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The map label for this gene is purH

Identifier: 108759861

GI number: 108759861

Start: 3411223

End: 3412767

Strand: Direct

Name: purH

Synonym: MXAN_2914

Alternate gene names: 108759861

Gene position: 3411223-3412767 (Clockwise)

Preceding gene: 108762633

Following gene: 108762465

Centisome position: 37.32

GC content: 70.23

Gene sequence:

>1545_bases
GTGCTGGCTCTCCTGAGCGTTTCTGATAAGCGAGGTCTGGTTCCCTTCGCCCAGGGGCTCGTCCGCCTGGGCTTCCGGTT
GTTGTCCACCGGGGGCACGCTGGAGGCGCTCAAGGGCGCGGGGGTGCCCGTCAACAAGGTGTCCGAGCACACGCAGAGCC
CCGAGATTCTGGGTGGCCGCGTGAAGACGCTCCACCCCCGCATCCACGGCGGCATCCTGGGACGGCTGGAGCTGGAGGCC
GACCGGGAGGAGATGAAGGCGCACGGCATCGAGCCCATCTCCCTGGTCGCGGTGAACCTGTATCCATTCCGGCAGACGGT
GGCCTCGGGCGCCGCGGAGCCGGAGGTCATCGAGCAGATTGATATCGGCGGGCCCGCGATGGTGCGCGCCTCCGCGAAGA
ACTTCCGGCACGTCTCGGTGGTGGTGGACCCGGACGACTATCCGGCGGTGCTGGCGGAGCTGGAGCAGCAGAAGGCGGTG
AGCGAGGACACGCGGCGCCGGCTGATGCGCAAGGCCTTCGCGCACACGGCGGCCTACGACGCCTCCATCTCCGCGTGGCT
GTCCGCGCAGGCGGGCGAGCCGTTCCCGGGGGAGCTGTCGTTGGCGTTCCAGAAGTCGCAGGACCTGCGCTACGGGGAGA
ACCCGCATCAGCGCGGCGCCTTCTACCGCGAGCACGCCGCGCCCCAGGAGCCGACGGTCGCCTTCGCCAAGGTGCTGCAG
GGCAAGGAGCTGTCGTACAACAACATCCTGGACCTGGACGCGGCGCTGGGCCTGCTGCTGGAGTTCCCGGAGGCCCCCGC
GGCCGTCATCATCAAGCACAACACGCCCTGCGGCGTGGCGGTGGACGCCGCCTTGGTGAAGGCCTACCGCACGGCCCGCG
CGGTGGACGAGGTCTCCGCCTTCGGGGGCATCGTCGCGCTCAACCGCGAGGTGGACGCGGCCACGGCCCAGGCCATGGCG
GAGACGTTCCTGGAGGCGGTCATCGCGCCGTCGTACTCCCCGGAGGCGTTGCAGGTGCTGGCGACGAAGAAGAACCTGCG
GCTCCTGGAGGCGGGCCCCGCGTTGGCCAGTCCCCAGGCCCGGCCGCGTGCCCAACTGGACGCTCGCAGCGTGTCCGGGG
GCATGCTGCTGATGGACCGGGACTCGGTGGAGCCGCCGCTGTCGTGGAAGGTGGTCTCCAAGCGGGCTCCCACGCCGGAG
GAGGAGCAGGCCATGCGCTTCGCCTGGAAGGTGTGCAAACACGTCAAGAGCAACGCCATCGTCTTCGCCTCCGGTGACCA
GCTCCTGGCGCAGGGCGGGGGGCAGACGAACCGGGTGGATTCGGTCCGCATCGCGATGCAGCGCGGCGGAGCGGCCCTCA
GGGGCAGCGCGGTGGCCTCGGACGCCTTCTTCCCGTTCCGGGATGGGCTGGACGAGGCCGCCCGGGCGGGGGCCACCTGT
GTCGTACAACCCGGCGGTTCGGTCCGTGACGCGGAGTTGATTGCCGCCGCGGATGAACATGGGATGGCCATGGTGCTGAC
GGGAGTGCGACACTTCCGGCACTGA

Upstream 100 bases:

>100_bases
GCGGGTGGTTTCCACCCGCAAACGGAGGGCCGACGTGTTGCGTTGACACCCCAGGGGGTGGTTGCTACTACCGCCGCTTC
CCGCACACCGAGGCCCACAC

Downstream 100 bases:

>100_bases
GCCATGCGCATCGTCTGTCAGAAATGCGCGGCCGCCTACGCGATTGATGACAAGCTCATCACCGCCAAGGGCGTTCGCGC
GCAGTGTCCTCGCTGCCGGA

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MLALLSVSDKRGLVPFAQGLVRLGFRLLSTGGTLEALKGAGVPVNKVSEHTQSPEILGGRVKTLHPRIHGGILGRLELEA
DREEMKAHGIEPISLVAVNLYPFRQTVASGAAEPEVIEQIDIGGPAMVRASAKNFRHVSVVVDPDDYPAVLAELEQQKAV
SEDTRRRLMRKAFAHTAAYDASISAWLSAQAGEPFPGELSLAFQKSQDLRYGENPHQRGAFYREHAAPQEPTVAFAKVLQ
GKELSYNNILDLDAALGLLLEFPEAPAAVIIKHNTPCGVAVDAALVKAYRTARAVDEVSAFGGIVALNREVDAATAQAMA
ETFLEAVIAPSYSPEALQVLATKKNLRLLEAGPALASPQARPRAQLDARSVSGGMLLMDRDSVEPPLSWKVVSKRAPTPE
EEQAMRFAWKVCKHVKSNAIVFASGDQLLAQGGGQTNRVDSVRIAMQRGGAALRGSAVASDAFFPFRDGLDEAARAGATC
VVQPGGSVRDAELIAAADEHGMAMVLTGVRHFRH

Sequences:

>Translated_514_residues
MLALLSVSDKRGLVPFAQGLVRLGFRLLSTGGTLEALKGAGVPVNKVSEHTQSPEILGGRVKTLHPRIHGGILGRLELEA
DREEMKAHGIEPISLVAVNLYPFRQTVASGAAEPEVIEQIDIGGPAMVRASAKNFRHVSVVVDPDDYPAVLAELEQQKAV
SEDTRRRLMRKAFAHTAAYDASISAWLSAQAGEPFPGELSLAFQKSQDLRYGENPHQRGAFYREHAAPQEPTVAFAKVLQ
GKELSYNNILDLDAALGLLLEFPEAPAAVIIKHNTPCGVAVDAALVKAYRTARAVDEVSAFGGIVALNREVDAATAQAMA
ETFLEAVIAPSYSPEALQVLATKKNLRLLEAGPALASPQARPRAQLDARSVSGGMLLMDRDSVEPPLSWKVVSKRAPTPE
EEQAMRFAWKVCKHVKSNAIVFASGDQLLAQGGGQTNRVDSVRIAMQRGGAALRGSAVASDAFFPFRDGLDEAARAGATC
VVQPGGSVRDAELIAAADEHGMAMVLTGVRHFRH
>Mature_514_residues
MLALLSVSDKRGLVPFAQGLVRLGFRLLSTGGTLEALKGAGVPVNKVSEHTQSPEILGGRVKTLHPRIHGGILGRLELEA
DREEMKAHGIEPISLVAVNLYPFRQTVASGAAEPEVIEQIDIGGPAMVRASAKNFRHVSVVVDPDDYPAVLAELEQQKAV
SEDTRRRLMRKAFAHTAAYDASISAWLSAQAGEPFPGELSLAFQKSQDLRYGENPHQRGAFYREHAAPQEPTVAFAKVLQ
GKELSYNNILDLDAALGLLLEFPEAPAAVIIKHNTPCGVAVDAALVKAYRTARAVDEVSAFGGIVALNREVDAATAQAMA
ETFLEAVIAPSYSPEALQVLATKKNLRLLEAGPALASPQARPRAQLDARSVSGGMLLMDRDSVEPPLSWKVVSKRAPTPE
EEQAMRFAWKVCKHVKSNAIVFASGDQLLAQGGGQTNRVDSVRIAMQRGGAALRGSAVASDAFFPFRDGLDEAARAGATC
VVQPGGSVRDAELIAAADEHGMAMVLTGVRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=476, Percent_Identity=38.4453781512605, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1790439, Length=530, Percent_Identity=50.7547169811321, Blast_Score=483, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI71985564, Length=474, Percent_Identity=35.4430379746835, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71985574, Length=309, Percent_Identity=28.8025889967638, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71985556, Length=60, Percent_Identity=50, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323056, Length=471, Percent_Identity=38.4288747346072, Blast_Score=273, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6323768, Length=471, Percent_Identity=37.5796178343949, Blast_Score=265, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24649832, Length=480, Percent_Identity=37.0833333333333, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_MYXXD (Q1D898)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631125.1
- ProteinModelPortal:   Q1D898
- SMR:   Q1D898
- STRING:   Q1D898
- GeneID:   4101505
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2914
- TIGR:   MXAN_2914
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- PhylomeDB:   Q1D898
- ProtClustDB:   PRK00881
- BioCyc:   MXAN246197:MXAN_2914-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 54953; Mature: 54953

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALLSVSDKRGLVPFAQGLVRLGFRLLSTGGTLEALKGAGVPVNKVSEHTQSPEILGGR
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHCCCCHHHCCC
VKTLHPRIHGGILGRLELEADREEMKAHGIEPISLVAVNLYPFRQTVASGAAEPEVIEQI
CEEECCHHCCCEEEEEEECCCHHHHHHCCCCCEEEEEEEEHHHHHHHHCCCCCCHHHHHH
DIGGPAMVRASAKNFRHVSVVVDPDDYPAVLAELEQQKAVSEDTRRRLMRKAFAHTAAYD
CCCCCCEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ASISAWLSAQAGEPFPGELSLAFQKSQDLRYGENPHQRGAFYREHAAPQEPTVAFAKVLQ
CHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCHHCCCHHHHHCCCCCCHHHHHHHHC
GKELSYNNILDLDAALGLLLEFPEAPAAVIIKHNTPCGVAVDAALVKAYRTARAVDEVSA
CCCCCCCCEECHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
FGGIVALNREVDAATAQAMAETFLEAVIAPSYSPEALQVLATKKNLRLLEAGPALASPQA
HCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCC
RPRAQLDARSVSGGMLLMDRDSVEPPLSWKVVSKRAPTPEEEQAMRFAWKVCKHVKSNAI
CCCHHCCHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEE
VFASGDQLLAQGGGQTNRVDSVRIAMQRGGAALRGSAVASDAFFPFRDGLDEAARAGATC
EEECCCHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCHHCCCCCCHHCCHHHHHHCCCEE
VVQPGGSVRDAELIAAADEHGMAMVLTGVRHFRH
EECCCCCCCCCCEEEECCCCCEEHHHHHHHHHCC
>Mature Secondary Structure
MLALLSVSDKRGLVPFAQGLVRLGFRLLSTGGTLEALKGAGVPVNKVSEHTQSPEILGGR
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHCCCCHHHCCC
VKTLHPRIHGGILGRLELEADREEMKAHGIEPISLVAVNLYPFRQTVASGAAEPEVIEQI
CEEECCHHCCCEEEEEEECCCHHHHHHCCCCCEEEEEEEEHHHHHHHHCCCCCCHHHHHH
DIGGPAMVRASAKNFRHVSVVVDPDDYPAVLAELEQQKAVSEDTRRRLMRKAFAHTAAYD
CCCCCCEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ASISAWLSAQAGEPFPGELSLAFQKSQDLRYGENPHQRGAFYREHAAPQEPTVAFAKVLQ
CHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCHHCCCHHHHHCCCCCCHHHHHHHHC
GKELSYNNILDLDAALGLLLEFPEAPAAVIIKHNTPCGVAVDAALVKAYRTARAVDEVSA
CCCCCCCCEECHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
FGGIVALNREVDAATAQAMAETFLEAVIAPSYSPEALQVLATKKNLRLLEAGPALASPQA
HCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCC
RPRAQLDARSVSGGMLLMDRDSVEPPLSWKVVSKRAPTPEEEQAMRFAWKVCKHVKSNAI
CCCHHCCHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEE
VFASGDQLLAQGGGQTNRVDSVRIAMQRGGAALRGSAVASDAFFPFRDGLDEAARAGATC
EEECCCHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCHHCCCCCCHHCCHHHHHHCCCEE
VVQPGGSVRDAELIAAADEHGMAMVLTGVRHFRH
EECCCCCCCCCCEEEECCCCCEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA