BacMap

Definition	Myxococcus xanthus DK 1622 chromosome, complete genome.
Accession	NC_008095
Length	9,139,763

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The map label for this gene is ephD [H]

Identifier: 108761191

GI number: 108761191

Start: 439471

End: 440298

Strand: Reverse

Name: ephD [H]

Synonym: MXAN_0374

Alternate gene names: 108761191

Gene position: 440298-439471 (Counterclockwise)

Preceding gene: 108763608

Following gene: 108759628

Centisome position: 4.82

GC content: 70.05

Gene sequence:

>828_bases
ATGAGCCTTCCATCCCATCCAAGAGCCGTCATCACGGGTGCAGGCAGCGGCCTGGGCCGCGCGCTCTGCGAGGAGCTCGC
ACGCAGACGGGCCCGCGTGCTCGTCACCGACATCAACGCCGCCTCCGCCGAGGAGACAGCGCTGCGCGTCACCCGCGCGG
GAGGCGAAGCGCACGTCCATGTCTGTGATGTCACCGAGCCGGCCCAGGTCGAAGCCATGGCCGACGCCGCGGAGCAGGCC
CTGGGCGGCGTGGACCTGCTGGTCAACAACGCGGGCGTCGTCAGCGCGGGCCCAGTGGGCGAGCTGTCACTCTCCGAATG
GAAGCGCGTGCTGGACATCAACCTGTGGGGCGTCATCCACGGCTGCCATGTCTTCGTCCCCCGGATGCGCAGGCAGGGGT
CCGGCCACATCCTCAACATCGCCTCGGCGGCGGGACTCGTGTACGTGCCCGACCTGGCGGCCTACAACGTGTCCAAGGCG
GGCGTGATCGCGCTCTCCGAAACACTCCACGCCGAACTGAAGGCCACCGGCATCGGCGTCACCGTGGCGTGCCCCAGCTT
CTTCCGCACCCGAATCGCCAGCACGGGCCACTACACCAAGGACACGCTTCGAACCCTCGCCGGCTTGATGCTGGATGAAG
CCCGCCTGGGCCCGGAGGTCGTCGCGCGCAGGCTCCTGAAGGCCGTGGACGCGCGAAGCCTCTACACCGTCCCCATGGCG
GATGCGCGCTGGGGCTGGCGCCTGCGCCGCATGGCCCCCAGCCTCTTCCTCCGCGCCGTCGCCGCGATGAACCCCTCCGC
TCGCGCGTGGCTTCTGCGACGACGCTGA

Upstream 100 bases:

>100_bases
CACCCGGTGTCAGGGCCGTTCTGGGCGCTCGCGTCAAGGCACCGCCGGGGAGATGGCGGCGAAGGCCGCGACAAGGACAT
GCTGAGCGCCAACGACACGC

Downstream 100 bases:

>100_bases
GCCCCTTCAAGGCGCTGGCCGACAGAGGCCGCGCTCGATGAGGCTCGACGGCAGCATCCCATCCTCGCCCGGCTTGAAGA
TGGGCTGCATTTTCGCCACG

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: 3alpha12alpha-dihydroxy-oxobeta-cholanate; NADH [C]

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSLPSHPRAVITGAGSGLGRALCEELARRRARVLVTDINAASAEETALRVTRAGGEAHVHVCDVTEPAQVEAMADAAEQA
LGGVDLLVNNAGVVSAGPVGELSLSEWKRVLDINLWGVIHGCHVFVPRMRRQGSGHILNIASAAGLVYVPDLAAYNVSKA
GVIALSETLHAELKATGIGVTVACPSFFRTRIASTGHYTKDTLRTLAGLMLDEARLGPEVVARRLLKAVDARSLYTVPMA
DARWGWRLRRMAPSLFLRAVAAMNPSARAWLLRRR

Sequences:

>Translated_275_residues
MSLPSHPRAVITGAGSGLGRALCEELARRRARVLVTDINAASAEETALRVTRAGGEAHVHVCDVTEPAQVEAMADAAEQA
LGGVDLLVNNAGVVSAGPVGELSLSEWKRVLDINLWGVIHGCHVFVPRMRRQGSGHILNIASAAGLVYVPDLAAYNVSKA
GVIALSETLHAELKATGIGVTVACPSFFRTRIASTGHYTKDTLRTLAGLMLDEARLGPEVVARRLLKAVDARSLYTVPMA
DARWGWRLRRMAPSLFLRAVAAMNPSARAWLLRRR
>Mature_274_residues
SLPSHPRAVITGAGSGLGRALCEELARRRARVLVTDINAASAEETALRVTRAGGEAHVHVCDVTEPAQVEAMADAAEQAL
GGVDLLVNNAGVVSAGPVGELSLSEWKRVLDINLWGVIHGCHVFVPRMRRQGSGHILNIASAAGLVYVPDLAAYNVSKAG
VIALSETLHAELKATGIGVTVACPSFFRTRIASTGHYTKDTLRTLAGLMLDEARLGPEVVARRLLKAVDARSLYTVPMAD
ARWGWRLRRMAPSLFLRAVAAMNPSARAWLLRRR

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI142976729, Length=252, Percent_Identity=31.7460317460317, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI40807363, Length=185, Percent_Identity=34.0540540540541, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI25282469, Length=284, Percent_Identity=31.3380281690141, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI210032110, Length=259, Percent_Identity=28.957528957529, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI20149619, Length=263, Percent_Identity=31.1787072243346, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI7705855, Length=272, Percent_Identity=25.3676470588235, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI310128830, Length=258, Percent_Identity=28.2945736434109, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI310115468, Length=258, Percent_Identity=28.2945736434109, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI31542939, Length=242, Percent_Identity=28.9256198347107, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI50726952, Length=197, Percent_Identity=35.0253807106599, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI44680136, Length=222, Percent_Identity=30.1801801801802, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI44680133, Length=222, Percent_Identity=30.1801801801802, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI17738292, Length=222, Percent_Identity=30.1801801801802, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4503817, Length=229, Percent_Identity=27.0742358078603, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4504503, Length=199, Percent_Identity=33.6683417085427, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI150247226, Length=205, Percent_Identity=32.6829268292683, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI126723191, Length=189, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI32483357, Length=186, Percent_Identity=27.9569892473118, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI66933014, Length=161, Percent_Identity=31.055900621118, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI22507405, Length=192, Percent_Identity=32.2916666666667, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI31543615, Length=211, Percent_Identity=30.8056872037915, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI40254992, Length=191, Percent_Identity=29.8429319371728, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7657478, Length=187, Percent_Identity=31.5508021390374, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI19743808, Length=189, Percent_Identity=32.2751322751323, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI224922801, Length=165, Percent_Identity=31.5151515151515, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4758504, Length=199, Percent_Identity=30.6532663316583, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4504505, Length=186, Percent_Identity=27.9569892473118, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI119392083, Length=212, Percent_Identity=30.188679245283, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI226371731, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4557649, Length=182, Percent_Identity=30.2197802197802, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI7706318, Length=198, Percent_Identity=26.7676767676768, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI5031737, Length=193, Percent_Identity=29.5336787564767, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI157739938, Length=186, Percent_Identity=25.2688172043011, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI109715829, Length=226, Percent_Identity=28.3185840707965, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI33667109, Length=186, Percent_Identity=30.1075268817204, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI40254986, Length=176, Percent_Identity=25.5681818181818, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI40548397, Length=188, Percent_Identity=26.063829787234, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI214010158, Length=188, Percent_Identity=26.063829787234, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI214010156, Length=188, Percent_Identity=26.063829787234, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI22758144, Length=188, Percent_Identity=26.063829787234, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI83715985, Length=182, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787905, Length=136, Percent_Identity=36.7647058823529, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082100, Length=188, Percent_Identity=32.9787234042553, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787335, Length=183, Percent_Identity=32.7868852459016, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790717, Length=183, Percent_Identity=27.8688524590164, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789057, Length=175, Percent_Identity=33.1428571428571, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI2367175, Length=194, Percent_Identity=34.020618556701, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789208, Length=187, Percent_Identity=29.9465240641711, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=25.5905511811024, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786701, Length=250, Percent_Identity=26.8, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788459, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787820, Length=179, Percent_Identity=26.8156424581006, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786812, Length=196, Percent_Identity=29.0816326530612, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=236, Percent_Identity=30.0847457627119, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17508895, Length=188, Percent_Identity=32.4468085106383, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17567345, Length=184, Percent_Identity=32.6086956521739, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193203117, Length=183, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193203115, Length=183, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994604, Length=199, Percent_Identity=29.1457286432161, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=186, Percent_Identity=30.1075268817204, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=190, Percent_Identity=28.9473684210526, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17507613, Length=191, Percent_Identity=32.4607329842932, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI32563809, Length=191, Percent_Identity=32.9842931937173, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=190, Percent_Identity=25.7894736842105, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=210, Percent_Identity=31.4285714285714, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115534660, Length=184, Percent_Identity=29.3478260869565, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=211, Percent_Identity=30.3317535545024, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17557780, Length=191, Percent_Identity=29.3193717277487, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997402, Length=258, Percent_Identity=26.7441860465116, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=185, Percent_Identity=25.9459459459459, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17570069, Length=253, Percent_Identity=25.6916996047431, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=173, Percent_Identity=28.3236994219653, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=204, Percent_Identity=25.4901960784314, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=190, Percent_Identity=28.4210526315789, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=190, Percent_Identity=29.4736842105263, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=196, Percent_Identity=27.5510204081633, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=194, Percent_Identity=27.319587628866, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=198, Percent_Identity=30.3030303030303, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=192, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320089, Length=207, Percent_Identity=29.951690821256, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323882, Length=224, Percent_Identity=27.6785714285714, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322226, Length=164, Percent_Identity=26.219512195122, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355631, Length=249, Percent_Identity=33.7349397590361, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281364892, Length=223, Percent_Identity=31.390134529148, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24649181, Length=187, Percent_Identity=33.6898395721925, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221510726, Length=224, Percent_Identity=33.4821428571429, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24581726, Length=233, Percent_Identity=28.3261802575107, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571526, Length=194, Percent_Identity=29.8969072164948, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI23397609, Length=192, Percent_Identity=32.8125, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357041, Length=202, Percent_Identity=29.7029702970297, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358495, Length=261, Percent_Identity=27.2030651340996, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24644339, Length=198, Percent_Identity=27.7777777777778, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640492, Length=220, Percent_Identity=26.8181818181818, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571387, Length=203, Percent_Identity=32.512315270936, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI18859837, Length=187, Percent_Identity=31.0160427807487, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24584752, Length=229, Percent_Identity=28.3842794759825, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI116007236, Length=204, Percent_Identity=29.9019607843137, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI116007238, Length=195, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640442, Length=193, Percent_Identity=30.5699481865285, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639444, Length=187, Percent_Identity=32.0855614973262, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357673, Length=189, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17737361, Length=195, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI116007234, Length=203, Percent_Identity=33.9901477832512, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281364494, Length=209, Percent_Identity=32.0574162679426, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648693, Length=213, Percent_Identity=31.4553990610329, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355889, Length=213, Percent_Identity=31.4553990610329, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355319, Length=210, Percent_Identity=26.1904761904762, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356301, Length=223, Percent_Identity=25.5605381165919, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007232, Length=193, Percent_Identity=35.2331606217617, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24665264, Length=240, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641232, Length=196, Percent_Identity=30.1020408163265, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24644337, Length=149, Percent_Identity=28.8590604026846, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665243, Length=183, Percent_Identity=26.775956284153, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641388, Length=204, Percent_Identity=30.8823529411765, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221331218, Length=183, Percent_Identity=26.775956284153, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24665247, Length=184, Percent_Identity=27.1739130434783, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221331216, Length=184, Percent_Identity=27.1739130434783, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00106 adh_short [H]

EC number: 1.1.1.159 [C]

Molecular weight: Translated: 29435; Mature: 29304

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPSHPRAVITGAGSGLGRALCEELARRRARVLVTDINAASAEETALRVTRAGGEAHVH
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEEEECCCCCCHHHHEEEEECCCCEEEE
VCDVTEPAQVEAMADAAEQALGGVDLLVNNAGVVSAGPVGELSLSEWKRVLDINLWGVIH
EECCCCCHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCCCHHHHHHHHHEEHHHHHH
GCHVFVPRMRRQGSGHILNIASAAGLVYVPDLAAYNVSKAGVIALSETLHAELKATGIGV
HHHHHHHHHHCCCCCCEEEEECCCCEEEECCHHHCCCCCCCEEEEHHHHHHHHHHCCCEE
TVACPSFFRTRIASTGHYTKDTLRTLAGLMLDEARLGPEVVARRLLKAVDARSLYTVPMA
EEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCC
DARWGWRLRRMAPSLFLRAVAAMNPSARAWLLRRR
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECC
>Mature Secondary Structure 
SLPSHPRAVITGAGSGLGRALCEELARRRARVLVTDINAASAEETALRVTRAGGEAHVH
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEEEECCCCCCHHHHEEEEECCCCEEEE
VCDVTEPAQVEAMADAAEQALGGVDLLVNNAGVVSAGPVGELSLSEWKRVLDINLWGVIH
EECCCCCHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCCCHHHHHHHHHEEHHHHHH
GCHVFVPRMRRQGSGHILNIASAAGLVYVPDLAAYNVSKAGVIALSETLHAELKATGIGV
HHHHHHHHHHCCCCCCEEEEECCCCEEEECCHHHCCCCCCCEEEEHHHHHHHHHHCCCEE
TVACPSFFRTRIASTGHYTKDTLRTLAGLMLDEARLGPEVVARRLLKAVDARSLYTVPMA
EEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCC
DARWGWRLRRMAPSLFLRAVAAMNPSARAWLLRRR
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 2-Mercaptoethanol; Dithiothreitol; NAD+; NADH [C]

Metal ions: CaCl2; KCl; MnCl2; NaCl [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.8 {cholic} 0.24 {taurochenodeoxycholic} 0.085 {glycochenodeoxycholic} 1 {glycocholic} 0.06 {chenodeoxycholic} [C]

Substrates: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate!; NAD [C]

Specific reaction: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate! + NAD+ = 3alpha12alpha-dihydroxy-oxobeta-cholanate + NADH [C]

General reaction: Redox reaction [C]

Inhibitor: Ascorbicacid; BaCl2; CoCl2; CuCl2; EDTA; FeCl3; HgCl2; MgCl2; NH4Cl; Potassiumoxalate; Sodiumcitrate; Sodiumlaurylsulfate; Sodiumperchlorate; Sodiumperiodate; Sodiumpersulfate; TritonX-100; Tween; ZnCl2 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]