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The map label for this gene is srrB [H]

Identifier: 108760725

GI number: 108760725

Start: 840186

End: 842030

Strand: Reverse

Name: srrB [H]

Synonym: MXAN_0736

Alternate gene names: 108760725

Gene position: 842030-840186 (Counterclockwise)

Preceding gene: 108762366

Following gene: 108760914

Centisome position: 9.21

GC content: 73.44

Gene sequence:

>1845_bases
ATGATGCGCCGTTGGACATTCGCCCAGCGAGTGAGCGCCGGCTTGTCCGCCTGCCTGTTCGCCGGGTTGCTGCTGCTCGC
GACGCTGCTGTCCGCCGTCTACGCGCAAGCCAGCATGCCCCCGGGCCACGGCGCCCAGCCCCAGGCCGTCCTGGCGGGGC
TGCTGGGTCTGGCCTGCGTGGCGGCGCTGGGCTTCGTGCTCCACCGCGCGCTGGCTCCGCTGCATGCGCGCCACCAATCC
AGCGAGCAGCACCTGCAGCTCCTCATGGACGGGGTGACGGACTATGCGCTGTGCTTCCTGGACCGGCACGGCCGGGTGAC
GGCGTGGAACGCGGGCGCCGAGCGCCTCACGGGCTGGTCCGAGGTGGAGCTCGCCGGACGCGACGCGGACCGCATCTACC
CGGTGGACGAGGTGGCCGCGGGCGTGCCCCGCGCGCACCGTGAGCGGGCCGCGCGCGAGGGGCGCCTGCTGGCGGAGGGC
TGGCGGGTGCGCCGCGATGGCAGCCGCTTCTGGGCGGAGACGCTGCTCACCGCGCTGTACGACGCGCACGGGCGGCTGCG
CGGCTTCGTGAAGGTGACACGTGACATCACCGAGCGCCGCCGGATGGAGCGGGCCCAGGCGCTCTTCGCGGAAGCCGGCC
GCGTGCTCCAGCCGCTGTCTGGCGCGCGCGAAGTGGGCGAGGCCCTCACCCGGCTGTGCGTGCCCGAGGTGGCCGACGCC
TGCATCCTCTTCCTCCCCTCCGAGGACGGCACGGTGCGTCCGCACGCGGTGGCCTGCGAGGACATCGCCGCCACCCACCG
CATGTGGGAGCCGCTGCTGCGCTGTCCGGAGGATGGCGAGGTGGGCCCCTCCCGCGTGGTGCGCACGGGCCGCAGCGAGC
TGCTCCCGGAGCTGGACGGCGCCCGGCTCCCGCCGGCGCTGGAAGGCAGCGCACACGGCGAGCTGCTGTGCGCGCTGGGC
GTGACGTCCGCCCTCACGGTGCCGCTGGCGGTGGGCTCCCGCGTGCTGGGCGCGCTGTGCCTGCTGTCCACCGGCACGCA
CCGCCGCTTCGGCGAGGTGGACCGGGCCTTCATGGAGGAGCTGGCGGCGCGCGCCGCGCTCGCGCTCGACAACGCCCGGC
TGCTGGCGCAGGCGCAGGACGCGCTGGAGCTCATCGGCATCGCCGCGCATGACCTGGGCAACCCACTCAGCTCGCTCCAA
CTGCGGCTGCGGCGCCTGTCCATGCAGAGCGCCGGCACCTCCGACACGCGGCTGCGCGACGGCCTGGCCGGAGCCGAGGG
CGAAACGCGGCGCCTGGGCCGGCTGGTGCACAACCTCCTGGACCTGTCCCGCCTGTCAGCGGGCCGCATGGTGCTGGACA
CGGAGCCGCTGGACCTGGCGCACCTGGTGCGCGAGGTGGTGGAACGTCACCGCGACCAGGCCAGCGCCGCGGGCTGCGCC
CTCGGCATCCGCGTGGAGGAAGGCGCCACCGGCCAGTGGGACCGGCAGCGCCTGGACCGCGTCATCACCAACCTGCTGAG
CAACGCCCTCAAGTTCGGCCGCGGCCACCCCGTGGAGCTGCGCGTCCAGGCCGACACCCGCTGCGTCCGCTTGGCCATCC
GGGACGGCGGCATCGGCATTGGCGTGGAAGCACAGCAGCGCCTGTTCCGCCGATTCCAGCGCGTCCATGCCGGCGGGCAG
CACCCCGGCACCGGCTTGGGGCTCTACATCGTCCGCCAGCTCGTCGAGGCCCACGGGGGCACCATCCACGTCCAGAGCCG
AACCGGGGAAGGCTCGGAATTCACGATTGAACTTCCCCGCAGGACAAACAAGGAATCCTGTTCAGTGAATGAAGTGCAGG
TATGA

Upstream 100 bases:

>100_bases
CACCCCGTCCACCAGGACGATGTCTTCCAGCAGGCAGTCTGGGTGATGCTTTCCTCACCGACGGCACGCCCGGAAGGGTG
CCTTGGGGGGGAGTCACCAC

Downstream 100 bases:

>100_bases
CCTTGTGGGTGGGGCAGCCCTGCGGGGCAGGCATTCATCTCCTTGAAAACACAGCAGGTTTGACTCCAGGTGGATTGTTT
TCCCAGAAGTTGAACAAATC

Product: sensory box histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MMRRWTFAQRVSAGLSACLFAGLLLLATLLSAVYAQASMPPGHGAQPQAVLAGLLGLACVAALGFVLHRALAPLHARHQS
SEQHLQLLMDGVTDYALCFLDRHGRVTAWNAGAERLTGWSEVELAGRDADRIYPVDEVAAGVPRAHRERAAREGRLLAEG
WRVRRDGSRFWAETLLTALYDAHGRLRGFVKVTRDITERRRMERAQALFAEAGRVLQPLSGAREVGEALTRLCVPEVADA
CILFLPSEDGTVRPHAVACEDIAATHRMWEPLLRCPEDGEVGPSRVVRTGRSELLPELDGARLPPALEGSAHGELLCALG
VTSALTVPLAVGSRVLGALCLLSTGTHRRFGEVDRAFMEELAARAALALDNARLLAQAQDALELIGIAAHDLGNPLSSLQ
LRLRRLSMQSAGTSDTRLRDGLAGAEGETRRLGRLVHNLLDLSRLSAGRMVLDTEPLDLAHLVREVVERHRDQASAAGCA
LGIRVEEGATGQWDRQRLDRVITNLLSNALKFGRGHPVELRVQADTRCVRLAIRDGGIGIGVEAQQRLFRRFQRVHAGGQ
HPGTGLGLYIVRQLVEAHGGTIHVQSRTGEGSEFTIELPRRTNKESCSVNEVQV

Sequences:

>Translated_614_residues
MMRRWTFAQRVSAGLSACLFAGLLLLATLLSAVYAQASMPPGHGAQPQAVLAGLLGLACVAALGFVLHRALAPLHARHQS
SEQHLQLLMDGVTDYALCFLDRHGRVTAWNAGAERLTGWSEVELAGRDADRIYPVDEVAAGVPRAHRERAAREGRLLAEG
WRVRRDGSRFWAETLLTALYDAHGRLRGFVKVTRDITERRRMERAQALFAEAGRVLQPLSGAREVGEALTRLCVPEVADA
CILFLPSEDGTVRPHAVACEDIAATHRMWEPLLRCPEDGEVGPSRVVRTGRSELLPELDGARLPPALEGSAHGELLCALG
VTSALTVPLAVGSRVLGALCLLSTGTHRRFGEVDRAFMEELAARAALALDNARLLAQAQDALELIGIAAHDLGNPLSSLQ
LRLRRLSMQSAGTSDTRLRDGLAGAEGETRRLGRLVHNLLDLSRLSAGRMVLDTEPLDLAHLVREVVERHRDQASAAGCA
LGIRVEEGATGQWDRQRLDRVITNLLSNALKFGRGHPVELRVQADTRCVRLAIRDGGIGIGVEAQQRLFRRFQRVHAGGQ
HPGTGLGLYIVRQLVEAHGGTIHVQSRTGEGSEFTIELPRRTNKESCSVNEVQV
>Mature_614_residues
MMRRWTFAQRVSAGLSACLFAGLLLLATLLSAVYAQASMPPGHGAQPQAVLAGLLGLACVAALGFVLHRALAPLHARHQS
SEQHLQLLMDGVTDYALCFLDRHGRVTAWNAGAERLTGWSEVELAGRDADRIYPVDEVAAGVPRAHRERAAREGRLLAEG
WRVRRDGSRFWAETLLTALYDAHGRLRGFVKVTRDITERRRMERAQALFAEAGRVLQPLSGAREVGEALTRLCVPEVADA
CILFLPSEDGTVRPHAVACEDIAATHRMWEPLLRCPEDGEVGPSRVVRTGRSELLPELDGARLPPALEGSAHGELLCALG
VTSALTVPLAVGSRVLGALCLLSTGTHRRFGEVDRAFMEELAARAALALDNARLLAQAQDALELIGIAAHDLGNPLSSLQ
LRLRRLSMQSAGTSDTRLRDGLAGAEGETRRLGRLVHNLLDLSRLSAGRMVLDTEPLDLAHLVREVVERHRDQASAAGCA
LGIRVEEGATGQWDRQRLDRVITNLLSNALKFGRGHPVELRVQADTRCVRLAIRDGGIGIGVEAQQRLFRRFQRVHAGGQ
HPGTGLGLYIVRQLVEAHGGTIHVQSRTGEGSEFTIELPRRTNKESCSVNEVQV

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=221, Percent_Identity=31.6742081447964, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=27.7777777777778, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI145693157, Length=257, Percent_Identity=29.9610894941634, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786912, Length=301, Percent_Identity=29.2358803986711, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=27.7777777777778, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1786783, Length=214, Percent_Identity=31.3084112149533, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=29.8165137614679, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=29.5454545454545, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788393, Length=220, Percent_Identity=28.6363636363636, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=26.0377358490566, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=273, Percent_Identity=27.8388278388278, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87081816, Length=187, Percent_Identity=30.4812834224599, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082128, Length=220, Percent_Identity=28.1818181818182, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66737; Mature: 66737

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRRWTFAQRVSAGLSACLFAGLLLLATLLSAVYAQASMPPGHGAQPQAVLAGLLGLACV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AALGFVLHRALAPLHARHQSSEQHLQLLMDGVTDYALCFLDRHGRVTAWNAGAERLTGWS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCC
EVELAGRDADRIYPVDEVAAGVPRAHRERAAREGRLLAEGWRVRRDGSRFWAETLLTALY
CEEECCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCEEHHCCCCCCCHHHHHHHHHHHHHH
DAHGRLRGFVKVTRDITERRRMERAQALFAEAGRVLQPLSGAREVGEALTRLCVPEVADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
CILFLPSEDGTVRPHAVACEDIAATHRMWEPLLRCPEDGEVGPSRVVRTGRSELLPELDG
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHCCCCCC
ARLPPALEGSAHGELLCALGVTSALTVPLAVGSRVLGALCLLSTGTHRRFGEVDRAFMEE
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LAARAALALDNARLLAQAQDALELIGIAAHDLGNPLSSLQLRLRRLSMQSAGTSDTRLRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHH
GLAGAEGETRRLGRLVHNLLDLSRLSAGRMVLDTEPLDLAHLVREVVERHRDQASAAGCA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCEE
LGIRVEEGATGQWDRQRLDRVITNLLSNALKFGRGHPVELRVQADTRCVRLAIRDGGIGI
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEEECCCEEC
GVEAQQRLFRRFQRVHAGGQHPGTGLGLYIVRQLVEAHGGTIHVQSRTGEGSEFTIELPR
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCC
RTNKESCSVNEVQV
CCCCCCCCCCCCCC
>Mature Secondary Structure
MMRRWTFAQRVSAGLSACLFAGLLLLATLLSAVYAQASMPPGHGAQPQAVLAGLLGLACV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AALGFVLHRALAPLHARHQSSEQHLQLLMDGVTDYALCFLDRHGRVTAWNAGAERLTGWS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCC
EVELAGRDADRIYPVDEVAAGVPRAHRERAAREGRLLAEGWRVRRDGSRFWAETLLTALY
CEEECCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCEEHHCCCCCCCHHHHHHHHHHHHHH
DAHGRLRGFVKVTRDITERRRMERAQALFAEAGRVLQPLSGAREVGEALTRLCVPEVADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
CILFLPSEDGTVRPHAVACEDIAATHRMWEPLLRCPEDGEVGPSRVVRTGRSELLPELDG
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHCCCCCC
ARLPPALEGSAHGELLCALGVTSALTVPLAVGSRVLGALCLLSTGTHRRFGEVDRAFMEE
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LAARAALALDNARLLAQAQDALELIGIAAHDLGNPLSSLQLRLRRLSMQSAGTSDTRLRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHH
GLAGAEGETRRLGRLVHNLLDLSRLSAGRMVLDTEPLDLAHLVREVVERHRDQASAAGCA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCEE
LGIRVEEGATGQWDRQRLDRVITNLLSNALKFGRGHPVELRVQADTRCVRLAIRDGGIGI
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEEECCCEEC
GVEAQQRLFRRFQRVHAGGQHPGTGLGLYIVRQLVEAHGGTIHVQSRTGEGSEFTIELPR
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCC
RTNKESCSVNEVQV
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA