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The map label for this gene is czcD [H]

Identifier: 108760363

GI number: 108760363

Start: 3931866

End: 3932873

Strand: Direct

Name: czcD [H]

Synonym: MXAN_3382

Alternate gene names: 108760363

Gene position: 3931866-3932873 (Clockwise)

Preceding gene: 108761772

Following gene: 108761572

Centisome position: 43.02

GC content: 66.67

Gene sequence:

>1008_bases
GTGACTACTTCCCCTTACACCCGCGGTGAATCCGGGCATGGCCACGAGCATGACCACGGCGACGGACATGGCCATGGCCA
TCATCATCATGGCCATGGGCACGGTCATGGGCACGGTCCCCGGAGGGGCGGACTGGCGGAGGAGCGGAAGAAGGACAAGC
GCCGGCTCATCTTCGCCCTGGTGCTGACGGCCACCATCGCGCTGGCGGAGGCGGTGGGCGGCTGGCTGACGAACTCGCTG
GCCCTGATGTCCGACGCGGGCCACATGCTGACGGACGTGTCCGCGCTGGCGCTGAGCCTGGTGGCGCTGTGGTTCGCGGG
CAAGCCGGCGGACGTGAAGAAGACGTACGGCTACTACCGGATGGAGATCCTCAGCGCGCTGCTCAACGGCGTGCTGCTGA
TGGGCATCACCGGCTTCATCCTCTATGAGGCCTGGGAGCGGGTGCGCTCGCCGGCGCAAGTGAACATCGGGCCCATGGCC
ATCGTGGCGTCGGTGGGCCTCTTGGCCAACCTGGGCGCGCTGGGGTTCCTGCACCGCTCCCACTCCATGAACGTGCGCGG
GGCCTTCCTGCACGTGCTGGGGGATACGCTGTCGTCGGTGGGCGTGCTCGTGGGCGCGGGCATCATGGCGTACACGGGCT
GGTACGTCGTGGACCCCATCATCTCGGTGGTCATCTCCATCGTCATCGTCATCGGCGCGGTGCGGCTGGTGCGCGACGCG
GTGGACGTGCTGATGGAGGCGGTTCCGGCGCACGTGGACCTGGCGCAAATCAAGGAGCTGATGCTGCGCGCGCAGGGCGT
CACGGCGGTGCATGACCTGCACGTGTGGACCATCTCCAGCGGCGTGTACGCGCTGTCCGCGCACCTGGTGGTGCAGGACC
CCATGGTCTGCAACAACGACGAGATTCTCTCCGCGGTGAAGCACGACCTGTTCGACCGCTTCGGAATCGACCACACCACG
ATTCAAATCGAGAGCGAGACCTACTCCCACCTGGGCGAGGTCCACTGA

Upstream 100 bases:

>100_bases
TCTCCCCACGCTCCGGAGCAGGGGATGCCGGGCCTGGCGGCAGCCAGATTCCCGGCCTCTCATACCTCATGACTGGGCAT
TAGCCGCACCCCTCACTCCC

Downstream 100 bases:

>100_bases
CGGCCCTGGGGCCCGGCCGGGGCCCCCCGTCCGCGTGCCCCAGCGGACGCTCCCAGCAGCTTCGCCTTGCCTCGGGCGGC
GCGGGCGGATGATTCTCCGC

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTTSPYTRGESGHGHEHDHGDGHGHGHHHHGHGHGHGHGPRRGGLAEERKKDKRRLIFALVLTATIALAEAVGGWLTNSL
ALMSDAGHMLTDVSALALSLVALWFAGKPADVKKTYGYYRMEILSALLNGVLLMGITGFILYEAWERVRSPAQVNIGPMA
IVASVGLLANLGALGFLHRSHSMNVRGAFLHVLGDTLSSVGVLVGAGIMAYTGWYVVDPIISVVISIVIVIGAVRLVRDA
VDVLMEAVPAHVDLAQIKELMLRAQGVTAVHDLHVWTISSGVYALSAHLVVQDPMVCNNDEILSAVKHDLFDRFGIDHTT
IQIESETYSHLGEVH

Sequences:

>Translated_335_residues
MTTSPYTRGESGHGHEHDHGDGHGHGHHHHGHGHGHGHGPRRGGLAEERKKDKRRLIFALVLTATIALAEAVGGWLTNSL
ALMSDAGHMLTDVSALALSLVALWFAGKPADVKKTYGYYRMEILSALLNGVLLMGITGFILYEAWERVRSPAQVNIGPMA
IVASVGLLANLGALGFLHRSHSMNVRGAFLHVLGDTLSSVGVLVGAGIMAYTGWYVVDPIISVVISIVIVIGAVRLVRDA
VDVLMEAVPAHVDLAQIKELMLRAQGVTAVHDLHVWTISSGVYALSAHLVVQDPMVCNNDEILSAVKHDLFDRFGIDHTT
IQIESETYSHLGEVH
>Mature_334_residues
TTSPYTRGESGHGHEHDHGDGHGHGHHHHGHGHGHGHGPRRGGLAEERKKDKRRLIFALVLTATIALAEAVGGWLTNSLA
LMSDAGHMLTDVSALALSLVALWFAGKPADVKKTYGYYRMEILSALLNGVLLMGITGFILYEAWERVRSPAQVNIGPMAI
VASVGLLANLGALGFLHRSHSMNVRGAFLHVLGDTLSSVGVLVGAGIMAYTGWYVVDPIISVVISIVIVIGAVRLVRDAV
DVLMEAVPAHVDLAQIKELMLRAQGVTAVHDLHVWTISSGVYALSAHLVVQDPMVCNNDEILSAVKHDLFDRFGIDHTTI
QIESETYSHLGEVH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=308, Percent_Identity=35.0649350649351, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI52352805, Length=317, Percent_Identity=33.4384858044164, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI21361112, Length=309, Percent_Identity=33.0097087378641, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI64762489, Length=311, Percent_Identity=34.4051446945338, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI289803013, Length=312, Percent_Identity=33.974358974359, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI289803009, Length=312, Percent_Identity=33.974358974359, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI289803007, Length=312, Percent_Identity=33.974358974359, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI289803003, Length=312, Percent_Identity=33.974358974359, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI20070323, Length=378, Percent_Identity=28.8359788359788, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI14210520, Length=221, Percent_Identity=33.0316742081448, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI222080086, Length=142, Percent_Identity=34.5070422535211, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI40255009, Length=142, Percent_Identity=34.5070422535211, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI52351208, Length=119, Percent_Identity=39.4957983193277, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI52352803, Length=131, Percent_Identity=38.9312977099237, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786966, Length=291, Percent_Identity=40.2061855670103, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1790349, Length=254, Percent_Identity=24.4094488188976, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17555794, Length=337, Percent_Identity=33.8278931750742, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17555796, Length=339, Percent_Identity=33.0383480825959, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI193210990, Length=344, Percent_Identity=30.2325581395349, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI32564488, Length=308, Percent_Identity=29.8701298701299, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17550442, Length=320, Percent_Identity=23.4375, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17550440, Length=320, Percent_Identity=23.4375, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323899, Length=148, Percent_Identity=37.1621621621622, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320411, Length=179, Percent_Identity=34.0782122905028, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324892, Length=149, Percent_Identity=30.8724832214765, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24583858, Length=359, Percent_Identity=30.3621169916435, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24656728, Length=334, Percent_Identity=30.5389221556886, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24656724, Length=334, Percent_Identity=30.5389221556886, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24656720, Length=334, Percent_Identity=30.5389221556886, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24656715, Length=334, Percent_Identity=30.5389221556886, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI21357035, Length=334, Percent_Identity=30.5389221556886, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24584409, Length=147, Percent_Identity=38.7755102040816, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI28574430, Length=147, Percent_Identity=38.7755102040816, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24645863, Length=149, Percent_Identity=34.8993288590604, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36057; Mature: 35926

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCC
>Mature Secondary Structure 
TTSPYTRGESGHGHEHDHGDGHGHGHHHHGHGHGHGHGPRRGGLAEERKKDKRRLIFAL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VLTATIALAEAVGGWLTNSLALMSDAGHMLTDVSALALSLVALWFAGKPADVKKTYGYYR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
MEILSALLNGVLLMGITGFILYEAWERVRSPAQVNIGPMAIVASVGLLANLGALGFLHRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
HSMNVRGAFLHVLGDTLSSVGVLVGAGIMAYTGWYVVDPIISVVISIVIVIGAVRLVRDA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDVLMEAVPAHVDLAQIKELMLRAQGVTAVHDLHVWTISSGVYALSAHLVVQDPMVCNND
HHHHHHHHCCCCCHHHHHHHHHHHCCCCEEHHEEEEEECCCCEEHHEEEEEECCCCCCCH
EILSAVKHDLFDRFGIDHTTIQIESETYSHLGEVH
HHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]