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The map label for this gene is fmt

Identifier: 108761879

GI number: 108761879

Start: 1647249

End: 1648187

Strand: Direct

Name: fmt

Synonym: MXAN_1399

Alternate gene names: 108761879

Gene position: 1647249-1648187 (Clockwise)

Preceding gene: 108760777

Following gene: 108760608

Centisome position: 18.02

GC content: 70.39

Gene sequence:

>939_bases
ATGAGCAGACCCCGCATCGTTTTCATGGGCACCCCCGAGTTCGCGGTGTCCTCACTGGCCGCCTGCTTCGAACTGGGAGA
CGTGGTGGCCGTCGTCACCCAACCCGACAAGCCGAAGGGCCGCGGCAACACGGTGACGGCGCCGCCGGTGAAGGAGCTGG
CCCTGTCGCGCGGCGTGCCCGTGCTCCAGCCCACCAAGCTGCGTACGCCGCCCTTCGCGGAGGAGCTGCGCCAGTACGCG
CCCGACGTCTGCGTGGTGACGGCCTATGGCCGCATCCTCCCCAAGGATTTGCTGGAGCTGCCCACCCACGGCTGCGTCAA
CGTGCACGGCTCGCTGCTGCCGCGCTTCCGGGGCGCCGCGCCCATCCAGTGGGCCATTGCCCACGGCGACACGGAGACGG
GTGTGTCGCTGATGGTGATGGATGAAGGATTGGACACCGGTCCGGTGTTGGCGATGAAGCGCATGGCCATTGCCCCGGAC
GAGACGAGCGCGTCGCTGTACCCGAAGCTGGCCGCGCTGGGCGGCGAGGTGCTGCGCGAGTTCCTGCCGGCCTACCTGAG
CGGGGAGCTGAAGCCGGTGCCGCAGCCTTCCGAGGGCATGGTGCTGGCCCCCATCATCGAGAAGGACCAGGGCCGGTTGG
ATTTCACGAAGCCCGCGGTGGAGCTGGAGCGGCGCCTGCGGGCCTTCACGCCGTGGCCCGGGGCCTTCACCACGCTGGGC
GGAAAGCTGCTGAAGGTCCACCGCGCGCAGGCCAGGGGTGGTAGTGGGGCTCCCGGCACGGTGCTGGCGTCCGGCCCGGA
CGGCATCGAGGTGGCATGCGGCGAAGGCTCGCTGGTGCTGCTGGACCTCCAGCCAGAAGGCAAGCGGGTGATGCGCGCCG
CGGACTTCCTGCAGGGGCACAAGCTGGCGCCGGGCAGCCAGCCCTTCGTCGCGGGCTGA

Upstream 100 bases:

>100_bases
GCGCCCTGCACACGCGCAAACGTCAGGCGGTGGACACTCCCACCGGGAGCACCTTCAAGTCCGTGGCCTGAGTCGCCCGG
CGCAGGAGAAGCGCAACACC

Downstream 100 bases:

>100_bases
TGGGAGAACGGGTGATGGCCATATGAGACTGCTGGTACTGCACGGACCCAACCTGAACCTGCTGGGCGTGCGGGATGGCT
CGTCCGGGGGGCGGCTGGAG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSRPRIVFMGTPEFAVSSLAACFELGDVVAVVTQPDKPKGRGNTVTAPPVKELALSRGVPVLQPTKLRTPPFAEELRQYA
PDVCVVTAYGRILPKDLLELPTHGCVNVHGSLLPRFRGAAPIQWAIAHGDTETGVSLMVMDEGLDTGPVLAMKRMAIAPD
ETSASLYPKLAALGGEVLREFLPAYLSGELKPVPQPSEGMVLAPIIEKDQGRLDFTKPAVELERRLRAFTPWPGAFTTLG
GKLLKVHRAQARGGSGAPGTVLASGPDGIEVACGEGSLVLLDLQPEGKRVMRAADFLQGHKLAPGSQPFVAG

Sequences:

>Translated_312_residues
MSRPRIVFMGTPEFAVSSLAACFELGDVVAVVTQPDKPKGRGNTVTAPPVKELALSRGVPVLQPTKLRTPPFAEELRQYA
PDVCVVTAYGRILPKDLLELPTHGCVNVHGSLLPRFRGAAPIQWAIAHGDTETGVSLMVMDEGLDTGPVLAMKRMAIAPD
ETSASLYPKLAALGGEVLREFLPAYLSGELKPVPQPSEGMVLAPIIEKDQGRLDFTKPAVELERRLRAFTPWPGAFTTLG
GKLLKVHRAQARGGSGAPGTVLASGPDGIEVACGEGSLVLLDLQPEGKRVMRAADFLQGHKLAPGSQPFVAG
>Mature_311_residues
SRPRIVFMGTPEFAVSSLAACFELGDVVAVVTQPDKPKGRGNTVTAPPVKELALSRGVPVLQPTKLRTPPFAEELRQYAP
DVCVVTAYGRILPKDLLELPTHGCVNVHGSLLPRFRGAAPIQWAIAHGDTETGVSLMVMDEGLDTGPVLAMKRMAIAPDE
TSASLYPKLAALGGEVLREFLPAYLSGELKPVPQPSEGMVLAPIIEKDQGRLDFTKPAVELERRLRAFTPWPGAFTTLGG
KLLKVHRAQARGGSGAPGTVLASGPDGIEVACGEGSLVLLDLQPEGKRVMRAADFLQGHKLAPGSQPFVAG

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=295, Percent_Identity=29.8305084745763, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI21614513, Length=294, Percent_Identity=27.891156462585, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI164663775, Length=329, Percent_Identity=29.483282674772, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1789683, Length=308, Percent_Identity=45.4545454545455, Blast_Score=250, Evalue=7e-68,
Organism=Escherichia coli, GI1788589, Length=299, Percent_Identity=33.1103678929766, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI133930964, Length=253, Percent_Identity=28.0632411067194, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI45550868, Length=305, Percent_Identity=33.1147540983607, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28571984, Length=226, Percent_Identity=34.5132743362832, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24585660, Length=246, Percent_Identity=24.390243902439, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_MYXXD (Q1DCG7)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_629656.1
- ProteinModelPortal:   Q1DCG7
- SMR:   Q1DCG7
- STRING:   Q1DCG7
- GeneID:   4105624
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_1399
- TIGR:   MXAN_1399
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- PhylomeDB:   Q1DCG7
- BioCyc:   MXAN246197:MXAN_1399-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 33076; Mature: 32945

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPRIVFMGTPEFAVSSLAACFELGDVVAVVTQPDKPKGRGNTVTAPPVKELALSRGVP
CCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCC
VLQPTKLRTPPFAEELRQYAPDVCVVTAYGRILPKDLLELPTHGCVNVHGSLLPRFRGAA
CCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHCCHHHHHCCCCCEEECCHHHHHHHCCCC
PIQWAIAHGDTETGVSLMVMDEGLDTGPVLAMKRMAIAPDETSASLYPKLAALGGEVLRE
CEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FLPAYLSGELKPVPQPSEGMVLAPIIEKDQGRLDFTKPAVELERRLRAFTPWPGAFTTLG
HHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHC
GKLLKVHRAQARGGSGAPGTVLASGPDGIEVACGEGSLVLLDLQPEGKRVMRAADFLQGH
HHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHCCC
KLAPGSQPFVAG
CCCCCCCCCCCC
>Mature Secondary Structure 
SRPRIVFMGTPEFAVSSLAACFELGDVVAVVTQPDKPKGRGNTVTAPPVKELALSRGVP
CCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCC
VLQPTKLRTPPFAEELRQYAPDVCVVTAYGRILPKDLLELPTHGCVNVHGSLLPRFRGAA
CCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHCCHHHHHCCCCCEEECCHHHHHHHCCCC
PIQWAIAHGDTETGVSLMVMDEGLDTGPVLAMKRMAIAPDETSASLYPKLAALGGEVLRE
CEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FLPAYLSGELKPVPQPSEGMVLAPIIEKDQGRLDFTKPAVELERRLRAFTPWPGAFTTLG
HHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHC
GKLLKVHRAQARGGSGAPGTVLASGPDGIEVACGEGSLVLLDLQPEGKRVMRAADFLQGH
HHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHCCC
KLAPGSQPFVAG
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA