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The map label for this gene is rfbA [H]

Identifier: 108762461

GI number: 108762461

Start: 5785784

End: 5786671

Strand: Reverse

Name: rfbA [H]

Synonym: MXAN_4611

Alternate gene names: 108762461

Gene position: 5786671-5785784 (Counterclockwise)

Preceding gene: 108763033

Following gene: 108759544

Centisome position: 63.31

GC content: 65.54

Gene sequence:

>888_bases
GTGGACATGAAGGGCATCATCCTCGCCGGTGGCTCGGGGACGCGGCTGTACCCACTGACGCGCGTGGTCAGCAAGCAGTT
GCTGCCCGTGCATGACAAGCCGATGATCTACTACCCCCTGAGCACACTGATGCTCGCGGGTATCCGGGACGTGCTGGTCA
TCTCCACGCCGCAGGACCTGCCGCGCTTCCAAGAACTGCTGGGCAGCGGCGACCAGTGGGGCATGCGTTTCAGCTATGCG
GAGCAGCCCAAGCCGGACGGCCTGGCCCAGGCCTTCGTCATCGGCCGGGACTTCGTGGGCGCTGACAGCGTGTCGCTGGT
GCTGGGCGACAACATCTTCTACGGCCACGGCCTGAGCGAGCTGGTGAAGCGCGCGGCGTCGCGTACCTCGGGAGCGACGG
TGTTCGGGTACTACGTGAAGGACCCGGAGCGTTACGGCGTGGTGGAGCTGGACGCGAAGAACCGAGCGGTGAGCCTGGAG
GAGAAGCCGCTGAAGCCGAAGTCCAACTACGCCGTCACCGGGCTGTACTTCTACGACAACCAGGTGCTGGACATCGCCGC
GGGCCTCAAGCCGAGCAAGCGGGGTGAGTTGGAGATTACCGACGTCAACGCGGAGTACCTGCGACGCGGCCAGCTCGACG
TGGAGCTCATGGGGCGTGGCTACGCGTGGCTGGACACCGGCACGCACGAGTCGCTGATGCAGGCGTCGAACTTCATCGAA
ATCATCGAGCGCCGCCAGGGCCTCAAGGTGTCGTGCCCGGAGGAGATTGCGTTCCGCATGGGATACATCGGCGCGCAGCA
ACTGCTGACGCTGGCCGAGCCCATGCTCAAGAACGACTACGGCCAGTACCTGCGGGCGCTCGCGGAGAACCGGGGGGCCG
TTTCGTGA

Upstream 100 bases:

>100_bases
GGTGCGTGCCGAACTTTCCGTTCCTCCCTTGGCGCTCGCGGAGTCCTTGTCGCGCTTCCATGCGACCTGGCTCGCGGCTC
GGGGACACTGACGTGCCGAG

Downstream 100 bases:

>100_bases
AGGTGACGCCGCTGGAGATTCCGGACGTGCTGCTGCTGGAGCCCAAGGTCTTCGGTGATGACCGCGGCTTCTTCATGGAG
ATGTTCCATGCGGCGCGGTA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MDMKGIILAGGSGTRLYPLTRVVSKQLLPVHDKPMIYYPLSTLMLAGIRDVLVISTPQDLPRFQELLGSGDQWGMRFSYA
EQPKPDGLAQAFVIGRDFVGADSVSLVLGDNIFYGHGLSELVKRAASRTSGATVFGYYVKDPERYGVVELDAKNRAVSLE
EKPLKPKSNYAVTGLYFYDNQVLDIAAGLKPSKRGELEITDVNAEYLRRGQLDVELMGRGYAWLDTGTHESLMQASNFIE
IIERRQGLKVSCPEEIAFRMGYIGAQQLLTLAEPMLKNDYGQYLRALAENRGAVS

Sequences:

>Translated_295_residues
MDMKGIILAGGSGTRLYPLTRVVSKQLLPVHDKPMIYYPLSTLMLAGIRDVLVISTPQDLPRFQELLGSGDQWGMRFSYA
EQPKPDGLAQAFVIGRDFVGADSVSLVLGDNIFYGHGLSELVKRAASRTSGATVFGYYVKDPERYGVVELDAKNRAVSLE
EKPLKPKSNYAVTGLYFYDNQVLDIAAGLKPSKRGELEITDVNAEYLRRGQLDVELMGRGYAWLDTGTHESLMQASNFIE
IIERRQGLKVSCPEEIAFRMGYIGAQQLLTLAEPMLKNDYGQYLRALAENRGAVS
>Mature_295_residues
MDMKGIILAGGSGTRLYPLTRVVSKQLLPVHDKPMIYYPLSTLMLAGIRDVLVISTPQDLPRFQELLGSGDQWGMRFSYA
EQPKPDGLAQAFVIGRDFVGADSVSLVLGDNIFYGHGLSELVKRAASRTSGATVFGYYVKDPERYGVVELDAKNRAVSLE
EKPLKPKSNYAVTGLYFYDNQVLDIAAGLKPSKRGELEITDVNAEYLRRGQLDVELMGRGYAWLDTGTHESLMQASNFIE
IIERRQGLKVSCPEEIAFRMGYIGAQQLLTLAEPMLKNDYGQYLRALAENRGAVS

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=271, Percent_Identity=26.1992619926199, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI11761619, Length=271, Percent_Identity=26.1992619926199, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788351, Length=287, Percent_Identity=70.0348432055749, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1790224, Length=289, Percent_Identity=61.5916955017301, Blast_Score=378, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI133931050, Length=191, Percent_Identity=28.2722513089005, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355443, Length=233, Percent_Identity=26.1802575107296, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644084, Length=233, Percent_Identity=26.1802575107296, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32711; Mature: 32711

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMKGIILAGGSGTRLYPLTRVVSKQLLPVHDKPMIYYPLSTLMLAGIRDVLVISTPQDL
CCCCCEEEECCCCCEEHHHHHHHHHHCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFQELLGSGDQWGMRFSYAEQPKPDGLAQAFVIGRDFVGADSVSLVLGDNIFYGHGLSE
HHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHEECCCCCCCCCEEEEECCCEEECCCHHH
LVKRAASRTSGATVFGYYVKDPERYGVVELDAKNRAVSLEEKPLKPKSNYAVTGLYFYDN
HHHHHHCCCCCCEEEEEEECCCCCCCEEEECCCCCEEECCCCCCCCCCCEEEEEEEEECC
QVLDIAAGLKPSKRGELEITDVNAEYLRRGQLDVELMGRGYAWLDTGTHESLMQASNFIE
CEEEHCCCCCCCCCCCEEEEECCHHHHHCCCCCEEEECCCEEEEECCCHHHHHHHHHHHH
IIERRQGLKVSCPEEIAFRMGYIGAQQLLTLAEPMLKNDYGQYLRALAENRGAVS
HHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDMKGIILAGGSGTRLYPLTRVVSKQLLPVHDKPMIYYPLSTLMLAGIRDVLVISTPQDL
CCCCCEEEECCCCCEEHHHHHHHHHHCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFQELLGSGDQWGMRFSYAEQPKPDGLAQAFVIGRDFVGADSVSLVLGDNIFYGHGLSE
HHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHEECCCCCCCCCEEEEECCCEEECCCHHH
LVKRAASRTSGATVFGYYVKDPERYGVVELDAKNRAVSLEEKPLKPKSNYAVTGLYFYDN
HHHHHHCCCCCCEEEEEEECCCCCCCEEEECCCCCEEECCCCCCCCCCCEEEEEEEEECC
QVLDIAAGLKPSKRGELEITDVNAEYLRRGQLDVELMGRGYAWLDTGTHESLMQASNFIE
CEEEHCCCCCCCCCCCEEEEECCHHHHHCCCCCEEEECCCEEEEECCCHHHHHHHHHHHH
IIERRQGLKVSCPEEIAFRMGYIGAQQLLTLAEPMLKNDYGQYLRALAENRGAVS
HHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]