Click here to switch to the map view.

The map label for this gene is cwhA [H]

Identifier: 108762055

GI number: 108762055

Start: 403478

End: 405337

Strand: Direct

Name: cwhA [H]

Synonym: MXAN_0345

Alternate gene names: 108762055

Gene position: 403478-405337 (Clockwise)

Preceding gene: 108757076

Following gene: 108763053

Centisome position: 4.41

GC content: 68.55

Gene sequence:

>1860_bases
ATGTGCGTCATTCCTGATTCCGGGTGGTTGCACCGTCGGGGGCCCGGGTTCGAGGGCAGATTTCTTGACGGGAAGGTGGA
GCATCCATGCTCCACCTGGGGTCGGGAAAAAGAGGTGCTCCCTGGGAATGCGCGGCTGGCATGCATGGTGCTCAGGAGTG
GCCCCCTGCGCCGCTCCCGTGGGACGGGGGCGACCGTGGAGCTGCTGACCCCCCTTCAAGGAGTTTCCATGCACGTGTTG
CGCAAGACGTTCGCGGTGACGGCCGCGGCCATGGCCCTGGCGGCCTGTGGCCCCCAGCCCGAAACGTCTCCGGAAGAAAC
AGCACCTGAGTCGCAGGTTCCCGCAGGCGCGGTGGACGACGCCGCCCGCGCGGTGGCCGACGCGGCTCGCCGCACGCCCA
ACGAACTGGACGCGCAGTTCACGAAGGCCGCTGGTGAGTTCAACGTTCCGGTGAGCCTGCTCAAGGCCATCTCCTACGCG
GAGACGCGCTGGGAGCACGTCCGCGGCGAGGAGGAGTTCGAGGGCCGCCCGGCGGCCTTTGGTCTGCTGGCCCTGCGCGG
TCAGCTCATCACCGACGGCGCCGCCCTGGCGGGTGTGTCCGCGGACGCGGTGCGTGACGAGCCGCTGGCCAACCTGCGCG
CCGGCGCTGCGCTGCTGTCGAAGTACGCCGATGAGGCGGGCATCGACCGCGCGGACCTGGGCGCGTGGGCCCCGGTGGCC
GTGCGCCTGACGGACATCTCCGACCCGGACATCCAGGCGCACTACATCCACAACGACGTGTACTCGGTGCTGCGCGAGGG
CGCGGGCGCCTTCACGCCGGCGGGCAAGGTGGCTGTGTCGCTGGAGGCCACCCAGGTCGAGCCGAAGTTCGCCCTGCCGA
AGATGCAGGCCCTTGCGGCCGGCCCGGACTACGCGGCCTCCATCTGGCGCCCGTCGCCCAACTACAACGCGCGGCCCGCT
GGCATCGGTCAGCAAATGGTCGTCATCCACACCTGTGAGGGTGGCTACTCGGGTTGCTGGAGCTGGCTGACCAACTCCGC
CGCGGGAGTGAGCGCGCACTACGTGGTCAACGAGAGCGGCACCGAGGTGTCGCAGCTCGTGCGTGAGTCGAGCCGCGCTT
GGCACGTGGCCGCTGCCTACCGCAGCAGCCTCAACGGCGGCGTCAAGTCGAACCTCAACGGCCGGTCGACGAACGACTTC
TCCATCGGCATCGAGCACGGTGGCTACGCCAGCTCGGCCTCGTTCTCCACGGGGATGATCACCACCTCCGCCAAGCTGAC
GTGCAACATCACCCGGGACCAGGGCATCCCGCGCGACAGCTACCACATCGTGGCGCACGGCCGGCTGCAGCCGGAGACCC
GCACGGACCCGGGCCCCAACTGGCCGTGGTCCACGTACATCAGCAAGATTCGCAGCGAGTGTGGTGACGGCGGCGGTGGA
ACGAACCCGGTCATCGTCGTGGACAGCAACAACGCCAACAACGACTCCAGCAAGGGCTACATCGCGGTGCCGTCCACCTG
GGCGCGTGGCACCAGCGCGGGCTACTACGGCAACGACTACTACTACGCCTCCACGCAGCCCGTCTCCGAGCCGGCGGTGT
TCCACTTCCACATGCCTGCGGCGGGCAGCCGGACCATCCAGGCCTGGTGGGTGCAGGGCACCAACCGCTCTCCCGCGGCG
CCCTTCATGATTACGCACGCGGGCGGCAACAGCACGGTGACGGTGAACCAGCAGACCAACGGCAGCAAGTGGGTGACGCT
GGGCACCTACAACTTCAACGCCGGCTGGAACAAGGTGCAGCTGAGCCGCTGGGCCACCGAAGGCTACGTCGTCATGGCGG
ACGCCCTCCGGATTCAGTGA

Upstream 100 bases:

>100_bases
GAACTGGAAAGGTAGTAAATAAACTTTACGTCGGGCTGTCTCGAAACACGTCAGTGCGACATCGGTTGGCCAATCCGACG
CCTGGATTGTCAGGGCTTAC

Downstream 100 bases:

>100_bases
GGTGGTGATGCGGGGCCTTGAACGGCTTCAACGTTCCTGGCCGTGGCGGGCGCGGTGTCTGACCGCGCTCGCCGTGCTCG
GTGTCGGATGTTCCGGCCGG

Product: putative N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MCVIPDSGWLHRRGPGFEGRFLDGKVEHPCSTWGREKEVLPGNARLACMVLRSGPLRRSRGTGATVELLTPLQGVSMHVL
RKTFAVTAAAMALAACGPQPETSPEETAPESQVPAGAVDDAARAVADAARRTPNELDAQFTKAAGEFNVPVSLLKAISYA
ETRWEHVRGEEEFEGRPAAFGLLALRGQLITDGAALAGVSADAVRDEPLANLRAGAALLSKYADEAGIDRADLGAWAPVA
VRLTDISDPDIQAHYIHNDVYSVLREGAGAFTPAGKVAVSLEATQVEPKFALPKMQALAAGPDYAASIWRPSPNYNARPA
GIGQQMVVIHTCEGGYSGCWSWLTNSAAGVSAHYVVNESGTEVSQLVRESSRAWHVAAAYRSSLNGGVKSNLNGRSTNDF
SIGIEHGGYASSASFSTGMITTSAKLTCNITRDQGIPRDSYHIVAHGRLQPETRTDPGPNWPWSTYISKIRSECGDGGGG
TNPVIVVDSNNANNDSSKGYIAVPSTWARGTSAGYYGNDYYYASTQPVSEPAVFHFHMPAAGSRTIQAWWVQGTNRSPAA
PFMITHAGGNSTVTVNQQTNGSKWVTLGTYNFNAGWNKVQLSRWATEGYVVMADALRIQ

Sequences:

>Translated_619_residues
MCVIPDSGWLHRRGPGFEGRFLDGKVEHPCSTWGREKEVLPGNARLACMVLRSGPLRRSRGTGATVELLTPLQGVSMHVL
RKTFAVTAAAMALAACGPQPETSPEETAPESQVPAGAVDDAARAVADAARRTPNELDAQFTKAAGEFNVPVSLLKAISYA
ETRWEHVRGEEEFEGRPAAFGLLALRGQLITDGAALAGVSADAVRDEPLANLRAGAALLSKYADEAGIDRADLGAWAPVA
VRLTDISDPDIQAHYIHNDVYSVLREGAGAFTPAGKVAVSLEATQVEPKFALPKMQALAAGPDYAASIWRPSPNYNARPA
GIGQQMVVIHTCEGGYSGCWSWLTNSAAGVSAHYVVNESGTEVSQLVRESSRAWHVAAAYRSSLNGGVKSNLNGRSTNDF
SIGIEHGGYASSASFSTGMITTSAKLTCNITRDQGIPRDSYHIVAHGRLQPETRTDPGPNWPWSTYISKIRSECGDGGGG
TNPVIVVDSNNANNDSSKGYIAVPSTWARGTSAGYYGNDYYYASTQPVSEPAVFHFHMPAAGSRTIQAWWVQGTNRSPAA
PFMITHAGGNSTVTVNQQTNGSKWVTLGTYNFNAGWNKVQLSRWATEGYVVMADALRIQ
>Mature_619_residues
MCVIPDSGWLHRRGPGFEGRFLDGKVEHPCSTWGREKEVLPGNARLACMVLRSGPLRRSRGTGATVELLTPLQGVSMHVL
RKTFAVTAAAMALAACGPQPETSPEETAPESQVPAGAVDDAARAVADAARRTPNELDAQFTKAAGEFNVPVSLLKAISYA
ETRWEHVRGEEEFEGRPAAFGLLALRGQLITDGAALAGVSADAVRDEPLANLRAGAALLSKYADEAGIDRADLGAWAPVA
VRLTDISDPDIQAHYIHNDVYSVLREGAGAFTPAGKVAVSLEATQVEPKFALPKMQALAAGPDYAASIWRPSPNYNARPA
GIGQQMVVIHTCEGGYSGCWSWLTNSAAGVSAHYVVNESGTEVSQLVRESSRAWHVAAAYRSSLNGGVKSNLNGRSTNDF
SIGIEHGGYASSASFSTGMITTSAKLTCNITRDQGIPRDSYHIVAHGRLQPETRTDPGPNWPWSTYISKIRSECGDGGGG
TNPVIVVDSNNANNDSSKGYIAVPSTWARGTSAGYYGNDYYYASTQPVSEPAVFHFHMPAAGSRTIQAWWVQGTNRSPAA
PFMITHAGGNSTVTVNQQTNGSKWVTLGTYNFNAGWNKVQLSRWATEGYVVMADALRIQ

Specific function: Antibacterial activity against Gram-positive bacteria M.luteus, S.aureus, E.faecalis and P.acidilactici and Gram- negative bacterium E.coli [H]

COG id: COG3023

COG function: function code V; Negative regulator of beta-lactamase expression

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002502 [H]

Pfam domain/function: PF01510 Amidase_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 66010; Mature: 66010

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVIPDSGWLHRRGPGFEGRFLDGKVEHPCSTWGREKEVLPGNARLACMVLRSGPLRRSR
CEECCCCCCCCCCCCCCCCEEECCCCCCCHHHCCCCCCCCCCCCEEEEEEECCCCCCCCC
GTGATVELLTPLQGVSMHVLRKTFAVTAAAMALAACGPQPETSPEETAPESQVPAGAVDD
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCHHH
AARAVADAARRTPNELDAQFTKAAGEFNVPVSLLKAISYAETRWEHVRGEEEFEGRPAAF
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCHHE
GLLALRGQLITDGAALAGVSADAVRDEPLANLRAGAALLSKYADEAGIDRADLGAWAPVA
EHHHHCCEEEECCHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEE
VRLTDISDPDIQAHYIHNDVYSVLREGAGAFTPAGKVAVSLEATQVEPKFALPKMQALAA
EEEECCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHC
GPDYAASIWRPSPNYNARPAGIGQQMVVIHTCEGGYSGCWSWLTNSAAGVSAHYVVNESG
CCCCHHEEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCEEEEEECCCC
TEVSQLVRESSRAWHVAAAYRSSLNGGVKSNLNGRSTNDFSIGIEHGGYASSASFSTGMI
HHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEE
TTSAKLTCNITRDQGIPRDSYHIVAHGRLQPETRTDPGPNWPWSTYISKIRSECGDGGGG
EECCEEEEEEECCCCCCCCCEEEEEECEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
TNPVIVVDSNNANNDSSKGYIAVPSTWARGTSAGYYGNDYYYASTQPVSEPAVFHFHMPA
CCCEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCC
AGSRTIQAWWVQGTNRSPAAPFMITHAGGNSTVTVNQQTNGSKWVTLGTYNFNAGWNKVQ
CCCCEEEEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCCCEEEEEEEEEECCCCCEEE
LSRWATEGYVVMADALRIQ
EEEECCCCEEEEEEEEECC
>Mature Secondary Structure
MCVIPDSGWLHRRGPGFEGRFLDGKVEHPCSTWGREKEVLPGNARLACMVLRSGPLRRSR
CEECCCCCCCCCCCCCCCCEEECCCCCCCHHHCCCCCCCCCCCCEEEEEEECCCCCCCCC
GTGATVELLTPLQGVSMHVLRKTFAVTAAAMALAACGPQPETSPEETAPESQVPAGAVDD
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCHHH
AARAVADAARRTPNELDAQFTKAAGEFNVPVSLLKAISYAETRWEHVRGEEEFEGRPAAF
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCHHE
GLLALRGQLITDGAALAGVSADAVRDEPLANLRAGAALLSKYADEAGIDRADLGAWAPVA
EHHHHCCEEEECCHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEE
VRLTDISDPDIQAHYIHNDVYSVLREGAGAFTPAGKVAVSLEATQVEPKFALPKMQALAA
EEEECCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHC
GPDYAASIWRPSPNYNARPAGIGQQMVVIHTCEGGYSGCWSWLTNSAAGVSAHYVVNESG
CCCCHHEEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCEEEEEECCCC
TEVSQLVRESSRAWHVAAAYRSSLNGGVKSNLNGRSTNDFSIGIEHGGYASSASFSTGMI
HHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEE
TTSAKLTCNITRDQGIPRDSYHIVAHGRLQPETRTDPGPNWPWSTYISKIRSECGDGGGG
EECCEEEEEEECCCCCCCCCEEEEEECEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
TNPVIVVDSNNANNDSSKGYIAVPSTWARGTSAGYYGNDYYYASTQPVSEPAVFHFHMPA
CCCEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCC
AGSRTIQAWWVQGTNRSPAAPFMITHAGGNSTVTVNQQTNGSKWVTLGTYNFNAGWNKVQ
CCCCEEEEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCCCEEEEEEEEEECCCCCEEE
LSRWATEGYVVMADALRIQ
EEEECCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10833271 [H]