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The map label for this gene is sdhA [H]

Identifier: 108759683

GI number: 108759683

Start: 6522287

End: 6524200

Strand: Reverse

Name: sdhA [H]

Synonym: MXAN_5224

Alternate gene names: 108759683

Gene position: 6524200-6522287 (Counterclockwise)

Preceding gene: 108757649

Following gene: 108756792

Centisome position: 71.38

GC content: 67.03

Gene sequence:

>1914_bases
ATGGATCTCGGCGCGAGGATTCCGAGCGGGCCGCTCGAGCAAAAGTGGGAGCGCCGACTGCGCGAAGGACGCCTGGTTGG
TCCGAGCAACCGGCGCAAGTACACACTGCTCGTGGTTGGCTCCGGGCTGGCGGGGGCTTCGGCCGCGGCGACGCTCGCCG
AGCTTGGCTACCGTGTGCACTGCTTCTCCTTTCACGACTCGCCGAGGCGCGCGCACAGCATCGCCGCGCAGGGCGGCATC
AATGCCGCGAAGAACTACCGCAACGACGGCGACAGCGTGTGGAGGCTGTTCTACGACACGCTGAAAGGCGGCGACTTCCG
CTCCCGCGAGGCGAATGTCTACAGGCTTGCCCAGGTGAGCAACCGCATCATCGACCAATGCGTGGCCCAGGGAGTCCCTT
TCGCCCGCGAATATGGAGGGCTCCTCGCCACACGCTCTTTCGGGGGCGCGCTCGTCTCGCGCACCTTCTATGCGCGTGGA
CAGACTGGGCAGCAACTTCTCCTCGGCGCCTACCAGGCGCTCGAGCGGCAAATCAGCGCGGGCCAGGTTCGCATGCATCC
GAGGACCGAAATGCTCGATCTCGTCATGGTCGACGGACGGGCGCGGGGAATCATCGCGCGCGACCTCCGGACGGGCGAGC
TGAGGGCGTTCGCCGGCGATGCTGTGATCCTCGCGACAGGAGGCTACGGCAACATCTACCATCTCTCGACCAACGCGCGA
GGCTCGAACGCGACCGCGATCTGGCGCGCGTACCGAAGGGGCGCCGGCTTCGCCAACCCTTGCTTCACGCAGATCCATCC
GACCTGCATCCCCGTCAGCGGGCCTCATCAGTCGAAGCTCACCCTGATGAGCGAGTCCTTGCGCAATGACGGGCGTGTCT
GGGTGCCGAAGCTCAAGGGGGACCAGCGGACACCGCGCGATATCCCGGAGAGCGAACGGGACTACTTCCTCGAGCGGCGG
TACCCAACCTACGGCAACCTCGCGCCGCGTGACATCGCCTCGCGCTCGGCCAAGGAAATCTGTGACCAGGGCAGGGGCGT
TGGCCCCGGCGGGCGCGGCGTGTATCTGGACCTCGGTGATGCCATTGAGCGTCTCGGGGCCGGTACCATTCGCGAACGTT
ACGGGAACGTCCTCGAGATGTACGAGCGCATCACGGGCGAGCACCCGTACCGGGCGCCGATGCGGATCTACCCCGCCGTC
CACTACACCATGGGCGGGCTCTGGGTGGACTACGACCTGCGCAGCACCCTGCCGGGCCTCTACGTGCTCGGCGAGGCGAA
CTTCTCCGACCACGGCGCGAACCGCCTCGGCGCGAGCGCCCTCATGCAGGGGCTCGCCGATGGCTACTTCATCGTCCCGA
ACACCATCGCGGCCGAGCTGGCGCGTTTCGGGCCAGGGTCGGTCGACCTTGACCATCCCGCGTTTCGAGACGCCGAGCGC
ATCGTGCAGGCAAAGCTCGAGCGCCTGCTCGCCTCGCGAGGCACGCGAACCGTCGAGGACCACTTCCGCGCGCTGGGTAG
CCTCCTCTGGGAACAATGCGGCATGGCGCGCAGCGAGCGCGGGCTGTCCTCCGCGCTCGAGAGCATCCAGGCGCTTCAGG
GCGACTTCGAGCGAGATCTCCGGCTGCCGGACACCGGCATCGAGCTGAACGACTCGCTCGAGCGAGCAGGGCGGCTCGCC
GATTACTACGAGCTCGCGGAGCTGATGTGCCGCGACGCGCTCGAGCGGCGCGAATCGTGCGGAGCGCACTTCCGCGAGGA
GTTTCAAACGGCGGAAGGTGAGGCGCGCCGAGATGACGAGCACTTCTGCCATGTGTCGGTATGGGAATACCGCGGCCAGG
ATCGACCTCCCGCGCTCCACAAGGAGCCACTCTCCTTCGAGTCGGTCGCGGCGGAGACCAGGAGCTACAAATGA

Upstream 100 bases:

>100_bases
GGCCGAAACGGCGACCGGTTGCGTGGATCCTCGCCCTGGTGCTCTGGGGCGGCTTCAGCAGCATTCCGCTCACGATCTGG
CTCGGAGGTGTGCGCTAGCC

Downstream 100 bases:

>100_bases
GCACGACCCGAAAGGCGGCCCGGTCCTGGGTGCGCAGCCGTCCGCGCACCCTCTGCCGCCGGAACCGATAGGAGACCTTC
GACATGGAACAGCGACTCGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MDLGARIPSGPLEQKWERRLREGRLVGPSNRRKYTLLVVGSGLAGASAAATLAELGYRVHCFSFHDSPRRAHSIAAQGGI
NAAKNYRNDGDSVWRLFYDTLKGGDFRSREANVYRLAQVSNRIIDQCVAQGVPFAREYGGLLATRSFGGALVSRTFYARG
QTGQQLLLGAYQALERQISAGQVRMHPRTEMLDLVMVDGRARGIIARDLRTGELRAFAGDAVILATGGYGNIYHLSTNAR
GSNATAIWRAYRRGAGFANPCFTQIHPTCIPVSGPHQSKLTLMSESLRNDGRVWVPKLKGDQRTPRDIPESERDYFLERR
YPTYGNLAPRDIASRSAKEICDQGRGVGPGGRGVYLDLGDAIERLGAGTIRERYGNVLEMYERITGEHPYRAPMRIYPAV
HYTMGGLWVDYDLRSTLPGLYVLGEANFSDHGANRLGASALMQGLADGYFIVPNTIAAELARFGPGSVDLDHPAFRDAER
IVQAKLERLLASRGTRTVEDHFRALGSLLWEQCGMARSERGLSSALESIQALQGDFERDLRLPDTGIELNDSLERAGRLA
DYYELAELMCRDALERRESCGAHFREEFQTAEGEARRDDEHFCHVSVWEYRGQDRPPALHKEPLSFESVAAETRSYK

Sequences:

>Translated_637_residues
MDLGARIPSGPLEQKWERRLREGRLVGPSNRRKYTLLVVGSGLAGASAAATLAELGYRVHCFSFHDSPRRAHSIAAQGGI
NAAKNYRNDGDSVWRLFYDTLKGGDFRSREANVYRLAQVSNRIIDQCVAQGVPFAREYGGLLATRSFGGALVSRTFYARG
QTGQQLLLGAYQALERQISAGQVRMHPRTEMLDLVMVDGRARGIIARDLRTGELRAFAGDAVILATGGYGNIYHLSTNAR
GSNATAIWRAYRRGAGFANPCFTQIHPTCIPVSGPHQSKLTLMSESLRNDGRVWVPKLKGDQRTPRDIPESERDYFLERR
YPTYGNLAPRDIASRSAKEICDQGRGVGPGGRGVYLDLGDAIERLGAGTIRERYGNVLEMYERITGEHPYRAPMRIYPAV
HYTMGGLWVDYDLRSTLPGLYVLGEANFSDHGANRLGASALMQGLADGYFIVPNTIAAELARFGPGSVDLDHPAFRDAER
IVQAKLERLLASRGTRTVEDHFRALGSLLWEQCGMARSERGLSSALESIQALQGDFERDLRLPDTGIELNDSLERAGRLA
DYYELAELMCRDALERRESCGAHFREEFQTAEGEARRDDEHFCHVSVWEYRGQDRPPALHKEPLSFESVAAETRSYK
>Mature_637_residues
MDLGARIPSGPLEQKWERRLREGRLVGPSNRRKYTLLVVGSGLAGASAAATLAELGYRVHCFSFHDSPRRAHSIAAQGGI
NAAKNYRNDGDSVWRLFYDTLKGGDFRSREANVYRLAQVSNRIIDQCVAQGVPFAREYGGLLATRSFGGALVSRTFYARG
QTGQQLLLGAYQALERQISAGQVRMHPRTEMLDLVMVDGRARGIIARDLRTGELRAFAGDAVILATGGYGNIYHLSTNAR
GSNATAIWRAYRRGAGFANPCFTQIHPTCIPVSGPHQSKLTLMSESLRNDGRVWVPKLKGDQRTPRDIPESERDYFLERR
YPTYGNLAPRDIASRSAKEICDQGRGVGPGGRGVYLDLGDAIERLGAGTIRERYGNVLEMYERITGEHPYRAPMRIYPAV
HYTMGGLWVDYDLRSTLPGLYVLGEANFSDHGANRLGASALMQGLADGYFIVPNTIAAELARFGPGSVDLDHPAFRDAER
IVQAKLERLLASRGTRTVEDHFRALGSLLWEQCGMARSERGLSSALESIQALQGDFERDLRLPDTGIELNDSLERAGRLA
DYYELAELMCRDALERRESCGAHFREEFQTAEGEARRDDEHFCHVSVWEYRGQDRPPALHKEPLSFESVAAETRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=567, Percent_Identity=28.7477954144621, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1790597, Length=575, Percent_Identity=28.695652173913, Blast_Score=196, Evalue=5e-51,
Organism=Escherichia coli, GI1786942, Length=568, Percent_Identity=29.7535211267606, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788928, Length=571, Percent_Identity=27.1453590192644, Blast_Score=138, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17505833, Length=541, Percent_Identity=28.6506469500924, Blast_Score=179, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17550100, Length=546, Percent_Identity=29.3040293040293, Blast_Score=175, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6322701, Length=599, Percent_Identity=30.3839732888147, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322416, Length=610, Percent_Identity=29.672131147541, Blast_Score=180, Evalue=6e-46,
Organism=Drosophila melanogaster, GI17137288, Length=588, Percent_Identity=29.7619047619048, Blast_Score=183, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24655642, Length=588, Percent_Identity=29.7619047619048, Blast_Score=183, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24655647, Length=588, Percent_Identity=29.7619047619048, Blast_Score=183, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24663005, Length=581, Percent_Identity=26.6781411359725, Blast_Score=153, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70840; Mature: 70840

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLGARIPSGPLEQKWERRLREGRLVGPSNRRKYTLLVVGSGLAGASAAATLAELGYRVH
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCEEE
CFSFHDSPRRAHSIAAQGGINAAKNYRNDGDSVWRLFYDTLKGGDFRSREANVYRLAQVS
EEECCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
NRIIDQCVAQGVPFAREYGGLLATRSFGGALVSRTFYARGQTGQQLLLGAYQALERQISA
HHHHHHHHHCCCCCHHHHCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
GQVRMHPRTEMLDLVMVDGRARGIIARDLRTGELRAFAGDAVILATGGYGNIYHLSTNAR
CEEEECCCHHHEEEEEECCCCCCEEEECCCCCCEEEEECCEEEEEECCCCCEEEEECCCC
GSNATAIWRAYRRGAGFANPCFTQIHPTCIPVSGPHQSKLTLMSESLRNDGRVWVPKLKG
CCCHHHHHHHHHHCCCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCC
DQRTPRDIPESERDYFLERRYPTYGNLAPRDIASRSAKEICDQGRGVGPGGRGVYLDLGD
CCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHH
AIERLGAGTIRERYGNVLEMYERITGEHPYRAPMRIYPAVHYTMGGLWVDYDLRSTLPGL
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHEEEECCEEEEECHHHCCCCE
YVLGEANFSDHGANRLGASALMQGLADGYFIVPNTIAAELARFGPGSVDLDHPAFRDAER
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCCCCCCCCHHHHHH
IVQAKLERLLASRGTRTVEDHFRALGSLLWEQCGMARSERGLSSALESIQALQGDFERDL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHCC
RLPDTGIELNDSLERAGRLADYYELAELMCRDALERRESCGAHFREEFQTAEGEARRDDE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
HFCHVSVWEYRGQDRPPALHKEPLSFESVAAETRSYK
CEEEEEEHHHCCCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MDLGARIPSGPLEQKWERRLREGRLVGPSNRRKYTLLVVGSGLAGASAAATLAELGYRVH
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCEEE
CFSFHDSPRRAHSIAAQGGINAAKNYRNDGDSVWRLFYDTLKGGDFRSREANVYRLAQVS
EEECCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
NRIIDQCVAQGVPFAREYGGLLATRSFGGALVSRTFYARGQTGQQLLLGAYQALERQISA
HHHHHHHHHCCCCCHHHHCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
GQVRMHPRTEMLDLVMVDGRARGIIARDLRTGELRAFAGDAVILATGGYGNIYHLSTNAR
CEEEECCCHHHEEEEEECCCCCCEEEECCCCCCEEEEECCEEEEEECCCCCEEEEECCCC
GSNATAIWRAYRRGAGFANPCFTQIHPTCIPVSGPHQSKLTLMSESLRNDGRVWVPKLKG
CCCHHHHHHHHHHCCCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCC
DQRTPRDIPESERDYFLERRYPTYGNLAPRDIASRSAKEICDQGRGVGPGGRGVYLDLGD
CCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHH
AIERLGAGTIRERYGNVLEMYERITGEHPYRAPMRIYPAVHYTMGGLWVDYDLRSTLPGL
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHEEEECCEEEEECHHHCCCCE
YVLGEANFSDHGANRLGASALMQGLADGYFIVPNTIAAELARFGPGSVDLDHPAFRDAER
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCCCCCCCCHHHHHH
IVQAKLERLLASRGTRTVEDHFRALGSLLWEQCGMARSERGLSSALESIQALQGDFERDL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHCC
RLPDTGIELNDSLERAGRLADYYELAELMCRDALERRESCGAHFREEFQTAEGEARRDDE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
HFCHVSVWEYRGQDRPPALHKEPLSFESVAAETRSYK
CEEEEEEHHHCCCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]