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The map label for this gene is 108759566

Identifier: 108759566

GI number: 108759566

Start: 2459374

End: 2460798

Strand: Reverse

Name: 108759566

Synonym: MXAN_2127

Alternate gene names: NA

Gene position: 2460798-2459374 (Counterclockwise)

Preceding gene: 108757333

Following gene: 108757876

Centisome position: 26.92

GC content: 63.79

Gene sequence:

>1425_bases
ATGGCAGAGGTGTGCCCCGAATCCTCGCAACAAAACCAGACTCCTTCTGATATACGCCGCCCCGAAATCCTCACAAGAAG
TGGAGAAATCATGTCACGAGACCTTTCGAGGTTGGCGTTGTCCGCACTATTCATCCCGAGTTTGCTGCTCATCGCCTGTG
GAGAGGAGAACCTGGCGCCGGGGCTCAACCTGGACCCGGAAATGGCCCGAGTACCAGCGGGGGCCCCGATTCGCGAGGGC
TACATCTGGAGCAACATGCGGGAGAAGTTCGTCCCGGTCACGTATGCCGAGGTGGACGGTCTGGCCATCCAAGAGGGCGA
CATGGTCCTGGGGACGGTGCAGCAGATGGAGGCGCGCGTGCGCGAGGTGAAGGCCCTGGGGCTGGATGCCTCGGGCCCCC
GAGCCCAGGGCCTCGCCAAGACCGACCTGAACTCGCGCTGGCCCAACGCCGTGGTTCCGTACACCATCGACTCGGGCGTT
GCGAACCAGAATCGAATCCAGGACGCCATCAATCACTGGCATGACCGGACCCACATCTCGTTCGTGCTCCGCACGGCGAA
CAACGCGGCGCAATATCCTGACTACGTTCGCATCCAGTCGGGCACCGGATGCTCCGCCCACTATGGCCGTCTGGGTGGGC
AACAAGGGGTGTGGCTGGATGGCAGTTGCAGCACGGGCACCATCATCCACGAGCTGGGACACAGCCTGGGACTCAACCAC
GAGCACAACCGCCAGGACCGCGACACCTACGTCATCATCCGGTGGGAGAACATGGTGGCGGGCGCGGCGTCCCAGTTCCA
GCAGAACAACAACGAGGACGACGACTTCTTTGGCTATGACTTCGGCTCCATCATGCACTACGGCCCGATGCAGGGCTCGA
AGAACGGGCGGCCGACCATCGAGGGCCGGGGTGGACAGACCATCGGGCAGCGCAACGCGCTGAGCACGCTCGACGTCGTG
ACGGTGACGCGGCTCTATTCGAGGACCATCACGCTTCGTGCTTCAAACGGCGACTACCTGGTGGCCGAGGGCGGCGGTGG
CGCCATGGTGGACGCCAATCGCGTCGCAGTGGGGCCTTGGGAGCGGTTCCAGTTGGTGGACCTGGACGGCAATGACCTGG
TGACGGGCGACCTTGTCCAACTCCAGACCATCAACGGCAACTTCGTCCAGGCGACGAACGGTGGTGGCTCGACGCTGAAC
GCCTGGGAGATGGCTCCCGGCAACTGGGAGACCTTCCGCATTTGGAAGATGGCCGGCACGGGTCTCTCCACCATCGCCAC
CGGCGACGGCGTGGTCCTGGGCACACTCACTCCGGGCTATCCCAAGTACTGGCAGGCGGTGAACGGCGGCGGCGCTGGAG
TGACCGTCAACACCGACACCATCAACCTGGGCCCCGCGAACATCTTCACCGTCGCGTTCCCGTGA

Upstream 100 bases:

>100_bases
CCGCACCCAATCCAAGCCGAACCCCTGGAGATGCACATCACCTCCACAAACCCACACGAGTCAACCTCGACCCAGTCAGC
CCTGACGCGTCACCAAGGCA

Downstream 100 bases:

>100_bases
GTGAAGCGTCCGTGCGATTCACGCACGGACCTTCGCCTTGAAACGACGCTGGGGATTCAGCCCCGCGACGCGGTGACTGA
ATCCCCAGGGGACTTCCTGC

Product: M12A family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MAEVCPESSQQNQTPSDIRRPEILTRSGEIMSRDLSRLALSALFIPSLLLIACGEENLAPGLNLDPEMARVPAGAPIREG
YIWSNMREKFVPVTYAEVDGLAIQEGDMVLGTVQQMEARVREVKALGLDASGPRAQGLAKTDLNSRWPNAVVPYTIDSGV
ANQNRIQDAINHWHDRTHISFVLRTANNAAQYPDYVRIQSGTGCSAHYGRLGGQQGVWLDGSCSTGTIIHELGHSLGLNH
EHNRQDRDTYVIIRWENMVAGAASQFQQNNNEDDDFFGYDFGSIMHYGPMQGSKNGRPTIEGRGGQTIGQRNALSTLDVV
TVTRLYSRTITLRASNGDYLVAEGGGGAMVDANRVAVGPWERFQLVDLDGNDLVTGDLVQLQTINGNFVQATNGGGSTLN
AWEMAPGNWETFRIWKMAGTGLSTIATGDGVVLGTLTPGYPKYWQAVNGGGAGVTVNTDTINLGPANIFTVAFP

Sequences:

>Translated_474_residues
MAEVCPESSQQNQTPSDIRRPEILTRSGEIMSRDLSRLALSALFIPSLLLIACGEENLAPGLNLDPEMARVPAGAPIREG
YIWSNMREKFVPVTYAEVDGLAIQEGDMVLGTVQQMEARVREVKALGLDASGPRAQGLAKTDLNSRWPNAVVPYTIDSGV
ANQNRIQDAINHWHDRTHISFVLRTANNAAQYPDYVRIQSGTGCSAHYGRLGGQQGVWLDGSCSTGTIIHELGHSLGLNH
EHNRQDRDTYVIIRWENMVAGAASQFQQNNNEDDDFFGYDFGSIMHYGPMQGSKNGRPTIEGRGGQTIGQRNALSTLDVV
TVTRLYSRTITLRASNGDYLVAEGGGGAMVDANRVAVGPWERFQLVDLDGNDLVTGDLVQLQTINGNFVQATNGGGSTLN
AWEMAPGNWETFRIWKMAGTGLSTIATGDGVVLGTLTPGYPKYWQAVNGGGAGVTVNTDTINLGPANIFTVAFP
>Mature_473_residues
AEVCPESSQQNQTPSDIRRPEILTRSGEIMSRDLSRLALSALFIPSLLLIACGEENLAPGLNLDPEMARVPAGAPIREGY
IWSNMREKFVPVTYAEVDGLAIQEGDMVLGTVQQMEARVREVKALGLDASGPRAQGLAKTDLNSRWPNAVVPYTIDSGVA
NQNRIQDAINHWHDRTHISFVLRTANNAAQYPDYVRIQSGTGCSAHYGRLGGQQGVWLDGSCSTGTIIHELGHSLGLNHE
HNRQDRDTYVIIRWENMVAGAASQFQQNNNEDDDFFGYDFGSIMHYGPMQGSKNGRPTIEGRGGQTIGQRNALSTLDVVT
VTRLYSRTITLRASNGDYLVAEGGGGAMVDANRVAVGPWERFQLVDLDGNDLVTGDLVQLQTINGNFVQATNGGGSTLNA
WEMAPGNWETFRIWKMAGTGLSTIATGDGVVLGTLTPGYPKYWQAVNGGGAGVTVNTDTINLGPANIFTVAFP

Specific function: Zinc metallendopeptidase that cleaves preferentially on amino-terminal side of aspartate-containing substrates [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ricin B-type lectin domain [H]

Homologues:

Organism=Homo sapiens, GI4502421, Length=258, Percent_Identity=31.3953488372093, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI5453579, Length=258, Percent_Identity=31.3953488372093, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI157502169, Length=182, Percent_Identity=34.0659340659341, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI22547221, Length=273, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI6912724, Length=280, Percent_Identity=29.2857142857143, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI153070264, Length=196, Percent_Identity=29.5918367346939, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI153070262, Length=203, Percent_Identity=30.0492610837438, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71981168, Length=232, Percent_Identity=36.2068965517241, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71986142, Length=223, Percent_Identity=36.322869955157, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71989620, Length=187, Percent_Identity=41.1764705882353, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71981193, Length=187, Percent_Identity=36.8983957219251, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71986189, Length=189, Percent_Identity=37.5661375661376, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71995692, Length=186, Percent_Identity=38.1720430107527, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI25149641, Length=189, Percent_Identity=35.4497354497354, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI115532764, Length=189, Percent_Identity=39.1534391534392, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71980967, Length=272, Percent_Identity=32.7205882352941, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71996833, Length=237, Percent_Identity=35.0210970464135, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17568533, Length=307, Percent_Identity=32.5732899022801, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI25152806, Length=223, Percent_Identity=31.390134529148, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71989942, Length=179, Percent_Identity=35.7541899441341, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71989946, Length=179, Percent_Identity=35.7541899441341, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193210526, Length=243, Percent_Identity=32.0987654320988, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983649, Length=240, Percent_Identity=30.4166666666667, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983640, Length=240, Percent_Identity=30.4166666666667, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17568805, Length=214, Percent_Identity=29.4392523364486, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71983097, Length=186, Percent_Identity=31.7204301075269, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI72000269, Length=246, Percent_Identity=30.8943089430894, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17509235, Length=192, Percent_Identity=30.7291666666667, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI86562912, Length=248, Percent_Identity=28.2258064516129, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71996558, Length=208, Percent_Identity=29.8076923076923, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71996566, Length=208, Percent_Identity=29.8076923076923, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71996019, Length=236, Percent_Identity=27.9661016949153, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25150905, Length=251, Percent_Identity=29.0836653386454, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115532766, Length=99, Percent_Identity=44.4444444444444, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71993835, Length=201, Percent_Identity=27.363184079602, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32566667, Length=190, Percent_Identity=28.4210526315789, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25149215, Length=190, Percent_Identity=28.4210526315789, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562122, Length=257, Percent_Identity=28.0155642023346, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71991562, Length=155, Percent_Identity=31.6129032258064, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71993705, Length=200, Percent_Identity=29, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534131, Length=161, Percent_Identity=32.9192546583851, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI72000541, Length=205, Percent_Identity=28.780487804878, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21355491, Length=192, Percent_Identity=39.0625, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24649626, Length=197, Percent_Identity=37.5634517766497, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24644493, Length=198, Percent_Identity=34.3434343434343, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24643089, Length=220, Percent_Identity=35.4545454545455, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI19921384, Length=194, Percent_Identity=34.020618556701, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45549230, Length=193, Percent_Identity=35.7512953367876, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI20129545, Length=197, Percent_Identity=35.5329949238579, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136740, Length=193, Percent_Identity=33.160621761658, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24649765, Length=193, Percent_Identity=33.160621761658, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI19921382, Length=240, Percent_Identity=32.9166666666667, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19921388, Length=187, Percent_Identity=34.7593582887701, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921390, Length=218, Percent_Identity=32.5688073394495, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921386, Length=200, Percent_Identity=31.5, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001506
- InterPro:   IPR006026
- InterPro:   IPR008997
- InterPro:   IPR000772 [H]

Pfam domain/function: PF01400 Astacin; PF00652 Ricin_B_lectin [H]

EC number: =3.4.24.76 [H]

Molecular weight: Translated: 51267; Mature: 51136

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVCPESSQQNQTPSDIRRPEILTRSGEIMSRDLSRLALSALFIPSLLLIACGEENLAP
CCCCCCCCCCCCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
GLNLDPEMARVPAGAPIREGYIWSNMREKFVPVTYAEVDGLAIQEGDMVLGTVQQMEARV
CCCCCHHHHHCCCCCCCCCCEEHHCHHHHCCEEEEEECCCEEEECCCEEEHHHHHHHHHH
REVKALGLDASGPRAQGLAKTDLNSRWPNAVVPYTIDSGVANQNRIQDAINHWHDRTHIS
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEE
FVLRTANNAAQYPDYVRIQSGTGCSAHYGRLGGQQGVWLDGSCSTGTIIHELGHSLGLNH
EEEEECCCCCCCCCEEEEECCCCCCHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHCCCC
EHNRQDRDTYVIIRWENMVAGAASQFQQNNNEDDDFFGYDFGSIMHYGPMQGSKNGRPTI
CCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEECCCHHHHHEECCCCCCCCCCCEE
EGRGGQTIGQRNALSTLDVVTVTRLYSRTITLRASNGDYLVAEGGGGAMVDANRVAVGPW
ECCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEECCEEEECCC
ERFQLVDLDGNDLVTGDLVQLQTINGNFVQATNGGGSTLNAWEMAPGNWETFRIWKMAGT
CCEEEEECCCCCEEECCEEEEEEECCCEEEEECCCCCCEEEEECCCCCCCEEEEEEECCC
GLSTIATGDGVVLGTLTPGYPKYWQAVNGGGAGVTVNTDTINLGPANIFTVAFP
CCEEEECCCCEEEECCCCCCHHHHHEECCCCCEEEEECCEEECCCCEEEEEECC
>Mature Secondary Structure 
AEVCPESSQQNQTPSDIRRPEILTRSGEIMSRDLSRLALSALFIPSLLLIACGEENLAP
CCCCCCCCCCCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
GLNLDPEMARVPAGAPIREGYIWSNMREKFVPVTYAEVDGLAIQEGDMVLGTVQQMEARV
CCCCCHHHHHCCCCCCCCCCEEHHCHHHHCCEEEEEECCCEEEECCCEEEHHHHHHHHHH
REVKALGLDASGPRAQGLAKTDLNSRWPNAVVPYTIDSGVANQNRIQDAINHWHDRTHIS
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEE
FVLRTANNAAQYPDYVRIQSGTGCSAHYGRLGGQQGVWLDGSCSTGTIIHELGHSLGLNH
EEEEECCCCCCCCCEEEEECCCCCCHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHCCCC
EHNRQDRDTYVIIRWENMVAGAASQFQQNNNEDDDFFGYDFGSIMHYGPMQGSKNGRPTI
CCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEECCCHHHHHEECCCCCCCCCCCEE
EGRGGQTIGQRNALSTLDVVTVTRLYSRTITLRASNGDYLVAEGGGGAMVDANRVAVGPW
ECCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEECCEEEECCC
ERFQLVDLDGNDLVTGDLVQLQTINGNFVQATNGGGSTLNAWEMAPGNWETFRIWKMAGT
CCEEEEECCCCCEEECCEEEEEEECCCEEEEECCCCCCEEEEECCCCCCCEEEEEEECCC
GLSTIATGDGVVLGTLTPGYPKYWQAVNGGGAGVTVNTDTINLGPANIFTVAFP
CCEEEECCCCEEEECCCCCCHHHHHEECCCCCEEEEECCEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7771796; 7768917 [H]