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The map label for this gene is ldh [H]

Identifier: 108760035

GI number: 108760035

Start: 1250245

End: 1251276

Strand: Direct

Name: ldh [H]

Synonym: MXAN_1074

Alternate gene names: 108760035

Gene position: 1250245-1251276 (Clockwise)

Preceding gene: 108757186

Following gene: 108761795

Centisome position: 13.68

GC content: 68.41

Gene sequence:

>1032_bases
ATGAGCTACTTCACGCAGTTGCTTGAGGGCGGCTACGAAGCCGTCCATTTGTTGAGTGATTCGAAGTCAGGCCTGCGTGC
CATTGTGGGCATGCACAACACGCGGCTCGGTCCGGGGTTGGGCGGCACTCGTGCGCTCGCCACCTATGCCAGCGAGGAGG
AAGCCGTCGCGGACGCGCTCCGGCTGGCGCGCGGAATGACATACAAGGCCGCGCTCGCGGGGGTGCCCCACGGCGGCGGC
AAGGCGGTCATCATGCTGCCGCGCGGCAGCTTCGACCGTGAGAAGATTTTCGAGTCCTTCGGCCGCGCGGTCGAGTCCCT
GGGCGGGCGCTACATCACCACCGAGGACAGCGGCACCAGCCCCGACGACATGGAGCACGTGCGCCGGCACACGAAGTATG
TCGTTGGACTGAAGGAGCGCAGCGGAGACCCGTCGCCGGTGACGGCGTATGGCGTGGCGCGCGCCATGGAAGCCACGGCG
AAGCACGTCTTCGGCAGCCCGGACCTGAAGGGCCTGCGCGTCACCGTGCTGGGCGTGGGGCACGTGGGCATGTACCTGGT
GAAGGAACTGCACCAGCGCGGCGCCAAGGTGTGGGTGAGCGACATCAACCCCGCCAGCGTGCAGCACGCGGTGACGCAGT
ACGGCGTCACGGCGGTGGACGCCGACGCACTGCATCGCATGGAGGCGGACATCTACGCCCCCTGTGCGCTGGGCGGCGCC
ATCAACGACACCACCCTGTCGCTGCTGAACGTCAAGGCGGTGTGCGGCGCGGCCAACAACCAGTTGCTCACGTCGCGTCA
CGGCGAGCAGTTGGCCCGGCGCGGCATCCTCTACGTGCCCGACTACGCGGCCAATGCCGGCGGCCTCATCAACGTGGCCC
AGGAGTGGGCGGGGTATGACCGGGACAAGGCGTACGCCCGCACCTCCCTCATCTTCGACACCATCGACACGGTGCTGACC
CGCGCGAAGGAATCCGGCCTGCGCCCCGAGCAGGTGGCGGACCGGATGGTCGAGGAGCGGCTGGCCGGCTGA

Upstream 100 bases:

>100_bases
TGCACGACGCGCTATGTCATTCCTGGAGACGAAATCCGCGGCATGTTGGAGCGCGGCGCCATTTGACTTGCACGAGGCGC
GACGGTACTTGCCGCGCGCC

Downstream 100 bases:

>100_bases
GCGCTCACGCACGCAGTGCGTGTGTTGCCGCGATACAAAGGCGACGTCTGGGGTGTGGCCGGATGTGGCCACCGTGCGGC
CCTCGGAGTATGACGGGGCC

Product: Glu/Leu/Phe/Val dehydrogenase family protein

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MSYFTQLLEGGYEAVHLLSDSKSGLRAIVGMHNTRLGPGLGGTRALATYASEEEAVADALRLARGMTYKAALAGVPHGGG
KAVIMLPRGSFDREKIFESFGRAVESLGGRYITTEDSGTSPDDMEHVRRHTKYVVGLKERSGDPSPVTAYGVARAMEATA
KHVFGSPDLKGLRVTVLGVGHVGMYLVKELHQRGAKVWVSDINPASVQHAVTQYGVTAVDADALHRMEADIYAPCALGGA
INDTTLSLLNVKAVCGAANNQLLTSRHGEQLARRGILYVPDYAANAGGLINVAQEWAGYDRDKAYARTSLIFDTIDTVLT
RAKESGLRPEQVADRMVEERLAG

Sequences:

>Translated_343_residues
MSYFTQLLEGGYEAVHLLSDSKSGLRAIVGMHNTRLGPGLGGTRALATYASEEEAVADALRLARGMTYKAALAGVPHGGG
KAVIMLPRGSFDREKIFESFGRAVESLGGRYITTEDSGTSPDDMEHVRRHTKYVVGLKERSGDPSPVTAYGVARAMEATA
KHVFGSPDLKGLRVTVLGVGHVGMYLVKELHQRGAKVWVSDINPASVQHAVTQYGVTAVDADALHRMEADIYAPCALGGA
INDTTLSLLNVKAVCGAANNQLLTSRHGEQLARRGILYVPDYAANAGGLINVAQEWAGYDRDKAYARTSLIFDTIDTVLT
RAKESGLRPEQVADRMVEERLAG
>Mature_342_residues
SYFTQLLEGGYEAVHLLSDSKSGLRAIVGMHNTRLGPGLGGTRALATYASEEEAVADALRLARGMTYKAALAGVPHGGGK
AVIMLPRGSFDREKIFESFGRAVESLGGRYITTEDSGTSPDDMEHVRRHTKYVVGLKERSGDPSPVTAYGVARAMEATAK
HVFGSPDLKGLRVTVLGVGHVGMYLVKELHQRGAKVWVSDINPASVQHAVTQYGVTAVDADALHRMEADIYAPCALGGAI
NDTTLSLLNVKAVCGAANNQLLTSRHGEQLARRGILYVPDYAANAGGLINVAQEWAGYDRDKAYARTSLIFDTIDTVLTR
AKESGLRPEQVADRMVEERLAG

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids, and plays an important role in spore germination in cooperation with alanine dehydrogenase [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

None

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 36755; Mature: 36624

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYFTQLLEGGYEAVHLLSDSKSGLRAIVGMHNTRLGPGLGGTRALATYASEEEAVADAL
CHHHHHHHHCCHHEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHHH
RLARGMTYKAALAGVPHGGGKAVIMLPRGSFDREKIFESFGRAVESLGGRYITTEDSGTS
HHHHCCCHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCC
PDDMEHVRRHTKYVVGLKERSGDPSPVTAYGVARAMEATAKHVFGSPDLKGLRVTVLGVG
CHHHHHHHHHHHHEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
HVGMYLVKELHQRGAKVWVSDINPASVQHAVTQYGVTAVDADALHRMEADIYAPCALGGA
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEECHHHHHHHHHHHCCCHHCCCC
INDTTLSLLNVKAVCGAANNQLLTSRHGEQLARRGILYVPDYAANAGGLINVAQEWAGYD
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHCCCC
RDKAYARTSLIFDTIDTVLTRAKESGLRPEQVADRMVEERLAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SYFTQLLEGGYEAVHLLSDSKSGLRAIVGMHNTRLGPGLGGTRALATYASEEEAVADAL
HHHHHHHHCCHHEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHHH
RLARGMTYKAALAGVPHGGGKAVIMLPRGSFDREKIFESFGRAVESLGGRYITTEDSGTS
HHHHCCCHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCC
PDDMEHVRRHTKYVVGLKERSGDPSPVTAYGVARAMEATAKHVFGSPDLKGLRVTVLGVG
CHHHHHHHHHHHHEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
HVGMYLVKELHQRGAKVWVSDINPASVQHAVTQYGVTAVDADALHRMEADIYAPCALGGA
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEECHHHHHHHHHHHCCCHHCCCC
INDTTLSLLNVKAVCGAANNQLLTSRHGEQLARRGILYVPDYAANAGGLINVAQEWAGYD
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHCCCC
RDKAYARTSLIFDTIDTVLTRAKESGLRPEQVADRMVEERLAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9188201 [H]