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The map label for this gene is pdhA [H]

Identifier: 108761872

GI number: 108761872

Start: 3113074

End: 3114243

Strand: Direct

Name: pdhA [H]

Synonym: MXAN_2666

Alternate gene names: 108761872

Gene position: 3113074-3114243 (Clockwise)

Preceding gene: 108761083

Following gene: 108758610

Centisome position: 34.06

GC content: 66.84

Gene sequence:

>1170_bases
TTGCCGCCCCGGGAGTTCCGTGGGCGGCCAGCATGGAGGCATTCCGCAGTGGCCAGCCCGTACTCAAAAGAACTGCTGTT
GGACATGTACCGGAAGATGTACCTCATCCGTCGCTTCGAGGAGCGCGCGGGTCAGCAGTACACGCTGGGGAAGATTGCCG
GTTTCTGCCACCTCTACATCGGCCAGGAGGCCGTGGCGGTGGGACCGGTGGAGGCCCTGCGACCGGATGACTACATGCTC
AGTGCGTATCGTGACCACGGCCAGCCGCTGGCCCGTGGCAGCGACGCGGGCATGGTCATGGCCGAGCTGATGGGCCGGGA
CACCGGCTACAGCAAGGGCAAGGGCGGCTCGATGCACATCTTCGACATCGAGCATCACTTCTACGGCGGCTACGGCATCG
TCGGCGGCCAGATTCCCCTGGCGGCGGGCATGGCCTTCGCGAGCCGTTATCGCAACGAGGACCGCGTCACCGTCTGCTAC
TTCGGCGACGCGGCGGCCAGCCAGGGCGCCCTCCACGAGACGTTCAACATGGCGTCCAAGTGGAAGCTCCCTGTCATCTA
CATCTGCGAGAACAACCGTTACGGGATGGGCACGGCCATTTCCCGCATCGCGGCGGTGCCGGAGATCTACAAGCGCGCCA
GCGCCTACGACATGCGCGGCGAGCCGGTGGATGGCATGGACGTGCTGGCCATGTACGAGGCCGTCAAGGACGCCGCCGAG
TACTGCCGCGCCGGCAAGGGCCCCGTGCTGCTGGAGGCCAACACGTACCGCTTCCGCGGCCACTCGATGGCCGACCCCGC
CACCTATCGCACCAAGCAGGAGGTGGAGGATGAGCGCAAGGGCGACCCGATTCCGAAGCTGCGCGCCTACATCCTGAAGC
AGGGGCTGGCCCAGGACGACGTCTTCGAGTCCATCGAAGCGGAGGTCAATGCGCAGGTGGACCAGGCAGTGAAGTTCGCC
GACGAGTCGCCCGAGCCCAGCCTGGACGAACTGTGGCGCGACACCATCGTGGAGGAGGGCGAGGAGGACGTGCGCCCCCG
CGAGCGCGTGCTGGGGCAGAAGGTGAACTGGCCGACGTACCCCAGTGGCCAGGAGCTGAAGGTGACGTGGGACCTGGAGC
CGCGCGAGCAGGCCGAGGCGGCCGACAAGAAGGCGGGCCTCATCCGCTAG

Upstream 100 bases:

>100_bases
CTGGGTTCCTGACGCACCGCGCCTGAAACAGACGTGGCGTGGACGGGGCTTGAAAGGCTTTGAAGTCCCACTGCCGCGCG
GCTATTGAGTCGCTCGGCGT

Downstream 100 bases:

>100_bases
GCGCGCGCTGACCTGTCTACCAACCCTTTTTCGAGTTCGAGTCGGAGCCGACGATGCCCGAGTTGATGTACCGCGAGGCG
CTGAACCAAGCGCTCGCCGA

Product: pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MPPREFRGRPAWRHSAVASPYSKELLLDMYRKMYLIRRFEERAGQQYTLGKIAGFCHLYIGQEAVAVGPVEALRPDDYML
SAYRDHGQPLARGSDAGMVMAELMGRDTGYSKGKGGSMHIFDIEHHFYGGYGIVGGQIPLAAGMAFASRYRNEDRVTVCY
FGDAAASQGALHETFNMASKWKLPVIYICENNRYGMGTAISRIAAVPEIYKRASAYDMRGEPVDGMDVLAMYEAVKDAAE
YCRAGKGPVLLEANTYRFRGHSMADPATYRTKQEVEDERKGDPIPKLRAYILKQGLAQDDVFESIEAEVNAQVDQAVKFA
DESPEPSLDELWRDTIVEEGEEDVRPRERVLGQKVNWPTYPSGQELKVTWDLEPREQAEAADKKAGLIR

Sequences:

>Translated_389_residues
MPPREFRGRPAWRHSAVASPYSKELLLDMYRKMYLIRRFEERAGQQYTLGKIAGFCHLYIGQEAVAVGPVEALRPDDYML
SAYRDHGQPLARGSDAGMVMAELMGRDTGYSKGKGGSMHIFDIEHHFYGGYGIVGGQIPLAAGMAFASRYRNEDRVTVCY
FGDAAASQGALHETFNMASKWKLPVIYICENNRYGMGTAISRIAAVPEIYKRASAYDMRGEPVDGMDVLAMYEAVKDAAE
YCRAGKGPVLLEANTYRFRGHSMADPATYRTKQEVEDERKGDPIPKLRAYILKQGLAQDDVFESIEAEVNAQVDQAVKFA
DESPEPSLDELWRDTIVEEGEEDVRPRERVLGQKVNWPTYPSGQELKVTWDLEPREQAEAADKKAGLIR
>Mature_388_residues
PPREFRGRPAWRHSAVASPYSKELLLDMYRKMYLIRRFEERAGQQYTLGKIAGFCHLYIGQEAVAVGPVEALRPDDYMLS
AYRDHGQPLARGSDAGMVMAELMGRDTGYSKGKGGSMHIFDIEHHFYGGYGIVGGQIPLAAGMAFASRYRNEDRVTVCYF
GDAAASQGALHETFNMASKWKLPVIYICENNRYGMGTAISRIAAVPEIYKRASAYDMRGEPVDGMDVLAMYEAVKDAAEY
CRAGKGPVLLEANTYRFRGHSMADPATYRTKQEVEDERKGDPIPKLRAYILKQGLAQDDVFESIEAEVNAQVDQAVKFAD
ESPEPSLDELWRDTIVEEGEEDVRPRERVLGQKVNWPTYPSGQELKVTWDLEPREQAEAADKKAGLIR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=321, Percent_Identity=47.3520249221184, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI291084742, Length=317, Percent_Identity=47.3186119873817, Blast_Score=278, Evalue=9e-75,
Organism=Homo sapiens, GI4505685, Length=317, Percent_Identity=47.3186119873817, Blast_Score=277, Evalue=9e-75,
Organism=Homo sapiens, GI291084744, Length=324, Percent_Identity=46.2962962962963, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI291084757, Length=317, Percent_Identity=42.9022082018927, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI11386135, Length=335, Percent_Identity=31.9402985074627, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI258645172, Length=340, Percent_Identity=31.7647058823529, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32564172, Length=345, Percent_Identity=44.6376811594203, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17536047, Length=345, Percent_Identity=44.6376811594203, Blast_Score=277, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI86563357, Length=321, Percent_Identity=31.1526479750779, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI86563355, Length=321, Percent_Identity=31.1526479750779, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321026, Length=333, Percent_Identity=46.5465465465465, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24639744, Length=326, Percent_Identity=43.8650306748466, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI28571106, Length=326, Percent_Identity=43.8650306748466, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24639740, Length=326, Percent_Identity=43.8650306748466, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24639748, Length=326, Percent_Identity=45.0920245398773, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24639746, Length=315, Percent_Identity=44.4444444444444, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI21355903, Length=320, Percent_Identity=29.375, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 43661; Mature: 43530

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPREFRGRPAWRHSAVASPYSKELLLDMYRKMYLIRRFEERAGQQYTLGKIAGFCHLYI
CCCCHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHEEE
GQEAVAVGPVEALRPDDYMLSAYRDHGQPLARGSDAGMVMAELMGRDTGYSKGKGGSMHI
CCCEEEECCHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEE
FDIEHHFYGGYGIVGGQIPLAAGMAFASRYRNEDRVTVCYFGDAAASQGALHETFNMASK
EEECCEEECCEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHC
WKLPVIYICENNRYGMGTAISRIAAVPEIYKRASAYDMRGEPVDGMDVLAMYEAVKDAAE
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
YCRAGKGPVLLEANTYRFRGHSMADPATYRTKQEVEDERKGDPIPKLRAYILKQGLAQDD
HHHCCCCCEEEECCCEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHH
VFESIEAEVNAQVDQAVKFADESPEPSLDELWRDTIVEEGEEDVRPRERVLGQKVNWPTY
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHCCCHHHHHHCCCCCCCCC
PSGQELKVTWDLEPREQAEAADKKAGLIR
CCCCEEEEEECCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PPREFRGRPAWRHSAVASPYSKELLLDMYRKMYLIRRFEERAGQQYTLGKIAGFCHLYI
CCCHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHEEE
GQEAVAVGPVEALRPDDYMLSAYRDHGQPLARGSDAGMVMAELMGRDTGYSKGKGGSMHI
CCCEEEECCHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEE
FDIEHHFYGGYGIVGGQIPLAAGMAFASRYRNEDRVTVCYFGDAAASQGALHETFNMASK
EEECCEEECCEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHC
WKLPVIYICENNRYGMGTAISRIAAVPEIYKRASAYDMRGEPVDGMDVLAMYEAVKDAAE
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
YCRAGKGPVLLEANTYRFRGHSMADPATYRTKQEVEDERKGDPIPKLRAYILKQGLAQDD
HHHCCCCCEEEECCCEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHH
VFESIEAEVNAQVDQAVKFADESPEPSLDELWRDTIVEEGEEDVRPRERVLGQKVNWPTY
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHCCCHHHHHHCCCCCCCCC
PSGQELKVTWDLEPREQAEAADKKAGLIR
CCCCEEEEEECCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]