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The map label for this gene is hemL

Identifier: 108759601

GI number: 108759601

Start: 455680

End: 456975

Strand: Direct

Name: hemL

Synonym: MXAN_0395

Alternate gene names: 108759601

Gene position: 455680-456975 (Clockwise)

Preceding gene: 108761351

Following gene: 108760331

Centisome position: 4.99

GC content: 68.9

Gene sequence:

>1296_bases
ATGAACCACGCTCACAGTCAGGCTCTCTTCGCTCGCGCGCAGGCTCGCATCCCCGGCGGAGTGAATTCCCCGGTGCGCGC
CTTCCGAGGCGTTGGCGGCGACCCTGTCTTCTTCCGTGAAGGCGCAGGTGCCTGGCTCACGGATGTGGACGGCAACCGCT
ACGTTGACCTCGTGGGGAGCTGGGGTCCGCTTATCCTGGGCCACGCGTATCCGCCCATCTTGGACGCCATCATCGACGCC
GCGCGCCGGGGTTCGTCCTATGGCGCGCCGCATGCGGATGAGGTGGAGTTCGCGGAGCTCATCTGCGCCACCATGCCCGC
GGTGGAGATGGTGCGCCTGGTCTCCAGTGGCACCGAGGCCACGGTGGCGGCCATCCGCGTCGCGCGAGGCTTCACCGGCC
GCGAGCACATCCTCAAGTTCGAAGGCTGCTTCCACGGCGCGGGAGACCCGTTCCTGGTGAAGGCGGGCAGTGGCGTGGAG
ACGCTGGGCCTGCCGGACTCTCCGGGCGTGCCGTCGGCGCTGGCGAAGCTCACGCTCACCGCGCCCTTCAACGACCTGGC
CGCCGTGGAGCGCATCTTCGCGGAGAATGGCCAGGACATCGCTTGCGCCATCATCGAGCCGGTGGTGGGCAACATGGGCG
TGCTGGTGCCGAAGCCGGGCTATCTCGAAGGGCTGCAGGCGCTCTGCCAGAAGCACGGCGTGCTGCTGGTGCTGGACGAG
GTCATGACGGGCTTCCGGCTGTCGCGAGGCGGCGCGCAGGAGCTGTACGGCCTCAAGCCGGACCTCACCACCATGGCGAA
GGTGATTGGCGGGGGCATGCCGATGGGCGCGTATGGTGGCCGCCGCGACATCATGGAGAAGGTGGCTCCCGCGGGCCCGG
TGTACCAGTCCGGCACGCTGTCGGGGAACCCGGTGGCGGTGGCGGCGGGCCTTGCGTGCCTCAAGGCCCTGGCGGCCCCC
GGCACCTACGCGCGGCTGGAGGAGGTCAGCCGCATGTTGGAGGTCGGCCTGCTCGCCGAGGCGAAGGCCGCGGACGTGCC
CGTCACCGTCAACCGCGTGGGCAGCATGCTCACGGTGTTCTTCACCGGTGAGCCCGTCTACGACTACACCAGCGCGAAGA
AGGCGGACACGGCGCGCTTCGGGAAGTTCTTCCACGCCATGCTGAACGAAAGCGTCTACCTGCCGCCCAGCCAGTTCGAG
GCGGCGTTCGTGTCGCTGGCCATTGGCGAGCCGGAAGTCGCGCACGTCCTCGCGGCGGCGAGAAAGGCCTTCCGTTCGCT
TGGCAAGACCGGTTGA

Upstream 100 bases:

>100_bases
CTGTCCATAATGTGTCGACGACGGCACGAAGAAGCGGGGGGCATGGGAGCGGGCGTGCGGGGACACAGACTGCCTCGTGC
CGCATGTTATGGAACGAGCC

Downstream 100 bases:

>100_bases
GCCCGCGCCCCTCGAGGGGCCCGTTCGCTTCGGTCCCTATACCCTCGTGCGCCGCATCGGCGCCGGGGGGATGGGAGAGG
TGTTCCTCGCGCGTGAGGAG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNHAHSQALFARAQARIPGGVNSPVRAFRGVGGDPVFFREGAGAWLTDVDGNRYVDLVGSWGPLILGHAYPPILDAIIDA
ARRGSSYGAPHADEVEFAELICATMPAVEMVRLVSSGTEATVAAIRVARGFTGREHILKFEGCFHGAGDPFLVKAGSGVE
TLGLPDSPGVPSALAKLTLTAPFNDLAAVERIFAENGQDIACAIIEPVVGNMGVLVPKPGYLEGLQALCQKHGVLLVLDE
VMTGFRLSRGGAQELYGLKPDLTTMAKVIGGGMPMGAYGGRRDIMEKVAPAGPVYQSGTLSGNPVAVAAGLACLKALAAP
GTYARLEEVSRMLEVGLLAEAKAADVPVTVNRVGSMLTVFFTGEPVYDYTSAKKADTARFGKFFHAMLNESVYLPPSQFE
AAFVSLAIGEPEVAHVLAAARKAFRSLGKTG

Sequences:

>Translated_431_residues
MNHAHSQALFARAQARIPGGVNSPVRAFRGVGGDPVFFREGAGAWLTDVDGNRYVDLVGSWGPLILGHAYPPILDAIIDA
ARRGSSYGAPHADEVEFAELICATMPAVEMVRLVSSGTEATVAAIRVARGFTGREHILKFEGCFHGAGDPFLVKAGSGVE
TLGLPDSPGVPSALAKLTLTAPFNDLAAVERIFAENGQDIACAIIEPVVGNMGVLVPKPGYLEGLQALCQKHGVLLVLDE
VMTGFRLSRGGAQELYGLKPDLTTMAKVIGGGMPMGAYGGRRDIMEKVAPAGPVYQSGTLSGNPVAVAAGLACLKALAAP
GTYARLEEVSRMLEVGLLAEAKAADVPVTVNRVGSMLTVFFTGEPVYDYTSAKKADTARFGKFFHAMLNESVYLPPSQFE
AAFVSLAIGEPEVAHVLAAARKAFRSLGKTG
>Mature_431_residues
MNHAHSQALFARAQARIPGGVNSPVRAFRGVGGDPVFFREGAGAWLTDVDGNRYVDLVGSWGPLILGHAYPPILDAIIDA
ARRGSSYGAPHADEVEFAELICATMPAVEMVRLVSSGTEATVAAIRVARGFTGREHILKFEGCFHGAGDPFLVKAGSGVE
TLGLPDSPGVPSALAKLTLTAPFNDLAAVERIFAENGQDIACAIIEPVVGNMGVLVPKPGYLEGLQALCQKHGVLLVLDE
VMTGFRLSRGGAQELYGLKPDLTTMAKVIGGGMPMGAYGGRRDIMEKVAPAGPVYQSGTLSGNPVAVAAGLACLKALAAP
GTYARLEEVSRMLEVGLLAEAKAADVPVTVNRVGSMLTVFFTGEPVYDYTSAKKADTARFGKFFHAMLNESVYLPPSQFE
AAFVSLAIGEPEVAHVLAAARKAFRSLGKTG

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=294, Percent_Identity=29.9319727891156, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI13994255, Length=344, Percent_Identity=27.0348837209302, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI37574042, Length=331, Percent_Identity=24.773413897281, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI284507298, Length=138, Percent_Identity=36.231884057971, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI24119277, Length=301, Percent_Identity=26.578073089701, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI226442705, Length=330, Percent_Identity=24.2424242424242, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI226442709, Length=298, Percent_Identity=25.503355704698, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786349, Length=425, Percent_Identity=55.2941176470588, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1789016, Length=359, Percent_Identity=31.7548746518106, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1787560, Length=359, Percent_Identity=32.3119777158774, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI145693181, Length=448, Percent_Identity=27.6785714285714, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1789759, Length=295, Percent_Identity=32.5423728813559, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788044, Length=291, Percent_Identity=32.6460481099656, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786991, Length=383, Percent_Identity=27.9373368146214, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=301, Percent_Identity=27.906976744186, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=338, Percent_Identity=26.9230769230769, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI25144274, Length=142, Percent_Identity=34.5070422535211, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=305, Percent_Identity=28.5245901639344, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=345, Percent_Identity=26.9565217391304, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357415, Length=290, Percent_Identity=26.8965517241379, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_MYXXD (Q1DFA7)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_628666.1
- ProteinModelPortal:   Q1DFA7
- SMR:   Q1DFA7
- STRING:   Q1DFA7
- GeneID:   4103370
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_0395
- TIGR:   MXAN_0395
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   NENAVRD
- PhylomeDB:   Q1DFA7
- ProtClustDB:   PRK00062
- BioCyc:   MXAN246197:MXAN_0395-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 45137; Mature: 45137

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHAHSQALFARAQARIPGGVNSPVRAFRGVGGDPVFFREGAGAWLTDVDGNRYVDLVGS
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEECCCCCEEEECCCCEEEEEECC
WGPLILGHAYPPILDAIIDAARRGSSYGAPHADEVEFAELICATMPAVEMVRLVSSGTEA
CCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHH
TVAAIRVARGFTGREHILKFEGCFHGAGDPFLVKAGSGVETLGLPDSPGVPSALAKLTLT
HHHHHHHHHCCCCHHHHEEECCCCCCCCCCEEEECCCCCEECCCCCCCCCCHHHHHEEEE
APFNDLAAVERIFAENGQDIACAIIEPVVGNMGVLVPKPGYLEGLQALCQKHGVLLVLDE
CCCHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCEEEEHHH
VMTGFRLSRGGAQELYGLKPDLTTMAKVIGGGMPMGAYGGRRDIMEKVAPAGPVYQSGTL
HHHHHEECCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCC
SGNPVAVAAGLACLKALAAPGTYARLEEVSRMLEVGLLAEAKAADVPVTVNRVGSMLTVF
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHCCEEEEE
FTGEPVYDYTSAKKADTARFGKFFHAMLNESVYLPPSQFEAAFVSLAIGEPEVAHVLAAA
ECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEECCCHHHHHHHHHH
RKAFRSLGKTG
HHHHHHHCCCC
>Mature Secondary Structure
MNHAHSQALFARAQARIPGGVNSPVRAFRGVGGDPVFFREGAGAWLTDVDGNRYVDLVGS
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEECCCCCEEEECCCCEEEEEECC
WGPLILGHAYPPILDAIIDAARRGSSYGAPHADEVEFAELICATMPAVEMVRLVSSGTEA
CCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHH
TVAAIRVARGFTGREHILKFEGCFHGAGDPFLVKAGSGVETLGLPDSPGVPSALAKLTLT
HHHHHHHHHCCCCHHHHEEECCCCCCCCCCEEEECCCCCEECCCCCCCCCCHHHHHEEEE
APFNDLAAVERIFAENGQDIACAIIEPVVGNMGVLVPKPGYLEGLQALCQKHGVLLVLDE
CCCHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCEEEEHHH
VMTGFRLSRGGAQELYGLKPDLTTMAKVIGGGMPMGAYGGRRDIMEKVAPAGPVYQSGTL
HHHHHEECCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCC
SGNPVAVAAGLACLKALAAPGTYARLEEVSRMLEVGLLAEAKAADVPVTVNRVGSMLTVF
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHCCEEEEE
FTGEPVYDYTSAKKADTARFGKFFHAMLNESVYLPPSQFEAAFVSLAIGEPEVAHVLAAA
ECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEECCCHHHHHHHHHH
RKAFRSLGKTG
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA