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The map label for this gene is pkn1 [H]

Identifier: 108761673

GI number: 108761673

Start: 2790555

End: 2792618

Strand: Direct

Name: pkn1 [H]

Synonym: MXAN_2399

Alternate gene names: 108761673

Gene position: 2790555-2792618 (Clockwise)

Preceding gene: 108759748

Following gene: 108756933

Centisome position: 30.53

GC content: 71.27

Gene sequence:

>2064_bases
GTGGCCGTGGCCGTGAGGTCGCCTCCCTTCCATCCGGATCAACTCGTCCCGGGCAGCGAGGTCGGCCCCTGGCGCGTGGT
GGCTTCGCTGGGCTCGGGGGGCTTCGGCCGGGTCTTCCAGGTGGAGCGGGCGGGCCGCCACTACTCGCTGAAGATGGCGC
TTCGCCCGGCGGGACTCCACGCGGCGGAGGAAGAGGACATCAACGGTCGGCTGGCGCACGAGGTCGCGGCGCTGCTGGCC
TGCGCTCCCCATCCGAACCTCCCGGCACTGCACGCCGTGGACCGCTGGCCCGAGCCTCCTGACGGCTACCTGTACTTCGT
CACCGACTACATCGATGGCGAGACGTTCCATGAGTGGCGCTGGCGGGTGAAGCCCACGGCGGCGCACCTGCTGACCGTCT
TCACGGAGCTGGTGCGCGTGGTGGCGGACCTGCACCGCCGGGGCGTGCACCACCGGGACATGAAGGGCGACAACGTCCTC
ATCCGCCGCGAGGACGAGCGCCCCATCCTCATCGACCTGGGCACGGTGCGTCTGCCCGGGGCCACGACGCTGACGGTGGG
CGTGGCGCCCGCCGCGCCTCACCTGCTGCCGCCCGAATGCGTCGCCTTCCTGCGTGAGGGCACCTGGCAGCAGGGGGCCA
ACTTCGACGCGGGCGTTCCCGGGGACCTCTACGCGCTGGGCGCGTTGCTGTACGAGGCGCTCACGGATGGCTACGCGTTC
GACCCGAAGCTTCCGTATGACCGCCTGCTGCCCGCCATCGAAACGGTGACGCCGCGCGCGCCCCACGTCGTCAACCCGAA
GGTGCCGCGCGCCCTGGGCGACATCGCCCTGCGGCTGCTCGCGAAGCGCCCCGAGGACCGCTACGCCAACACGGAGGCCC
TGCTTCAGGCCCTCTGGGACGTGGCCAAGGAGAAGCGGCAGCCCGCCTGGAAGGTGTCGTTGGACCGCCCGCCCGAGGGC
GCCGACGCGGAGGCGCCGCGGGTGCGCATGGTGCCCGACGCCTCCACGTCCTCGCGGCCCGTCCGTTCTCGGGAGCCGTC
CGAGGTCGCCGCGGTGCTGCCCCTCAATCCGGAGCCCCGGGATGTGCCCGTGGCGGATGCGAATGCGCCCGTCACTCCCT
CAGAGCCGCCCGGAGTGCCCGCGGTCGAGGCGCCCGCCGTGCCCGCATCGGCGGCGCCCGTGGCGGAGACGCCCGCGCCG
CCAGCACCGCGTTCGAGGCGCCGAGCCGTCATGGGGTGGGGGGGAGCCGCCCTGCTGGGCGTGGGGTTGGTGGTGTTCGG
GGTGAGCCGCCTCGCGATGCCCATCGCGGGAGCCCCGGCTCCTGCCCCGCCTGTTCCCATTGAGAAAGGAAGTCACGCAG
TGACGAGTCGTTCTTCGAATCCCTCCGAGATGCCCCTCCTAGAGGCGGTGCCGTCCTCTCCGGACGCGGGCGCGGTCCAC
GACACGGACGCGCAGGACGAAGTGTCCGCGCAGGTGGCTTCCTCCGACGCGGAGGGGGAAGCAGCCCACGCGTCACCGTT
GAAGAAGCGCCCGTCGCCAGGAAGCGCGCTGGGTAAGGCCGCCGCCGTGGCCTGCCTCTCGGCCGCGTGCGCCAGCGGGC
CCCAGGTGCGGGACATGCCGCCTCGCATCCAGTGCCCGACGGAGGTGTTGGACTCCATGGCGAAGCTGGGCTTCCACCCG
CCCAAGATGATTGGCAACGACTTGACGCTCTCCATGACGCCCAAGGTTTCCGTGCGTCCGGTGCCCGTGCCGCCAGACGG
GGAGCCCATCACCCTCTATGCCATCGACGAGGTCCGGAGCGCTTGGAGCGGCCGCCTCCCGAAGGGGAGCCGCTTCTATG
GGACGGTGTACCACGGGAAGACGGCCATCTACGGGTGGTTCACGGAGGTGGAGTACCCGGACGGCCGGCGCATCCCCATC
TGCGCCAACATCGTGGACAGCGCCGCCCGGGAAGCCGTGGGGATGGAGTATGACCCTTCCAGCACTCCCGGCAGACCGAT
GATGTTTCCGGGCGTCAACCTGGCGATCTCCCAGGTTCTTGGAGAAATGGGGCACCGCAGGTAG

Upstream 100 bases:

>100_bases
GCCCCGCTCACTGGGTGGTTACCGAGTCTTTCGCGCGAATGGCGCCGCCACGGGCCGTGCGTCCCGCGCGTGACGTCGCG
GGTGGGGCGGGGGGAGGGCA

Downstream 100 bases:

>100_bases
CCCTCCACCTGTCATGGTGTGGAGGCGTCCTTGCTGGAGGTTGCTCGGCCTTGACTGGTTCGCCCACTTTCATCGTGCTC
GCGTGGGGCTTGTTGTGGGC

Product: serine/threonine-protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 687; Mature: 686

Protein sequence:

>687_residues
MAVAVRSPPFHPDQLVPGSEVGPWRVVASLGSGGFGRVFQVERAGRHYSLKMALRPAGLHAAEEEDINGRLAHEVAALLA
CAPHPNLPALHAVDRWPEPPDGYLYFVTDYIDGETFHEWRWRVKPTAAHLLTVFTELVRVVADLHRRGVHHRDMKGDNVL
IRREDERPILIDLGTVRLPGATTLTVGVAPAAPHLLPPECVAFLREGTWQQGANFDAGVPGDLYALGALLYEALTDGYAF
DPKLPYDRLLPAIETVTPRAPHVVNPKVPRALGDIALRLLAKRPEDRYANTEALLQALWDVAKEKRQPAWKVSLDRPPEG
ADAEAPRVRMVPDASTSSRPVRSREPSEVAAVLPLNPEPRDVPVADANAPVTPSEPPGVPAVEAPAVPASAAPVAETPAP
PAPRSRRRAVMGWGGAALLGVGLVVFGVSRLAMPIAGAPAPAPPVPIEKGSHAVTSRSSNPSEMPLLEAVPSSPDAGAVH
DTDAQDEVSAQVASSDAEGEAAHASPLKKRPSPGSALGKAAAVACLSAACASGPQVRDMPPRIQCPTEVLDSMAKLGFHP
PKMIGNDLTLSMTPKVSVRPVPVPPDGEPITLYAIDEVRSAWSGRLPKGSRFYGTVYHGKTAIYGWFTEVEYPDGRRIPI
CANIVDSAAREAVGMEYDPSSTPGRPMMFPGVNLAISQVLGEMGHRR

Sequences:

>Translated_687_residues
MAVAVRSPPFHPDQLVPGSEVGPWRVVASLGSGGFGRVFQVERAGRHYSLKMALRPAGLHAAEEEDINGRLAHEVAALLA
CAPHPNLPALHAVDRWPEPPDGYLYFVTDYIDGETFHEWRWRVKPTAAHLLTVFTELVRVVADLHRRGVHHRDMKGDNVL
IRREDERPILIDLGTVRLPGATTLTVGVAPAAPHLLPPECVAFLREGTWQQGANFDAGVPGDLYALGALLYEALTDGYAF
DPKLPYDRLLPAIETVTPRAPHVVNPKVPRALGDIALRLLAKRPEDRYANTEALLQALWDVAKEKRQPAWKVSLDRPPEG
ADAEAPRVRMVPDASTSSRPVRSREPSEVAAVLPLNPEPRDVPVADANAPVTPSEPPGVPAVEAPAVPASAAPVAETPAP
PAPRSRRRAVMGWGGAALLGVGLVVFGVSRLAMPIAGAPAPAPPVPIEKGSHAVTSRSSNPSEMPLLEAVPSSPDAGAVH
DTDAQDEVSAQVASSDAEGEAAHASPLKKRPSPGSALGKAAAVACLSAACASGPQVRDMPPRIQCPTEVLDSMAKLGFHP
PKMIGNDLTLSMTPKVSVRPVPVPPDGEPITLYAIDEVRSAWSGRLPKGSRFYGTVYHGKTAIYGWFTEVEYPDGRRIPI
CANIVDSAAREAVGMEYDPSSTPGRPMMFPGVNLAISQVLGEMGHRR
>Mature_686_residues
AVAVRSPPFHPDQLVPGSEVGPWRVVASLGSGGFGRVFQVERAGRHYSLKMALRPAGLHAAEEEDINGRLAHEVAALLAC
APHPNLPALHAVDRWPEPPDGYLYFVTDYIDGETFHEWRWRVKPTAAHLLTVFTELVRVVADLHRRGVHHRDMKGDNVLI
RREDERPILIDLGTVRLPGATTLTVGVAPAAPHLLPPECVAFLREGTWQQGANFDAGVPGDLYALGALLYEALTDGYAFD
PKLPYDRLLPAIETVTPRAPHVVNPKVPRALGDIALRLLAKRPEDRYANTEALLQALWDVAKEKRQPAWKVSLDRPPEGA
DAEAPRVRMVPDASTSSRPVRSREPSEVAAVLPLNPEPRDVPVADANAPVTPSEPPGVPAVEAPAVPASAAPVAETPAPP
APRSRRRAVMGWGGAALLGVGLVVFGVSRLAMPIAGAPAPAPPVPIEKGSHAVTSRSSNPSEMPLLEAVPSSPDAGAVHD
TDAQDEVSAQVASSDAEGEAAHASPLKKRPSPGSALGKAAAVACLSAACASGPQVRDMPPRIQCPTEVLDSMAKLGFHPP
KMIGNDLTLSMTPKVSVRPVPVPPDGEPITLYAIDEVRSAWSGRLPKGSRFYGTVYHGKTAIYGWFTEVEYPDGRRIPIC
ANIVDSAAREAVGMEYDPSSTPGRPMMFPGVNLAISQVLGEMGHRR

Specific function: Plays an essential role in proper timing of early development events [H]

COG id: COG0515

COG function: function code RTKL; Serine/threonine protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TPR repeat [H]

Homologues:

Organism=Homo sapiens, GI148839316, Length=267, Percent_Identity=26.5917602996255, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR009875
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF07238 PilZ; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 73334; Mature: 73203

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00108 PROTEIN_KINASE_ST ; PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVAVRSPPFHPDQLVPGSEVGPWRVVASLGSGGFGRVFQVERAGRHYSLKMALRPAGLH
CEEECCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCEEEEECCCCEEEEEEEECCCCCC
AAEEEDINGRLAHEVAALLACAPHPNLPALHAVDRWPEPPDGYLYFVTDYIDGETFHEWR
CCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCEECCE
WRVKPTAAHLLTVFTELVRVVADLHRRGVHHRDMKGDNVLIRREDERPILIDLGTVRLPG
EEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEECCEECCC
ATTLTVGVAPAAPHLLPPECVAFLREGTWQQGANFDAGVPGDLYALGALLYEALTDGYAF
CCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
DPKLPYDRLLPAIETVTPRAPHVVNPKVPRALGDIALRLLAKRPEDRYANTEALLQALWD
CCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHH
VAKEKRQPAWKVSLDRPPEGADAEAPRVRMVPDASTSSRPVRSREPSEVAAVLPLNPEPR
HHHHHCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCC
DVPVADANAPVTPSEPPGVPAVEAPAVPASAAPVAETPAPPAPRSRRRAVMGWGGAALLG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCEEECCCHHHHHH
VGLVVFGVSRLAMPIAGAPAPAPPVPIEKGSHAVTSRSSNPSEMPLLEAVPSSPDAGAVH
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCCCC
DTDAQDEVSAQVASSDAEGEAAHASPLKKRPSPGSALGKAAAVACLSAACASGPQVRDMP
CCCCHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
PRIQCPTEVLDSMAKLGFHPPKMIGNDLTLSMTPKVSVRPVPVPPDGEPITLYAIDEVRS
CCCCCHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCEEEECCCCCCCCEEEEEEHHHHHH
AWSGRLPKGSRFYGTVYHGKTAIYGWFTEVEYPDGRRIPICANIVDSAAREAVGMEYDPS
HHCCCCCCCCCEEEEEEECCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCC
STPGRPMMFPGVNLAISQVLGEMGHRR
CCCCCEEECCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVAVRSPPFHPDQLVPGSEVGPWRVVASLGSGGFGRVFQVERAGRHYSLKMALRPAGLH
EEECCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCCEEEEECCCCEEEEEEEECCCCCC
AAEEEDINGRLAHEVAALLACAPHPNLPALHAVDRWPEPPDGYLYFVTDYIDGETFHEWR
CCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCEECCE
WRVKPTAAHLLTVFTELVRVVADLHRRGVHHRDMKGDNVLIRREDERPILIDLGTVRLPG
EEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEECCEECCC
ATTLTVGVAPAAPHLLPPECVAFLREGTWQQGANFDAGVPGDLYALGALLYEALTDGYAF
CCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
DPKLPYDRLLPAIETVTPRAPHVVNPKVPRALGDIALRLLAKRPEDRYANTEALLQALWD
CCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHH
VAKEKRQPAWKVSLDRPPEGADAEAPRVRMVPDASTSSRPVRSREPSEVAAVLPLNPEPR
HHHHHCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCC
DVPVADANAPVTPSEPPGVPAVEAPAVPASAAPVAETPAPPAPRSRRRAVMGWGGAALLG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCEEECCCHHHHHH
VGLVVFGVSRLAMPIAGAPAPAPPVPIEKGSHAVTSRSSNPSEMPLLEAVPSSPDAGAVH
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCCCC
DTDAQDEVSAQVASSDAEGEAAHASPLKKRPSPGSALGKAAAVACLSAACASGPQVRDMP
CCCCHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
PRIQCPTEVLDSMAKLGFHPPKMIGNDLTLSMTPKVSVRPVPVPPDGEPITLYAIDEVRS
CCCCCHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCEEEECCCCCCCCEEEEEEHHHHHH
AWSGRLPKGSRFYGTVYHGKTAIYGWFTEVEYPDGRRIPICANIVDSAAREAVGMEYDPS
HHCCCCCCCCCEEEEEEECCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCC
STPGRPMMFPGVNLAISQVLGEMGHRR
CCCCCEEECCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1835671 [H]