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The map label for this gene is ahpC [C]

Identifier: 108762609

GI number: 108762609

Start: 1836128

End: 1836682

Strand: Reverse

Name: ahpC [C]

Synonym: MXAN_1564

Alternate gene names: 108762609

Gene position: 1836682-1836128 (Counterclockwise)

Preceding gene: 108762118

Following gene: 108761398

Centisome position: 20.1

GC content: 63.24

Gene sequence:

>555_bases
ATGCTGACCGTTGGCGACAAGATCCCGAACTTCAAGGTGAAGGCCACCGTGTCCCTGGAGAAGGGCAAGGAGTTCCAGGA
CATCACGAACGAGACCTTCAAGGGCAAGTGGCTGGTCCTGTTCGCGTGGCCGAAGGACTTCACCTTCATCTGCCCCACGG
AGATCGCGGAGTTCGGCAAGAAGAACAAGGACTTCACTGACCGTGACGCGCAGGTCCTCGGCCTGAGCACCGACAGCGAG
TTCGTGCACCACGCGTGGCGCACGCACCACCCGGACCTGAAGAACCTGCCCTTCCCGATGCTGGCGGACATCAAGCACGA
GCTGTGCAACGCGCTGGGCATCCTCCACAAGGAAGAGGGCGTGGCCCTCCGCGCGACGTTCATCGCGGACCCCGAGGGCA
TCATCCGCCACGTGACGGTCAACGACCTGTCCGTGGGCCGCAACGTCTCCGAGACGATTCGCACGCTGGACGCGCTCCAG
ACGGACGAGCTGTGCCCCTGCAACTGGACCAAGGGTGAGGAGACCCTGACCCAGAAGCTGTCGAAGGCGGGGTAA

Upstream 100 bases:

>100_bases
TCATTGATTCGAGGTTCTGGCACGGTGACTGCTAAGCGGTAGGACAGAACACGTTCACTGGGGTCGGCTCACCGCCGGGC
CCCCATCCCAAGGAGCCGTA

Downstream 100 bases:

>100_bases
TCCACCATGGCCTCGCTCGAAGTCGTCCGCTCTGAACTCGCGGACTCCCACAAGGACACCCGCCTCAACCTCCAGGGTGT
CCTGGAAGGTGGCAGCCTCA

Product: alkyl hydroperoxide reductase C

Products: NA

Alternate protein names: Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MLTVGDKIPNFKVKATVSLEKGKEFQDITNETFKGKWLVLFAWPKDFTFICPTEIAEFGKKNKDFTDRDAQVLGLSTDSE
FVHHAWRTHHPDLKNLPFPMLADIKHELCNALGILHKEEGVALRATFIADPEGIIRHVTVNDLSVGRNVSETIRTLDALQ
TDELCPCNWTKGEETLTQKLSKAG

Sequences:

>Translated_184_residues
MLTVGDKIPNFKVKATVSLEKGKEFQDITNETFKGKWLVLFAWPKDFTFICPTEIAEFGKKNKDFTDRDAQVLGLSTDSE
FVHHAWRTHHPDLKNLPFPMLADIKHELCNALGILHKEEGVALRATFIADPEGIIRHVTVNDLSVGRNVSETIRTLDALQ
TDELCPCNWTKGEETLTQKLSKAG
>Mature_184_residues
MLTVGDKIPNFKVKATVSLEKGKEFQDITNETFKGKWLVLFAWPKDFTFICPTEIAEFGKKNKDFTDRDAQVLGLSTDSE
FVHHAWRTHHPDLKNLPFPMLADIKHELCNALGILHKEEGVALRATFIADPEGIIRHVTVNDLSVGRNVSETIRTLDALQ
TDELCPCNWTKGEETLTQKLSKAG

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=187, Percent_Identity=40.6417112299465, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI32455266, Length=187, Percent_Identity=40.6417112299465, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI32455264, Length=187, Percent_Identity=40.6417112299465, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI32189392, Length=180, Percent_Identity=41.6666666666667, Blast_Score=146, Evalue=8e-36,
Organism=Homo sapiens, GI32483377, Length=178, Percent_Identity=41.5730337078652, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI5802974, Length=181, Percent_Identity=41.4364640883978, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI5453549, Length=160, Percent_Identity=40.625, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI4758638, Length=192, Percent_Identity=28.6458333333333, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI33188454, Length=88, Percent_Identity=42.0454545454545, Blast_Score=80, Evalue=7e-16,
Organism=Escherichia coli, GI1786822, Length=189, Percent_Identity=33.8624338624339, Blast_Score=123, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI193204376, Length=180, Percent_Identity=41.6666666666667, Blast_Score=150, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI32565831, Length=180, Percent_Identity=41.6666666666667, Blast_Score=149, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17554494, Length=178, Percent_Identity=41.0112359550562, Blast_Score=146, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI25153706, Length=194, Percent_Identity=30.4123711340206, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320661, Length=181, Percent_Identity=46.4088397790055, Blast_Score=149, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323613, Length=181, Percent_Identity=45.8563535911602, Blast_Score=148, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6319407, Length=191, Percent_Identity=31.413612565445, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17738015, Length=187, Percent_Identity=40.6417112299465, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI17157991, Length=166, Percent_Identity=42.1686746987952, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24641739, Length=166, Percent_Identity=42.1686746987952, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21357347, Length=183, Percent_Identity=37.7049180327869, Blast_Score=136, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24656348, Length=176, Percent_Identity=38.6363636363636, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17864676, Length=176, Percent_Identity=38.6363636363636, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17975518, Length=191, Percent_Identity=32.4607329842932, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24652436, Length=191, Percent_Identity=32.4607329842932, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24652434, Length=191, Percent_Identity=32.4607329842932, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24581278, Length=195, Percent_Identity=28.7179487179487, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20733; Mature: 20733

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVGDKIPNFKVKATVSLEKGKEFQDITNETFKGKWLVLFAWPKDFTFICPTEIAEFGK
CCCCCCCCCCEEEEEEEECCCCCCHHHHHCCCCCCCEEEEEECCCCCEEECCHHHHHHCC
KNKDFTDRDAQVLGLSTDSEFVHHAWRTHHPDLKNLPFPMLADIKHELCNALGILHKEEG
CCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCC
VALRATFIADPEGIIRHVTVNDLSVGRNVSETIRTLDALQTDELCPCNWTKGEETLTQKL
CEEEEEEEECCCHHEEEEEECCHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
SKAG
HHCC
>Mature Secondary Structure
MLTVGDKIPNFKVKATVSLEKGKEFQDITNETFKGKWLVLFAWPKDFTFICPTEIAEFGK
CCCCCCCCCCEEEEEEEECCCCCCHHHHHCCCCCCCEEEEEECCCCCEEECCHHHHHHCC
KNKDFTDRDAQVLGLSTDSEFVHHAWRTHHPDLKNLPFPMLADIKHELCNALGILHKEEG
CCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCC
VALRATFIADPEGIIRHVTVNDLSVGRNVSETIRTLDALQTDELCPCNWTKGEETLTQKL
CEEEEEEEECCCHHEEEEEECCHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
SKAG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA