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The map label for this gene is srrA [H]

Identifier: 108762639

GI number: 108762639

Start: 819220

End: 820356

Strand: Direct

Name: srrA [H]

Synonym: MXAN_0715

Alternate gene names: 108762639

Gene position: 819220-820356 (Clockwise)

Preceding gene: 108761052

Following gene: 108761646

Centisome position: 8.96

GC content: 71.94

Gene sequence:

>1137_bases
TTGAGCGGCGCGCCGACGCGCGAGCGCCTGCCGGCGATTCCGGCGGAGCCCGTCTGCCTGCTGCTGGTGGATGACCAGCC
GGAGAACCTGCTGGCGCTGGAGGCGACGCTTGCGCCCCTGGGGCAGCGGCTGGTCACCGCGAGCAGCGGCCGCGAGGCGC
TGCGTCACCTGCTGACGCAGGACTTCGCCGTCATCCTCCTGGACGTCGTCATGCCGGACATGGACGGCTTCGAGACGGCC
CAGCTCATCCGCGAGCGAGAGCGCAGTCGCGGCACGCCCGTCATCTTCCTCACCGGGCTGTCGCGGGGGCCACATCCGGA
GCTGCGCGGCTATGCCATGGGCGCGGTGGACTTCCTGCTCAAGCCCTTCGAGCCCGCCATCCTGCGCTCCAAGGTGAGCG
TCTTCGTGGAGCTGTACCGCAAGACGGAGCTGGTGCGGCGGCAGGCGGAGGCGCTGCGCGAGGCCCAGCAGCGCGAGCAC
GCGCGGGAGTTGCTGGAGGCGCAGCGGCGCGTGGAGGCCGAACGGCTTCGTTCAGAAACCAACCGAAACCAGCAGCGCTG
GCTGGAGGCGGCGATTGCCGCGCTCCCCATGCCGCTGGCGTTGGTGGAGCCGGGAAGCGGCCACACCCTGCTGGCCAACC
GGGCGGCGCAAGGGCTGGCGGGGGGCTGTCTGGCCTACCGCGAGGCGCGCGCGCTGCATGCGGACGCATGCTTCCGCGGC
GCGGATGGCCGGCTGCTCGCGGATGAAGACCTGCCGCTGATGCGCGCCGCGCGCGGTGAGGTGTTCCAGGCGTTCCCCGT
GGAGTGGAACGTGGGCGGCCAGCGCGGTTCGGTGCTCGCTTCCAGTGAGCGGCTGCCTCGCATGCATGGACGCCCGGAGA
CCATGGTGCTGGGCCTCTTGGACGTGACGGCGCTCCGAGCCGCCGCTCGCCACGACTGGCTCCCCCTGCCGCTGACGGAG
CACATCGCTACACTGGAGGCGCAGGGGGAGGACACAGGCCCGCTCACTCGGCTCATCGAGGTGCTGCGGAACCTTCCGGG
CTTGAGCACCGGGAGCCCCGGACAGGAGCGCGAGGAGGGCTCCTTGCTAGCGGAAGAGGGCAGCCAGGCGGGCAACCCTC
CTCGGCCCGCGCGCTGA

Upstream 100 bases:

>100_bases
GCGGAGCGGGTGAGGAGGGAGCGATGGCGCAATTGACGTTGGGTTCCGTGGGAGGGTGGCTCGCGCGGCTGGCCTATGTG
CCGCGTTCTAAGGTGCTGCC

Downstream 100 bases:

>100_bases
ACATCGCCGGTCGAGAAATGGTTGACGCACAAAATAACATGGGCAAGGTGGCCGTGTGAGTGACGCCGGAATCCCACAGC
GGGTCCAGCGCTTCATCTCG

Product: response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MSGAPTRERLPAIPAEPVCLLLVDDQPENLLALEATLAPLGQRLVTASSGREALRHLLTQDFAVILLDVVMPDMDGFETA
QLIRERERSRGTPVIFLTGLSRGPHPELRGYAMGAVDFLLKPFEPAILRSKVSVFVELYRKTELVRRQAEALREAQQREH
ARELLEAQRRVEAERLRSETNRNQQRWLEAAIAALPMPLALVEPGSGHTLLANRAAQGLAGGCLAYREARALHADACFRG
ADGRLLADEDLPLMRAARGEVFQAFPVEWNVGGQRGSVLASSERLPRMHGRPETMVLGLLDVTALRAAARHDWLPLPLTE
HIATLEAQGEDTGPLTRLIEVLRNLPGLSTGSPGQEREEGSLLAEEGSQAGNPPRPAR

Sequences:

>Translated_378_residues
MSGAPTRERLPAIPAEPVCLLLVDDQPENLLALEATLAPLGQRLVTASSGREALRHLLTQDFAVILLDVVMPDMDGFETA
QLIRERERSRGTPVIFLTGLSRGPHPELRGYAMGAVDFLLKPFEPAILRSKVSVFVELYRKTELVRRQAEALREAQQREH
ARELLEAQRRVEAERLRSETNRNQQRWLEAAIAALPMPLALVEPGSGHTLLANRAAQGLAGGCLAYREARALHADACFRG
ADGRLLADEDLPLMRAARGEVFQAFPVEWNVGGQRGSVLASSERLPRMHGRPETMVLGLLDVTALRAAARHDWLPLPLTE
HIATLEAQGEDTGPLTRLIEVLRNLPGLSTGSPGQEREEGSLLAEEGSQAGNPPRPAR
>Mature_377_residues
SGAPTRERLPAIPAEPVCLLLVDDQPENLLALEATLAPLGQRLVTASSGREALRHLLTQDFAVILLDVVMPDMDGFETAQ
LIRERERSRGTPVIFLTGLSRGPHPELRGYAMGAVDFLLKPFEPAILRSKVSVFVELYRKTELVRRQAEALREAQQREHA
RELLEAQRRVEAERLRSETNRNQQRWLEAAIAALPMPLALVEPGSGHTLLANRAAQGLAGGCLAYREARALHADACFRGA
DGRLLADEDLPLMRAARGEVFQAFPVEWNVGGQRGSVLASSERLPRMHGRPETMVLGLLDVTALRAAARHDWLPLPLTEH
IATLEAQGEDTGPLTRLIEVLRNLPGLSTGSPGQEREEGSLLAEEGSQAGNPPRPAR

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=137, Percent_Identity=29.9270072992701, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI87082012, Length=113, Percent_Identity=33.6283185840708, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 41437; Mature: 41306

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGAPTRERLPAIPAEPVCLLLVDDQPENLLALEATLAPLGQRLVTASSGREALRHLLTQ
CCCCCCHHHCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DFAVILLDVVMPDMDGFETAQLIRERERSRGTPVIFLTGLSRGPHPELRGYAMGAVDFLL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
KPFEPAILRSKVSVFVELYRKTELVRRQAEALREAQQREHARELLEAQRRVEAERLRSET
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRNQQRWLEAAIAALPMPLALVEPGSGHTLLANRAAQGLAGGCLAYREARALHADACFRG
CCHHHHHHHHHHHHCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADGRLLADEDLPLMRAARGEVFQAFPVEWNVGGQRGSVLASSERLPRMHGRPETMVLGLL
CCCCEEECCCCHHHHHHCCCCEEECCCEECCCCCCCCEEECCCCCCCCCCCCHHHHHHHH
DVTALRAAARHDWLPLPLTEHIATLEAQGEDTGPLTRLIEVLRNLPGLSTGSPGQEREEG
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHC
SLLAEEGSQAGNPPRPAR
CEEHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SGAPTRERLPAIPAEPVCLLLVDDQPENLLALEATLAPLGQRLVTASSGREALRHLLTQ
CCCCCHHHCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DFAVILLDVVMPDMDGFETAQLIRERERSRGTPVIFLTGLSRGPHPELRGYAMGAVDFLL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
KPFEPAILRSKVSVFVELYRKTELVRRQAEALREAQQREHARELLEAQRRVEAERLRSET
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRNQQRWLEAAIAALPMPLALVEPGSGHTLLANRAAQGLAGGCLAYREARALHADACFRG
CCHHHHHHHHHHHHCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADGRLLADEDLPLMRAARGEVFQAFPVEWNVGGQRGSVLASSERLPRMHGRPETMVLGLL
CCCCEEECCCCHHHHHHCCCCEEECCCEECCCCCCCCEEECCCCCCCCCCCCHHHHHHHH
DVTALRAAARHDWLPLPLTEHIATLEAQGEDTGPLTRLIEVLRNLPGLSTGSPGQEREEG
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHC
SLLAEEGSQAGNPPRPAR
CEEHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA