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The map label for this gene is sthA [H]

Identifier: 108762684

GI number: 108762684

Start: 2805118

End: 2806521

Strand: Reverse

Name: sthA [H]

Synonym: MXAN_2411

Alternate gene names: 108762684

Gene position: 2806521-2805118 (Counterclockwise)

Preceding gene: 108759074

Following gene: 108763323

Centisome position: 30.71

GC content: 71.01

Gene sequence:

>1404_bases
ATGGCGGACTTCGACCTGGTGGTGATTGGCTCCGGCCCGGCGGGTGAGTGGGGCGCGGTACAAGCGGCGCTGGCGGGCAA
GCGCGTAGCGGTGGTGGAGCGGGAGCCCGTGCTGGGTGGTACCGCGGCGAACACAGGCACCCTTCCCTCCAAGACGCTGC
GCGAGACGGCGCTGCACCTGTCCGGCTTCCGGGCGCGCGGGCTGTACAGCGTGGAGACGACGCTGCGGCACGAGGCCACG
GTGTCCGACTTCCTCTTCCGCGAACGGCGGGTGAAGGACATCGAGCGCGAGCGAATCGCCCGCAACCTCCAGCGCCACAA
GGTGGAAATCATCCAGGGCACCGGCGCGCTCGTGGACGCGAACACCGTCGTCGTGCGGCGCCAGGACGCCCCGGAGCGGC
GCCTCACCGGCGGCACCATCCTGGTGGCCACCGGCTCGTCGCCGTACCGGCCGCCGCTGTACCCCTTCGAGGACCCGCGC
ATCCACGACTCGGACGAGGTGCTGGAGCTCGAAAGGCTGCCGCGCTCGCTGGTGGTGGTGGGCGCCGGCGTCATCGGCTG
TGAGTACGCCTGCATGTTCGCCGCCATGGACATCCCGGTGACGCTGGTGGAGGCGCGCGCGGAGCTGCTGCCCTTCCTGG
ACGACGAGTTCTCCGCGCTGCTGGGCCAGCGCATGGAGGCGCTCGGCATCCAACTGCGCTTCGGGCAGGTGGTGGAGCAG
GTAGACGTGCCGCGGGACGCGGACACTCCCATCCGGATGATGCTCTCCTCCGGCGCCGTGCTTGAGACGGACCAGGTCCT
GGTCGCCTCCGGCCGCACCGCCAACACGGCGGGCCTGGGGCTGGAGGCCCTGGGCGTGCAGGTGGGCCCGCGCGGCCAGG
TGGAGGTGGGCCCCACCTACCAGACGGCCCTGCCCCACATCTATGCCGTGGGGGACGTCATCGGCTTCCCGGCGCTGGCC
TCCACGTCCATGGACCAGGCGCGCATCGCCGTGGAGCACGCGTTCGACCTGGGCGGCGTGCGCACCATGGCGCCGGTGCT
GCCCTACGGCATCTACACCATCCCCGAAGTGTCGATGGCCGGCGAGACAGAGGAGGCCCTGCGCACGCTGAACGTGCCCT
ACGTGGCCGGCCGCGCCGCCTTCGCCACCAACCCGCGCGGTCAGATTCTGGGAGACACGCACGGCCTGCTGAAGCTGCTC
TTCCACCGGGAGAGCCTCAAGCTGCTGGGCGTGCACGTCATGGGGCCCCAGGCCTCCGAGCTGGTGCACGTGGGCCTCAC
CGCCCTGCTCACCGGCTCCACGGCCCGGCTCTTCGTGGAGACGTGCTTCAACTACCCGACGCTGTCGGAGGCCTACAAGG
CGGCCACCTTCGACGCGTTGGATCAGCTCAGCGGCTGCCCCTGA

Upstream 100 bases:

>100_bases
CGCCGGACGCAACACGGCACGGAACGGCGGCGCGGCATCCGCCCCGGCGGCACGGGGGATTGCCTTCAAACGACCGGCGG
GGTCGCGTACCTTCGCGCCC

Downstream 100 bases:

>100_bases
GGCTGCCCACCGTGAGGCCCGTGGCGAAAGGGGCCGCTTCGTGCAGCTCGTCCGCCGAGCCCCGCGCCAGCCGGGGTGCC
TCGGCGGGCGCTTCCCGGGC

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MADFDLVVIGSGPAGEWGAVQAALAGKRVAVVEREPVLGGTAANTGTLPSKTLRETALHLSGFRARGLYSVETTLRHEAT
VSDFLFRERRVKDIERERIARNLQRHKVEIIQGTGALVDANTVVVRRQDAPERRLTGGTILVATGSSPYRPPLYPFEDPR
IHDSDEVLELERLPRSLVVVGAGVIGCEYACMFAAMDIPVTLVEARAELLPFLDDEFSALLGQRMEALGIQLRFGQVVEQ
VDVPRDADTPIRMMLSSGAVLETDQVLVASGRTANTAGLGLEALGVQVGPRGQVEVGPTYQTALPHIYAVGDVIGFPALA
STSMDQARIAVEHAFDLGGVRTMAPVLPYGIYTIPEVSMAGETEEALRTLNVPYVAGRAAFATNPRGQILGDTHGLLKLL
FHRESLKLLGVHVMGPQASELVHVGLTALLTGSTARLFVETCFNYPTLSEAYKAATFDALDQLSGCP

Sequences:

>Translated_467_residues
MADFDLVVIGSGPAGEWGAVQAALAGKRVAVVEREPVLGGTAANTGTLPSKTLRETALHLSGFRARGLYSVETTLRHEAT
VSDFLFRERRVKDIERERIARNLQRHKVEIIQGTGALVDANTVVVRRQDAPERRLTGGTILVATGSSPYRPPLYPFEDPR
IHDSDEVLELERLPRSLVVVGAGVIGCEYACMFAAMDIPVTLVEARAELLPFLDDEFSALLGQRMEALGIQLRFGQVVEQ
VDVPRDADTPIRMMLSSGAVLETDQVLVASGRTANTAGLGLEALGVQVGPRGQVEVGPTYQTALPHIYAVGDVIGFPALA
STSMDQARIAVEHAFDLGGVRTMAPVLPYGIYTIPEVSMAGETEEALRTLNVPYVAGRAAFATNPRGQILGDTHGLLKLL
FHRESLKLLGVHVMGPQASELVHVGLTALLTGSTARLFVETCFNYPTLSEAYKAATFDALDQLSGCP
>Mature_466_residues
ADFDLVVIGSGPAGEWGAVQAALAGKRVAVVEREPVLGGTAANTGTLPSKTLRETALHLSGFRARGLYSVETTLRHEATV
SDFLFRERRVKDIERERIARNLQRHKVEIIQGTGALVDANTVVVRRQDAPERRLTGGTILVATGSSPYRPPLYPFEDPRI
HDSDEVLELERLPRSLVVVGAGVIGCEYACMFAAMDIPVTLVEARAELLPFLDDEFSALLGQRMEALGIQLRFGQVVEQV
DVPRDADTPIRMMLSSGAVLETDQVLVASGRTANTAGLGLEALGVQVGPRGQVEVGPTYQTALPHIYAVGDVIGFPALAS
TSMDQARIAVEHAFDLGGVRTMAPVLPYGIYTIPEVSMAGETEEALRTLNVPYVAGRAAFATNPRGQILGDTHGLLKLLF
HRESLKLLGVHVMGPQASELVHVGLTALLTGSTARLFVETCFNYPTLSEAYKAATFDALDQLSGCP

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=466, Percent_Identity=32.4034334763949, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=27.4298056155508, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI33519430, Length=483, Percent_Identity=26.0869565217391, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI33519428, Length=483, Percent_Identity=26.0869565217391, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI33519426, Length=483, Percent_Identity=26.0869565217391, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI148277065, Length=483, Percent_Identity=26.0869565217391, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI291045266, Length=492, Percent_Identity=25.2032520325203, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI148277071, Length=483, Percent_Identity=26.0869565217391, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI22035672, Length=466, Percent_Identity=27.2532188841202, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI291045268, Length=480, Percent_Identity=24.7916666666667, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=40.7327586206897, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI1786307, Length=460, Percent_Identity=30.2173913043478, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=28.3842794759825, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1789915, Length=447, Percent_Identity=25.7270693512304, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32565766, Length=477, Percent_Identity=30.8176100628931, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=23.6897274633124, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71982272, Length=506, Percent_Identity=24.3083003952569, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71983419, Length=285, Percent_Identity=27.719298245614, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71983429, Length=285, Percent_Identity=27.719298245614, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321091, Length=483, Percent_Identity=29.8136645962733, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=28.8421052631579, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=25.1612903225806, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21358499, Length=463, Percent_Identity=33.2613390928726, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17737741, Length=486, Percent_Identity=27.7777777777778, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=27.2921108742004, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=27.2921108742004, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=27.2921108742004, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 50159; Mature: 50028

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADFDLVVIGSGPAGEWGAVQAALAGKRVAVVEREPVLGGTAANTGTLPSKTLRETALHL
CCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
SGFRARGLYSVETTLRHEATVSDFLFRERRVKDIERERIARNLQRHKVEIIQGTGALVDA
CCHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEC
NTVVVRRQDAPERRLTGGTILVATGSSPYRPPLYPFEDPRIHDSDEVLELERLPRSLVVV
CEEEEECCCCCCHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEE
GAGVIGCEYACMFAAMDIPVTLVEARAELLPFLDDEFSALLGQRMEALGIQLRFGQVVEQ
ECCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEEHHHHHHHH
VDVPRDADTPIRMMLSSGAVLETDQVLVASGRTANTAGLGLEALGVQVGPRGQVEVGPTY
HCCCCCCCCHHHHHHCCCCEEECCCEEEECCCCCCCCCCCHHHCCEEECCCCCEEECCCH
QTALPHIYAVGDVIGFPALASTSMDQARIAVEHAFDLGGVRTMAPVLPYGIYTIPEVSMA
HHHCCHHEEHHHHHCCCHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCEECCCCCCC
GETEEALRTLNVPYVAGRAAFATNPRGQILGDTHGLLKLLFHRESLKLLGVHVMGPQASE
CCHHHHHHHCCCCEEECCEEECCCCCCCEECCHHHHHHHHHHHCCEEEEEEEEECCCHHH
LVHVGLTALLTGSTARLFVETCFNYPTLSEAYKAATFDALDQLSGCP
HHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADFDLVVIGSGPAGEWGAVQAALAGKRVAVVEREPVLGGTAANTGTLPSKTLRETALHL
CCCEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
SGFRARGLYSVETTLRHEATVSDFLFRERRVKDIERERIARNLQRHKVEIIQGTGALVDA
CCHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEC
NTVVVRRQDAPERRLTGGTILVATGSSPYRPPLYPFEDPRIHDSDEVLELERLPRSLVVV
CEEEEECCCCCCHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEE
GAGVIGCEYACMFAAMDIPVTLVEARAELLPFLDDEFSALLGQRMEALGIQLRFGQVVEQ
ECCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCEEEHHHHHHHH
VDVPRDADTPIRMMLSSGAVLETDQVLVASGRTANTAGLGLEALGVQVGPRGQVEVGPTY
HCCCCCCCCHHHHHHCCCCEEECCCEEEECCCCCCCCCCCHHHCCEEECCCCCEEECCCH
QTALPHIYAVGDVIGFPALASTSMDQARIAVEHAFDLGGVRTMAPVLPYGIYTIPEVSMA
HHHCCHHEEHHHHHCCCHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCEECCCCCCC
GETEEALRTLNVPYVAGRAAFATNPRGQILGDTHGLLKLLFHRESLKLLGVHVMGPQASE
CCHHHHHHHCCCCEEECCEEECCCCCCCEECCHHHHHHHHHHHCCEEEEEEEEECCCHHH
LVHVGLTALLTGSTARLFVETCFNYPTLSEAYKAATFDALDQLSGCP
HHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]