIDARCALCGTPPVRKHSEHLFFKLSRHEDFLQDVLRKPGFIHPGLATQLQGFFEKGLSDWDISRDGPYFGFA
IPGETDKYFYVWLDAPIGYIATTEKWAKETGKAKSALDYWSADADTRIIHFIGKDIVYFHALFWPAVLNVAGFHIPSEIK
VHGHLMLNGEKMSKTRGTMVPVRDYLDQLDPSYLRYFYAANLGPGVEDLDLNLKDFRQRVNGELVNNVGNLANRALSLLA
GPLEKRLAPGRAEGPGRELVEAALARVPEVRDAFDKLEYRSAIRVITEIASAANGFLQTAAPWAQVKKDAEVARADLSDA
ADVAYLLGALLAPVTPRLSEKLFAQLGAEPLTFQALEGAKYPLLDRSRPIGTPEPLLPRLEEERVNAIIKLPEGAAAPQA
AEARPAKGAKTEKKPAEAPAATQAAAPSAGAAESPGEIEYDDFAKVVLKAGKVLAAEKVQKADKLLKLTVDVGEGSPRTI
VSGIAEAFAPEALTGRNVVVVANLKPRKLKGIESRGMLLTAGPGGKELSLLDPGDVAPGSEVK

Sequences:

>Translated_703_residues
MAERTLVTSALPYANGPLHIGHAVEYVQTDIYVRFLRSCGRDVVYFCADDTHGTPIELNAAKQGLKPEEFIARFHEEHQR
DFHDLDVRFDYFHSTNSPENRQYAELIYGRLKEKGDIERRNIEQTYCENDRRFLPDRFIKGTCPNCKASDQYGDACEKCG
KAYDPTDLIDARCALCGTPPVRKHSEHLFFKLSRHEDFLQDVLRKPGFIHPGLATQLQGFFEKGLSDWDISRDGPYFGFA
IPGETDKYFYVWLDAPIGYIATTEKWAKETGKAKSALDYWSADADTRIIHFIGKDIVYFHALFWPAVLNVAGFHIPSEIK
VHGHLMLNGEKMSKTRGTMVPVRDYLDQLDPSYLRYFYAANLGPGVEDLDLNLKDFRQRVNGELVNNVGNLANRALSLLA
GPLEKRLAPGRAEGPGRELVEAALARVPEVRDAFDKLEYRSAIRVITEIASAANGFLQTAAPWAQVKKDAEVARADLSDA
ADVAYLLGALLAPVTPRLSEKLFAQLGAEPLTFQALEGAKYPLLDRSRPIGTPEPLLPRLEEERVNAIIKLPEGAAAPQA
AEARPAKGAKTEKKPAEAPAATQAAAPSAGAAESPGEIEYDDFAKVVLKAGKVLAAEKVQKADKLLKLTVDVGEGSPRTI
VSGIAEAFAPEALTGRNVVVVANLKPRKLKGIESRGMLLTAGPGGKELSLLDPGDVAPGSEVK
>Mature_702_residues
AERTLVTSALPYANGPLHIGHAVEYVQTDIYVRFLRSCGRDVVYFCADDTHGTPIELNAAKQGLKPEEFIARFHEEHQRD
FHDLDVRFDYFHSTNSPENRQYAELIYGRLKEKGDIERRNIEQTYCENDRRFLPDRFIKGTCPNCKASDQYGDACEKCGK
AYDPTDLIDARCALCGTPPVRKHSEHLFFKLSRHEDFLQDVLRKPGFIHPGLATQLQGFFEKGLSDWDISRDGPYFGFAI
PGETDKYFYVWLDAPIGYIATTEKWAKETGKAKSALDYWSADADTRIIHFIGKDIVYFHALFWPAVLNVAGFHIPSEIKV
HGHLMLNGEKMSKTRGTMVPVRDYLDQLDPSYLRYFYAANLGPGVEDLDLNLKDFRQRVNGELVNNVGNLANRALSLLAG
PLEKRLAPGRAEGPGRELVEAALARVPEVRDAFDKLEYRSAIRVITEIASAANGFLQTAAPWAQVKKDAEVARADLSDAA
DVAYLLGALLAPVTPRLSEKLFAQLGAEPLTFQALEGAKYPLLDRSRPIGTPEPLLPRLEEERVNAIIKLPEGAAAPQAA
EARPAKGAKTEKKPAEAPAATQAAAPSAGAAESPGEIEYDDFAKVVLKAGKVLAAEKVQKADKLLKLTVDVGEGSPRTIV
SGIAEAFAPEALTGRNVVVVANLKPRKLKGIESRGMLLTAGPGGKELSLLDPGDVAPGSEVK

Specific function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation

COG id: COG0143

COG function: function code J; Methionyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 tRNA-binding domain

Homologues:

Organism=Homo sapiens, GI14043022, Length=656, Percent_Identity=29.1158536585366, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI24308436, Length=581, Percent_Identity=29.2598967297762, Blast_Score=187, Evalue=4e-47,
Organism=Homo sapiens, GI4507947, Length=102, Percent_Identity=43.1372549019608, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788432, Length=709, Percent_Identity=42.3131170662906, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1789455, Length=103, Percent_Identity=35.9223300970874, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17540794, Length=639, Percent_Identity=27.5430359937402, Blast_Score=262, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI212645096, Length=534, Percent_Identity=25.6554307116105, Blast_Score=168, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71992781, Length=360, Percent_Identity=27.2222222222222, Blast_Score=135, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6321704, Length=562, Percent_Identity=27.5800711743772, Blast_Score=230, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6321610, Length=592, Percent_Identity=24.3243243243243, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24655311, Length=586, Percent_Identity=31.9112627986348, Blast_Score=281, Evalue=9e-76,
Organism=Drosophila melanogaster, GI21358483, Length=524, Percent_Identity=24.618320610687, Blast_Score=133, Evalue=5e-31,

Paralogues:

None

Copy number: 871 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): SYM_MYXXD (Q1D8K2)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631021.1
- ProteinModelPortal:   Q1D8K2
- STRING:   Q1D8K2
- GeneID:   4106589
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2804
- TIGR:   MXAN_2804
- eggNOG:   COG0143
- HOGENOM:   HBG721667
- OMA:   SAYQPEQ
- PhylomeDB:   Q1D8K2
- ProtClustDB:   PRK00133
- BioCyc:   MXAN246197:MXAN_2804-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00098
- InterPro:   IPR001412
- InterPro:   IPR015413
- InterPro:   IPR004495
- InterPro:   IPR014758
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR014729
- InterPro:   IPR002547
- InterPro:   IPR009080
- Gene3D:   G3DSA:2.40.50.140
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR01041
- TIGRFAMs:   TIGR00398
- TIGRFAMs:   TIGR00399

Pfam domain/function: PF09334 tRNA-synt_1g; PF01588 tRNA_bind; SSF50249 Nucleic_acid_OB; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.10

Molecular weight: Translated: 77333; Mature: 77201

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50886 TRBD

Important sites: BINDING 334-334

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERTLVTSALPYANGPLHIGHAVEYVQTDIYVRFLRSCGRDVVYFCADDTHGTPIELNA
CCCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEHH
AKQGLKPEEFIARFHEEHQRDFHDLDVRFDYFHSTNSPENRQYAELIYGRLKEKGDIERR
HHCCCCHHHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHH
NIEQTYCENDRRFLPDRFIKGTCPNCKASDQYGDACEKCGKAYDPTDLIDARCALCGTPP
HHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCC
VRKHSEHLFFKLSRHEDFLQDVLRKPGFIHPGLATQLQGFFEKGLSDWDISRDGPYFGFA
CCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEE
IPGETDKYFYVWLDAPIGYIATTEKWAKETGKAKSALDYWSADADTRIIHFIGKDIVYFH
CCCCCCCEEEEEEECCCCCEECCHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ALFWPAVLNVAGFHIPSEIKVHGHLMLNGEKMSKTRGTMVPVRDYLDQLDPSYLRYFYAA
HHHHHHHHHHHCCCCCCCEEEEEEEEECCHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHH
NLGPGVEDLDLNLKDFRQRVNGELVNNVGNLANRALSLLAGPLEKRLAPGRAEGPGRELV
CCCCCCHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
EAALARVPEVRDAFDKLEYRSAIRVITEIASAANGFLQTAAPWAQVKKDAEVARADLSDA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ADVAYLLGALLAPVTPRLSEKLFAQLGAEPLTFQALEGAKYPLLDRSRPIGTPEPLLPRL
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEHHHCCCCCCCCCCCCCCCCCCHHHCCH
EEERVNAIIKLPEGAAAPQAAEARPAKGAKTEKKPAEAPAATQAAAPSAGAAESPGEIEY
HHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCH
DDFAKVVLKAGKVLAAEKVQKADKLLKLTVDVGEGSPRTIVSGIAEAFAPEALTGRNVVV
HHHHHHHHHHCHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEE
VANLKPRKLKGIESRGMLLTAGPGGKELSLLDPGDVAPGSEVK
EECCCCHHHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
AERTLVTSALPYANGPLHIGHAVEYVQTDIYVRFLRSCGRDVVYFCADDTHGTPIELNA
CCCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEHH
AKQGLKPEEFIARFHEEHQRDFHDLDVRFDYFHSTNSPENRQYAELIYGRLKEKGDIERR
HHCCCCHHHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHH
NIEQTYCENDRRFLPDRFIKGTCPNCKASDQYGDACEKCGKAYDPTDLIDARCALCGTPP
HHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCC
VRKHSEHLFFKLSRHEDFLQDVLRKPGFIHPGLATQLQGFFEKGLSDWDISRDGPYFGFA
CCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEE
IPGETDKYFYVWLDAPIGYIATTEKWAKETGKAKSALDYWSADADTRIIHFIGKDIVYFH
CCCCCCCEEEEEEECCCCCEECCHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ALFWPAVLNVAGFHIPSEIKVHGHLMLNGEKMSKTRGTMVPVRDYLDQLDPSYLRYFYAA
HHHHHHHHHHHCCCCCCCEEEEEEEEECCHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHH
NLGPGVEDLDLNLKDFRQRVNGELVNNVGNLANRALSLLAGPLEKRLAPGRAEGPGRELV
CCCCCCHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
EAALARVPEVRDAFDKLEYRSAIRVITEIASAANGFLQTAAPWAQVKKDAEVARADLSDA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ADVAYLLGALLAPVTPRLSEKLFAQLGAEPLTFQALEGAKYPLLDRSRPIGTPEPLLPRL
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEHHHCCCCCCCCCCCCCCCCCCHHHCCH
EEERVNAIIKLPEGAAAPQAAEARPAKGAKTEKKPAEAPAATQAAAPSAGAAESPGEIEY
HHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCH
DDFAKVVLKAGKVLAAEKVQKADKLLKLTVDVGEGSPRTIVSGIAEAFAPEALTGRNVVV
HHHHHHHHHHCHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEE
VANLKPRKLKGIESRGMLLTAGPGGKELSLLDPGDVAPGSEVK
EECCCCHHHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA