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The map label for this gene is panC

Identifier: 108761160

GI number: 108761160

Start: 2387815

End: 2388693

Strand: Direct

Name: panC

Synonym: MXAN_2056

Alternate gene names: 108761160

Gene position: 2387815-2388693 (Clockwise)

Preceding gene: 108756848

Following gene: 108763344

Centisome position: 26.13

GC content: 70.76

Gene sequence:

>879_bases
ATGGCTCCCGCCGTCCTGAAAACCGTTGCGGACGTGAAGGACTGGACGGCGGGGCTGCGCCGGGAGGGGCACCGGCTCGC
GCTGGTGCCCACCATGGGCTTCCTGCATGAAGGTCACCTCTCGCTCATTCGCGAGGGGCGGCGCCGCGCGGACGTGGTGG
CCGTGTCCATCTTCGTGAACCCCACGCAGTTCGGGCCGAAGGAGGACTTGTCCCGCTACCCCCGCGACTTCGAGGGTGAC
GTCGCCAAGTGCATCAGCGCGGGCGCGCAGGCCATCTTCGCGCCCGCGGGCCCGGAGGTGATGTACCCGCAGGGCTACCA
GACGTACGTGGAGGTGACGGACGTCAGCCAGGGCCTGTGCGGGGCCCGGCGTCCGGGGCACTTCCGCGGGGTGGCCACCG
TCGTCACGAAGCTGCTGACGCTGTTCCGCCCGGAGGTGGCGCTCTTCGGGGAGAAGGACTACCAGCAGCTCCAGGTCATC
CGGGCGCTCAACCAGGACCTGCACCTGGGCGCGGACATCGTCGGCATGCCGACGGTGCGCGAGCCGGACGGCCTGGCGAT
GAGCAGCCGCAATGCCTACTTGTCCCCCGAGGAGCGGCAGCGGGCGCTGGCCCTGTCCCGGGGGCTCAAGGCCGCCCAGG
CGCTGCTGCGCGAGGGCACGCGGGAGTCGGAGCCCCTGGTGGCGGCCGTCCGGCGCGAATTGGAGGCGGCGGGGCTTCGG
GAAGACTACGTGGAACTGGTGGATGCGGAACGGCTGACGCCTCTGGCTTCGGTGGCGCCCGGGCAGCCTGCCCGGTTGCT
CGTCGCGGCCTTCAGTGGCACGACGCGCCTCATCGACAACATGCAGTTGGGTGGTGAGGAGAACGCGGGACGCGTATGA

Upstream 100 bases:

>100_bases
TGGCGCCGGGGGCTCCGGCTCCGGCGGCCCGGGTGGAGCCGTCCGCGCCCGCCGAGGCTGGCGAGAAGCTGGGCCCCGTC
TACGGGAGACCCGCCTAGTC

Downstream 100 bases:

>100_bases
CATCCGGAGGGAAGTCAAAGGGAGTGGGCAGTGAGCCCGGCGTGAGAGTCATCGCGGAAAACCGTCGTGCGCGTTTCGAC
TACACGGTCGACGAAAAGGT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MAPAVLKTVADVKDWTAGLRREGHRLALVPTMGFLHEGHLSLIREGRRRADVVAVSIFVNPTQFGPKEDLSRYPRDFEGD
VAKCISAGAQAIFAPAGPEVMYPQGYQTYVEVTDVSQGLCGARRPGHFRGVATVVTKLLTLFRPEVALFGEKDYQQLQVI
RALNQDLHLGADIVGMPTVREPDGLAMSSRNAYLSPEERQRALALSRGLKAAQALLREGTRESEPLVAAVRRELEAAGLR
EDYVELVDAERLTPLASVAPGQPARLLVAAFSGTTRLIDNMQLGGEENAGRV

Sequences:

>Translated_292_residues
MAPAVLKTVADVKDWTAGLRREGHRLALVPTMGFLHEGHLSLIREGRRRADVVAVSIFVNPTQFGPKEDLSRYPRDFEGD
VAKCISAGAQAIFAPAGPEVMYPQGYQTYVEVTDVSQGLCGARRPGHFRGVATVVTKLLTLFRPEVALFGEKDYQQLQVI
RALNQDLHLGADIVGMPTVREPDGLAMSSRNAYLSPEERQRALALSRGLKAAQALLREGTRESEPLVAAVRRELEAAGLR
EDYVELVDAERLTPLASVAPGQPARLLVAAFSGTTRLIDNMQLGGEENAGRV
>Mature_291_residues
APAVLKTVADVKDWTAGLRREGHRLALVPTMGFLHEGHLSLIREGRRRADVVAVSIFVNPTQFGPKEDLSRYPRDFEGDV
AKCISAGAQAIFAPAGPEVMYPQGYQTYVEVTDVSQGLCGARRPGHFRGVATVVTKLLTLFRPEVALFGEKDYQQLQVIR
ALNQDLHLGADIVGMPTVREPDGLAMSSRNAYLSPEERQRALALSRGLKAAQALLREGTRESEPLVAAVRRELEAAGLRE
DYVELVDAERLTPLASVAPGQPARLLVAAFSGTTRLIDNMQLGGEENAGRV

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=278, Percent_Identity=44.9640287769784, Blast_Score=236, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322046, Length=306, Percent_Identity=37.9084967320261, Blast_Score=182, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_MYXXD (Q1DAN8)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_630285.1
- ProteinModelPortal:   Q1DAN8
- SMR:   Q1DAN8
- STRING:   Q1DAN8
- GeneID:   4102344
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2056
- TIGR:   MXAN_2056
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   Q1DAN8
- ProtClustDB:   PRK00380
- BioCyc:   MXAN246197:MXAN_2056-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31779; Mature: 31648

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: ACT_SITE 39-39 BINDING 63-63 BINDING 63-63 BINDING 156-156 BINDING 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPAVLKTVADVKDWTAGLRREGHRLALVPTMGFLHEGHLSLIREGRRRADVVAVSIFVN
CCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCHHHCEEEEEEEEC
PTQFGPKEDLSRYPRDFEGDVAKCISAGAQAIFAPAGPEVMYPQGYQTYVEVTDVSQGLC
CCCCCCHHHHHHCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEEEHHHCCCC
GARRPGHFRGVATVVTKLLTLFRPEVALFGEKDYQQLQVIRALNQDLHLGADIVGMPTVR
CCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHCHHHHCCCCEECCCCCC
EPDGLAMSSRNAYLSPEERQRALALSRGLKAAQALLREGTRESEPLVAAVRRELEAAGLR
CCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCH
EDYVELVDAERLTPLASVAPGQPARLLVAAFSGTTRLIDNMQLGGEENAGRV
HHHHHHHHHHHCCHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
APAVLKTVADVKDWTAGLRREGHRLALVPTMGFLHEGHLSLIREGRRRADVVAVSIFVN
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCHHHCEEEEEEEEC
PTQFGPKEDLSRYPRDFEGDVAKCISAGAQAIFAPAGPEVMYPQGYQTYVEVTDVSQGLC
CCCCCCHHHHHHCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEEEHHHCCCC
GARRPGHFRGVATVVTKLLTLFRPEVALFGEKDYQQLQVIRALNQDLHLGADIVGMPTVR
CCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHCHHHHCCCCEECCCCCC
EPDGLAMSSRNAYLSPEERQRALALSRGLKAAQALLREGTRESEPLVAAVRRELEAAGLR
CCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCH
EDYVELVDAERLTPLASVAPGQPARLLVAAFSGTTRLIDNMQLGGEENAGRV
HHHHHHHHHHHCCHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA