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The map label for this gene is cqsS [H]

Identifier: 108760607

GI number: 108760607

Start: 590225

End: 590734

Strand: Direct

Name: cqsS [H]

Synonym: MXAN_0524

Alternate gene names: 108760607

Gene position: 590225-590734 (Clockwise)

Preceding gene: 108762971

Following gene: 108763258

Centisome position: 6.46

GC content: 65.69

Gene sequence:

>510_bases
GTGTATAGATTGTTCAACGCCCGTTCCAACCCGAGAGGCGTCTGTCCCATGAAGAGCACGGCGATGACAGTCCCGGCAGA
AGACATGCCAACCGCCAAGGAGCCCGCGCCGGGCGGGAACAAGAAGCGCGTGCTCGTGGTGGACGACTTCGACGATGCCC
GGGAGATGTACGCGGAGTACCTGGAGTTCGTCGGCTTCGAGGTGGACACCGCCCGCAACGGCGTGGAAGCGGTGGAGAAG
GCCAGCGAGGGCGAGCCCGACATCATCCTGATGGACCTGTCCCTCCCCGTCATGGACGGCTGGGAGGCGACGCGGCGCAT
CAAGCAGGACTCCCGCACCCGGGACATCCCCGTCATGGCGCTCACCGGCCATGTGCTCGCGGGGAACGCGGAGCATGCCC
GGGACGCTGGCGCGGACGAGTTCGTCGCCAAGCCCTGTCTGCCGCAGGATTTGGAGAACAAGATCCGAAACATGCTCAAG
CCGAGCAAGGGGAAGGTCCGGGGCGGCTGA

Upstream 100 bases:

>100_bases
CGTTTCTCCATCCAGCCCACCTGTCCTCCACTGAACACGTACTGGCACTCTGGTCCGCATTCGTTGAAGAGCCGGGTGGG
GTGGGCACGTCGGGAGGGGC

Downstream 100 bases:

>100_bases
GGCCCAAGGACAACACCACTGCTCGGCAACGGACACTCCTGCGGCCCTGGCGTCCTGGAGTCTCCTCCCTCGCGGCCCGT
TCAGTTGACCCCTGCCGGAC

Product: response regulator

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MYRLFNARSNPRGVCPMKSTAMTVPAEDMPTAKEPAPGGNKKRVLVVDDFDDAREMYAEYLEFVGFEVDTARNGVEAVEK
ASEGEPDIILMDLSLPVMDGWEATRRIKQDSRTRDIPVMALTGHVLAGNAEHARDAGADEFVAKPCLPQDLENKIRNMLK
PSKGKVRGG

Sequences:

>Translated_169_residues
MYRLFNARSNPRGVCPMKSTAMTVPAEDMPTAKEPAPGGNKKRVLVVDDFDDAREMYAEYLEFVGFEVDTARNGVEAVEK
ASEGEPDIILMDLSLPVMDGWEATRRIKQDSRTRDIPVMALTGHVLAGNAEHARDAGADEFVAKPCLPQDLENKIRNMLK
PSKGKVRGG
>Mature_169_residues
MYRLFNARSNPRGVCPMKSTAMTVPAEDMPTAKEPAPGGNKKRVLVVDDFDDAREMYAEYLEFVGFEVDTARNGVEAVEK
ASEGEPDIILMDLSLPVMDGWEATRRIKQDSRTRDIPVMALTGHVLAGNAEHARDAGADEFVAKPCLPQDLENKIRNMLK
PSKGKVRGG

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=121, Percent_Identity=33.0578512396694, Blast_Score=77, Evalue=6e-16,
Organism=Escherichia coli, GI1786599, Length=119, Percent_Identity=35.2941176470588, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=121, Percent_Identity=34.7107438016529, Blast_Score=68, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=104, Percent_Identity=35.5769230769231, Blast_Score=68, Evalue=3e-13,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=32.7731092436975, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1786784, Length=121, Percent_Identity=30.5785123966942, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=114, Percent_Identity=29.8245614035088, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788394, Length=124, Percent_Identity=26.6129032258064, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 18620; Mature: 18620

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRLFNARSNPRGVCPMKSTAMTVPAEDMPTAKEPAPGGNKKRVLVVDDFDDAREMYAEY
CCEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHH
LEFVGFEVDTARNGVEAVEKASEGEPDIILMDLSLPVMDGWEATRRIKQDSRTRDIPVMA
HHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEE
LTGHVLAGNAEHARDAGADEFVAKPCLPQDLENKIRNMLKPSKGKVRGG
EECEEEECCCHHHHHCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MYRLFNARSNPRGVCPMKSTAMTVPAEDMPTAKEPAPGGNKKRVLVVDDFDDAREMYAEY
CCEECCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHH
LEFVGFEVDTARNGVEAVEKASEGEPDIILMDLSLPVMDGWEATRRIKQDSRTRDIPVMA
HHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEE
LTGHVLAGNAEHARDAGADEFVAKPCLPQDLENKIRNMLKPSKGKVRGG
EECEEEECCCHHHHHCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA