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The map label for this gene is frzE

Identifier: 108760926

GI number: 108760926

Start: 5086084

End: 5088417

Strand: Reverse

Name: frzE

Synonym: MXAN_4140

Alternate gene names: 108760926

Gene position: 5088417-5086084 (Counterclockwise)

Preceding gene: 108758065

Following gene: 108763031

Centisome position: 55.67

GC content: 71.21

Gene sequence:

>2334_bases
ATGGACACCGAGGCTCTCAAGAAATCCCTCCTGAAGAAGTTCCAGGAGGTCACCGCCGACCGCCTCCAGAAGATTCAGCT
GGGGGTATTGGACCTGGAGAAGGAGACCGCGGACCAGGCCGCGGAGGACGTCGCGCGCGAGCTGCACACGATGAAGGGCG
AGGCCCGCATGTTGGGTCTGGCCGCCATCGGGCAGCTGGCGCACGCCGCCGAGGACGTCCTGCGCGCAGAGCGCGAGGGC
AAGACGGCCACCGAGGTGGCCACCGACGTCCTGCTCAGGGCGTGCGACGTCCTCTCCGATCTCAACGAAGACCTGTCCGG
CGCCAACACGGGCAACCCGGCCAGCGAGGAGATGGTCCGCATGCTCGCGGAAGTCTCCGGACAGACGCCGCCCGCCATCG
CTGGCGCACGGCCCGTGGCGCCGCCTCCTGCACCGCCGCCGGCCCCTGTCGCCGCGCCCGTGGTGACACCGGCAGCCGTC
GCCGCGCCGCCCGCGCCGGTGCAGGCTCCGGTGGCTCCGCCCCCGACGCAGGCCCCCGTGGCCGAGCCGGGGGCGCACGC
CGCCGCAGCCGCGCCTCACCCGGCTGCCGCGCATGGCCGTGACGAGGAGGCCCCGAGCGCCGCGAAGTCCGCGGTGGCCG
ACCGGAGCATCCGCGTCAACGTGGAGGTGCTCGACGCGTTGGGGTTGCTCGCGGGCGACCTGCTGGTGGAGAGCGCCCGC
GGCCGGCTGCGCAGCTCGGAGACGGAGGCGTTGTTCGAGCGCTTCAGCCGCCTGGGGGACCGCTTCCTCCGGCTGGCGGA
AGAGATCGACATCTCGAACGAGGTGCGTGAGCAGTTGGACCGCGTGGAGAGCGACCTCCACATGCTGCGCGACGACGCGT
TCCGCTTCGTGCGCCGCAACGACGACGGCATCAACACGCTGCACGGCAACCTGGCGAAGATGGCGGACCACGTGGCCGAG
GCCCGGCTGGTGCCGCTGTCCACCGTGTTCGACGCCTTCCCGCGCGCCGTTCGCGAGATGTCGCGCACGCAGGGCAAGGA
AGTGGACCTGGTCATCGAGAACGCCGACATCGGCGTGGACCGGTCCATGCTGGGCGACGTGCGAGACGCGCTGGTGCACC
TGCTGCGCAACTCGGTGGACCACGGCGTGGAGTCCCCGGACACGCGCCAGCAGTTGGGCAAGCCGCTCAACGGCCGCATC
CGCATCCGCGTGCGCGTGGACGGCGACATGCTCCACATCGAGGTGGAGGACGACGGCCGCGGCATCGACCCGGAGCGGCT
GCGTCAGGCGGCCATCTCCAAGCGCCTCATCAACGCGGTGCAGGCCGCCGCGCTGTCGGAGCGCGAGGCCATCGAGCTCA
TCTTCCGCCCCGGCTTCTCCACCCGCGACCAGGTCAGCGAGCTGTCTGGCCGTGGCGTGGGCATGGACGTGGTGAAGCGC
AAGGTGGAGACGCTGGGCGGCTCGGTGGGCGTGAGCAGCCGAATCGGCCGTGGCTCCACCATCACCCTGCGCCTGCCGCA
GTCGCTGGCGTTGATGAAGGTGCTGCTGGTGCGCCTGGGGGACGACGTCTACGGCATGCCCGCCGCGGACGTGGAAGCCG
TCATGCGCGTCAAGCCGGATGACCGGCTGGAGATCTTCGGCACGCTGGCCGTGCGGCACCGTGGCAAGCCCACGGCGCTG
GTGGCGCTGGGGCCGCTGTTGGGCCTCAACGGCGGCAATCGCTTCGACAAGCCACCCGCGGTGGTGGTGCGTCACGGCGA
GGACCACGCGGCGCTGGTGGTGGACGGCTTCGTGGACGAGCGCGAAGTGGCCGTGAAGCCTTGCGGCGGCGAGTTCCTCA
AGGCCGCGCCCTTCATCGCCGGCACCGCGGCGCTGGAGGACGGGCGCATCGCCGTGCTGCTCCATGTCCCGGACATCATG
GCGGAGGTGCGACGGATGGCCCGCCCCGTCACCCAGGCCCCCGCCGCCAAGCGCCTCCGGGTGCTGCTGGTGGACGACTC
GCCCATTGCCCGCGCTACGGAAGGGGCGCTGGTGAAGGCGCTGGGGCACTCGGTGGAGGAAGCCCAGGACGGCGAAGAGG
CCTACGTGAAGGTGCAGAACAACACCTACGACCTCATCCTCACGGACGTGCAGATGCCCAAGCTGGACGGGTTCTCGCTG
GCGCGGCGGCTCAAGTCGACGCCCGCGGTGGCTCGCATTCCGGTCATCATCCTGTCGTCGCTCGCCTCGCCCGAGGACAA
GCGGCGCGGGTTGGATGCCGGCGCGGACGCGTACCTCGTCAAGGGCGAGCTGGGCGTGGAGGTTCTCGCGCAGGCCATCG
ACCGGCTGACCTGA

Upstream 100 bases:

>100_bases
GGCCGCGGAGCTGACGCAGTTGGCCGGACGGCTGGCCGAGCTCATCAAGCGGTTCAAGGCCGACTAGCGCTTCCTGGAAG
GGGAGGGGCGTACGCCGGCC

Downstream 100 bases:

>100_bases
GGAGCCAGGCTTGGGCGGTGGCGCGGTAGTCGCAGGAATGGCGTTTCGGGTGCTCATGGTGGGCAAGGGGCTGCGTGCGC
TCGCGGCCCGGGGCCTGTTC

Product: gliding motility regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 777; Mature: 777

Protein sequence:

>777_residues
MDTEALKKSLLKKFQEVTADRLQKIQLGVLDLEKETADQAAEDVARELHTMKGEARMLGLAAIGQLAHAAEDVLRAEREG
KTATEVATDVLLRACDVLSDLNEDLSGANTGNPASEEMVRMLAEVSGQTPPAIAGARPVAPPPAPPPAPVAAPVVTPAAV
AAPPAPVQAPVAPPPTQAPVAEPGAHAAAAAPHPAAAHGRDEEAPSAAKSAVADRSIRVNVEVLDALGLLAGDLLVESAR
GRLRSSETEALFERFSRLGDRFLRLAEEIDISNEVREQLDRVESDLHMLRDDAFRFVRRNDDGINTLHGNLAKMADHVAE
ARLVPLSTVFDAFPRAVREMSRTQGKEVDLVIENADIGVDRSMLGDVRDALVHLLRNSVDHGVESPDTRQQLGKPLNGRI
RIRVRVDGDMLHIEVEDDGRGIDPERLRQAAISKRLINAVQAAALSEREAIELIFRPGFSTRDQVSELSGRGVGMDVVKR
KVETLGGSVGVSSRIGRGSTITLRLPQSLALMKVLLVRLGDDVYGMPAADVEAVMRVKPDDRLEIFGTLAVRHRGKPTAL
VALGPLLGLNGGNRFDKPPAVVVRHGEDHAALVVDGFVDEREVAVKPCGGEFLKAAPFIAGTAALEDGRIAVLLHVPDIM
AEVRRMARPVTQAPAAKRLRVLLVDDSPIARATEGALVKALGHSVEEAQDGEEAYVKVQNNTYDLILTDVQMPKLDGFSL
ARRLKSTPAVARIPVIILSSLASPEDKRRGLDAGADAYLVKGELGVEVLAQAIDRLT

Sequences:

>Translated_777_residues
MDTEALKKSLLKKFQEVTADRLQKIQLGVLDLEKETADQAAEDVARELHTMKGEARMLGLAAIGQLAHAAEDVLRAEREG
KTATEVATDVLLRACDVLSDLNEDLSGANTGNPASEEMVRMLAEVSGQTPPAIAGARPVAPPPAPPPAPVAAPVVTPAAV
AAPPAPVQAPVAPPPTQAPVAEPGAHAAAAAPHPAAAHGRDEEAPSAAKSAVADRSIRVNVEVLDALGLLAGDLLVESAR
GRLRSSETEALFERFSRLGDRFLRLAEEIDISNEVREQLDRVESDLHMLRDDAFRFVRRNDDGINTLHGNLAKMADHVAE
ARLVPLSTVFDAFPRAVREMSRTQGKEVDLVIENADIGVDRSMLGDVRDALVHLLRNSVDHGVESPDTRQQLGKPLNGRI
RIRVRVDGDMLHIEVEDDGRGIDPERLRQAAISKRLINAVQAAALSEREAIELIFRPGFSTRDQVSELSGRGVGMDVVKR
KVETLGGSVGVSSRIGRGSTITLRLPQSLALMKVLLVRLGDDVYGMPAADVEAVMRVKPDDRLEIFGTLAVRHRGKPTAL
VALGPLLGLNGGNRFDKPPAVVVRHGEDHAALVVDGFVDEREVAVKPCGGEFLKAAPFIAGTAALEDGRIAVLLHVPDIM
AEVRRMARPVTQAPAAKRLRVLLVDDSPIARATEGALVKALGHSVEEAQDGEEAYVKVQNNTYDLILTDVQMPKLDGFSL
ARRLKSTPAVARIPVIILSSLASPEDKRRGLDAGADAYLVKGELGVEVLAQAIDRLT
>Mature_777_residues
MDTEALKKSLLKKFQEVTADRLQKIQLGVLDLEKETADQAAEDVARELHTMKGEARMLGLAAIGQLAHAAEDVLRAEREG
KTATEVATDVLLRACDVLSDLNEDLSGANTGNPASEEMVRMLAEVSGQTPPAIAGARPVAPPPAPPPAPVAAPVVTPAAV
AAPPAPVQAPVAPPPTQAPVAEPGAHAAAAAPHPAAAHGRDEEAPSAAKSAVADRSIRVNVEVLDALGLLAGDLLVESAR
GRLRSSETEALFERFSRLGDRFLRLAEEIDISNEVREQLDRVESDLHMLRDDAFRFVRRNDDGINTLHGNLAKMADHVAE
ARLVPLSTVFDAFPRAVREMSRTQGKEVDLVIENADIGVDRSMLGDVRDALVHLLRNSVDHGVESPDTRQQLGKPLNGRI
RIRVRVDGDMLHIEVEDDGRGIDPERLRQAAISKRLINAVQAAALSEREAIELIFRPGFSTRDQVSELSGRGVGMDVVKR
KVETLGGSVGVSSRIGRGSTITLRLPQSLALMKVLLVRLGDDVYGMPAADVEAVMRVKPDDRLEIFGTLAVRHRGKPTAL
VALGPLLGLNGGNRFDKPPAVVVRHGEDHAALVVDGFVDEREVAVKPCGGEFLKAAPFIAGTAALEDGRIAVLLHVPDIM
AEVRRMARPVTQAPAAKRLRVLLVDDSPIARATEGALVKALGHSVEEAQDGEEAYVKVQNNTYDLILTDVQMPKLDGFSL
ARRLKSTPAVARIPVIILSSLASPEDKRRGLDAGADAYLVKGELGVEVLAQAIDRLT

Specific function: FrzE is involved in a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. FrzE seems to be capable of autophosphorylating itself on an histidine residue and then to transfer that group to an aspartate r

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1788197, Length=346, Percent_Identity=34.1040462427746, Blast_Score=183, Evalue=4e-47,
Organism=Escherichia coli, GI1788713, Length=120, Percent_Identity=35, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788191, Length=108, Percent_Identity=36.1111111111111, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=103, Percent_Identity=34.9514563106796, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787375, Length=113, Percent_Identity=33.6283185840708, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FRZE_MYXXA (P18769)

Other databases:

- EMBL:   M35192
- PIR:   A35966
- ProteinModelPortal:   P18769
- SMR:   P18769
- BRENDA:   2.7.13.3
- GO:   GO:0005622
- GO:   GO:0006935
- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR005467
- InterPro:   IPR001789
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:1.20.120.160
- PRINTS:   PR00344
- SMART:   SM00260
- SMART:   SM00387
- SMART:   SM00073
- SMART:   SM00448

Pfam domain/function: PF01584 CheW; PF02518 HATPase_c; PF01627 Hpt; PF00072 Response_reg; SSF55874 ATP_bd_ATPase; SSF50341 CheW; SSF52172 CheY_like; SSF47226 Hpt

EC number: =2.7.13.3

Molecular weight: Translated: 83191; Mature: 83191

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50851 CHEW; PS50109 HIS_KIN; PS50894 HPT; PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTEALKKSLLKKFQEVTADRLQKIQLGVLDLEKETADQAAEDVARELHTMKGEARMLGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
AAIGQLAHAAEDVLRAEREGKTATEVATDVLLRACDVLSDLNEDLSGANTGNPASEEMVR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
MLAEVSGQTPPAIAGARPVAPPPAPPPAPVAAPVVTPAAVAAPPAPVQAPVAPPPTQAPV
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCC
AEPGAHAAAAAPHPAAAHGRDEEAPSAAKSAVADRSIRVNVEVLDALGLLAGDLLVESAR
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHH
GRLRSSETEALFERFSRLGDRFLRLAEEIDISNEVREQLDRVESDLHMLRDDAFRFVRRN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DDGINTLHGNLAKMADHVAEARLVPLSTVFDAFPRAVREMSRTQGKEVDLVIENADIGVD
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
RSMLGDVRDALVHLLRNSVDHGVESPDTRQQLGKPLNGRIRIRVRVDGDMLHIEVEDDGR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEEEECCCEEEEEECCCCC
GIDPERLRQAAISKRLINAVQAAALSEREAIELIFRPGFSTRDQVSELSGRGVGMDVVKR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCCCCHHHHHH
KVETLGGSVGVSSRIGRGSTITLRLPQSLALMKVLLVRLGDDVYGMPAADVEAVMRVKPD
HHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCC
DRLEIFGTLAVRHRGKPTALVALGPLLGLNGGNRFDKPPAVVVRHGEDHAALVVDGFVDE
CHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCC
REVAVKPCGGEFLKAAPFIAGTAALEDGRIAVLLHVPDIMAEVRRMARPVTQAPAAKRLR
CCEEEECCCCHHHHHCCCCCCHHEECCCCEEEEEECHHHHHHHHHHHCCHHCCCCCCCEE
VLLVDDSPIARATEGALVKALGHSVEEAQDGEEAYVKVQNNTYDLILTDVQMPKLDGFSL
EEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCEEEEEEECCCCCCCHHHH
ARRLKSTPAVARIPVIILSSLASPEDKRRGLDAGADAYLVKGELGVEVLAQAIDRLT
HHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MDTEALKKSLLKKFQEVTADRLQKIQLGVLDLEKETADQAAEDVARELHTMKGEARMLGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
AAIGQLAHAAEDVLRAEREGKTATEVATDVLLRACDVLSDLNEDLSGANTGNPASEEMVR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
MLAEVSGQTPPAIAGARPVAPPPAPPPAPVAAPVVTPAAVAAPPAPVQAPVAPPPTQAPV
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCC
AEPGAHAAAAAPHPAAAHGRDEEAPSAAKSAVADRSIRVNVEVLDALGLLAGDLLVESAR
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHH
GRLRSSETEALFERFSRLGDRFLRLAEEIDISNEVREQLDRVESDLHMLRDDAFRFVRRN
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DDGINTLHGNLAKMADHVAEARLVPLSTVFDAFPRAVREMSRTQGKEVDLVIENADIGVD
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
RSMLGDVRDALVHLLRNSVDHGVESPDTRQQLGKPLNGRIRIRVRVDGDMLHIEVEDDGR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEEEECCCEEEEEECCCCC
GIDPERLRQAAISKRLINAVQAAALSEREAIELIFRPGFSTRDQVSELSGRGVGMDVVKR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCCCCHHHHHH
KVETLGGSVGVSSRIGRGSTITLRLPQSLALMKVLLVRLGDDVYGMPAADVEAVMRVKPD
HHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCC
DRLEIFGTLAVRHRGKPTALVALGPLLGLNGGNRFDKPPAVVVRHGEDHAALVVDGFVDE
CHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCC
REVAVKPCGGEFLKAAPFIAGTAALEDGRIAVLLHVPDIMAEVRRMARPVTQAPAAKRLR
CCEEEECCCCHHHHHCCCCCCHHEECCCCEEEEEECHHHHHHHHHHHCCHHCCCCCCCEE
VLLVDDSPIARATEGALVKALGHSVEEAQDGEEAYVKVQNNTYDLILTDVQMPKLDGFSL
EEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCEEEEEEECCCEEEEEEECCCCCCCHHHH
ARRLKSTPAVARIPVIILSSLASPEDKRRGLDAGADAYLVKGELGVEVLAQAIDRLT
HHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2165608; 2123853