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The map label for this gene is hsrA [H]

Identifier: 108759991

GI number: 108759991

Start: 5783799

End: 5785232

Strand: Reverse

Name: hsrA [H]

Synonym: MXAN_4609

Alternate gene names: 108759991

Gene position: 5785232-5783799 (Counterclockwise)

Preceding gene: 108759544

Following gene: 108758945

Centisome position: 63.3

GC content: 68.62

Gene sequence:

>1434_bases
GTGCCTGGGCATCCGGCTTCCAGCAGCGCTGAGGCAGGTGGAGATGCTCCAAGGGGCTCGCGGCTGGCCTCGATTGCTGT
GGCCAGCGCGCTGTTCATGGAGTTCGTGGACTCCACCGCGCTGTCGACCGCGTTGCCCCGGTTGTCGTTGGCGTTCGGCA
CCGACCCCATCCATCTGAAGCTGGCGCTGACGTCGTACATCCTGGCGTTGGCGGTGCTCGCGCCCGCGAGCGGCTGGGTG
GCGGACCGGTTCGGGCCCCGTCGCGTCTTCATGCTTGCGATGAGCGTGTTCCTGCTGGGCTCGGTGCTCTGCGGCTTCTC
TCAGTCGCTGACCCAGTTGGTCATCTTCCGCACCCTCCAGGGGCTGGGCGGCGCGTTGATGACGCCCGTGGGGCGCATCA
TCGTGGTGAGCTCGGCGCCGCGAGAGCGCCTGGTGGCCGCCTTGAGCTGGTTCACCATGCCCGCGCTGGTGGGCCCGCTG
GTGGGGCCTCCGTTGGCGGGCCTCATCCTGGGCGTCGCGGACTGGCCGTGGATTTTCTTCATCAACGTGCCCGTGGGCAT
CCTGGGCATGCTCGCGGTGGCGCGCTTCGTTCCGCCGCTGCACCAGCCGGACCCGGGGCCCTTCGACACGCGGGGCTTCG
TGCTCGTGGCCGTCGCCATCACTACGCTGATTGGCGCGGCGGAGACGGTGGGCATCGGGCTGATGCCGCTGTCGTTGCAA
CTGGGGCTCGCGGCCGTCGCGTTCTTGTCGCTGGGGGCCTACGTGTGGCACGCGCTGCGCGTGGAGCGGCCCGTGTTGAA
TCTCCGGTTGCTGCGCATCGACACCTTCCGGGCCAGCATGATTGGCGGAACCCTGACGCGCATGGGCCTGGGGGCGTCGC
CCTTCCTCCTGCCGCTGCTGTTTCAGGTCGGCTTGGGCTGGACGCCCGTCGAGGCAGGGCTGGTGACCATTGGCGGCGGC
GTGGGCGCGCTCGCCTGCAAGTCGGTGGCGCCCTACATCATCCGGCGGTTCGGCTTCCGGCAAACGCTCATCTTCGCCAA
CCTGACGTCCGCTGTCCTGACCGCGATGCCGGCCTTCTTCCGGAACAGCACGCCGATTCCGCTCATCGTTGGCGTGCTCA
TGGTCAGCGGATTCATGCGCTCGATGCAGTTCACCGCGATCAATACCGTGGCGTATGCGGACATCCCCCCAGACACGGTG
AGCAACGCGTCCACGCTGTCCGTGGTGACGATGCAGATGGCGCTGGGGTTGGGCATCAGCTTCGGCGGGTTGATGCTGCA
CCTGGCGCGCGGCGCTGGCGAGGCGCCGTTGACGCCGGACCGCTTCGTGCTGCCGTTCATCGCGGTGGGCATCATGTCGT
CGCTGGCCGGACCGCTCTATCGCCGGTTGTCGCCCAATGCCGGGGCGCACATCGGGGGCCGCAGGGTGGGGTGA

Upstream 100 bases:

>100_bases
GATTCCCTGGCCGGTGAGCGAGCCGTTGTTGTCGCCCAAGGATGCCCAGGCCCCGAGACTCCGCGACGCACCCTTGCTTC
CGGAGTACGTGGGCTGAACC

Downstream 100 bases:

>100_bases
GCCGAGCGGCTCATGTGCCCGAGCGAAGCCACTCCGCGAGTCTTGCGCGTTTCTTCCCGCGAAGGTTCGTAAACAACGTG
CTGTCGCTGATGTTCCACGC

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MPGHPASSSAEAGGDAPRGSRLASIAVASALFMEFVDSTALSTALPRLSLAFGTDPIHLKLALTSYILALAVLAPASGWV
ADRFGPRRVFMLAMSVFLLGSVLCGFSQSLTQLVIFRTLQGLGGALMTPVGRIIVVSSAPRERLVAALSWFTMPALVGPL
VGPPLAGLILGVADWPWIFFINVPVGILGMLAVARFVPPLHQPDPGPFDTRGFVLVAVAITTLIGAAETVGIGLMPLSLQ
LGLAAVAFLSLGAYVWHALRVERPVLNLRLLRIDTFRASMIGGTLTRMGLGASPFLLPLLFQVGLGWTPVEAGLVTIGGG
VGALACKSVAPYIIRRFGFRQTLIFANLTSAVLTAMPAFFRNSTPIPLIVGVLMVSGFMRSMQFTAINTVAYADIPPDTV
SNASTLSVVTMQMALGLGISFGGLMLHLARGAGEAPLTPDRFVLPFIAVGIMSSLAGPLYRRLSPNAGAHIGGRRVG

Sequences:

>Translated_477_residues
MPGHPASSSAEAGGDAPRGSRLASIAVASALFMEFVDSTALSTALPRLSLAFGTDPIHLKLALTSYILALAVLAPASGWV
ADRFGPRRVFMLAMSVFLLGSVLCGFSQSLTQLVIFRTLQGLGGALMTPVGRIIVVSSAPRERLVAALSWFTMPALVGPL
VGPPLAGLILGVADWPWIFFINVPVGILGMLAVARFVPPLHQPDPGPFDTRGFVLVAVAITTLIGAAETVGIGLMPLSLQ
LGLAAVAFLSLGAYVWHALRVERPVLNLRLLRIDTFRASMIGGTLTRMGLGASPFLLPLLFQVGLGWTPVEAGLVTIGGG
VGALACKSVAPYIIRRFGFRQTLIFANLTSAVLTAMPAFFRNSTPIPLIVGVLMVSGFMRSMQFTAINTVAYADIPPDTV
SNASTLSVVTMQMALGLGISFGGLMLHLARGAGEAPLTPDRFVLPFIAVGIMSSLAGPLYRRLSPNAGAHIGGRRVG
>Mature_476_residues
PGHPASSSAEAGGDAPRGSRLASIAVASALFMEFVDSTALSTALPRLSLAFGTDPIHLKLALTSYILALAVLAPASGWVA
DRFGPRRVFMLAMSVFLLGSVLCGFSQSLTQLVIFRTLQGLGGALMTPVGRIIVVSSAPRERLVAALSWFTMPALVGPLV
GPPLAGLILGVADWPWIFFINVPVGILGMLAVARFVPPLHQPDPGPFDTRGFVLVAVAITTLIGAAETVGIGLMPLSLQL
GLAAVAFLSLGAYVWHALRVERPVLNLRLLRIDTFRASMIGGTLTRMGLGASPFLLPLLFQVGLGWTPVEAGLVTIGGGV
GALACKSVAPYIIRRFGFRQTLIFANLTSAVLTAMPAFFRNSTPIPLIVGVLMVSGFMRSMQFTAINTVAYADIPPDTVS
NASTLSVVTMQMALGLGISFGGLMLHLARGAGEAPLTPDRFVLPFIAVGIMSSLAGPLYRRLSPNAGAHIGGRRVG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=448, Percent_Identity=35.0446428571429, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1788392, Length=471, Percent_Identity=33.7579617834395, Blast_Score=251, Evalue=9e-68,
Organism=Escherichia coli, GI1789042, Length=435, Percent_Identity=26.4367816091954, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788710, Length=391, Percent_Identity=27.3657289002558, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87081983, Length=309, Percent_Identity=28.4789644012945, Blast_Score=109, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49886; Mature: 49755

Theoretical pI: Translated: 11.62; Mature: 11.62

Prosite motif: PS00178 AA_TRNA_LIGASE_I ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGHPASSSAEAGGDAPRGSRLASIAVASALFMEFVDSTALSTALPRLSLAFGTDPIHLK
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEE
LALTSYILALAVLAPASGWVADRFGPRRVFMLAMSVFLLGSVLCGFSQSLTQLVIFRTLQ
HHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGGALMTPVGRIIVVSSAPRERLVAALSWFTMPALVGPLVGPPLAGLILGVADWPWIFF
HCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEE
INVPVGILGMLAVARFVPPLHQPDPGPFDTRGFVLVAVAITTLIGAAETVGIGLMPLSLQ
EECCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHH
LGLAAVAFLSLGAYVWHALRVERPVLNLRLLRIDTFRASMIGGTLTRMGLGASPFLLPLL
HHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEHHHHHHHCCHHHHHCCCCCHHHHHHH
FQVGLGWTPVEAGLVTIGGGVGALACKSVAPYIIRRFGFRQTLIFANLTSAVLTAMPAFF
HHHCCCCCCHHCCEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RNSTPIPLIVGVLMVSGFMRSMQFTAINTVAYADIPPDTVSNASTLSVVTMQMALGLGIS
CCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCC
FGGLMLHLARGAGEAPLTPDRFVLPFIAVGIMSSLAGPLYRRLSPNAGAHIGGRRVG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PGHPASSSAEAGGDAPRGSRLASIAVASALFMEFVDSTALSTALPRLSLAFGTDPIHLK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEE
LALTSYILALAVLAPASGWVADRFGPRRVFMLAMSVFLLGSVLCGFSQSLTQLVIFRTLQ
HHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGGALMTPVGRIIVVSSAPRERLVAALSWFTMPALVGPLVGPPLAGLILGVADWPWIFF
HCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEE
INVPVGILGMLAVARFVPPLHQPDPGPFDTRGFVLVAVAITTLIGAAETVGIGLMPLSLQ
EECCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHH
LGLAAVAFLSLGAYVWHALRVERPVLNLRLLRIDTFRASMIGGTLTRMGLGASPFLLPLL
HHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEHHHHHHHCCHHHHHCCCCCHHHHHHH
FQVGLGWTPVEAGLVTIGGGVGALACKSVAPYIIRRFGFRQTLIFANLTSAVLTAMPAFF
HHHCCCCCCHHCCEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RNSTPIPLIVGVLMVSGFMRSMQFTAINTVAYADIPPDTVSNASTLSVVTMQMALGLGIS
CCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCC
FGGLMLHLARGAGEAPLTPDRFVLPFIAVGIMSSLAGPLYRRLSPNAGAHIGGRRVG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]