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The map label for this gene is ptp [H]

Identifier: 108759655

GI number: 108759655

Start: 2039409

End: 2040986

Strand: Reverse

Name: ptp [H]

Synonym: MXAN_1721

Alternate gene names: 108759655

Gene position: 2040986-2039409 (Counterclockwise)

Preceding gene: 108758388

Following gene: 108758050

Centisome position: 22.33

GC content: 67.81

Gene sequence:

>1578_bases
GTGTATCCCATGACGAAGACTCACAGGCCCGCCTTGCTGCTGGCCATGGTGCTGCTGGCGTGCGGGGACACATCCCTCGC
GGAGCCAGCCTCATCGGAGCAGCCTGCGGCCGCGCTCGAGACCGCGGCGGAGCCAGAGGACATCCTCGCCCGGCTCCAAT
CCATTCCCGGGCTCAGCGTTGTCCTCGAGCAGCCCTCGCCCTTTCCGGGCACACGCTTCTTCTTGCTTCAGCTCGAACAG
CCCGCAGACCACGAGCGTCCTCAAGGGGAGCGCTTCCAGCTCCGGATGACGCTCCTTCACCGCTCGGTGGACGCGCCCAT
GGTGCTCTCCACCGAGGGCTACATGCTGGCGCCCAGGCCCTGGCAGGCCGAGCCCACCGCCTTGCTCGGTGCCAACCAGC
TCTCCGTGGAGCACCGCTTCATGGGGACATCCGTGCCGGCATCCCGGGATACGCGGCTGCTCACCATCTACCAGGCCGCG
AGCGACAGCCACCGCGCCGTCCAGGCCTTCAAACCCCTGTACCCCGCGCGCTGGCTCTCCACCGGAGGCAGCAAGGGCGG
CGTGACGGCCGTGTATCACCGCTATTTCTACCCGGATGACGTGGACGCCACCCTGCCGTATGTCGCGCCCAGCAACCATG
GGCTGCGCGACGTGCGCTACGTCCACTTCCTCGCGGAGCTGGGGGATGCGGACTGCCGCACGAAGCTGGAGGCCTTCCAG
CAGGACGTGCTGCTACGCCGCGGGGAGCTGCTGCCCTTCGTGGATGCGCTAGGTACGAAGTGGAACACCGGCTTCACCGT
CGTGGGCGGTCCGGACCGCGCGCTGGAGTTCTCCGCCGTCGAGGCATCCTTCTACTTCTGGCAGTACGGCACCGCGTCCG
CTTGCGCGAGCATTCCCGCCGCCGGCGCGCCGGCGGCGGAGACATTCGCCTTCCTGGACGATGTCGTCGGCGTTGCCTTC
ACCTACTCGGACCGCTTCATCGCCCCCTTCGAGTACGCCTACTACCAAGCCGCGACGCAGTTGGGCTGGTCGCGCTACCC
CGCGAATCACCTGCGAGGGCTTCTGCGCTACCCAGGGGAGAACACGCCCGACGTGTACGTGAGCTTCCCTGTGACGGAGC
CGTTCGACATGAGGGCCATGCTTCGGGTGGAGCACTGGGTCCGCAACCACGGCAAGCGGATGCTCTTCATCTACGGGGAG
AACGACCCGTATTCCGCCACGGCATTTTCCGTGCGCGAGGACAACGACGCGTTCCGCTACTTCGCTCCGGAGGGCAACCA
CGGTGCGAGCATCGGCGGCCTTGCCGAGCCCGAGCGGGCCCTCGTCATGGAGCGCCTCTTCACGTGGATGGGGATGAGCG
TTCCCTCCGCGGCGGTTCGCGCGCAGGCACTCGAGCATGCGACCGAGGCGGCGACTTCGAAGCCCGCTGCGTCATGGGTG
CCACGAGGCCACCTTCAGCAGCGCGTCCATGCGAGTGAGTGGGACGCGCGGTCATCGGGCTTCATCCGCCTGGACAGCGA
CGCGCCCAACCGCAAGACGATGGCGGAGTCGCTCCAAGCCCCAAGGGCCCGCCGGTGA

Upstream 100 bases:

>100_bases
GGCGCGGAGGGATTCGTGCTCGGGACTCCGCCGCTGGTGTCCGGCATGCCCGATATGGCGGTGCACGGCATGCGTTTGAG
CGGCACCTCGAAGGCCCCTG

Downstream 100 bases:

>100_bases
TACCCACCCCCTCACGGCGGGCGCCAGGGAACTGAACCTCACGACAGCGGACCACGTGCTTCAGGAGGCCCCATGGCGGA
GCCCCTCCGTGATGGGGGGC

Product: putative lipoprotein

Products: NA

Alternate protein names: PTP-SM; Tripeptidyl aminopeptidase; SM-TAP [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MYPMTKTHRPALLLAMVLLACGDTSLAEPASSEQPAAALETAAEPEDILARLQSIPGLSVVLEQPSPFPGTRFFLLQLEQ
PADHERPQGERFQLRMTLLHRSVDAPMVLSTEGYMLAPRPWQAEPTALLGANQLSVEHRFMGTSVPASRDTRLLTIYQAA
SDSHRAVQAFKPLYPARWLSTGGSKGGVTAVYHRYFYPDDVDATLPYVAPSNHGLRDVRYVHFLAELGDADCRTKLEAFQ
QDVLLRRGELLPFVDALGTKWNTGFTVVGGPDRALEFSAVEASFYFWQYGTASACASIPAAGAPAAETFAFLDDVVGVAF
TYSDRFIAPFEYAYYQAATQLGWSRYPANHLRGLLRYPGENTPDVYVSFPVTEPFDMRAMLRVEHWVRNHGKRMLFIYGE
NDPYSATAFSVREDNDAFRYFAPEGNHGASIGGLAEPERALVMERLFTWMGMSVPSAAVRAQALEHATEAATSKPAASWV
PRGHLQQRVHASEWDARSSGFIRLDSDAPNRKTMAESLQAPRARR

Sequences:

>Translated_525_residues
MYPMTKTHRPALLLAMVLLACGDTSLAEPASSEQPAAALETAAEPEDILARLQSIPGLSVVLEQPSPFPGTRFFLLQLEQ
PADHERPQGERFQLRMTLLHRSVDAPMVLSTEGYMLAPRPWQAEPTALLGANQLSVEHRFMGTSVPASRDTRLLTIYQAA
SDSHRAVQAFKPLYPARWLSTGGSKGGVTAVYHRYFYPDDVDATLPYVAPSNHGLRDVRYVHFLAELGDADCRTKLEAFQ
QDVLLRRGELLPFVDALGTKWNTGFTVVGGPDRALEFSAVEASFYFWQYGTASACASIPAAGAPAAETFAFLDDVVGVAF
TYSDRFIAPFEYAYYQAATQLGWSRYPANHLRGLLRYPGENTPDVYVSFPVTEPFDMRAMLRVEHWVRNHGKRMLFIYGE
NDPYSATAFSVREDNDAFRYFAPEGNHGASIGGLAEPERALVMERLFTWMGMSVPSAAVRAQALEHATEAATSKPAASWV
PRGHLQQRVHASEWDARSSGFIRLDSDAPNRKTMAESLQAPRARR
>Mature_525_residues
MYPMTKTHRPALLLAMVLLACGDTSLAEPASSEQPAAALETAAEPEDILARLQSIPGLSVVLEQPSPFPGTRFFLLQLEQ
PADHERPQGERFQLRMTLLHRSVDAPMVLSTEGYMLAPRPWQAEPTALLGANQLSVEHRFMGTSVPASRDTRLLTIYQAA
SDSHRAVQAFKPLYPARWLSTGGSKGGVTAVYHRYFYPDDVDATLPYVAPSNHGLRDVRYVHFLAELGDADCRTKLEAFQ
QDVLLRRGELLPFVDALGTKWNTGFTVVGGPDRALEFSAVEASFYFWQYGTASACASIPAAGAPAAETFAFLDDVVGVAF
TYSDRFIAPFEYAYYQAATQLGWSRYPANHLRGLLRYPGENTPDVYVSFPVTEPFDMRAMLRVEHWVRNHGKRMLFIYGE
NDPYSATAFSVREDNDAFRYFAPEGNHGASIGGLAEPERALVMERLFTWMGMSVPSAAVRAQALEHATEAATSKPAASWV
PRGHLQQRVHASEWDARSSGFIRLDSDAPNRKTMAESLQAPRARR

Specific function: Has proline-specific tripeptidyl aminopeptidase and tetrapeptidyl aminopeptidase activity. Activity is highest against tripeptides containing an Ala-Pro motif. Involved in the final processing of transglutaminase, by removing either the tetrapeptide Phe-A

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Cell surface. Note=Secreted (PubMed:14519127). Cell surface (PubMed:15598885) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S37 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008761 [H]

Pfam domain/function: PF05576 Peptidase_S37 [H]

EC number: NA

Molecular weight: Translated: 58199; Mature: 58199

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPMTKTHRPALLLAMVLLACGDTSLAEPASSEQPAAALETAAEPEDILARLQSIPGLSV
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCEE
VLEQPSPFPGTRFFLLQLEQPADHERPQGERFQLRMTLLHRSVDAPMVLSTEGYMLAPRP
EEECCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEHHHHHHCCCCCEEEECCCEEECCCC
WQAEPTALLGANQLSVEHRFMGTSVPASRDTRLLTIYQAASDSHRAVQAFKPLYPARWLS
CCCCCCEEECCCHHCHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCHHHHH
TGGSKGGVTAVYHRYFYPDDVDATLPYVAPSNHGLRDVRYVHFLAELGDADCRTKLEAFQ
CCCCCCCEEEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
QDVLLRRGELLPFVDALGTKWNTGFTVVGGPDRALEFSAVEASFYFWQYGTASACASIPA
HHHHHHCCCCCHHHHHHCCCCCCCEEEECCCCCCEEEEEEEEEEEEEECCCHHHHHCCCC
AGAPAAETFAFLDDVVGVAFTYSDRFIAPFEYAYYQAATQLGWSRYPANHLRGLLRYPGE
CCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
NTPDVYVSFPVTEPFDMRAMLRVEHWVRNHGKRMLFIYGENDPYSATAFSVREDNDAFRY
CCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEECCCCCEEE
FAPEGNHGASIGGLAEPERALVMERLFTWMGMSVPSAAVRAQALEHATEAATSKPAASWV
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHCC
PRGHLQQRVHASEWDARSSGFIRLDSDAPNRKTMAESLQAPRARR
CCHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYPMTKTHRPALLLAMVLLACGDTSLAEPASSEQPAAALETAAEPEDILARLQSIPGLSV
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCEE
VLEQPSPFPGTRFFLLQLEQPADHERPQGERFQLRMTLLHRSVDAPMVLSTEGYMLAPRP
EEECCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEHHHHHHCCCCCEEEECCCEEECCCC
WQAEPTALLGANQLSVEHRFMGTSVPASRDTRLLTIYQAASDSHRAVQAFKPLYPARWLS
CCCCCCEEECCCHHCHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCHHHHH
TGGSKGGVTAVYHRYFYPDDVDATLPYVAPSNHGLRDVRYVHFLAELGDADCRTKLEAFQ
CCCCCCCEEEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
QDVLLRRGELLPFVDALGTKWNTGFTVVGGPDRALEFSAVEASFYFWQYGTASACASIPA
HHHHHHCCCCCHHHHHHCCCCCCCEEEECCCCCCEEEEEEEEEEEEEECCCHHHHHCCCC
AGAPAAETFAFLDDVVGVAFTYSDRFIAPFEYAYYQAATQLGWSRYPANHLRGLLRYPGE
CCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
NTPDVYVSFPVTEPFDMRAMLRVEHWVRNHGKRMLFIYGENDPYSATAFSVREDNDAFRY
CCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEECCCCCEEE
FAPEGNHGASIGGLAEPERALVMERLFTWMGMSVPSAAVRAQALEHATEAATSKPAASWV
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHCC
PRGHLQQRVHASEWDARSSGFIRLDSDAPNRKTMAESLQAPRARR
CCHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA