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The map label for this gene is cbs [H]

Identifier: 108762052

GI number: 108762052

Start: 2369811

End: 2371178

Strand: Reverse

Name: cbs [H]

Synonym: MXAN_2041

Alternate gene names: 108762052

Gene position: 2371178-2369811 (Counterclockwise)

Preceding gene: 108764017

Following gene: 108763044

Centisome position: 25.94

GC content: 65.64

Gene sequence:

>1368_bases
ATGGACATCCACGAGAACATCCTCACCGCCATTGGCAACACGCCGCTGGTCAAGCTCAACAAGCTTGTCGGGCCGAACGA
CGCGACCGTGCTGGTCAAGTGCGAGTTCATGAACCCGGGCGCGTCCATCAAGGACCGCATGGCGCTCTACATCCTCGAGA
AGGCCGAGCGGGAGGGGAAGCTCAAGCCCGGCGGCACCATCGTCGAGAACACGTCCGGCAACACCGGCATGGGCGTGGCG
CTGGCCGCGGCCGTCAAAGGCTACAAGTGCATCTTCACCATGCCGGACAAGATGTCCCTGGAGAAGATCAACCGCCTCAA
GGCGCTGGGCGCGCAGGTGGTGGTGACGCCGACGAACGTGCCGGCCGAGGACCCGCGCAGCTACTACGAGACGGCCAAGC
GCCTGCACCGCGAGACGCCGGGCGCGTTCATGCTCAACCAGTACCACAACCCCGACAACATCGAGGCGCACTACAACACC
ACCGGTCCTGAGATCTACAAGCAGACCGAGGGCAAGTTCGACTACTTCGTCGCGGGCCTGGGCACCGGCGGCACCATGAG
CGGCGCCGGCAAGTTCCTGAAGGAGAAGATTCCCGGCCTCAAGAACGTGGGCGTGGACCCGGAGGGCTCCGTCTACGAGG
GCTACTTCAAGACGGGCAAGCTGACCGAGCCGCACGTCTACAAGGTGGAAGGCATCGGCGAGGACATGCTGTGCGGCGCC
ATGGACTTCACCCACCTGGACGACGTGCGCCAGGTCGATGACCGCCAGTGCTTCATCGCCGCGCGCCGCCTGGCGCGTGA
GGAAGGCATCTTCGCCGGCGGCTCCTCGGGCGCGGCGATTCACGTCGCGGTGCAGCTGGCCAAGGAAGTGGGCAAGGGCA
AGACGATTGTCGTCGTGCTGCCGGACTCGGGCAGCAGCTACATCAGCAAGTTCCACTCCGACGAGTGGATGCGCGACAAC
GGCTTCCTGGAGGAGAAGGGCGCCGGCACCATCCGCGACATCCTGGGCGACAAGCGCAAGGACGTGAAGACGGCGCGCCG
CGGTGACAAGGTCGACCAGGTGGTCGAGACGATGCGCGGCCACGGCATCAGCCAGATGCCGGTGGTGGGCGACGACGGCC
GCACGGTGGGCATGGTGCACGAGTACGACCTGCTCAACGCGCTGGTCGCCGGCAAGGCGAAGTTCTCCGACACCATCGAC
AGCATCATCGCGCCGCTGCAGGGCGCGCTGTCGCTCGACACCAGCATCGCCCGCCTGCGCGAAGTCTTCGCTCAGGACAA
CGTGGCGGTGGTGAAGGACGGCGAGAAGGTGGTCGGCATCGTCACCAAGATCGACCTCATCGACTACCTGCACCGCACGG
CGGCGTAG

Upstream 100 bases:

>100_bases
AACGCTCTCCGGGGTCGCAAGAGGCCACACGCTGTCGACCGGGCCAGTGCGGCGGCATATAAGACGCGCCGCGAACCCTC
ATTAACTTACGGAAGCCGCG

Downstream 100 bases:

>100_bases
TCCCCGGCGCGCTCGCGCCAGGGAAGCACCGAGGGCCTCCACGTTTCCGCAGTGGAAACGGGAGGCCCTTCGTGTTCACG
GACGCCGGCCGAAGAGCACG

Product: putative cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MDIHENILTAIGNTPLVKLNKLVGPNDATVLVKCEFMNPGASIKDRMALYILEKAEREGKLKPGGTIVENTSGNTGMGVA
LAAAVKGYKCIFTMPDKMSLEKINRLKALGAQVVVTPTNVPAEDPRSYYETAKRLHRETPGAFMLNQYHNPDNIEAHYNT
TGPEIYKQTEGKFDYFVAGLGTGGTMSGAGKFLKEKIPGLKNVGVDPEGSVYEGYFKTGKLTEPHVYKVEGIGEDMLCGA
MDFTHLDDVRQVDDRQCFIAARRLAREEGIFAGGSSGAAIHVAVQLAKEVGKGKTIVVVLPDSGSSYISKFHSDEWMRDN
GFLEEKGAGTIRDILGDKRKDVKTARRGDKVDQVVETMRGHGISQMPVVGDDGRTVGMVHEYDLLNALVAGKAKFSDTID
SIIAPLQGALSLDTSIARLREVFAQDNVAVVKDGEKVVGIVTKIDLIDYLHRTAA

Sequences:

>Translated_455_residues
MDIHENILTAIGNTPLVKLNKLVGPNDATVLVKCEFMNPGASIKDRMALYILEKAEREGKLKPGGTIVENTSGNTGMGVA
LAAAVKGYKCIFTMPDKMSLEKINRLKALGAQVVVTPTNVPAEDPRSYYETAKRLHRETPGAFMLNQYHNPDNIEAHYNT
TGPEIYKQTEGKFDYFVAGLGTGGTMSGAGKFLKEKIPGLKNVGVDPEGSVYEGYFKTGKLTEPHVYKVEGIGEDMLCGA
MDFTHLDDVRQVDDRQCFIAARRLAREEGIFAGGSSGAAIHVAVQLAKEVGKGKTIVVVLPDSGSSYISKFHSDEWMRDN
GFLEEKGAGTIRDILGDKRKDVKTARRGDKVDQVVETMRGHGISQMPVVGDDGRTVGMVHEYDLLNALVAGKAKFSDTID
SIIAPLQGALSLDTSIARLREVFAQDNVAVVKDGEKVVGIVTKIDLIDYLHRTAA
>Mature_455_residues
MDIHENILTAIGNTPLVKLNKLVGPNDATVLVKCEFMNPGASIKDRMALYILEKAEREGKLKPGGTIVENTSGNTGMGVA
LAAAVKGYKCIFTMPDKMSLEKINRLKALGAQVVVTPTNVPAEDPRSYYETAKRLHRETPGAFMLNQYHNPDNIEAHYNT
TGPEIYKQTEGKFDYFVAGLGTGGTMSGAGKFLKEKIPGLKNVGVDPEGSVYEGYFKTGKLTEPHVYKVEGIGEDMLCGA
MDFTHLDDVRQVDDRQCFIAARRLAREEGIFAGGSSGAAIHVAVQLAKEVGKGKTIVVVLPDSGSSYISKFHSDEWMRDN
GFLEEKGAGTIRDILGDKRKDVKTARRGDKVDQVVETMRGHGISQMPVVGDDGRTVGMVHEYDLLNALVAGKAKFSDTID
SIIAPLQGALSLDTSIARLREVFAQDNVAVVKDGEKVVGIVTKIDLIDYLHRTAA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=470, Percent_Identity=41.063829787234, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI295821200, Length=470, Percent_Identity=41.063829787234, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI4557415, Length=470, Percent_Identity=41.063829787234, Blast_Score=348, Evalue=6e-96,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=38.3333333333333, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI1788754, Length=310, Percent_Identity=40.3225806451613, Blast_Score=191, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=330, Percent_Identity=44.2424242424242, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI25147552, Length=328, Percent_Identity=44.2073170731707, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17535051, Length=314, Percent_Identity=43.312101910828, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI115535073, Length=316, Percent_Identity=42.4050632911392, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17562970, Length=311, Percent_Identity=38.9067524115756, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI32566674, Length=300, Percent_Identity=39.6666666666667, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17561720, Length=305, Percent_Identity=40, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI32566672, Length=227, Percent_Identity=36.5638766519824, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71996324, Length=340, Percent_Identity=26.1764705882353, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539640, Length=338, Percent_Identity=25.4437869822485, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=505, Percent_Identity=36.039603960396, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6321449, Length=335, Percent_Identity=37.6119402985075, Blast_Score=170, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24643623, Length=403, Percent_Identity=41.6873449131514, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI20129101, Length=403, Percent_Identity=41.6873449131514, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49363; Mature: 49363

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIHENILTAIGNTPLVKLNKLVGPNDATVLVKCEFMNPGASIKDRMALYILEKAEREGK
CCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
LKPGGTIVENTSGNTGMGVALAAAVKGYKCIFTMPDKMSLEKINRLKALGAQVVVTPTNV
CCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCC
PAEDPRSYYETAKRLHRETPGAFMLNQYHNPDNIEAHYNTTGPEIYKQTEGKFDYFVAGL
CCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEECCCCHHHHHHCCCCEEEEEEEC
GTGGTMSGAGKFLKEKIPGLKNVGVDPEGSVYEGYFKTGKLTEPHVYKVEGIGEDMLCGA
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECEECCCCCCCCCEEEECCCCCCHHHCC
MDFTHLDDVRQVDDRQCFIAARRLAREEGIFAGGSSGAAIHVAVQLAKEVGKGKTIVVVL
CCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCEEHHHHHHHHHHCCCCEEEEEE
PDSGSSYISKFHSDEWMRDNGFLEEKGAGTIRDILGDKRKDVKTARRGDKVDQVVETMRG
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHC
HGISQMPVVGDDGRTVGMVHEYDLLNALVAGKAKFSDTIDSIIAPLQGALSLDTSIARLR
CCCCCCCEECCCCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVFAQDNVAVVKDGEKVVGIVTKIDLIDYLHRTAA
HHHHCCCEEEEECCCEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIHENILTAIGNTPLVKLNKLVGPNDATVLVKCEFMNPGASIKDRMALYILEKAEREGK
CCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCC
LKPGGTIVENTSGNTGMGVALAAAVKGYKCIFTMPDKMSLEKINRLKALGAQVVVTPTNV
CCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCC
PAEDPRSYYETAKRLHRETPGAFMLNQYHNPDNIEAHYNTTGPEIYKQTEGKFDYFVAGL
CCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEECCCCHHHHHHCCCCEEEEEEEC
GTGGTMSGAGKFLKEKIPGLKNVGVDPEGSVYEGYFKTGKLTEPHVYKVEGIGEDMLCGA
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECEECCCCCCCCCEEEECCCCCCHHHCC
MDFTHLDDVRQVDDRQCFIAARRLAREEGIFAGGSSGAAIHVAVQLAKEVGKGKTIVVVL
CCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCEEHHHHHHHHHHCCCCEEEEEE
PDSGSSYISKFHSDEWMRDNGFLEEKGAGTIRDILGDKRKDVKTARRGDKVDQVVETMRG
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHC
HGISQMPVVGDDGRTVGMVHEYDLLNALVAGKAKFSDTIDSIIAPLQGALSLDTSIARLR
CCCCCCCEECCCCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVFAQDNVAVVKDGEKVVGIVTKIDLIDYLHRTAA
HHHHCCCEEEEECCCEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]