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The map label for this gene is mutS2 [H]

Identifier: 108761022

GI number: 108761022

Start: 5144966

End: 5147371

Strand: Direct

Name: mutS2 [H]

Synonym: MXAN_4190

Alternate gene names: 108761022

Gene position: 5144966-5147371 (Clockwise)

Preceding gene: 108760007

Following gene: 108757764

Centisome position: 56.29

GC content: 70.41

Gene sequence:

>2406_bases
ATGACCGTGCAGATATCGCAAAGAACGCTGGAAGACCTGGGCTTCGCGGATGTGCTCCGCGCGTTGGCGCAACGCTGCCG
GACGGAGCCCGGCAGGGAGCGGGTGCTCGCCCGGCCGTTCCTGGCCACCCCCGAGGCCGTGGCGGAGGCCCTCGCGCTCG
TCGCCGAGACCCGCTCGTTGTCCCAGGAGCAGTTCTCCCTCCCCTTGGGTGGCGTGACGGACCTGCGTACGCCCATCGGC
CATGCGGCCAAGGGCGGCATGCTGGAGCCCCGCCAGCTCATCGACTCGGCGCAGCTCCTGTTCGCCTTCGTCCGCACCCG
CGAGGCACTGGACGAACGCCGGGCCCGCGTCCCCCGGCTGGTGGAGATTGCCCGCCGGATGCCATCGCTGGAGCCGCTGG
CTCGCCGCATCGACCAGTGTTTCGAACCGGACGGTGAGATCTCCGACCGTGCCAGCCCGGAGCTGCGCGAAGCCCGGGAC
CGCGCACGTGGGCTCCATCGCCGCATCAAGTCGCGGCTCGAGGAGATGCTCCACGATGAGACCTTCCTCCCCAAGCTGCG
GGAGAACTACTACACGATCCGCAACGGGCGTTACGTGGTGCCGGTGGTGGCCAACTACCGCTCGGAAGTGGACGGCATCG
TCCACAACGCCAGCCAGACGGGCCAGACGCTCTTCATGGAGCCTCAGGCCATGGTGGGCCTGGGCAACGACCTCGCCATC
GCCCAGTCGGAGGTGACCGAGGAGGAGCGCAAGGTGCTCCAGGCCCTGAGCGACCAGCTCGGCCGGGAGTCGGAGCGCAT
CCTGGAGGGCCTGGACGCCGTGGCGGAGCTGGACGAGGCCGAATCCGTGGCCATCCTCTCCGCGGACCTGGGCGCCAGCA
TGCCGGCCTTCGAGAACGTCACGGAAATGCAGCTGCGGCAGCTGCGCCACCCGCGCCTGGTGCTCAAGGGCGCCGAGGTG
GTGGCCAACGACGTGACGCTCACGGGCGATGCGAAGGCCCTGGTCGTCTCAGGCCCCAACGCGGGCGGCAAGACGGTGAC
GCTGACGGGCGTGGGCCTCTGCGCGCTGATGCTCCGCGCCGGCCTGCCGATTCCGGTGGCCGAAGGCTCTCGGATGCCGC
TGTACCGCTCCGTCCACTCCACCGTGGGTGACGCGCAGGACCTGGAGCAGGGCCTGTCCACGTTCAGCGCGCACGTGGTG
ATGCTGCGAGACATCATCGGCGCCGTGGGCGAGGGCTCATTGGTCCTCATCGACGAAATCGCCGCGGACACCGACCCGCG
CGAGGGCGCGGCAATCGCCATCGCCGTGCTGGAGGAGCTGATGTCCAAGGGCGTGGTGGTACTCGTCACCACGCACCTGG
AGGAGCTGAAGGCGCTGGCGCACATGGACCCGCGCTTCCTCAACGCGCGCGTGGGCTTCGACTCGAAGCGCATGGCCCCC
ACCTACCGGCTCCAGATTGGCGCCGCGGGCCAGTCGTCGGCCATCGAGATGGCGGCGCGCGTGGGCCTGCCCCAGAACGT
GTGCGAGCGCGCCCGGGAGCTGTCCGTCAGTGCCGGCGGTCCGCTCACCAAGGCGCTGGCGGCGGCCGAGGAGGAACGGC
GCAAGCTCTACGAGGAGCTGGAACGCGCCCGCGTGGCGGCCCAGGAGGCCGAGGCGCTCCGGGCCGACCTGGAGAAGCAG
AAGCAGTCCTTCGAGCGCGAGCGCCGCGCCCGGATGATGCAGTTCAACGACGACGTACACGCGGCGAGCGAGCACGCGGC
GGCGGAAGTTCAGAAGCTGCTGACGAAGCTTCGAGCCGAGCAGAACGAGAAGGCCCTCGCCGAGGCCCGGCAGCAACTCC
AGCAGCGCGCGGATGAGGCGCTGAAGCGCGCCCAGGCCGCCAAGGCGGAGCTGTTCCAGGTGGAAGCACCTGGCCCGGCC
AACCTGAAGGTGGGCGCCTGGGTGCACCACTCGGGGCTGAACCGCGATGTGGAAATCCTGGAGCTGGCGGACAACCACGC
GGTGGTGTCCGCGGGTGGCGCGCTGAAGATGCGCGTGCCCATCACGGAGCTGTCGGGCGCGCGCACGCGCAAGCCGCAGC
AGGCGAAGTTCCCAGAGCGGCAGAAGCAGGATGCGGCGCTCAAGCGCGCGGCCTCCGCGGCCCCCTCCGAGGTGGAGGCC
ACCCATTTCCGCTGCGACGTGCGCGGCATGCGCGCGGACGACGCGCTGGCGGAGCTGGAGTCGTTCCTGGACCGCGGCAT
GCGCAGCGGAGAAGACGCCGCGCTCGTCATCCATGGCCATGGCACGGGGGCGCTCAAGCAGGCCATCCGTGACTACCTGG
CCGCGTCTCCGTACATCCGCATGTACCGGCCGGGTGAAGGCCACGAAGGCGGCGACGGGGTGACCGTGGTCGCCCTGCGC
GCCTGA

Upstream 100 bases:

>100_bases
AAGCCACCAGGATGACCCACCTCATGTGCGGCTGATAGCAGAGCCGACCCGGGCGCCTCAATAGATCCTCTTGACGGCCG
AACGGCCGCGCATGAAACCC

Downstream 100 bases:

>100_bases
CCGCACCCGCGATACGGACTGAAGCATCCAGGGCCGGAGGTGGCTGGAAACGGCTGCCTCCGGCCCTTCGTCTGTCAGGC
CAGCCCGCGCGACTGCCAGC

Product: MutS2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 801; Mature: 800

Protein sequence:

>801_residues
MTVQISQRTLEDLGFADVLRALAQRCRTEPGRERVLARPFLATPEAVAEALALVAETRSLSQEQFSLPLGGVTDLRTPIG
HAAKGGMLEPRQLIDSAQLLFAFVRTREALDERRARVPRLVEIARRMPSLEPLARRIDQCFEPDGEISDRASPELREARD
RARGLHRRIKSRLEEMLHDETFLPKLRENYYTIRNGRYVVPVVANYRSEVDGIVHNASQTGQTLFMEPQAMVGLGNDLAI
AQSEVTEEERKVLQALSDQLGRESERILEGLDAVAELDEAESVAILSADLGASMPAFENVTEMQLRQLRHPRLVLKGAEV
VANDVTLTGDAKALVVSGPNAGGKTVTLTGVGLCALMLRAGLPIPVAEGSRMPLYRSVHSTVGDAQDLEQGLSTFSAHVV
MLRDIIGAVGEGSLVLIDEIAADTDPREGAAIAIAVLEELMSKGVVVLVTTHLEELKALAHMDPRFLNARVGFDSKRMAP
TYRLQIGAAGQSSAIEMAARVGLPQNVCERARELSVSAGGPLTKALAAAEEERRKLYEELERARVAAQEAEALRADLEKQ
KQSFERERRARMMQFNDDVHAASEHAAAEVQKLLTKLRAEQNEKALAEARQQLQQRADEALKRAQAAKAELFQVEAPGPA
NLKVGAWVHHSGLNRDVEILELADNHAVVSAGGALKMRVPITELSGARTRKPQQAKFPERQKQDAALKRAASAAPSEVEA
THFRCDVRGMRADDALAELESFLDRGMRSGEDAALVIHGHGTGALKQAIRDYLAASPYIRMYRPGEGHEGGDGVTVVALR
A

Sequences:

>Translated_801_residues
MTVQISQRTLEDLGFADVLRALAQRCRTEPGRERVLARPFLATPEAVAEALALVAETRSLSQEQFSLPLGGVTDLRTPIG
HAAKGGMLEPRQLIDSAQLLFAFVRTREALDERRARVPRLVEIARRMPSLEPLARRIDQCFEPDGEISDRASPELREARD
RARGLHRRIKSRLEEMLHDETFLPKLRENYYTIRNGRYVVPVVANYRSEVDGIVHNASQTGQTLFMEPQAMVGLGNDLAI
AQSEVTEEERKVLQALSDQLGRESERILEGLDAVAELDEAESVAILSADLGASMPAFENVTEMQLRQLRHPRLVLKGAEV
VANDVTLTGDAKALVVSGPNAGGKTVTLTGVGLCALMLRAGLPIPVAEGSRMPLYRSVHSTVGDAQDLEQGLSTFSAHVV
MLRDIIGAVGEGSLVLIDEIAADTDPREGAAIAIAVLEELMSKGVVVLVTTHLEELKALAHMDPRFLNARVGFDSKRMAP
TYRLQIGAAGQSSAIEMAARVGLPQNVCERARELSVSAGGPLTKALAAAEEERRKLYEELERARVAAQEAEALRADLEKQ
KQSFERERRARMMQFNDDVHAASEHAAAEVQKLLTKLRAEQNEKALAEARQQLQQRADEALKRAQAAKAELFQVEAPGPA
NLKVGAWVHHSGLNRDVEILELADNHAVVSAGGALKMRVPITELSGARTRKPQQAKFPERQKQDAALKRAASAAPSEVEA
THFRCDVRGMRADDALAELESFLDRGMRSGEDAALVIHGHGTGALKQAIRDYLAASPYIRMYRPGEGHEGGDGVTVVALR
A
>Mature_800_residues
TVQISQRTLEDLGFADVLRALAQRCRTEPGRERVLARPFLATPEAVAEALALVAETRSLSQEQFSLPLGGVTDLRTPIGH
AAKGGMLEPRQLIDSAQLLFAFVRTREALDERRARVPRLVEIARRMPSLEPLARRIDQCFEPDGEISDRASPELREARDR
ARGLHRRIKSRLEEMLHDETFLPKLRENYYTIRNGRYVVPVVANYRSEVDGIVHNASQTGQTLFMEPQAMVGLGNDLAIA
QSEVTEEERKVLQALSDQLGRESERILEGLDAVAELDEAESVAILSADLGASMPAFENVTEMQLRQLRHPRLVLKGAEVV
ANDVTLTGDAKALVVSGPNAGGKTVTLTGVGLCALMLRAGLPIPVAEGSRMPLYRSVHSTVGDAQDLEQGLSTFSAHVVM
LRDIIGAVGEGSLVLIDEIAADTDPREGAAIAIAVLEELMSKGVVVLVTTHLEELKALAHMDPRFLNARVGFDSKRMAPT
YRLQIGAAGQSSAIEMAARVGLPQNVCERARELSVSAGGPLTKALAAAEEERRKLYEELERARVAAQEAEALRADLEKQK
QSFERERRARMMQFNDDVHAASEHAAAEVQKLLTKLRAEQNEKALAEARQQLQQRADEALKRAQAAKAELFQVEAPGPAN
LKVGAWVHHSGLNRDVEILELADNHAVVSAGGALKMRVPITELSGARTRKPQQAKFPERQKQDAALKRAASAAPSEVEAT
HFRCDVRGMRADDALAELESFLDRGMRSGEDAALVIHGHGTGALKQAIRDYLAASPYIRMYRPGEGHEGGDGVTVVALRA

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=315, Percent_Identity=26.6666666666667, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI26638666, Length=295, Percent_Identity=26.7796610169492, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI4505253, Length=295, Percent_Identity=26.7796610169492, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI4557761, Length=257, Percent_Identity=27.2373540856031, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI26638664, Length=298, Percent_Identity=27.1812080536913, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI284813531, Length=332, Percent_Identity=23.4939759036145, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI4504191, Length=236, Percent_Identity=27.9661016949153, Blast_Score=75, Evalue=4e-13,
Organism=Homo sapiens, GI262231786, Length=211, Percent_Identity=28.436018957346, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789089, Length=331, Percent_Identity=28.3987915407855, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17534743, Length=193, Percent_Identity=28.4974093264249, Blast_Score=87, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17508445, Length=217, Percent_Identity=26.7281105990783, Blast_Score=83, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17539736, Length=334, Percent_Identity=23.9520958083832, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321912, Length=411, Percent_Identity=23.3576642335766, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324482, Length=404, Percent_Identity=23.5148514851485, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6319935, Length=359, Percent_Identity=25.3481894150418, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321109, Length=283, Percent_Identity=25.7950530035336, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24584320, Length=222, Percent_Identity=28.3783783783784, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664545, Length=276, Percent_Identity=26.8115942028986, Blast_Score=83, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 87446; Mature: 87315

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQISQRTLEDLGFADVLRALAQRCRTEPGRERVLARPFLATPEAVAEALALVAETRSL
CEEEECHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
SQEQFSLPLGGVTDLRTPIGHAAKGGMLEPRQLIDSAQLLFAFVRTREALDERRARVPRL
CHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VEIARRMPSLEPLARRIDQCFEPDGEISDRASPELREARDRARGLHRRIKSRLEEMLHDE
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCH
TFLPKLRENYYTIRNGRYVVPVVANYRSEVDGIVHNASQTGQTLFMEPQAMVGLGNDLAI
HHHHHHHHCCEEECCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEECCHHHHCCCCCHHH
AQSEVTEEERKVLQALSDQLGRESERILEGLDAVAELDEAESVAILSADLGASMPAFENV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCH
TEMQLRQLRHPRLVLKGAEVVANDVTLTGDAKALVVSGPNAGGKTVTLTGVGLCALMLRA
HHHHHHHHCCCCEEEECCHHHCCCEEEECCCCEEEEECCCCCCCEEEEHHHHHHHHHHHC
GLPIPVAEGSRMPLYRSVHSTVGDAQDLEQGLSTFSAHVVMLRDIIGAVGEGSLVLIDEI
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHH
AADTDPREGAAIAIAVLEELMSKGVVVLVTTHLEELKALAHMDPRFLNARVGFDSKRMAP
HCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCHHHHEEECCCCCCCCCC
TYRLQIGAAGQSSAIEMAARVGLPQNVCERARELSVSAGGPLTKALAAAEEERRKLYEEL
EEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
ERARVAAQEAEALRADLEKQKQSFERERRARMMQFNDDVHAASEHAAAEVQKLLTKLRAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
QNEKALAEARQQLQQRADEALKRAQAAKAELFQVEAPGPANLKVGAWVHHSGLNRDVEIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEECCCCCCCCEEE
ELADNHAVVSAGGALKMRVPITELSGARTRKPQQAKFPERQKQDAALKRAASAAPSEVEA
EECCCCEEEECCCEEEEEECHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHH
THFRCDVRGMRADDALAELESFLDRGMRSGEDAALVIHGHGTGALKQAIRDYLAASPYIR
HHEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEE
MYRPGEGHEGGDGVTVVALRA
EECCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure 
TVQISQRTLEDLGFADVLRALAQRCRTEPGRERVLARPFLATPEAVAEALALVAETRSL
EEEECHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
SQEQFSLPLGGVTDLRTPIGHAAKGGMLEPRQLIDSAQLLFAFVRTREALDERRARVPRL
CHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VEIARRMPSLEPLARRIDQCFEPDGEISDRASPELREARDRARGLHRRIKSRLEEMLHDE
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCH
TFLPKLRENYYTIRNGRYVVPVVANYRSEVDGIVHNASQTGQTLFMEPQAMVGLGNDLAI
HHHHHHHHCCEEECCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEECCHHHHCCCCCHHH
AQSEVTEEERKVLQALSDQLGRESERILEGLDAVAELDEAESVAILSADLGASMPAFENV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCH
TEMQLRQLRHPRLVLKGAEVVANDVTLTGDAKALVVSGPNAGGKTVTLTGVGLCALMLRA
HHHHHHHHCCCCEEEECCHHHCCCEEEECCCCEEEEECCCCCCCEEEEHHHHHHHHHHHC
GLPIPVAEGSRMPLYRSVHSTVGDAQDLEQGLSTFSAHVVMLRDIIGAVGEGSLVLIDEI
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHH
AADTDPREGAAIAIAVLEELMSKGVVVLVTTHLEELKALAHMDPRFLNARVGFDSKRMAP
HCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHCCHHHHEEECCCCCCCCCC
TYRLQIGAAGQSSAIEMAARVGLPQNVCERARELSVSAGGPLTKALAAAEEERRKLYEEL
EEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
ERARVAAQEAEALRADLEKQKQSFERERRARMMQFNDDVHAASEHAAAEVQKLLTKLRAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
QNEKALAEARQQLQQRADEALKRAQAAKAELFQVEAPGPANLKVGAWVHHSGLNRDVEIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEECCCCCCCCEEE
ELADNHAVVSAGGALKMRVPITELSGARTRKPQQAKFPERQKQDAALKRAASAAPSEVEA
EECCCCEEEECCCEEEEEECHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHH
THFRCDVRGMRADDALAELESFLDRGMRSGEDAALVIHGHGTGALKQAIRDYLAASPYIR
HHEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEE
MYRPGEGHEGGDGVTVVALRA
EECCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA