Click here to switch to the map view.

The map label for this gene is ybhO [H]

Identifier: 108760017

GI number: 108760017

Start: 1598211

End: 1599572

Strand: Direct

Name: ybhO [H]

Synonym: MXAN_1362

Alternate gene names: 108760017

Gene position: 1598211-1599572 (Clockwise)

Preceding gene: 108762869

Following gene: 108761045

Centisome position: 17.49

GC content: 71.07

Gene sequence:

>1362_bases
TTGTCCCGTTGGCTTCCGGACACCGGCTGGCACTGGAAGACGGGCTGCGATGCGGCTCGGGTTGCCGGGTCGCGCGGGCA
TCCGCACCGTTGGGAGGCCATGCGTGACCAGGAGGCGTTGACCGAGCAGTCGGGGGAAGTGGACACGGGCGCGCCGCGGC
GTGCGCCCACGCCCCCAGCGCCCGTGCCGGAGCATGGGCCGGTGTGGAGCCCCGGCGTCTCCGGGGGGCTCCTGACGCGC
TACTACCTGCCGCGCCGCCACGGGGTGGTGCAGGGCAACGCATGCCAGTTGCTGCGCGACGGCGTGGAGGCCTACCCGGC
GATGCTGGAGGCCATCCGCGGGGCGCGCCGTTATGTCCGTATGGAGACGTACATGTTCGTCTCCGACGCCGTCGGCGAAC
TGTTTGGCCAGGCGCTGGCGGAGGCGGCCGAGCGCGGCGTGCACGTGAAGGTGTTGTACGACGCGGTGGGCTCCTGGACG
AGCCGCCGGAGCTTCTTCGCAGGGCTGCGCGCGCGGGGCGTGGACATCCGCGCCTTCAAGCCCTTCAGCCTGTCACGCGG
GCTGCGGCACCTGCTGCGGAGGGACCACCGCAAAATCCTGGTGGTGGACGGCGAGGTGGCCTTCACCGGTGGGGTGAACA
TCTCCGCCCACTGGGCGCCCGCGGAGATGGGCGCGGCGTGGCGGGACGATGTGCTGCGCATCGAAGGGCCGGCCGTCCAC
GAACTGGAGCGGTGTTTCTCCGCCACGTGGCGGATGATGTTCCAGGGCCGCTTCCACCGGCTGACCCGGCGGCTGGAGCG
CCTGCGCAACCCTCCGCCTCGGCGCGGCGCGGTGGGGCTGGTGGTGTTGTCCAGTCGGCGAAGCATCCACCGGGCCTACC
TGCACGCCATCCGCCGGGCCCGGCGCAGCGTGCTGGTGGCCGCCGCCTATTTCATTCCGGACCGGCGCATGGTGATGGCG
CTGCGCGAGGCGGCCCGGCGCGGGGTGGAGGTCCATCTGCTGCTCAACGCTCGCAGCGACCACCCCATCCTGGAGTTCAT
GGCCCGGGCCTTCTACGAGCGGCTGCTGGGCGCGGGCGTCCGCATCTTCGAGTGGCAGCGCGGCGTGCTGCACGCCAAGA
CGGCCGTGGTGGACGGGGTGTGGGGCACCATCGGCTCATTCAACCTGGAGCGCCTCAGCCTGGCCTTCAATCACGAGGTG
AACGCGGTCTTCGCCGACCCTCGCTTGGGGCAGCAACTGGAGGACTCCTTCCGCGGCGACTGCGGGGACTGCCGCGAGGT
GACGCTGGCGGAGTTCCGCCGCCGGCCCCTGTGGCAGAAGCTGCTGGAGCGGGCACTGTCTCTGCTTCGCAAAATCATTT
GA

Upstream 100 bases:

>100_bases
GGAGTTCGACCAGCCGTGCGCCACCCGCGCGGACGCCAAGCGCGCGGAGTACGGCCTCTAGGCTGCGCCACGGCTTTCCG
GTGTCCGTGAAGTCGCGGGA

Downstream 100 bases:

>100_bases
GCCACGCCTGTCCGGTCCTCAGCGGGCCGCATGGTTCCGATGAGCGGGGCTGCACACCCGCGGCTCGAAGCGTCCGGCCC
TCAATGCGCTCGCAGGAACC

Product: phospholipase family protein

Products: cardiolipin; glycerol [C]

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSRWLPDTGWHWKTGCDAARVAGSRGHPHRWEAMRDQEALTEQSGEVDTGAPRRAPTPPAPVPEHGPVWSPGVSGGLLTR
YYLPRRHGVVQGNACQLLRDGVEAYPAMLEAIRGARRYVRMETYMFVSDAVGELFGQALAEAAERGVHVKVLYDAVGSWT
SRRSFFAGLRARGVDIRAFKPFSLSRGLRHLLRRDHRKILVVDGEVAFTGGVNISAHWAPAEMGAAWRDDVLRIEGPAVH
ELERCFSATWRMMFQGRFHRLTRRLERLRNPPPRRGAVGLVVLSSRRSIHRAYLHAIRRARRSVLVAAAYFIPDRRMVMA
LREAARRGVEVHLLLNARSDHPILEFMARAFYERLLGAGVRIFEWQRGVLHAKTAVVDGVWGTIGSFNLERLSLAFNHEV
NAVFADPRLGQQLEDSFRGDCGDCREVTLAEFRRRPLWQKLLERALSLLRKII

Sequences:

>Translated_453_residues
MSRWLPDTGWHWKTGCDAARVAGSRGHPHRWEAMRDQEALTEQSGEVDTGAPRRAPTPPAPVPEHGPVWSPGVSGGLLTR
YYLPRRHGVVQGNACQLLRDGVEAYPAMLEAIRGARRYVRMETYMFVSDAVGELFGQALAEAAERGVHVKVLYDAVGSWT
SRRSFFAGLRARGVDIRAFKPFSLSRGLRHLLRRDHRKILVVDGEVAFTGGVNISAHWAPAEMGAAWRDDVLRIEGPAVH
ELERCFSATWRMMFQGRFHRLTRRLERLRNPPPRRGAVGLVVLSSRRSIHRAYLHAIRRARRSVLVAAAYFIPDRRMVMA
LREAARRGVEVHLLLNARSDHPILEFMARAFYERLLGAGVRIFEWQRGVLHAKTAVVDGVWGTIGSFNLERLSLAFNHEV
NAVFADPRLGQQLEDSFRGDCGDCREVTLAEFRRRPLWQKLLERALSLLRKII
>Mature_452_residues
SRWLPDTGWHWKTGCDAARVAGSRGHPHRWEAMRDQEALTEQSGEVDTGAPRRAPTPPAPVPEHGPVWSPGVSGGLLTRY
YLPRRHGVVQGNACQLLRDGVEAYPAMLEAIRGARRYVRMETYMFVSDAVGELFGQALAEAAERGVHVKVLYDAVGSWTS
RRSFFAGLRARGVDIRAFKPFSLSRGLRHLLRRDHRKILVVDGEVAFTGGVNISAHWAPAEMGAAWRDDVLRIEGPAVHE
LERCFSATWRMMFQGRFHRLTRRLERLRNPPPRRGAVGLVVLSSRRSIHRAYLHAIRRARRSVLVAAAYFIPDRRMVMAL
REAARRGVEVHLLLNARSDHPILEFMARAFYERLLGAGVRIFEWQRGVLHAKTAVVDGVWGTIGSFNLERLSLAFNHEVN
AVFADPRLGQQLEDSFRGDCGDCREVTLAEFRRRPLWQKLLERALSLLRKII

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=359, Percent_Identity=37.3259052924791, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1787502, Length=379, Percent_Identity=28.4960422163588, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 51345; Mature: 51214

Theoretical pI: Translated: 11.33; Mature: 11.33

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRWLPDTGWHWKTGCDAARVAGSRGHPHRWEAMRDQEALTEQSGEVDTGAPRRAPTPPA
CCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
PVPEHGPVWSPGVSGGLLTRYYLPRRHGVVQGNACQLLRDGVEAYPAMLEAIRGARRYVR
CCCCCCCCCCCCCCCCHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
METYMFVSDAVGELFGQALAEAAERGVHVKVLYDAVGSWTSRRSFFAGLRARGVDIRAFK
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCHHHHHHHHHHHHHCCCEEEEEC
PFSLSRGLRHLLRRDHRKILVVDGEVAFTGGVNISAHWAPAEMGAAWRDDVLRIEGPAVH
CHHHHHHHHHHHHCCCCEEEEEECCEEEECCCEEEEECCCHHHCCHHHCCCEEECCCHHH
ELERCFSATWRMMFQGRFHRLTRRLERLRNPPPRRGAVGLVVLSSRRSIHRAYLHAIRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
RRSVLVAAAYFIPDRRMVMALREAARRGVEVHLLLNARSDHPILEFMARAFYERLLGAGV
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
RIFEWQRGVLHAKTAVVDGVWGTIGSFNLERLSLAFNHEVNAVFADPRLGQQLEDSFRGD
EEEEHHCCHHHHHHHHHHCHHHHCCCCCHHHEEEEECCCCEEEECCCCCCHHHHHHHCCC
CGDCREVTLAEFRRRPLWQKLLERALSLLRKII
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SRWLPDTGWHWKTGCDAARVAGSRGHPHRWEAMRDQEALTEQSGEVDTGAPRRAPTPPA
CCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
PVPEHGPVWSPGVSGGLLTRYYLPRRHGVVQGNACQLLRDGVEAYPAMLEAIRGARRYVR
CCCCCCCCCCCCCCCCHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
METYMFVSDAVGELFGQALAEAAERGVHVKVLYDAVGSWTSRRSFFAGLRARGVDIRAFK
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCHHHHHHHHHHHHHCCCEEEEEC
PFSLSRGLRHLLRRDHRKILVVDGEVAFTGGVNISAHWAPAEMGAAWRDDVLRIEGPAVH
CHHHHHHHHHHHHCCCCEEEEEECCEEEECCCEEEEECCCHHHCCHHHCCCEEECCCHHH
ELERCFSATWRMMFQGRFHRLTRRLERLRNPPPRRGAVGLVVLSSRRSIHRAYLHAIRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
RRSVLVAAAYFIPDRRMVMALREAARRGVEVHLLLNARSDHPILEFMARAFYERLLGAGV
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
RIFEWQRGVLHAKTAVVDGVWGTIGSFNLERLSLAFNHEVNAVFADPRLGQQLEDSFRGD
EEEEHHCCHHHHHHHHHHCHHHHCCCCCHHHEEEEECCCCEEEECCCCCCHHHHHHHCCC
CGDCREVTLAEFRRRPLWQKLLERALSLLRKII
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 L-1-phosphatidyl-glycerol [C]

Specific reaction: 2 L-1-phosphatidyl-glycerol = cardiolipin + glycerol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]