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The map label for this gene is relA [H]

Identifier: 108762300

GI number: 108762300

Start: 3752571

End: 3754832

Strand: Direct

Name: relA [H]

Synonym: MXAN_3204

Alternate gene names: 108762300

Gene position: 3752571-3754832 (Clockwise)

Preceding gene: 108760153

Following gene: 108763061

Centisome position: 41.06

GC content: 64.19

Gene sequence:

>2262_bases
TTGCCCCTCCGTTGGTGCAAAGTTACGATTGCTCCTCATTCGATGATTCGCCTGAACGACATCCTCCAACGGGTTTCCCA
GTACCACCCCGACCCCGACCTGGACATCATCAAGAAGGCCTACGTCTATTCGGCCAAGGTCCATCAGGGTCAACTCCGGA
AGTCAGGCGAGCCCTACCTCGTCCATCCGCTCGAGGTCGCCGGCATCCTGGGCGAGCTCAAGCTGGACGAGGCGTCCATC
GTCACCGGACTCCTTCACGACACCATTGAGGACACGCTGGCCACCGAGGAGGAGCTGACGGAGCTCTTCGGTTCGGAAGT
AGCCCACCTGGTAGACGGCGTCACCAAGCTGTCCAAGTTCTCCGCATCCGCCAGCCTGTCGCAGGAGGAGAAGCAGGCGG
AGAACTTCCGGAAGATGATCATCGCGATGGCGCAGGACATCCGCGTCATCCTGGTGAAGCTGGCGGACCGCACGCACAAC
ATGCGGACGTTGGATCACATGTCGGAGGAGAAGCAGGCCCGCATCGCGCAGGAGACGCTGGACATCTACGCGCCGCTGGC
CAACCGGCTGGGCATCTCGTGGATCAAGACGGAGCTGGAGGACCTGAGCTTCCGCTACGTCAAACCGCAGGAGTTCTTCG
CGCTCCAGGCGAAGCTGAACAAGCGCAAGAAGGAGCGGGAGAAGTACATCGAGGACACGTGCGACCTCATCCGCTCCAAG
CTGGCCGAGCGCGGGCTGAAGGGCGAGGTGAGCGGACGCTTCAAGCACGTCTACAGCATCTACAAGAAGATCAAGTCACA
GGGCATCGACTTCGATCAGATCCACGACATCATCGCCTTTCGCATCATCGCGCCCACCGCGCCCTCCTGTTACGAGGCGC
TGGGGCTCGTGCACGAGATGTGGAAGCCGGTGCCGGGGCGCTTCAAGGACTTCATCGCGATTCCGAAGCCCAACATGTAC
CAGTCGCTGCACACGACCATCATCGGTCCGCTCAGCGAGCGCGTGGAGGTGCAGATCCGCACCTCGGAGATGCACAAGAT
CGCCGAGGAAGGCATCGCCGCGCACTGGAAGTACAAGGAGGGCAAGGCCGTCATCTCCAAGGATGACGAGAAGTTCGCCT
GGCTGCGGCAGCTGATGGAGTGGCAGCAGGACCTGAAGGACCCGAAGGAGTTCCTGGAGACGGTGAAGGTGGACCTCTTC
ACCGACGAGGTCTTCGTCTTCACGCCCAAGGGCGACGTGCGCTCGCTGCCTCGCGGCGCCACGCCGGTGGACTTCGCCTA
CGCCATCCATTCGGACGTGGGCAACCGGTGCGTGGGCGCCAAGGTGAACGGGAAGATCGTCCCGCTCCGCTACAAGATGA
AGAACGGGGACACGGTGGAGGTGCTCACCAGCCCCCAGCAGCACCCGTCCAAGGATTGGCTCACCTTCGTCAAGACGAGC
CGGGCGCAGCAGCGCATCCGCGGCTTCATCAAGCAGCAGCAGCGCGAGAAGAGCCTTCAGCTGGGACGCGAGCTGGCGGA
CCGCGAGCTCAAGCGCTTCCAGCTCAACTTCAACCGGTTGCTCAAGTCCGGCGAGATGAAGAAGGCCGCCGTGGACCTGG
GCTTCCGTGTGGAAGACGACATGCTGGTGGCCATTGGCTACGGCAAGGTGACGCCGCAGCAGCTGTCGCACCGGCTCGTC
CCCCAGGAGAAGCTCAACGCCGCGGAGGCCGGGGGGCGCGCGGATGCCAACCCCGCCGCGACAACCTCCGGTGGAGCCGG
CAACTCGGTGCTGCCGGGCCTGTCCCGGGTCACCGACCTGGCGAAGCGGCTGGTGGGCCGCAGCAACCGCAGCGGCGTAC
AGATTGGCGGCGTGGACGATGTCCTCGTGCGCTTCGGGCGGTGTTGCAACCCCGTCCCCGGAGATCCCATCGCCGGCTTC
ATCACCCGGGGGCGGGGCGTCACGGTTCACACGGTCGGCTGTGAAAAGGCACTGGCCACGGACCCCGAGCGGCGCGTGGA
CGTGTCGTGGGACGTCCGGGGCGACTTCAAGCGCCCCGTCACCCTGCGCGTCCTCACTGCGGACCGGCCGGGCCTGCTGG
CGGACATCACCAACACCTTCTCCAAGAAGGGCGTCAACATCTCCCAGGCCAACTGCCGGGCCACCGGAGATGACCGGGCG
GTGAACACTTTCGAGGTCATCATCTCCGACCTCAAGCAGCTCACCGACCTGATGCGAACCATCGAGCGGCTCCAGGGCGT
CTACTCGGTCGAGCGCATCTAA

Upstream 100 bases:

>100_bases
CGGAGGCGAATCTACGGGGCCGTAAAACACCGGGTCAACGAAAGCGAACGCACCAACTGGGGTGTCCTAGAGGAAGGTGA
CGTCCAGGTGTGGGGCAACG

Downstream 100 bases:

>100_bases
CCGCCTTCGCCTTTCGTGGTAGAGCGCCCGGAAACCCCGGCGGCCCGATTCGGGCCGCTCTCACCCCGAGGTGCGCCGCA
TGGCTCGCAAGGCAATCCAC

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 753; Mature: 752

Protein sequence:

>753_residues
MPLRWCKVTIAPHSMIRLNDILQRVSQYHPDPDLDIIKKAYVYSAKVHQGQLRKSGEPYLVHPLEVAGILGELKLDEASI
VTGLLHDTIEDTLATEEELTELFGSEVAHLVDGVTKLSKFSASASLSQEEKQAENFRKMIIAMAQDIRVILVKLADRTHN
MRTLDHMSEEKQARIAQETLDIYAPLANRLGISWIKTELEDLSFRYVKPQEFFALQAKLNKRKKEREKYIEDTCDLIRSK
LAERGLKGEVSGRFKHVYSIYKKIKSQGIDFDQIHDIIAFRIIAPTAPSCYEALGLVHEMWKPVPGRFKDFIAIPKPNMY
QSLHTTIIGPLSERVEVQIRTSEMHKIAEEGIAAHWKYKEGKAVISKDDEKFAWLRQLMEWQQDLKDPKEFLETVKVDLF
TDEVFVFTPKGDVRSLPRGATPVDFAYAIHSDVGNRCVGAKVNGKIVPLRYKMKNGDTVEVLTSPQQHPSKDWLTFVKTS
RAQQRIRGFIKQQQREKSLQLGRELADRELKRFQLNFNRLLKSGEMKKAAVDLGFRVEDDMLVAIGYGKVTPQQLSHRLV
PQEKLNAAEAGGRADANPAATTSGGAGNSVLPGLSRVTDLAKRLVGRSNRSGVQIGGVDDVLVRFGRCCNPVPGDPIAGF
ITRGRGVTVHTVGCEKALATDPERRVDVSWDVRGDFKRPVTLRVLTADRPGLLADITNTFSKKGVNISQANCRATGDDRA
VNTFEVIISDLKQLTDLMRTIERLQGVYSVERI

Sequences:

>Translated_753_residues
MPLRWCKVTIAPHSMIRLNDILQRVSQYHPDPDLDIIKKAYVYSAKVHQGQLRKSGEPYLVHPLEVAGILGELKLDEASI
VTGLLHDTIEDTLATEEELTELFGSEVAHLVDGVTKLSKFSASASLSQEEKQAENFRKMIIAMAQDIRVILVKLADRTHN
MRTLDHMSEEKQARIAQETLDIYAPLANRLGISWIKTELEDLSFRYVKPQEFFALQAKLNKRKKEREKYIEDTCDLIRSK
LAERGLKGEVSGRFKHVYSIYKKIKSQGIDFDQIHDIIAFRIIAPTAPSCYEALGLVHEMWKPVPGRFKDFIAIPKPNMY
QSLHTTIIGPLSERVEVQIRTSEMHKIAEEGIAAHWKYKEGKAVISKDDEKFAWLRQLMEWQQDLKDPKEFLETVKVDLF
TDEVFVFTPKGDVRSLPRGATPVDFAYAIHSDVGNRCVGAKVNGKIVPLRYKMKNGDTVEVLTSPQQHPSKDWLTFVKTS
RAQQRIRGFIKQQQREKSLQLGRELADRELKRFQLNFNRLLKSGEMKKAAVDLGFRVEDDMLVAIGYGKVTPQQLSHRLV
PQEKLNAAEAGGRADANPAATTSGGAGNSVLPGLSRVTDLAKRLVGRSNRSGVQIGGVDDVLVRFGRCCNPVPGDPIAGF
ITRGRGVTVHTVGCEKALATDPERRVDVSWDVRGDFKRPVTLRVLTADRPGLLADITNTFSKKGVNISQANCRATGDDRA
VNTFEVIISDLKQLTDLMRTIERLQGVYSVERI
>Mature_752_residues
PLRWCKVTIAPHSMIRLNDILQRVSQYHPDPDLDIIKKAYVYSAKVHQGQLRKSGEPYLVHPLEVAGILGELKLDEASIV
TGLLHDTIEDTLATEEELTELFGSEVAHLVDGVTKLSKFSASASLSQEEKQAENFRKMIIAMAQDIRVILVKLADRTHNM
RTLDHMSEEKQARIAQETLDIYAPLANRLGISWIKTELEDLSFRYVKPQEFFALQAKLNKRKKEREKYIEDTCDLIRSKL
AERGLKGEVSGRFKHVYSIYKKIKSQGIDFDQIHDIIAFRIIAPTAPSCYEALGLVHEMWKPVPGRFKDFIAIPKPNMYQ
SLHTTIIGPLSERVEVQIRTSEMHKIAEEGIAAHWKYKEGKAVISKDDEKFAWLRQLMEWQQDLKDPKEFLETVKVDLFT
DEVFVFTPKGDVRSLPRGATPVDFAYAIHSDVGNRCVGAKVNGKIVPLRYKMKNGDTVEVLTSPQQHPSKDWLTFVKTSR
AQQRIRGFIKQQQREKSLQLGRELADRELKRFQLNFNRLLKSGEMKKAAVDLGFRVEDDMLVAIGYGKVTPQQLSHRLVP
QEKLNAAEAGGRADANPAATTSGGAGNSVLPGLSRVTDLAKRLVGRSNRSGVQIGGVDDVLVRFGRCCNPVPGDPIAGFI
TRGRGVTVHTVGCEKALATDPERRVDVSWDVRGDFKRPVTLRVLTADRPGLLADITNTFSKKGVNISQANCRATGDDRAV
NTFEVIISDLKQLTDLMRTIERLQGVYSVERI

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=753, Percent_Identity=40.5046480743692, Blast_Score=540, Evalue=1e-154,
Organism=Escherichia coli, GI1789147, Length=729, Percent_Identity=36.8998628257888, Blast_Score=486, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84739; Mature: 84607

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRWCKVTIAPHSMIRLNDILQRVSQYHPDPDLDIIKKAYVYSAKVHQGQLRKSGEPYL
CCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
VHPLEVAGILGELKLDEASIVTGLLHDTIEDTLATEEELTELFGSEVAHLVDGVTKLSKF
ECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SASASLSQEEKQAENFRKMIIAMAQDIRVILVKLADRTHNMRTLDHMSEEKQARIAQETL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
DIYAPLANRLGISWIKTELEDLSFRYVKPQEFFALQAKLNKRKKEREKYIEDTCDLIRSK
HHHHHHHHHCCHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAERGLKGEVSGRFKHVYSIYKKIKSQGIDFDQIHDIIAFRIIAPTAPSCYEALGLVHEM
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHH
WKPVPGRFKDFIAIPKPNMYQSLHTTIIGPLSERVEVQIRTSEMHKIAEEGIAAHWKYKE
HCCCCCCHHHEEECCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCEEEEECC
GKAVISKDDEKFAWLRQLMEWQQDLKDPKEFLETVKVDLFTDEVFVFTPKGDVRSLPRGA
CCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCEEEECCCCCHHCCCCCC
TPVDFAYAIHSDVGNRCVGAKVNGKIVPLRYKMKNGDTVEVLTSPQQHPSKDWLTFVKTS
CCHHHHHHHHHCCCCCEECCCCCCEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHH
RAQQRIRGFIKQQQREKSLQLGRELADRELKRFQLNFNRLLKSGEMKKAAVDLGFRVEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEECCC
MLVAIGYGKVTPQQLSHRLVPQEKLNAAEAGGRADANPAATTSGGAGNSVLPGLSRVTDL
EEEEEECCCCCHHHHHHHCCCHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AKRLVGRSNRSGVQIGGVDDVLVRFGRCCNPVPGDPIAGFITRGRGVTVHTVGCEKALAT
HHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCEEEEECCCCHHHCC
DPERRVDVSWDVRGDFKRPVTLRVLTADRPGLLADITNTFSKKGVNISQANCRATGDDRA
CCCCCEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCC
VNTFEVIISDLKQLTDLMRTIERLQGVYSVERI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLRWCKVTIAPHSMIRLNDILQRVSQYHPDPDLDIIKKAYVYSAKVHQGQLRKSGEPYL
CCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
VHPLEVAGILGELKLDEASIVTGLLHDTIEDTLATEEELTELFGSEVAHLVDGVTKLSKF
ECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SASASLSQEEKQAENFRKMIIAMAQDIRVILVKLADRTHNMRTLDHMSEEKQARIAQETL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
DIYAPLANRLGISWIKTELEDLSFRYVKPQEFFALQAKLNKRKKEREKYIEDTCDLIRSK
HHHHHHHHHCCHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAERGLKGEVSGRFKHVYSIYKKIKSQGIDFDQIHDIIAFRIIAPTAPSCYEALGLVHEM
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHH
WKPVPGRFKDFIAIPKPNMYQSLHTTIIGPLSERVEVQIRTSEMHKIAEEGIAAHWKYKE
HCCCCCCHHHEEECCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCEEEEECC
GKAVISKDDEKFAWLRQLMEWQQDLKDPKEFLETVKVDLFTDEVFVFTPKGDVRSLPRGA
CCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCEEEECCCCCHHCCCCCC
TPVDFAYAIHSDVGNRCVGAKVNGKIVPLRYKMKNGDTVEVLTSPQQHPSKDWLTFVKTS
CCHHHHHHHHHCCCCCEECCCCCCEEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHH
RAQQRIRGFIKQQQREKSLQLGRELADRELKRFQLNFNRLLKSGEMKKAAVDLGFRVEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEECCC
MLVAIGYGKVTPQQLSHRLVPQEKLNAAEAGGRADANPAATTSGGAGNSVLPGLSRVTDL
EEEEEECCCCCHHHHHHHCCCHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AKRLVGRSNRSGVQIGGVDDVLVRFGRCCNPVPGDPIAGFITRGRGVTVHTVGCEKALAT
HHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCCCCCHHHHHCCCCCEEEEECCCCHHHCC
DPERRVDVSWDVRGDFKRPVTLRVLTADRPGLLADITNTFSKKGVNISQANCRATGDDRA
CCCCCEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCC
VNTFEVIISDLKQLTDLMRTIERLQGVYSVERI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA