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The map label for this gene is atoC [H]

Identifier: 108759399

GI number: 108759399

Start: 4810782

End: 4812371

Strand: Direct

Name: atoC [H]

Synonym: MXAN_3952

Alternate gene names: 108759399

Gene position: 4810782-4812371 (Clockwise)

Preceding gene: 108763293

Following gene: 108762476

Centisome position: 52.64

GC content: 71.07

Gene sequence:

>1590_bases
ATGCCCTCTGGATGTTATGGTGCGGCCTCCGCCTTCGTCCTGCCGCCGTTGCCCGCCATGCCCCAAGCCCCCTCGGACGT
CTCCCAGGTCCTCCTCCCCTTCGGAGGACTCGTCGGCAGGGAGGTGGACCTCGACGCGTTCCTCCAGACGCTGATGGACC
GCATCGCCATCACCCTGCAAGCGGACCGCGGCACGCTCTGGCTGCTGGACCCGGCCCGCCGCGAGCTGTTCAGCCGCGCC
GCGCACCTGCCCGAGGTGTCCCAGATTCGCGTCAAGCTGGGCCAGGGCGTCGCCGGCACCGTCGCCAAGGCGGGGCACGC
CATCAACGTGCCGGACCCGCGCGGCGAGCAGCGCTTCTTCGCGGACATCGACCGGATGACGGGCTACCGCACCACCAGCC
TGCTCGCCGTGCCACTGCGCGACGGGGACGGCGCCCTCTACGGCGTGCTCCAGGTCCTCAACCGCCGCGGCGAGGACCGC
TTCACCGACGAGGACACGCAGCGGCTCACCGCCATCGCCTCGCAGGTGAGCACCGCCCTCCAGAGCACCAGCCTCTATCA
AGAGCTCCAGCGCGCGAAGGAGCAGCCCCAGGTACCGGTGGGCTACTTCTTCAACCGCATCATCGGCGAGTCCCCGCAGC
TCCAGGCCATCTACCGACTGGTGCGCAAGGCCGCGCCCACCGATGCGACGGTGCTGCTGCGCGGCGAGAGTGGCAGCGGC
AAGGAGCTGTTCGCCCGTGCCGTCCACGTGAATGGTCCCCGCAGGGACCAGCCCTTCATCAAGGTGGACTGCGCGGCGCT
GCCCGCCACGCTCATCGAGAACGAGCTCTTCGGCCACGAACGCGGCGCCTTCACCGGCGCGGACCACCGCGTGCCCGGCA
AGTTCGAGGCGGCCAGCGGCGGCACGGTGTTCATCGACGAGATTGGCGAGCTGCCCCTGCCGGTGCAGGGCAAGTTGCTG
CGGGTCATCCAGGATCGCGAGTTCGAGCGCGTGGGAGGCACCCAGGCCGTGAAGGTGGACGTGCGCATCGTCGCGGCCAC
CCATCGGGACCTGGCCCGCATGGTGGCCGAGGGCCGCTTCCGCGAGGACCTCTACTACCGCATCAAGGTGGTCGAGGTGG
TGCTGCCGCCGCTGCGGGAGCGCGGCGCGGAGGACATCGAGCGGCTCGCCCGCCACTTCGTCGCCGCCGTCGCCCGGAGG
CACCGGCTGACGCCGCCCCGCCTCAGCGCCGCCGCGGTGGAGCGCCTCAAGCGCTACCGCTGGCCCGGAAACGTGCGGGA
GCTGGAGAACTGTATCGAGAGCGCCGTGGTGCTCTGTGAAGGGGAGATTCTCGAAGAGCACCTGCCCCTGCCCGATGTGG
ACCGGGCCGCCCTGCCGCCTCCCGCAGCCGCTCAGGGTGTCAACGCGCCGACTGCGCCTGCGCCCCTGGATGCGGGCCTG
CTGCCACTGGCGGAGGTCGAACGCCGCCACATCCTGCGCGTGCTGGACGCCGTGAAGGGCAACCGCACCGCCGCGGCCCG
CGTGCTGGCGATTGGCCGCAACACGCTCGCGCGGAAACTCAAGGAGTACGGATTGGGCGACGAGCCCTGA

Upstream 100 bases:

>100_bases
ACATGGCGGAGCAGGCCCGCGCCCTCTTCCCCGTGTGCGAGCCCGCACGCGAAGGCCAGCGGCTGGTGCTGGGCCGCGCG
GCCTGAGAGGGGGCAGTCCC

Downstream 100 bases:

>100_bases
CGCACCGCGCGGGGGCGGCTCCCACCCCACCCTCCAGGGCATCTGTCCGCTGACCACCGGTCTTTTCTGGTATCCGCCTT
GTTCCGAGCTGGGCAACGGC

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MPSGCYGAASAFVLPPLPAMPQAPSDVSQVLLPFGGLVGREVDLDAFLQTLMDRIAITLQADRGTLWLLDPARRELFSRA
AHLPEVSQIRVKLGQGVAGTVAKAGHAINVPDPRGEQRFFADIDRMTGYRTTSLLAVPLRDGDGALYGVLQVLNRRGEDR
FTDEDTQRLTAIASQVSTALQSTSLYQELQRAKEQPQVPVGYFFNRIIGESPQLQAIYRLVRKAAPTDATVLLRGESGSG
KELFARAVHVNGPRRDQPFIKVDCAALPATLIENELFGHERGAFTGADHRVPGKFEAASGGTVFIDEIGELPLPVQGKLL
RVIQDREFERVGGTQAVKVDVRIVAATHRDLARMVAEGRFREDLYYRIKVVEVVLPPLRERGAEDIERLARHFVAAVARR
HRLTPPRLSAAAVERLKRYRWPGNVRELENCIESAVVLCEGEILEEHLPLPDVDRAALPPPAAAQGVNAPTAPAPLDAGL
LPLAEVERRHILRVLDAVKGNRTAAARVLAIGRNTLARKLKEYGLGDEP

Sequences:

>Translated_529_residues
MPSGCYGAASAFVLPPLPAMPQAPSDVSQVLLPFGGLVGREVDLDAFLQTLMDRIAITLQADRGTLWLLDPARRELFSRA
AHLPEVSQIRVKLGQGVAGTVAKAGHAINVPDPRGEQRFFADIDRMTGYRTTSLLAVPLRDGDGALYGVLQVLNRRGEDR
FTDEDTQRLTAIASQVSTALQSTSLYQELQRAKEQPQVPVGYFFNRIIGESPQLQAIYRLVRKAAPTDATVLLRGESGSG
KELFARAVHVNGPRRDQPFIKVDCAALPATLIENELFGHERGAFTGADHRVPGKFEAASGGTVFIDEIGELPLPVQGKLL
RVIQDREFERVGGTQAVKVDVRIVAATHRDLARMVAEGRFREDLYYRIKVVEVVLPPLRERGAEDIERLARHFVAAVARR
HRLTPPRLSAAAVERLKRYRWPGNVRELENCIESAVVLCEGEILEEHLPLPDVDRAALPPPAAAQGVNAPTAPAPLDAGL
LPLAEVERRHILRVLDAVKGNRTAAARVLAIGRNTLARKLKEYGLGDEP
>Mature_528_residues
PSGCYGAASAFVLPPLPAMPQAPSDVSQVLLPFGGLVGREVDLDAFLQTLMDRIAITLQADRGTLWLLDPARRELFSRAA
HLPEVSQIRVKLGQGVAGTVAKAGHAINVPDPRGEQRFFADIDRMTGYRTTSLLAVPLRDGDGALYGVLQVLNRRGEDRF
TDEDTQRLTAIASQVSTALQSTSLYQELQRAKEQPQVPVGYFFNRIIGESPQLQAIYRLVRKAAPTDATVLLRGESGSGK
ELFARAVHVNGPRRDQPFIKVDCAALPATLIENELFGHERGAFTGADHRVPGKFEAASGGTVFIDEIGELPLPVQGKLLR
VIQDREFERVGGTQAVKVDVRIVAATHRDLARMVAEGRFREDLYYRIKVVEVVLPPLRERGAEDIERLARHFVAAVARRH
RLTPPRLSAAAVERLKRYRWPGNVRELENCIESAVVLCEGEILEEHLPLPDVDRAALPPPAAAQGVNAPTAPAPLDAGLL
PLAEVERRHILRVLDAVKGNRTAAARVLAIGRNTLARKLKEYGLGDEP

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG3604

COG function: function code KT; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Homo sapiens, GI116536085, Length=231, Percent_Identity=25.5411255411255, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI194595488, Length=190, Percent_Identity=25.2631578947368, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI5729972, Length=190, Percent_Identity=25.2631578947368, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI61744432, Length=183, Percent_Identity=27.3224043715847, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI61744435, Length=183, Percent_Identity=27.3224043715847, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI61744430, Length=183, Percent_Identity=27.3224043715847, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4505657, Length=153, Percent_Identity=25.4901960784314, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI219802706, Length=153, Percent_Identity=25.4901960784314, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI226246591, Length=153, Percent_Identity=25.4901960784314, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788550, Length=351, Percent_Identity=46.1538461538462, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1790437, Length=331, Percent_Identity=47.1299093655589, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1789087, Length=411, Percent_Identity=41.8491484184915, Blast_Score=278, Evalue=8e-76,
Organism=Escherichia coli, GI87082117, Length=416, Percent_Identity=41.1057692307692, Blast_Score=278, Evalue=9e-76,
Organism=Escherichia coli, GI1790299, Length=369, Percent_Identity=45.2574525745258, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1789233, Length=330, Percent_Identity=41.2121212121212, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788905, Length=355, Percent_Identity=38.3098591549296, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI87082152, Length=330, Percent_Identity=42.4242424242424, Blast_Score=226, Evalue=4e-60,
Organism=Escherichia coli, GI87081872, Length=325, Percent_Identity=40.9230769230769, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786524, Length=338, Percent_Identity=39.0532544378698, Blast_Score=211, Evalue=9e-56,
Organism=Escherichia coli, GI1787583, Length=326, Percent_Identity=37.7300613496933, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1789828, Length=284, Percent_Identity=35.5633802816901, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI87081858, Length=327, Percent_Identity=30.8868501529052, Blast_Score=138, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI193202333, Length=171, Percent_Identity=28.0701754385965, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161076955, Length=177, Percent_Identity=28.8135593220339, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI161076953, Length=177, Percent_Identity=28.8135593220339, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI281361762, Length=165, Percent_Identity=24.8484848484848, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57925; Mature: 57794

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSGCYGAASAFVLPPLPAMPQAPSDVSQVLLPFGGLVGREVDLDAFLQTLMDRIAITLQ
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEEE
ADRGTLWLLDPARRELFSRAAHLPEVSQIRVKLGQGVAGTVAKAGHAINVPDPRGEQRFF
ECCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCEECCCCCCCCHHHH
ADIDRMTGYRTTSLLAVPLRDGDGALYGVLQVLNRRGEDRFTDEDTQRLTAIASQVSTAL
HHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
QSTSLYQELQRAKEQPQVPVGYFFNRIIGESPQLQAIYRLVRKAAPTDATVLLRGESGSG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCC
KELFARAVHVNGPRRDQPFIKVDCAALPATLIENELFGHERGAFTGADHRVPGKFEAASG
HHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCC
GTVFIDEIGELPLPVQGKLLRVIQDREFERVGGTQAVKVDVRIVAATHRDLARMVAEGRF
CEEEEECCCCCCCCCCHHHHHHHHHCCHHHCCCCEEEEEEEEEEEHHHHHHHHHHHCCCH
REDLYYRIKVVEVVLPPLRERGAEDIERLARHFVAAVARRHRLTPPRLSAAAVERLKRYR
HHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
WPGNVRELENCIESAVVLCEGEILEEHLPLPDVDRAALPPPAAAQGVNAPTAPAPLDAGL
CCCCHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCC
LPLAEVERRHILRVLDAVKGNRTAAARVLAIGRNTLARKLKEYGLGDEP
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PSGCYGAASAFVLPPLPAMPQAPSDVSQVLLPFGGLVGREVDLDAFLQTLMDRIAITLQ
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEEE
ADRGTLWLLDPARRELFSRAAHLPEVSQIRVKLGQGVAGTVAKAGHAINVPDPRGEQRFF
ECCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCEECCCCCCCCHHHH
ADIDRMTGYRTTSLLAVPLRDGDGALYGVLQVLNRRGEDRFTDEDTQRLTAIASQVSTAL
HHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
QSTSLYQELQRAKEQPQVPVGYFFNRIIGESPQLQAIYRLVRKAAPTDATVLLRGESGSG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCC
KELFARAVHVNGPRRDQPFIKVDCAALPATLIENELFGHERGAFTGADHRVPGKFEAASG
HHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCC
GTVFIDEIGELPLPVQGKLLRVIQDREFERVGGTQAVKVDVRIVAATHRDLARMVAEGRF
CEEEEECCCCCCCCCCHHHHHHHHHCCHHHCCCCEEEEEEEEEEEHHHHHHHHHHHCCCH
REDLYYRIKVVEVVLPPLRERGAEDIERLARHFVAAVARRHRLTPPRLSAAAVERLKRYR
HHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
WPGNVRELENCIESAVVLCEGEILEEHLPLPDVDRAALPPPAAAQGVNAPTAPAPLDAGL
CCCCHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCC
LPLAEVERRHILRVLDAVKGNRTAAARVLAIGRNTLARKLKEYGLGDEP
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]