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The map label for this gene is dfrA [H]

Identifier: 108760075

GI number: 108760075

Start: 1789113

End: 1790141

Strand: Reverse

Name: dfrA [H]

Synonym: MXAN_1527

Alternate gene names: 108760075

Gene position: 1790141-1789113 (Counterclockwise)

Preceding gene: 108758938

Following gene: 108762622

Centisome position: 19.59

GC content: 69.19

Gene sequence:

>1029_bases
GTGAAGCTGCTGGTGACGGGAGGCACGGGCTTTCTGGGCACGCACCTGGTGCCCAGGCTGGTGGCGGCGGGCCACGAGGT
GCGGCTCATCGGCCGCTCGCGGCCTTCGGGCGCCCCCTACGCGGGCACGGAGTACGTCCCCGGTGACTTGAAGAACCGGG
ACGCGGTGCGCCGCGCGCTGGAGGGCGTGGACGCCGTCTACCACCTGGCGGGGCTCGTCTCCTTCCAGCCGAAGGACGCG
CGGAAGATGTTCGAGCTGCACGTGGACAGCACGCGCGAGCTGCTGCGGGACGTGCGCGAGGCCGGCGTGAAGCGCGTGGT
GCTGGCCTCCACCTCCGGCACCATCGCGGTGTCGAAGGAGGCGCACGTCCGCGACGAGAGCGCCGACTACCCGATTACGG
TGGTGGGCCAGTGGCCCTACTACCTGTCGAAAATCTACGAGGAGAAGCTGGCGCTCGCATACTGCCGCAAGCACGAGATT
CCCCTGGTGGTGCTCAACCCCAGCCTGCTGATGGGGCCCGGGGATGACCGGCTGTCCTCCACATGGACGGTGGTGAAGTT
CCTCAACCGCGAGATTCCGGCCATGCCGGGCGGCGGCATCTCCTTCGTGGACGCGCGCGACGCGGCGGACGCCTTCGTCC
AGGCGCTCACCCGGGGCGAGGTGTACGGCCGTCACCTCATGGGGGTGAATCTGTCCATGAAGGACTTCTTCCAGCGGCTG
GAGCGCCTGTCGGGCGTGCCCGCGCCGAAGCTGAAGCTCCCCTCCAAGGTCAACGTGCTCGGCGGGAAGCTGCTGGAGCG
CTGGGCCAAGGTGCGCGGCACCACGCCGACGCTGGACCCGCAGGAAATCGACATCGGCGAGCACTGGTTCTGGCTGGACG
CATCCAAGGCGGAGGCCGAGCTCGGCTTCCGCGCGCGCGACATCCAGGAGACGCTCTCCGAGACGGTGCAGCACATCTAC
GGGAAGATGCCGCCCCAGAGCCTGCCTGGCACCAAGGGCCGGCTGGCGGAGCTGCGCGAGAACACCTGA

Upstream 100 bases:

>100_bases
GGGCGCTGCGCGACGGCCGGGTGCTGAACCTGGAGCGCGTGGACCTGCCTCCGGCCGGGGCCAGTCCCCGCGCGTCCACG
TCCACGGAAGGGAAGGACTC

Downstream 100 bases:

>100_bases
GCGAAGCTCGCGGCGGGAGCTTCCGGGCACCGGACTCCCGCCCCTGACCTGGCCGCGGGGAGCGCACCGCAGCCCGGCGT
CGCGCCGCGACCGGAGCCAT

Product: NAD dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: DFR; Dihydrokaempferol 4-reductase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKLLVTGGTGFLGTHLVPRLVAAGHEVRLIGRSRPSGAPYAGTEYVPGDLKNRDAVRRALEGVDAVYHLAGLVSFQPKDA
RKMFELHVDSTRELLRDVREAGVKRVVLASTSGTIAVSKEAHVRDESADYPITVVGQWPYYLSKIYEEKLALAYCRKHEI
PLVVLNPSLLMGPGDDRLSSTWTVVKFLNREIPAMPGGGISFVDARDAADAFVQALTRGEVYGRHLMGVNLSMKDFFQRL
ERLSGVPAPKLKLPSKVNVLGGKLLERWAKVRGTTPTLDPQEIDIGEHWFWLDASKAEAELGFRARDIQETLSETVQHIY
GKMPPQSLPGTKGRLAELRENT

Sequences:

>Translated_342_residues
MKLLVTGGTGFLGTHLVPRLVAAGHEVRLIGRSRPSGAPYAGTEYVPGDLKNRDAVRRALEGVDAVYHLAGLVSFQPKDA
RKMFELHVDSTRELLRDVREAGVKRVVLASTSGTIAVSKEAHVRDESADYPITVVGQWPYYLSKIYEEKLALAYCRKHEI
PLVVLNPSLLMGPGDDRLSSTWTVVKFLNREIPAMPGGGISFVDARDAADAFVQALTRGEVYGRHLMGVNLSMKDFFQRL
ERLSGVPAPKLKLPSKVNVLGGKLLERWAKVRGTTPTLDPQEIDIGEHWFWLDASKAEAELGFRARDIQETLSETVQHIY
GKMPPQSLPGTKGRLAELRENT
>Mature_342_residues
MKLLVTGGTGFLGTHLVPRLVAAGHEVRLIGRSRPSGAPYAGTEYVPGDLKNRDAVRRALEGVDAVYHLAGLVSFQPKDA
RKMFELHVDSTRELLRDVREAGVKRVVLASTSGTIAVSKEAHVRDESADYPITVVGQWPYYLSKIYEEKLALAYCRKHEI
PLVVLNPSLLMGPGDDRLSSTWTVVKFLNREIPAMPGGGISFVDARDAADAFVQALTRGEVYGRHLMGVNLSMKDFFQRL
ERLSGVPAPKLKLPSKVNVLGGKLLERWAKVRGTTPTLDPQEIDIGEHWFWLDASKAEAELGFRARDIQETLSETVQHIY
GKMPPQSLPGTKGRLAELRENT

Specific function: Unknown

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroflavonol-4-reductase family [H]

Homologues:

Organism=Homo sapiens, GI193211614, Length=342, Percent_Identity=23.6842105263158, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI8393516, Length=342, Percent_Identity=23.6842105263158, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71987463, Length=344, Percent_Identity=27.6162790697674, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR017829
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.219 [H]

Molecular weight: Translated: 37803; Mature: 37803

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVTGGTGFLGTHLVPRLVAAGHEVRLIGRSRPSGAPYAGTEYVPGDLKNRDAVRRAL
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHH
EGVDAVYHLAGLVSFQPKDARKMFELHVDSTRELLRDVREAGVKRVVLASTSGTIAVSKE
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCEEECCC
AHVRDESADYPITVVGQWPYYLSKIYEEKLALAYCRKHEIPLVVLNPSLLMGPGDDRLSS
CCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEECCCCCHHHH
TWTVVKFLNREIPAMPGGGISFVDARDAADAFVQALTRGEVYGRHLMGVNLSMKDFFQRL
HHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHH
ERLSGVPAPKLKLPSKVNVLGGKLLERWAKVRGTTPTLDPQEIDIGEHWFWLDASKAEAE
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHH
LGFRARDIQETLSETVQHIYGKMPPQSLPGTKGRLAELRENT
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MKLLVTGGTGFLGTHLVPRLVAAGHEVRLIGRSRPSGAPYAGTEYVPGDLKNRDAVRRAL
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHH
EGVDAVYHLAGLVSFQPKDARKMFELHVDSTRELLRDVREAGVKRVVLASTSGTIAVSKE
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCEEECCC
AHVRDESADYPITVVGQWPYYLSKIYEEKLALAYCRKHEIPLVVLNPSLLMGPGDDRLSS
CCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEECCCCCHHHH
TWTVVKFLNREIPAMPGGGISFVDARDAADAFVQALTRGEVYGRHLMGVNLSMKDFFQRL
HHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHH
ERLSGVPAPKLKLPSKVNVLGGKLLERWAKVRGTTPTLDPQEIDIGEHWFWLDASKAEAE
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHH
LGFRARDIQETLSETVQHIYGKMPPQSLPGTKGRLAELRENT
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]