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The map label for this gene is dnaN [H]

Identifier: 108761971

GI number: 108761971

Start: 285058

End: 286164

Strand: Direct

Name: dnaN [H]

Synonym: MXAN_0236

Alternate gene names: 108761971

Gene position: 285058-286164 (Clockwise)

Preceding gene: 108763964

Following gene: 108761853

Centisome position: 3.12

GC content: 65.94

Gene sequence:

>1107_bases
ATGGAATTCCGCATCGCCGCCGACGAGCTGAAGAAGGCCCTCTACCGCGCCCAGGGCATCGTGGAGCGCAAGACGACGAT
GCCCATCCTGGCGAACGTGCTCGTCACCGCGAACAAGGGCGGCATCACCGTCACCGCCTTCGACCTGGACATCGGCGTCG
TGTCCGAGCACCCGGCCGAGGTCATCAAGACGGGCGCCGTCACGCTGAGCGCCAAGTACGTCTTCGACATCGTCCAGAAC
CTCCCGGACGCGCAGGTCACGCTGAAGAAGCTGGCCAACAACTACGTGGACATCTCCAGCGGCTCGGCCCACTTCAAAAT
CGTGGGCATGGCGGCCGAGGAGTACCCCAAGCTGCCGAAGGAAGAGAACGCGCCCCTGGTGCAGGTGGGGGGCAACACGC
TGCTGGAGATGATCAAGAAGACGCAGTTCGCCATCTCCAGCGACGAGACGCGCTACATCCTCAACGGCGTCTTCTTCGAG
CCCCAGTCCACCGGCAAGGTCCGCATGGTGGCGACCGACGGCCACCGGCTGGCGCTGGTGGAGCGTGAGCTGCCGGGCGA
CTTCAAGCTCAAGAGCGGCGTCATCATCCCCCGCAAGGGCCTGATGGAGCTCAAGCGCCTGCTGGACGAGGCGCCGGACG
CGGAGTGCCACCTGGGCTTCGCGGAGAACTCGGCGCTGTTCAAGAAGCCGGGCCTCACCATGGTGATGCGCCTCATCGAC
GGCCAGTTCCCGGAGTACCAGCGCGTCATCCCCAAGGAAGGGGAGAAGATCGTCCTGGTGCCCAAGGTGCGCCTGCTGGA
GAGCCTCAAGCGCATCGCCCTGCTGTCGGCGGACAAGAGCAACGCGGTCCGCATCGGCCTGGAGGAGAACCAGCTCATCA
TCACCGCGAGCAACCCGGACCTGGGCGAGGCCAAGGACGTGCTGGAGCTGGCCTACCGCGGCAACGGCATCACCATCGGC
TTCAACGCGCGCTACCTGATGGATGTGCTCGCCGTGACGGAGACGGACGAGGTCTCCTTCGAGCTGGGTGACGAGCACAG
CCCGGGCGTGCTCCACGCCCCCGGCGACCGGAGCTTCACCGCCGTCGTCATGCCCATGCGCGTGTGA

Upstream 100 bases:

>100_bases
TTCCCCGTCGCTCAGGGTTCGTTGACGGACTGGAGTGCAGGGGCTACATCCGGCCTCGTAGATCGGCCTTCGCGGCCGAG
ACCCGTAAGGACGCCCTCCG

Downstream 100 bases:

>100_bases
GTCGGGTGGGCCCCCTCGAGAGGGCCCGCACCGTTCACTCGTGACGCGATAGGCCCCCTGGGGGCCTGACACCCGGCCGG
TGCCTTCCTATGGTGAGGGC

Product: DNA polymerase III subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MEFRIAADELKKALYRAQGIVERKTTMPILANVLVTANKGGITVTAFDLDIGVVSEHPAEVIKTGAVTLSAKYVFDIVQN
LPDAQVTLKKLANNYVDISSGSAHFKIVGMAAEEYPKLPKEENAPLVQVGGNTLLEMIKKTQFAISSDETRYILNGVFFE
PQSTGKVRMVATDGHRLALVERELPGDFKLKSGVIIPRKGLMELKRLLDEAPDAECHLGFAENSALFKKPGLTMVMRLID
GQFPEYQRVIPKEGEKIVLVPKVRLLESLKRIALLSADKSNAVRIGLEENQLIITASNPDLGEAKDVLELAYRGNGITIG
FNARYLMDVLAVTETDEVSFELGDEHSPGVLHAPGDRSFTAVVMPMRV

Sequences:

>Translated_368_residues
MEFRIAADELKKALYRAQGIVERKTTMPILANVLVTANKGGITVTAFDLDIGVVSEHPAEVIKTGAVTLSAKYVFDIVQN
LPDAQVTLKKLANNYVDISSGSAHFKIVGMAAEEYPKLPKEENAPLVQVGGNTLLEMIKKTQFAISSDETRYILNGVFFE
PQSTGKVRMVATDGHRLALVERELPGDFKLKSGVIIPRKGLMELKRLLDEAPDAECHLGFAENSALFKKPGLTMVMRLID
GQFPEYQRVIPKEGEKIVLVPKVRLLESLKRIALLSADKSNAVRIGLEENQLIITASNPDLGEAKDVLELAYRGNGITIG
FNARYLMDVLAVTETDEVSFELGDEHSPGVLHAPGDRSFTAVVMPMRV
>Mature_368_residues
MEFRIAADELKKALYRAQGIVERKTTMPILANVLVTANKGGITVTAFDLDIGVVSEHPAEVIKTGAVTLSAKYVFDIVQN
LPDAQVTLKKLANNYVDISSGSAHFKIVGMAAEEYPKLPKEENAPLVQVGGNTLLEMIKKTQFAISSDETRYILNGVFFE
PQSTGKVRMVATDGHRLALVERELPGDFKLKSGVIIPRKGLMELKRLLDEAPDAECHLGFAENSALFKKPGLTMVMRLID
GQFPEYQRVIPKEGEKIVLVPKVRLLESLKRIALLSADKSNAVRIGLEENQLIITASNPDLGEAKDVLELAYRGNGITIG
FNARYLMDVLAVTETDEVSFELGDEHSPGVLHAPGDRSFTAVVMPMRV

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped

COG id: COG0592

COG function: function code L; DNA polymerase sliding clamp subunit (PCNA homolog)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790136, Length=372, Percent_Identity=33.0645161290323, Blast_Score=199, Evalue=3e-52,

Paralogues:

None

Copy number: 5954 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001001
- InterPro:   IPR022635
- InterPro:   IPR022637
- InterPro:   IPR022634 [H]

Pfam domain/function: PF00712 DNA_pol3_beta; PF02767 DNA_pol3_beta_2; PF02768 DNA_pol3_beta_3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 40356; Mature: 40356

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFRIAADELKKALYRAQGIVERKTTMPILANVLVTANKGGITVTAFDLDIGVVSEHPAE
CCEEECHHHHHHHHHHHHCHHHHHHHHHEEEEEEEEECCCCEEEEEEEEEEEECCCCCHH
VIKTGAVTLSAKYVFDIVQNLPDAQVTLKKLANNYVDISSGSAHFKIVGMAAEEYPKLPK
HHHCCCEEEEHHHHHHHHHCCCCHHHHHHHHHCCEEEECCCCCEEEEEEEEHHHCCCCCC
EENAPLVQVGGNTLLEMIKKTQFAISSDETRYILNGVFFEPQSTGKVRMVATDGHRLALV
CCCCCEEEECCHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCCCEEEEEEECCCEEEEE
ERELPGDFKLKSGVIIPRKGLMELKRLLDEAPDAECHLGFAENSALFKKPGLTMVMRLID
EECCCCCEEECCCEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCEECCCCHHHHHHHHC
GQFPEYQRVIPKEGEKIVLVPKVRLLESLKRIALLSADKSNAVRIGLEENQLIITASNPD
CCCCHHHHCCCCCCCEEEEECCHHHHHHHHHHHEEECCCCCEEEEEECCCEEEEEECCCC
LGEAKDVLELAYRGNGITIGFNARYLMDVLAVTETDEVSFELGDEHSPGVLHAPGDRSFT
CCHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCCCEEEEECCCCCCCEEECCCCCCEE
AVVMPMRV
EEEEEECC
>Mature Secondary Structure
MEFRIAADELKKALYRAQGIVERKTTMPILANVLVTANKGGITVTAFDLDIGVVSEHPAE
CCEEECHHHHHHHHHHHHCHHHHHHHHHEEEEEEEEECCCCEEEEEEEEEEEECCCCCHH
VIKTGAVTLSAKYVFDIVQNLPDAQVTLKKLANNYVDISSGSAHFKIVGMAAEEYPKLPK
HHHCCCEEEEHHHHHHHHHCCCCHHHHHHHHHCCEEEECCCCCEEEEEEEEHHHCCCCCC
EENAPLVQVGGNTLLEMIKKTQFAISSDETRYILNGVFFEPQSTGKVRMVATDGHRLALV
CCCCCEEEECCHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCCCEEEEEEECCCEEEEE
ERELPGDFKLKSGVIIPRKGLMELKRLLDEAPDAECHLGFAENSALFKKPGLTMVMRLID
EECCCCCEEECCCEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCEECCCCHHHHHHHHC
GQFPEYQRVIPKEGEKIVLVPKVRLLESLKRIALLSADKSNAVRIGLEENQLIITASNPD
CCCCHHHHCCCCCCCEEEEECCHHHHHHHHHHHEEECCCCCEEEEEECCCEEEEEECCCC
LGEAKDVLELAYRGNGITIGFNARYLMDVLAVTETDEVSFELGDEHSPGVLHAPGDRSFT
CCHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCCCEEEEECCCCCCCEEECCCCCCEE
AVVMPMRV
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9079919; 8226640 [H]