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The map label for this gene is hemN [C]

Identifier: 108759540

GI number: 108759540

Start: 3373153

End: 3374469

Strand: Direct

Name: hemN [C]

Synonym: MXAN_2888

Alternate gene names: 108759540

Gene position: 3373153-3374469 (Clockwise)

Preceding gene: 108757554

Following gene: 108756838

Centisome position: 36.91

GC content: 68.11

Gene sequence:

>1317_bases
ATGACGCGTCTGGAGCAGATGCTCGAAGGGTCGCCCTACGTGGCGTACCTCTACGGCTACCCTCACAAGACGGCCTACCG
GCCCTTCACGCCCGCGCTCCCGTTGGAGTCCGTCTGGGCGGAGGAGCGGCGCGACGCGCTGTTCCTCTACATCCACGTGC
CCTTCTGCGAGATGCGCTGCGGCTTCTGCAATCTCTTCACCGCCGCCGGGCCGAAGCAGGACGTGGTGGACGGGTACCTG
GGCGCGCTGGTGCGCGAGACGAAGCGGGTGAAGGAGGCGCTGGGGACGGCGAGCTTCGCCCGGGCCGCCATTGGCGGCGG
CACGCCGACGCTGCTGGACGTGGCGGGGTTGAACACCGTGTTCGACATGGCCGAAGGCGTCATGGGCGCCGACATGAAGA
ACATCCCCGTGTCCGTGGAGGTGTCTCCGGAGACGGTGGACGCGCAGAAGCTCCAGGTGCTGCGCTCGCGCGGCACGGAC
CGGGTGAGCATGGGCATCCAGAGCTTCATCGAGGCGGAGGTGGCCGCGGTGAAGCGGCCCCAGAAGACGGCGCAGGTGGA
GGCCGCGCTGGACCTCATCCGCTCCACGGGCTTCCCCACGCTGAACCTGGACCTCATCTACGGCATGGAGGGGCAGACGG
AGGAGAGCTTCCTCTACTCGCTGCGCACGGCGCTTCGTTACTCGCCGGAGGAGATTTATCTCTACCCGCTCTACGTCCGG
CCACTGACCTTCCTGGGCAAGAAGGCGCGGGCGTGGGACGACCTGCGCCTCTCGCTGTATCGCGTGGGCCGCGACTTCCT
CCTGTCGGAGGGCTACACGCAGGTCTCCATGCGGATGTTCCGTGCGCGCCATGCGCCGGACGCGGGCGGTCCGGTGTATC
GCTGCCAGGAGGACGGCATGGTGGGGTTGGGCTGCGGGGCGCGCTCGTACACGGGCCAGGTGCATTACTCGTCGGAATAC
GCGGTGGGCTCTCGCGAGGTTCGCTCCATCATCTCGTCGTACAGCGAGCGGTCCGAGGCGTCGTTCGGCGAGGTGGGCTA
CGGCTTCCGCCTGGACTCCGCGGAGCGGCGGCGCCGTTACATGCTGCTGTCGCTGCTGGCGGATGGCGTGGATCTTGCCG
TCTACCGGCAGCGCTTCTGCTCCGACGCGCTGGAGGACTTCCCGGAGCTGGAGGAGCTGGAGGCGCACGGACTGGCGCGG
AAGAATGGTGGGGTGGTGCAGCTCACCGCGGCGGGCGTGGAGCGCTCCGACATGATTGGCCCCTGGCTGCACTCCGACCA
GGTGCAGGCGATGATGAAGGAGTACGCCTGGCGATGA

Upstream 100 bases:

>100_bases
CCACCTACGGCGAGGACGGCTTCACCGGCCATCGTCTGGCCCACCCCGTGGTGTGGACGGTGCCCTACGCTGAACTCCTG
CTACCTCGAGAAACCGCACC

Downstream 100 bases:

>100_bases
AGCTCACCGTGCTCTATCGAGGCCCGCTGTCGAGCTGCAACTACGGATGCGAGTACTGCCCCTTCGGCAAGTGGAAGCAC
ACCGACGAGGAGCTGGCCAA

Product: coproporphyrinogen III oxidase

Products: Protoporphyrinogen-IX; CO2 [C]

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTRLEQMLEGSPYVAYLYGYPHKTAYRPFTPALPLESVWAEERRDALFLYIHVPFCEMRCGFCNLFTAAGPKQDVVDGYL
GALVRETKRVKEALGTASFARAAIGGGTPTLLDVAGLNTVFDMAEGVMGADMKNIPVSVEVSPETVDAQKLQVLRSRGTD
RVSMGIQSFIEAEVAAVKRPQKTAQVEAALDLIRSTGFPTLNLDLIYGMEGQTEESFLYSLRTALRYSPEEIYLYPLYVR
PLTFLGKKARAWDDLRLSLYRVGRDFLLSEGYTQVSMRMFRARHAPDAGGPVYRCQEDGMVGLGCGARSYTGQVHYSSEY
AVGSREVRSIISSYSERSEASFGEVGYGFRLDSAERRRRYMLLSLLADGVDLAVYRQRFCSDALEDFPELEELEAHGLAR
KNGGVVQLTAAGVERSDMIGPWLHSDQVQAMMKEYAWR

Sequences:

>Translated_438_residues
MTRLEQMLEGSPYVAYLYGYPHKTAYRPFTPALPLESVWAEERRDALFLYIHVPFCEMRCGFCNLFTAAGPKQDVVDGYL
GALVRETKRVKEALGTASFARAAIGGGTPTLLDVAGLNTVFDMAEGVMGADMKNIPVSVEVSPETVDAQKLQVLRSRGTD
RVSMGIQSFIEAEVAAVKRPQKTAQVEAALDLIRSTGFPTLNLDLIYGMEGQTEESFLYSLRTALRYSPEEIYLYPLYVR
PLTFLGKKARAWDDLRLSLYRVGRDFLLSEGYTQVSMRMFRARHAPDAGGPVYRCQEDGMVGLGCGARSYTGQVHYSSEY
AVGSREVRSIISSYSERSEASFGEVGYGFRLDSAERRRRYMLLSLLADGVDLAVYRQRFCSDALEDFPELEELEAHGLAR
KNGGVVQLTAAGVERSDMIGPWLHSDQVQAMMKEYAWR
>Mature_437_residues
TRLEQMLEGSPYVAYLYGYPHKTAYRPFTPALPLESVWAEERRDALFLYIHVPFCEMRCGFCNLFTAAGPKQDVVDGYLG
ALVRETKRVKEALGTASFARAAIGGGTPTLLDVAGLNTVFDMAEGVMGADMKNIPVSVEVSPETVDAQKLQVLRSRGTDR
VSMGIQSFIEAEVAAVKRPQKTAQVEAALDLIRSTGFPTLNLDLIYGMEGQTEESFLYSLRTALRYSPEEIYLYPLYVRP
LTFLGKKARAWDDLRLSLYRVGRDFLLSEGYTQVSMRMFRARHAPDAGGPVYRCQEDGMVGLGCGARSYTGQVHYSSEYA
VGSREVRSIISSYSERSEASFGEVGYGFRLDSAERRRRYMLLSLLADGVDLAVYRQRFCSDALEDFPELEELEAHGLARK
NGGVVQLTAAGVERSDMIGPWLHSDQVQAMMKEYAWR

Specific function: Anaerobic Transformation Of Coproporphyrinogen-III Into Protoporphyrinogen-IX. [C]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=246, Percent_Identity=26.8292682926829, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082341, Length=392, Percent_Identity=28.0612244897959, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789325, Length=273, Percent_Identity=27.8388278388278, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 48932; Mature: 48801

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLEQMLEGSPYVAYLYGYPHKTAYRPFTPALPLESVWAEERRDALFLYIHVPFCEMRC
CCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCHHHHHC
GFCNLFTAAGPKQDVVDGYLGALVRETKRVKEALGTASFARAAIGGGTPTLLDVAGLNTV
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEHHHHHHH
FDMAEGVMGADMKNIPVSVEVSPETVDAQKLQVLRSRGTDRVSMGIQSFIEAEVAAVKRP
HHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
QKTAQVEAALDLIRSTGFPTLNLDLIYGMEGQTEESFLYSLRTALRYSPEEIYLYPLYVR
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHH
PLTFLGKKARAWDDLRLSLYRVGRDFLLSEGYTQVSMRMFRARHAPDAGGPVYRCQEDGM
HHHHHCCHHCCHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEECCCCE
VGLGCGARSYTGQVHYSSEYAVGSREVRSIISSYSERSEASFGEVGYGFRLDSAERRRRY
EEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHH
MLLSLLADGVDLAVYRQRFCSDALEDFPELEELEAHGLARKNGGVVQLTAAGVERSDMIG
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCC
PWLHSDQVQAMMKEYAWR
CCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TRLEQMLEGSPYVAYLYGYPHKTAYRPFTPALPLESVWAEERRDALFLYIHVPFCEMRC
CHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCHHHHHC
GFCNLFTAAGPKQDVVDGYLGALVRETKRVKEALGTASFARAAIGGGTPTLLDVAGLNTV
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEHHHHHHH
FDMAEGVMGADMKNIPVSVEVSPETVDAQKLQVLRSRGTDRVSMGIQSFIEAEVAAVKRP
HHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
QKTAQVEAALDLIRSTGFPTLNLDLIYGMEGQTEESFLYSLRTALRYSPEEIYLYPLYVR
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHHH
PLTFLGKKARAWDDLRLSLYRVGRDFLLSEGYTQVSMRMFRARHAPDAGGPVYRCQEDGM
HHHHHCCHHCCHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEECCCCE
VGLGCGARSYTGQVHYSSEYAVGSREVRSIISSYSERSEASFGEVGYGFRLDSAERRRRY
EEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHH
MLLSLLADGVDLAVYRQRFCSDALEDFPELEELEAHGLARKNGGVVQLTAAGVERSDMIG
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCC
PWLHSDQVQAMMKEYAWR
CCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen-III; O2 [C]

Specific reaction: coproporphyrinogen-III + O2 = protoporphyrinogen-IX + 2 CO2 [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With oxygen as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]