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The map label for this gene is mutY [H]

Identifier: 108759592

GI number: 108759592

Start: 2311673

End: 2312845

Strand: Reverse

Name: mutY [H]

Synonym: MXAN_1976

Alternate gene names: 108759592

Gene position: 2312845-2311673 (Counterclockwise)

Preceding gene: 108757570

Following gene: 108759129

Centisome position: 25.31

GC content: 72.21

Gene sequence:

>1173_bases
ATGAGCTCCCCGTCCAAGGCAGCACCCGCACGGAAGCCCCGCGCCGGGCGTCCCCCTTCCGCGCCGCTCGCGGCCACTGT
CACACCCGCGCAGGCGCACCTGGCCAGCGTGCGTGGGCCGCTGCTGGACTGGTACGACCGGAACAAGCGCGACCTGCCCT
GGCGCCGCACTCGGGATTCGTATGCCATCTGGCTGAGCGAAGTCATGCTCCAGCAGACCCAGGTGTCGACGGTGATTCCC
TACTGGGAGCGGTTCCTCGCGCGATTCCCCACGGCGCGCGCGTTGGCCTCGGCGCCGCTGGATGACGTGCTCGCGGGCTG
GAAGGGACTGGGCTACTACAGCCGCGCCCGCAACCTGCACCGCGCCGCACAGGAAGTCGTCGCGCGCTTCGGCGGCACCC
TGCCCTCCACCGCCGCCGAGCTGCTCGAACTGCCCGGCTTCGGCCGCTACACCGCGGGCGCGGTCGCCTCCATCGCCTTT
GGCGAAGAAGCGCCGCTGGTGGACGGCAACGTCGCGCGCGTCTTCTCTCGCATCTTCGAGGTCGAAGGCCTTCCAGGAGA
CCGCCAGCGAGAGGCCACACTGTGGGCACTCGCCACCGCACTGGTGAAGGGCGAGCGGCCCGGTGACTTCAACCAGGCCC
TCATGGAGCACGGCGCAACCACATGCCGGCCAGAGAACCCGCTTTGCCTGCTGTGCCCCGTGCGCGGAGCCTGCGTCGCC
TTCCGCAAGGGCCGCGTGGACGAGCTGCCCCCCGCCAAGGTGCGCGCCACGCCCAAGAAGCTGACGCTGGCCGTCGCCGT
GTGGCCCCATGCCGGCACCCTCCTCTTCGCCCGCCGCGCGGACGCCGGGCTCTTCGGGGGCCTGTGGGAGCTGCCGGCCG
CCGAAATCGCCGACGACGCACCGGACAGCGAAGCCCGTGCCCGGCTCTCCGCCGCGCTGGGCGTCGACGTGACCCTGGAA
GGCGCGCTGGGCACCGTGAAGCGGCAGCTCACCCACCGAGACCTCTCGCTTCGGCTGCTGCGCGTCTCCGGCCCTCGCCG
GCCCGCGAGCACGCCCGCCTTCCAGGAGCTTCGCTGGTGCGCCCCTGATGACGCGGAGAAGCTCGGCATGAGCACCGCGA
TGCAGCGAGCGCTCGACATCGCGCTGGGAGCGGGCGTGCTGCCAGGCGGCTGA

Upstream 100 bases:

>100_bases
CGCTGCCCGGCCGGGTGATGGTGGTGGCCAACCGGTGGGTGCCTTCCCTGTTCGACCGTGTCGCCCGCCGCATGGCGCTT
GCTTCGAAGAAGAAGGACGC

Downstream 100 bases:

>100_bases
AGGCCTCTACGTCGGCCCTACATACGCCACCTGTCCGTCGCTCGACACAGAGGCAGTCCTCCTGTCGCACTGACAACCCC
GGCCCCCCGCCTGCCGGTTC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSSPSKAAPARKPRAGRPPSAPLAATVTPAQAHLASVRGPLLDWYDRNKRDLPWRRTRDSYAIWLSEVMLQQTQVSTVIP
YWERFLARFPTARALASAPLDDVLAGWKGLGYYSRARNLHRAAQEVVARFGGTLPSTAAELLELPGFGRYTAGAVASIAF
GEEAPLVDGNVARVFSRIFEVEGLPGDRQREATLWALATALVKGERPGDFNQALMEHGATTCRPENPLCLLCPVRGACVA
FRKGRVDELPPAKVRATPKKLTLAVAVWPHAGTLLFARRADAGLFGGLWELPAAEIADDAPDSEARARLSAALGVDVTLE
GALGTVKRQLTHRDLSLRLLRVSGPRRPASTPAFQELRWCAPDDAEKLGMSTAMQRALDIALGAGVLPGG

Sequences:

>Translated_390_residues
MSSPSKAAPARKPRAGRPPSAPLAATVTPAQAHLASVRGPLLDWYDRNKRDLPWRRTRDSYAIWLSEVMLQQTQVSTVIP
YWERFLARFPTARALASAPLDDVLAGWKGLGYYSRARNLHRAAQEVVARFGGTLPSTAAELLELPGFGRYTAGAVASIAF
GEEAPLVDGNVARVFSRIFEVEGLPGDRQREATLWALATALVKGERPGDFNQALMEHGATTCRPENPLCLLCPVRGACVA
FRKGRVDELPPAKVRATPKKLTLAVAVWPHAGTLLFARRADAGLFGGLWELPAAEIADDAPDSEARARLSAALGVDVTLE
GALGTVKRQLTHRDLSLRLLRVSGPRRPASTPAFQELRWCAPDDAEKLGMSTAMQRALDIALGAGVLPGG
>Mature_389_residues
SSPSKAAPARKPRAGRPPSAPLAATVTPAQAHLASVRGPLLDWYDRNKRDLPWRRTRDSYAIWLSEVMLQQTQVSTVIPY
WERFLARFPTARALASAPLDDVLAGWKGLGYYSRARNLHRAAQEVVARFGGTLPSTAAELLELPGFGRYTAGAVASIAFG
EEAPLVDGNVARVFSRIFEVEGLPGDRQREATLWALATALVKGERPGDFNQALMEHGATTCRPENPLCLLCPVRGACVAF
RKGRVDELPPAKVRATPKKLTLAVAVWPHAGTLLFARRADAGLFGGLWELPAAEIADDAPDSEARARLSAALGVDVTLEG
ALGTVKRQLTHRDLSLRLLRVSGPRRPASTPAFQELRWCAPDDAEKLGMSTAMQRALDIALGAGVLPGG

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=433, Percent_Identity=36.0277136258661, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI115298654, Length=433, Percent_Identity=36.0277136258661, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI115298652, Length=433, Percent_Identity=36.0277136258661, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI190358497, Length=411, Percent_Identity=36.7396593673966, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI115298650, Length=433, Percent_Identity=36.0277136258661, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI6912520, Length=411, Percent_Identity=36.7396593673966, Blast_Score=235, Evalue=4e-62,
Organism=Escherichia coli, GI1789331, Length=260, Percent_Identity=46.5384615384615, Blast_Score=241, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 42029; Mature: 41897

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPSKAAPARKPRAGRPPSAPLAATVTPAQAHLASVRGPLLDWYDRNKRDLPWRRTRDS
CCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCHHHHHCCCCCCCCCHHCCCH
YAIWLSEVMLQQTQVSTVIPYWERFLARFPTARALASAPLDDVLAGWKGLGYYSRARNLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHH
RAAQEVVARFGGTLPSTAAELLELPGFGRYTAGAVASIAFGEEAPLVDGNVARVFSRIFE
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
VEGLPGDRQREATLWALATALVKGERPGDFNQALMEHGATTCRPENPLCLLCPVRGACVA
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCHHHH
FRKGRVDELPPAKVRATPKKLTLAVAVWPHAGTLLFARRADAGLFGGLWELPAAEIADDA
HHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCHHCCHHHCCHHHHCCCC
PDSEARARLSAALGVDVTLEGALGTVKRQLTHRDLSLRLLRVSGPRRPASTPAFQELRWC
CCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHCC
APDDAEKLGMSTAMQRALDIALGAGVLPGG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSPSKAAPARKPRAGRPPSAPLAATVTPAQAHLASVRGPLLDWYDRNKRDLPWRRTRDS
CCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCHHHHHCCCCCCCCCHHCCCH
YAIWLSEVMLQQTQVSTVIPYWERFLARFPTARALASAPLDDVLAGWKGLGYYSRARNLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHH
RAAQEVVARFGGTLPSTAAELLELPGFGRYTAGAVASIAFGEEAPLVDGNVARVFSRIFE
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
VEGLPGDRQREATLWALATALVKGERPGDFNQALMEHGATTCRPENPLCLLCPVRGACVA
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCHHHH
FRKGRVDELPPAKVRATPKKLTLAVAVWPHAGTLLFARRADAGLFGGLWELPAAEIADDA
HHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCHHCCHHHCCHHHHCCCC
PDSEARARLSAALGVDVTLEGALGTVKRQLTHRDLSLRLLRVSGPRRPASTPAFQELRWC
CCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHCC
APDDAEKLGMSTAMQRALDIALGAGVLPGG
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]