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The map label for this gene is luxQ [H]

Identifier: 108759725

GI number: 108759725

Start: 277754

End: 279280

Strand: Reverse

Name: luxQ [H]

Synonym: MXAN_0229

Alternate gene names: 108759725

Gene position: 279280-277754 (Counterclockwise)

Preceding gene: 108759989

Following gene: 108759887

Centisome position: 3.06

GC content: 69.88

Gene sequence:

>1527_bases
GTGGGTGAGCCCCATCCAGCCACCGTCCTCAACGTCAACGACGACGACGCCAACCGATACCTCGTCAACCGGCTGCTCTC
GCTGGCGGGATACAACGTGGTGGAGGCGGCCACCGGCATGGGCGCGTTGCTGATGGCGCAGCAACACCGCCCGGACGTCA
TCATCCTCGACGTGAAGCTGCCGGACATCAGCGGCTACGAGGTCTGCGAGCGGCTGCGCGCCAATCCCCAGACCGCGGCC
ATGGCGGTGCTGCACACCTCCGCCACATTCGTCACCTCCGACAAGAAGGTGCGCGGCCTGGACGGCGGCGCGGACGCCTA
CCTCACCCAGCCCTTCGAGGGCGCGGAGCTCATCGCCACGGTGAAGTCGCTGTTGCGCCTGCGCCACGCGGAGCAGGTGG
CGCGCCAACGCGCCAACGCGCTGGCGGAGATGGACCGCCGCAAGGACGAGTTCCTGGCCATGCTGGGGCACGAGCTGCGC
AACCCGCTGGCCGCCATCATGACAGCCATTGGCATCCTGGAGCGCAGGCCCACCAGCGATGACAAGGAAGCGCGGATGCG
CGGCATCATCCAACGCCAGACAAACCACTTGGCGCGGCTGGTGGATGACCTGCTCGACGTCAGCCGCATCACCCGCGACA
AGGTGGAGCTGCGCCCCGGCAGCGTGGACCTGGTGCCCGTGCTGCGGCAGGTGCTCCAAATCGTGCAGCCCATGGCGGAT
TCGCGTGGGTTGGGTTTGGACGTCTCGCTGCCTTCCGGTCCGCTCTGGCTGCAGGCGGATGCCACGCGGTTGGAGCAGGT
CTTCACCAACCTGCTCGACAACGCCATCAAGTACACCGACGCGGGTGGCGTCCACCTGCGCGCGGAACAGGAAGGCGTGG
GCGGCGCGGCCCAGGCGGTGGTGCGGGTGAAGGACTCTGGCATCGGCATCCCGCCGGAGGTGCTGCCGCACATCTTCGAG
CTGTTCGCGCAGGCGGACACCTCGCTGGAGCGCTCGCGCGGCGGCCTGGGTATTGGCCTGACGCTGGTGCGCAAGCTGAT
CCAGCTCCACGGCGGCGAGGTGACGGCGCGAAGCAACGGCCCCGGCCACGGCAGCGAGTTCGTGGTGAAGCTGCCCCTGG
ACCACACGATGGGCAAGTCCGCGCCCGCGCGCGACGCGGTGGACCTCCGCCGCGGCCGGCGCGTCCTGGTGGTGGAGGAC
AACTCGGACGCGCGTCAGGCCATGCGCGACCTGCTGGAGCTGTGGGGCCACCAGGTGGCGGTGGCGCCGGACGGCCTCCA
GGGCGTGGCGCTCGCGATGGCGCAGCCGCCCGAGCTGGCGCTGGTGGACATCGGCCTGCCAGGGTTGGACGGATACCGGG
TGGCGCAGACGCTGCGCGCCCAGGTGGGCAACGGCATCCGGCTGGTGGCCATGACGGGCTACGGCAGCCCCCATGGACGG
GACCAGGCACTGCGCGCCGGGTTCGACCGGCATCTGGTCAAGCCCGTGAAGCCTGACGAGCTGGACCGAATCCTCTCCGA
GCTGTGA

Upstream 100 bases:

>100_bases
AAGCACACGCTGAGCCGCGAGGTGGCCATCACCCGCATCCGGGACGCACTGTCCAAGGCCGGCCTGGGCTCCCAAGCGTT
GCCGCAGGAGGCAAGCCGCC

Downstream 100 bases:

>100_bases
GGGATTGAAGCGGCGGAGGCTCAGCGGCGGTTCAGCGCGTTGGCCACCAGCCCCAACAGCTTCACCTTCGCGGGCTCCAG
CGGACGCACGGTGCGCAGCA

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MGEPHPATVLNVNDDDANRYLVNRLLSLAGYNVVEAATGMGALLMAQQHRPDVIILDVKLPDISGYEVCERLRANPQTAA
MAVLHTSATFVTSDKKVRGLDGGADAYLTQPFEGAELIATVKSLLRLRHAEQVARQRANALAEMDRRKDEFLAMLGHELR
NPLAAIMTAIGILERRPTSDDKEARMRGIIQRQTNHLARLVDDLLDVSRITRDKVELRPGSVDLVPVLRQVLQIVQPMAD
SRGLGLDVSLPSGPLWLQADATRLEQVFTNLLDNAIKYTDAGGVHLRAEQEGVGGAAQAVVRVKDSGIGIPPEVLPHIFE
LFAQADTSLERSRGGLGIGLTLVRKLIQLHGGEVTARSNGPGHGSEFVVKLPLDHTMGKSAPARDAVDLRRGRRVLVVED
NSDARQAMRDLLELWGHQVAVAPDGLQGVALAMAQPPELALVDIGLPGLDGYRVAQTLRAQVGNGIRLVAMTGYGSPHGR
DQALRAGFDRHLVKPVKPDELDRILSEL

Sequences:

>Translated_508_residues
MGEPHPATVLNVNDDDANRYLVNRLLSLAGYNVVEAATGMGALLMAQQHRPDVIILDVKLPDISGYEVCERLRANPQTAA
MAVLHTSATFVTSDKKVRGLDGGADAYLTQPFEGAELIATVKSLLRLRHAEQVARQRANALAEMDRRKDEFLAMLGHELR
NPLAAIMTAIGILERRPTSDDKEARMRGIIQRQTNHLARLVDDLLDVSRITRDKVELRPGSVDLVPVLRQVLQIVQPMAD
SRGLGLDVSLPSGPLWLQADATRLEQVFTNLLDNAIKYTDAGGVHLRAEQEGVGGAAQAVVRVKDSGIGIPPEVLPHIFE
LFAQADTSLERSRGGLGIGLTLVRKLIQLHGGEVTARSNGPGHGSEFVVKLPLDHTMGKSAPARDAVDLRRGRRVLVVED
NSDARQAMRDLLELWGHQVAVAPDGLQGVALAMAQPPELALVDIGLPGLDGYRVAQTLRAQVGNGIRLVAMTGYGSPHGR
DQALRAGFDRHLVKPVKPDELDRILSEL
>Mature_507_residues
GEPHPATVLNVNDDDANRYLVNRLLSLAGYNVVEAATGMGALLMAQQHRPDVIILDVKLPDISGYEVCERLRANPQTAAM
AVLHTSATFVTSDKKVRGLDGGADAYLTQPFEGAELIATVKSLLRLRHAEQVARQRANALAEMDRRKDEFLAMLGHELRN
PLAAIMTAIGILERRPTSDDKEARMRGIIQRQTNHLARLVDDLLDVSRITRDKVELRPGSVDLVPVLRQVLQIVQPMADS
RGLGLDVSLPSGPLWLQADATRLEQVFTNLLDNAIKYTDAGGVHLRAEQEGVGGAAQAVVRVKDSGIGIPPEVLPHIFEL
FAQADTSLERSRGGLGIGLTLVRKLIQLHGGEVTARSNGPGHGSEFVVKLPLDHTMGKSAPARDAVDLRRGRRVLVVEDN
SDARQAMRDLLELWGHQVAVAPDGLQGVALAMAQPPELALVDIGLPGLDGYRVAQTLRAQVGNGIRLVAMTGYGSPHGRD
QALRAGFDRHLVKPVKPDELDRILSEL

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=288, Percent_Identity=30.5555555555556, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081816, Length=407, Percent_Identity=30.958230958231, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788713, Length=368, Percent_Identity=27.445652173913, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789149, Length=298, Percent_Identity=32.2147651006711, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI48994928, Length=373, Percent_Identity=31.3672922252011, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788393, Length=252, Percent_Identity=30.952380952381, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1786912, Length=260, Percent_Identity=31.5384615384615, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=239, Percent_Identity=29.7071129707113, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787894, Length=248, Percent_Identity=29.4354838709677, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1790436, Length=267, Percent_Identity=29.2134831460674, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=26.8722466960352, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788549, Length=239, Percent_Identity=28.4518828451883, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=215, Percent_Identity=34.4186046511628, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=25.8620689655172, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082012, Length=122, Percent_Identity=34.4262295081967, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786911, Length=128, Percent_Identity=41.40625, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786784, Length=118, Percent_Identity=36.4406779661017, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790860, Length=120, Percent_Identity=39.1666666666667, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=34.7457627118644, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=228, Percent_Identity=25, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1789809, Length=220, Percent_Identity=29.5454545454545, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55107; Mature: 54976

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEPHPATVLNVNDDDANRYLVNRLLSLAGYNVVEAATGMGALLMAQQHRPDVIILDVKL
CCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHCCCCCEEEEEEEC
PDISGYEVCERLRANPQTAAMAVLHTSATFVTSDKKVRGLDGGADAYLTQPFEGAELIAT
CCCCHHHHHHHHHCCCHHHHHHHHCCCEEEEECCCCEECCCCCCCCEEECCCCCHHHHHH
VKSLLRLRHAEQVARQRANALAEMDRRKDEFLAMLGHELRNPLAAIMTAIGILERRPTSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DKEARMRGIIQRQTNHLARLVDDLLDVSRITRDKVELRPGSVDLVPVLRQVLQIVQPMAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCC
SRGLGLDVSLPSGPLWLQADATRLEQVFTNLLDNAIKYTDAGGVHLRAEQEGVGGAAQAV
CCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCHHHHEE
VRVKDSGIGIPPEVLPHIFELFAQADTSLERSRGGLGIGLTLVRKLIQLHGGEVTARSNG
EEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCEEHHHHHHHHHHHCCCEEEECCCC
PGHGSEFVVKLPLDHTMGKSAPARDAVDLRRGRRVLVVEDNSDARQAMRDLLELWGHQVA
CCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCEEE
VAPDGLQGVALAMAQPPELALVDIGLPGLDGYRVAQTLRAQVGNGIRLVAMTGYGSPHGR
ECCCCCCHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
DQALRAGFDRHLVKPVKPDELDRILSEL
HHHHHHCHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
GEPHPATVLNVNDDDANRYLVNRLLSLAGYNVVEAATGMGALLMAQQHRPDVIILDVKL
CCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHCCCCCEEEEEEEC
PDISGYEVCERLRANPQTAAMAVLHTSATFVTSDKKVRGLDGGADAYLTQPFEGAELIAT
CCCCHHHHHHHHHCCCHHHHHHHHCCCEEEEECCCCEECCCCCCCCEEECCCCCHHHHHH
VKSLLRLRHAEQVARQRANALAEMDRRKDEFLAMLGHELRNPLAAIMTAIGILERRPTSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DKEARMRGIIQRQTNHLARLVDDLLDVSRITRDKVELRPGSVDLVPVLRQVLQIVQPMAD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCC
SRGLGLDVSLPSGPLWLQADATRLEQVFTNLLDNAIKYTDAGGVHLRAEQEGVGGAAQAV
CCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEECCCCCCHHHHEE
VRVKDSGIGIPPEVLPHIFELFAQADTSLERSRGGLGIGLTLVRKLIQLHGGEVTARSNG
EEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCEEHHHHHHHHHHHCCCEEEECCCC
PGHGSEFVVKLPLDHTMGKSAPARDAVDLRRGRRVLVVEDNSDARQAMRDLLELWGHQVA
CCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCEEE
VAPDGLQGVALAMAQPPELALVDIGLPGLDGYRVAQTLRAQVGNGIRLVAMTGYGSPHGR
ECCCCCCHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
DQALRAGFDRHLVKPVKPDELDRILSEL
HHHHHHCHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]