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The map label for this gene is cobA [H]

Identifier: 108761459

GI number: 108761459

Start: 2718573

End: 2719373

Strand: Reverse

Name: cobA [H]

Synonym: MXAN_2338

Alternate gene names: 108761459

Gene position: 2719373-2718573 (Counterclockwise)

Preceding gene: 108756853

Following gene: 108762479

Centisome position: 29.75

GC content: 72.28

Gene sequence:

>801_bases
ATGAGAGAGCAGACGAGAGGCCGAGTGTTCCTGGTCGGCGCGGGGCCGGGAGACCCGGAGCTGTTGACCTTGCGCGCCGC
GCGCGTGCTCCGGGAGGCGGACACCGTCGTTCATGACCGGTTGGTCCACCCTGGCGTGCTCGAGCATGCGCGGCCCCACG
CCCGGCTCATCTACGTGGGCAAGGAGGGCGGCGGGGACTCCGTGAGCCAGGAGGAGATTCACGTCATCCTCATCGCCCAG
GCGCTGCTGGGGCGCCGCGTGGTGCGGCTCAAGGGCGGTGACCCTTTCGTCTTCGGCCGCGGCGGCGAGGAAGCGCTCGC
GCTGGAAGAGGCGGGCATCCCCTATGAAGTCGTGCCCGGCCTCACCGCGGGGACAGCCGTGCCCGCGGCGGCGGCCATTC
CCGTCACGCACCGGGGTGTCTCCGGGGCGGTGACGTTCGCCACTGCATACCGAGGCGGCAGCGCGCCGGCCTGGGACTTC
CTGGCGAAGGCCCAGACGTTGGTCCTCTACATGGCGGGCAGCCGGTTGGAGGAGACGGTGCGCGCGCTGGTCGGCGCGGG
GCGTTCCGCGTCCACCCCGGCCGCCGTGGTGGAGGCGGGCACGTGGGCGCATCAACGGGTGGTGGAGGCTCCGCTGAGCC
ACATCGCCCAGGCGGCGACGCGTGACGCAATCGGCTCGCCGTCGCTGCTCATCGTGGGCGAGGTCGTCTCGCTGCGCGGG
CGCCTGCCTTCGCTGGTAGCGCAAGGAACCTCGGAGCATGGACACGCGCCAGCGCGCGTGGCGGAGGGCGGTCATGAGTG
A

Upstream 100 bases:

>100_bases
TGGGAGACATCGGCGCGCTGCTGGAGCGAGGCGAGCGCAAGGCCGCCTGGGCTCGGCTCCGCACGGAGTTGGAGCACTCG
AAGATACCTGGAGAGACACG

Downstream 100 bases:

>100_bases
GCACACGTTCGCGCGGGCGTCCCACCTGTCGGAGCTGGAAGCGGAGAGCATCCACATCCTCCGGGAGACGGTGGCCGAGT
TCGCCAACCCGGTGATGCTC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MREQTRGRVFLVGAGPGDPELLTLRAARVLREADTVVHDRLVHPGVLEHARPHARLIYVGKEGGGDSVSQEEIHVILIAQ
ALLGRRVVRLKGGDPFVFGRGGEEALALEEAGIPYEVVPGLTAGTAVPAAAAIPVTHRGVSGAVTFATAYRGGSAPAWDF
LAKAQTLVLYMAGSRLEETVRALVGAGRSASTPAAVVEAGTWAHQRVVEAPLSHIAQAATRDAIGSPSLLIVGEVVSLRG
RLPSLVAQGTSEHGHAPARVAEGGHE

Sequences:

>Translated_266_residues
MREQTRGRVFLVGAGPGDPELLTLRAARVLREADTVVHDRLVHPGVLEHARPHARLIYVGKEGGGDSVSQEEIHVILIAQ
ALLGRRVVRLKGGDPFVFGRGGEEALALEEAGIPYEVVPGLTAGTAVPAAAAIPVTHRGVSGAVTFATAYRGGSAPAWDF
LAKAQTLVLYMAGSRLEETVRALVGAGRSASTPAAVVEAGTWAHQRVVEAPLSHIAQAATRDAIGSPSLLIVGEVVSLRG
RLPSLVAQGTSEHGHAPARVAEGGHE
>Mature_266_residues
MREQTRGRVFLVGAGPGDPELLTLRAARVLREADTVVHDRLVHPGVLEHARPHARLIYVGKEGGGDSVSQEEIHVILIAQ
ALLGRRVVRLKGGDPFVFGRGGEEALALEEAGIPYEVVPGLTAGTAVPAAAAIPVTHRGVSGAVTFATAYRGGSAPAWDF
LAKAQTLVLYMAGSRLEETVRALVGAGRSASTPAAVVEAGTWAHQRVVEAPLSHIAQAATRDAIGSPSLLIVGEVVSLRG
RLPSLVAQGTSEHGHAPARVAEGGHE

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=239, Percent_Identity=45.6066945606695, Blast_Score=198, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6322922, Length=234, Percent_Identity=32.9059829059829, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 27647; Mature: 27647

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREQTRGRVFLVGAGPGDPELLTLRAARVLREADTVVHDRLVHPGVLEHARPHARLIYVG
CCCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEE
KEGGGDSVSQEEIHVILIAQALLGRRVVRLKGGDPFVFGRGGEEALALEEAGIPYEVVPG
CCCCCCCCCCCCEEEEEEHHHHHCCEEEEEECCCEEEEECCCCCEEEHHHCCCCEEECCC
LTAGTAVPAAAAIPVTHRGVSGAVTFATAYRGGSAPAWDFLAKAQTLVLYMAGSRLEETV
CCCCCCCCCHHCCCEECCCCCCEEEEEEEECCCCCCHHHHHHHHHEEEEEECCCHHHHHH
RALVGAGRSASTPAAVVEAGTWAHQRVVEAPLSHIAQAATRDAIGSPSLLIVGEVVSLRG
HHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHC
RLPSLVAQGTSEHGHAPARVAEGGHE
CCHHHHHCCCCCCCCCCCHHCCCCCC
>Mature Secondary Structure
MREQTRGRVFLVGAGPGDPELLTLRAARVLREADTVVHDRLVHPGVLEHARPHARLIYVG
CCCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEE
KEGGGDSVSQEEIHVILIAQALLGRRVVRLKGGDPFVFGRGGEEALALEEAGIPYEVVPG
CCCCCCCCCCCCEEEEEEHHHHHCCEEEEEECCCEEEEECCCCCEEEHHHCCCCEEECCC
LTAGTAVPAAAAIPVTHRGVSGAVTFATAYRGGSAPAWDFLAKAQTLVLYMAGSRLEETV
CCCCCCCCCHHCCCEECCCCCCEEEEEEEECCCCCCHHHHHHHHHEEEEEECCCHHHHHH
RALVGAGRSASTPAAVVEAGTWAHQRVVEAPLSHIAQAATRDAIGSPSLLIVGEVVSLRG
HHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHC
RLPSLVAQGTSEHGHAPARVAEGGHE
CCHHHHHCCCCCCCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA