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The map label for this gene is atoC [H]

Identifier: 108760941

GI number: 108760941

Start: 5199163

End: 5200578

Strand: Direct

Name: atoC [H]

Synonym: MXAN_4240

Alternate gene names: 108760941

Gene position: 5199163-5200578 (Clockwise)

Preceding gene: 108763989

Following gene: 108758958

Centisome position: 56.89

GC content: 68.36

Gene sequence:

>1416_bases
ATGTCCCCACAGCGAATCCTGGTCGTCGACGATGAGGACAATGCCCGCCGGGCGATTGCCACCATCCTGAATGAGGAAGG
CTACGAAGTGGCCGAGGCCGCCAATGGCGCCGAGGCCCTGGCTCGCATCGGCGAGTTCTCCCCCGCGGTGGTGCTCACCG
ACGTGCGCATGCCGCAGATGGACGGCCTCACGCTGCTGAAGACGGCCCGCGAGCAGGGCAGCGACGCCACCTTCGTGATG
ATGACGGCGTTCGCCAGCGTGGAGACGGCCGTGGAGGCCATGAAGTCCGGCGCGGACAACTTCCTGCTCAAGCCGTTGGA
CGCGGACCAGGTGCTCGTCACCCTGGGCAAGGTGCTGGAGAAGCGCAGCCTGCGCCAGGAGGCCGAGGCGCTGCGGGACC
AGGTGCGCTCGCGCGTCCGCCGCTTCCACGACATCATCGGCGAATCGCCCCAGCTCCAAGGCATCTACGACGTCATCCGG
AGGGCGGCGGGCACGCGTGCCACGGTGCTCATCCTGGGCGAATCGGGCACGGGCAAGGAGTTGATTGCCCAGGCCCTGCA
CCAGGAGTCGCCACGCAAGGACAAGCCCTTCATCCGTGTGCACTGCGCGGCCCTGTCCGAGAACCTGCTGGAGAGCGAGC
TGTTCGGCCACGAGAAGGGCTCATTCACGGGAGCGCTGGCCCGGAAGGAAGGCCGCTTCGAGCTGGCGGACGGTGGCACG
CTGTTCCTGGACGAGATTGGAGAAATCTCTCCCGCCGTGCAGGTGAAGCTGCTGCGCGTCCTCCAGCAGCGTGAGTTCGA
GCGCGTGGGTGGCACCCAGACGCTGAAGGTGGACGTGCGCATCGTCGCGGCCACGCACCGGGACCTGGTGGCCGAGGTGA
AGGCGGGGCGGTTCCGCGAGGACCTCTACTACCGGCTCAACGTGGTGAGCGTGACGCTGCCGCCGCTGAGGGACCGCAAG
AGCGACGTCCCCGCGCTGGTGAACCACTTCCTGGAGAAGTACAGCGATTCATACGGCAAGCAGGTGCGAGGCCTGGCACC
CGGGACGCTCCAGGCGCTGCTGTCCCATGACTGGCCGGGCAACATCCGCGAGTTGGAGAACGCCATCGAGCGCGCGGTGG
TGCTGGCGCAGGGGCAGGAGCTGTCCACGGATGACCTGCCGCCCGTGCTGCGTGGGCCCCGGCCGCACGGGACGTCCACG
GGCGCGCTCATCCCGGGCGCCACGCTGGCGGCGATTGAACGCGAGGCCATCCTGCGCACGCTGGAGATGGTGCAGGGCTC
CACATCCCGGGCCGCCGAGGTGCTGGGCATCAGCGTGCGGAAGATTCAGTACCGGCTCAAGGAATACAGCACGCCGGATG
GCGCGCCGCTCAAGGTCGTGGCCGATGAGGCGGAGGACCTGGCCGCGGAGTCGTAG

Upstream 100 bases:

>100_bases
ACCGGTGGTCGAGACGTGGCACGCTCGTAGCAGTGGTCGAAGCGTACCCGCCGCGACCGCCCCCGCATCCTGACCTGACA
GCAAAGGCTCCACCTCCCCC

Downstream 100 bases:

>100_bases
CGGTTTGATGGGTGGGCTGGGGCACTGCTACCGTGCCCTGGATGGGATGGCATTCGAGGCGAGCCTCGGTTCACCGGGGC
AACGTGCTGCTGAGGGTCCT

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSPQRILVVDDEDNARRAIATILNEEGYEVAEAANGAEALARIGEFSPAVVLTDVRMPQMDGLTLLKTAREQGSDATFVM
MTAFASVETAVEAMKSGADNFLLKPLDADQVLVTLGKVLEKRSLRQEAEALRDQVRSRVRRFHDIIGESPQLQGIYDVIR
RAAGTRATVLILGESGTGKELIAQALHQESPRKDKPFIRVHCAALSENLLESELFGHEKGSFTGALARKEGRFELADGGT
LFLDEIGEISPAVQVKLLRVLQQREFERVGGTQTLKVDVRIVAATHRDLVAEVKAGRFREDLYYRLNVVSVTLPPLRDRK
SDVPALVNHFLEKYSDSYGKQVRGLAPGTLQALLSHDWPGNIRELENAIERAVVLAQGQELSTDDLPPVLRGPRPHGTST
GALIPGATLAAIEREAILRTLEMVQGSTSRAAEVLGISVRKIQYRLKEYSTPDGAPLKVVADEAEDLAAES

Sequences:

>Translated_471_residues
MSPQRILVVDDEDNARRAIATILNEEGYEVAEAANGAEALARIGEFSPAVVLTDVRMPQMDGLTLLKTAREQGSDATFVM
MTAFASVETAVEAMKSGADNFLLKPLDADQVLVTLGKVLEKRSLRQEAEALRDQVRSRVRRFHDIIGESPQLQGIYDVIR
RAAGTRATVLILGESGTGKELIAQALHQESPRKDKPFIRVHCAALSENLLESELFGHEKGSFTGALARKEGRFELADGGT
LFLDEIGEISPAVQVKLLRVLQQREFERVGGTQTLKVDVRIVAATHRDLVAEVKAGRFREDLYYRLNVVSVTLPPLRDRK
SDVPALVNHFLEKYSDSYGKQVRGLAPGTLQALLSHDWPGNIRELENAIERAVVLAQGQELSTDDLPPVLRGPRPHGTST
GALIPGATLAAIEREAILRTLEMVQGSTSRAAEVLGISVRKIQYRLKEYSTPDGAPLKVVADEAEDLAAES
>Mature_470_residues
SPQRILVVDDEDNARRAIATILNEEGYEVAEAANGAEALARIGEFSPAVVLTDVRMPQMDGLTLLKTAREQGSDATFVMM
TAFASVETAVEAMKSGADNFLLKPLDADQVLVTLGKVLEKRSLRQEAEALRDQVRSRVRRFHDIIGESPQLQGIYDVIRR
AAGTRATVLILGESGTGKELIAQALHQESPRKDKPFIRVHCAALSENLLESELFGHEKGSFTGALARKEGRFELADGGTL
FLDEIGEISPAVQVKLLRVLQQREFERVGGTQTLKVDVRIVAATHRDLVAEVKAGRFREDLYYRLNVVSVTLPPLRDRKS
DVPALVNHFLEKYSDSYGKQVRGLAPGTLQALLSHDWPGNIRELENAIERAVVLAQGQELSTDDLPPVLRGPRPHGTSTG
ALIPGATLAAIEREAILRTLEMVQGSTSRAAEVLGISVRKIQYRLKEYSTPDGAPLKVVADEAEDLAAES

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=47.6718403547672, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1790437, Length=443, Percent_Identity=48.9841986455982, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1790299, Length=466, Percent_Identity=41.8454935622318, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1788905, Length=434, Percent_Identity=38.4792626728111, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI87082117, Length=282, Percent_Identity=49.645390070922, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1789087, Length=334, Percent_Identity=44.0119760479042, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=40, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI87082152, Length=233, Percent_Identity=52.3605150214592, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1786524, Length=345, Percent_Identity=41.1594202898551, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI87081872, Length=317, Percent_Identity=42.5867507886435, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1787583, Length=364, Percent_Identity=38.1868131868132, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI87081858, Length=358, Percent_Identity=29.8882681564246, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1789828, Length=254, Percent_Identity=35.0393700787402, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788191, Length=123, Percent_Identity=36.5853658536585, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI145693157, Length=116, Percent_Identity=36.2068965517241, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=31.0679611650485, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787375, Length=119, Percent_Identity=26.890756302521, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790863, Length=132, Percent_Identity=28.7878787878788, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=146, Percent_Identity=28.7671232876712, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=27.8688524590164, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51521; Mature: 51390

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPQRILVVDDEDNARRAIATILNEEGYEVAEAANGAEALARIGEFSPAVVLTDVRMPQM
CCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCC
DGLTLLKTAREQGSDATFVMMTAFASVETAVEAMKSGADNFLLKPLDADQVLVTLGKVLE
CCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHH
KRSLRQEAEALRDQVRSRVRRFHDIIGESPQLQGIYDVIRRAAGTRATVLILGESGTGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCHH
LIAQALHQESPRKDKPFIRVHCAALSENLLESELFGHEKGSFTGALARKEGRFELADGGT
HHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEECCCCE
LFLDEIGEISPAVQVKLLRVLQQREFERVGGTQTLKVDVRIVAATHRDLVAEVKAGRFRE
EEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEHHHHHHHHHHHCHHHH
DLYYRLNVVSVTLPPLRDRKSDVPALVNHFLEKYSDSYGKQVRGLAPGTLQALLSHDWPG
HHEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
NIRELENAIERAVVLAQGQELSTDDLPPVLRGPRPHGTSTGALIPGATLAAIEREAILRT
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LEMVQGSTSRAAEVLGISVRKIQYRLKEYSTPDGAPLKVVADEAEDLAAES
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHCCCC
>Mature Secondary Structure 
SPQRILVVDDEDNARRAIATILNEEGYEVAEAANGAEALARIGEFSPAVVLTDVRMPQM
CCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCC
DGLTLLKTAREQGSDATFVMMTAFASVETAVEAMKSGADNFLLKPLDADQVLVTLGKVLE
CCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHH
KRSLRQEAEALRDQVRSRVRRFHDIIGESPQLQGIYDVIRRAAGTRATVLILGESGTGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCHH
LIAQALHQESPRKDKPFIRVHCAALSENLLESELFGHEKGSFTGALARKEGRFELADGGT
HHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEECCCCE
LFLDEIGEISPAVQVKLLRVLQQREFERVGGTQTLKVDVRIVAATHRDLVAEVKAGRFRE
EEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEHHHHHHHHHHHCHHHH
DLYYRLNVVSVTLPPLRDRKSDVPALVNHFLEKYSDSYGKQVRGLAPGTLQALLSHDWPG
HHEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
NIRELENAIERAVVLAQGQELSTDDLPPVLRGPRPHGTSTGALIPGATLAAIEREAILRT
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LEMVQGSTSRAAEVLGISVRKIQYRLKEYSTPDGAPLKVVADEAEDLAAES
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]