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The map label for this gene is fdhF [H]

Identifier: 108759308

GI number: 108759308

Start: 965615

End: 967624

Strand: Reverse

Name: fdhF [H]

Synonym: MXAN_0850

Alternate gene names: 108759308

Gene position: 967624-965615 (Counterclockwise)

Preceding gene: 108761693

Following gene: 108757301

Centisome position: 10.59

GC content: 71.84

Gene sequence:

>2010_bases
ATGCGCCGCACCGCCAGCGGTTGGGAGCCCGTCTCCTGGGACGACGCATTGGATGAGACCGCGCGCCGCCTGCATGCCAT
CCAACGGGAGCACGGCCGTGACGCGGTGGGCGCATATCTGGGCAACCCCAACGTCCACAACCTGGGCAACATGCTGTTCG
GTCCGGAGCTGCTGCGCACGCTGCGCTCGCGCAACCGCTTCTCCGCGACGTCCGTGGACCAGCTGCCGCACCAGCTCACC
GCCTACCTCATGTTCGGCCACCAGCTGATGGTGCCGATTCCCGACATCGACCACACCGGCTACATGCTCGTGCTGGGCGC
CAATCCCCTGGCGTCCAATGGCAGCTTGATGACGGCGCCCGACGTGCGCGCCCGCCTGCGTGCCATCCAGCAGCGCGGCG
GCCGCATCGTCGTCATGGACCCGCGCCGCACGGAGACGGCGGCCATCGCCGACACGCACGTCTTCATCCGGCCGGGCACC
GATGCGCTCGCGCTGCTCGCCCTGCTGCACGTGGCGGTGGTGGAGCACGCGCCGCGCCTGGGGCCGCTGGATGCCTTCAC
CGACGGCCTGGAGACCGTGTGCGCGCTGGCCCGGGACTTTCCTCCGGAGAAGGTCTCACCGCACACGGGCGTGCCCGCGC
ACACCCTGCGCCGCATCGCCCGGGACTTCCTCTCCGCGCGAGCCGCCGTGTGTTACGGCCGCATGGGCGTGTCCACCCAA
TCCTTCGGCGCGCTCTGCCAATGGCTCATCACCGTGCTCAACGTGGTGAGCGGCAACCTGGACCGGCGCGGCGGCGCCAT
GTTCACCCTGCCCGCGTTCGACGTCGTCGGAGGTCCACGGGCCCTGGCCGTGGGCCGCGGCGGCTTCGGCCGCTGGAAGA
GCCGCGTGCGAGGGCTTCCCGAGTTCGCGGGGGAGTTGCCCACGGCGGCGATGGCGGAGGAGATGCTCACGCCGGGCCCA
GGCCGCATCCGCGCGCTGCTCACCGTCGCGGGCAACCCCGCGCTGTCCACGCCTGATGGCGCTCGGATGGAACAGGCGCT
CGCGGGCCTGGACTTCATGGTGAGCATCGACCCGTACCTCAACGAGACGACGCGCCACGCGCACCTCATCCTCCCGCCGG
TGTCACCGCTGGAGCGCAGCCACTACGACATCGCCTTCCACGCGCTGGCGGTGCGCAACACCGCGAAGTACTCGCCCGCC
CTCTTCGAGCCCGGGCCGGGCAGCCGCCAGGACTGGCAGATTCTGCTCGCCCTCCAGCACCGGCTGCTGACGCTGCGCAA
GGGCCGCCCCTCCGTGCGCGCCACGCTCAAGTACCAGGCCCTGTCCCGTCTGGGTCCGGAGCGAGTGCTGGACCTGGGCC
TGCGGCTGGGGCCCTACGGCGCGCGCTTCCACCCGGCGAAGCAGGGCCTCACCCTGGAGAAGCTGCGCCAGTCGCCCCAC
GGCATCGACCTGGGGCCGCTCCAGTCCTGCCTGCCCCAGCGCCTCCAGACGAAGGACCGCCGCATCCACCTGGCGCCGGA
GCTGCTGGTGGCGGACGTGCGACGCCTGCAAGCAGCCTTCCCCCAGGACACCGTCCCCGAGCAGCACAGTGGCGAGCTGC
TGCTCATCGGCCGGCGGCACCTGCGCGACAACAACTCCTGGATGCACAACGTACCGGGCCTGCTGAAGGGCAAGCCGCGC
TGCACGTTGATGATGCACCCGGAGGACGCGGCCCGGCGGGCGCTCGCCGACGGCATGGAGGCCACCGTCACCTCGCGCGT
GGGCACAGTGACGGTGCCCATCCACGTGACGGACGAGGTGATGCCCGGTGTGGTGAGCCTGCCCCACGGTTACGGACATG
GCCGCCAGGGCACCCGGCTCGCCGTGGCCACCGCCCACGCGGGCGCCAGCCACAACGACCTCACGGACGCGCAGGCCGTG
GACGCGCTCTGCGGCAACGCCGCCTTCAGCGGCACGCCGGTGCGGGTGCTACGGGCAGCGGCGCCCGAATCCGCCACACC
AGCGGGATGA

Upstream 100 bases:

>100_bases
CCGGGGCGACGCGGAGGACCCCTTCAGCCGGGGCCACGTCTGTCCCAAGGCCCTGGCGCTGGAGGACCTGCACCAGGACC
CGGACCGGCTGCGCGGCCCC

Downstream 100 bases:

>100_bases
GCGCCCCCACCAGCACGAACAGCAACTGCACCAGGTGCCCCAGCAGCGCCACCGACATGGCGCGCGCGGCCGTGGTGTCC
AGCACGCCCGCAGCCAGCGC

Product: molybdopterin-binding oxidoreductase

Products: NA

Alternate protein names: Formate dehydrogenase-H subunit alpha; FDH-H; Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide [H]

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MRRTASGWEPVSWDDALDETARRLHAIQREHGRDAVGAYLGNPNVHNLGNMLFGPELLRTLRSRNRFSATSVDQLPHQLT
AYLMFGHQLMVPIPDIDHTGYMLVLGANPLASNGSLMTAPDVRARLRAIQQRGGRIVVMDPRRTETAAIADTHVFIRPGT
DALALLALLHVAVVEHAPRLGPLDAFTDGLETVCALARDFPPEKVSPHTGVPAHTLRRIARDFLSARAAVCYGRMGVSTQ
SFGALCQWLITVLNVVSGNLDRRGGAMFTLPAFDVVGGPRALAVGRGGFGRWKSRVRGLPEFAGELPTAAMAEEMLTPGP
GRIRALLTVAGNPALSTPDGARMEQALAGLDFMVSIDPYLNETTRHAHLILPPVSPLERSHYDIAFHALAVRNTAKYSPA
LFEPGPGSRQDWQILLALQHRLLTLRKGRPSVRATLKYQALSRLGPERVLDLGLRLGPYGARFHPAKQGLTLEKLRQSPH
GIDLGPLQSCLPQRLQTKDRRIHLAPELLVADVRRLQAAFPQDTVPEQHSGELLLIGRRHLRDNNSWMHNVPGLLKGKPR
CTLMMHPEDAARRALADGMEATVTSRVGTVTVPIHVTDEVMPGVVSLPHGYGHGRQGTRLAVATAHAGASHNDLTDAQAV
DALCGNAAFSGTPVRVLRAAAPESATPAG

Sequences:

>Translated_669_residues
MRRTASGWEPVSWDDALDETARRLHAIQREHGRDAVGAYLGNPNVHNLGNMLFGPELLRTLRSRNRFSATSVDQLPHQLT
AYLMFGHQLMVPIPDIDHTGYMLVLGANPLASNGSLMTAPDVRARLRAIQQRGGRIVVMDPRRTETAAIADTHVFIRPGT
DALALLALLHVAVVEHAPRLGPLDAFTDGLETVCALARDFPPEKVSPHTGVPAHTLRRIARDFLSARAAVCYGRMGVSTQ
SFGALCQWLITVLNVVSGNLDRRGGAMFTLPAFDVVGGPRALAVGRGGFGRWKSRVRGLPEFAGELPTAAMAEEMLTPGP
GRIRALLTVAGNPALSTPDGARMEQALAGLDFMVSIDPYLNETTRHAHLILPPVSPLERSHYDIAFHALAVRNTAKYSPA
LFEPGPGSRQDWQILLALQHRLLTLRKGRPSVRATLKYQALSRLGPERVLDLGLRLGPYGARFHPAKQGLTLEKLRQSPH
GIDLGPLQSCLPQRLQTKDRRIHLAPELLVADVRRLQAAFPQDTVPEQHSGELLLIGRRHLRDNNSWMHNVPGLLKGKPR
CTLMMHPEDAARRALADGMEATVTSRVGTVTVPIHVTDEVMPGVVSLPHGYGHGRQGTRLAVATAHAGASHNDLTDAQAV
DALCGNAAFSGTPVRVLRAAAPESATPAG
>Mature_669_residues
MRRTASGWEPVSWDDALDETARRLHAIQREHGRDAVGAYLGNPNVHNLGNMLFGPELLRTLRSRNRFSATSVDQLPHQLT
AYLMFGHQLMVPIPDIDHTGYMLVLGANPLASNGSLMTAPDVRARLRAIQQRGGRIVVMDPRRTETAAIADTHVFIRPGT
DALALLALLHVAVVEHAPRLGPLDAFTDGLETVCALARDFPPEKVSPHTGVPAHTLRRIARDFLSARAAVCYGRMGVSTQ
SFGALCQWLITVLNVVSGNLDRRGGAMFTLPAFDVVGGPRALAVGRGGFGRWKSRVRGLPEFAGELPTAAMAEEMLTPGP
GRIRALLTVAGNPALSTPDGARMEQALAGLDFMVSIDPYLNETTRHAHLILPPVSPLERSHYDIAFHALAVRNTAKYSPA
LFEPGPGSRQDWQILLALQHRLLTLRKGRPSVRATLKYQALSRLGPERVLDLGLRLGPYGARFHPAKQGLTLEKLRQSPH
GIDLGPLQSCLPQRLQTKDRRIHLAPELLVADVRRLQAAFPQDTVPEQHSGELLLIGRRHLRDNNSWMHNVPGLLKGKPR
CTLMMHPEDAARRALADGMEATVTSRVGTVTVPIHVTDEVMPGVVSLPHGYGHGRQGTRLAVATAHAGASHNDLTDAQAV
DALCGNAAFSGTPVRVLRAAAPESATPAG

Specific function: Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=442, Percent_Identity=28.5067873303167, Blast_Score=129, Evalue=8e-31,
Organism=Escherichia coli, GI1787870, Length=684, Percent_Identity=21.3450292397661, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI171474008, Length=665, Percent_Identity=22.1052631578947, Blast_Score=83, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 72509; Mature: 72509

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTASGWEPVSWDDALDETARRLHAIQREHGRDAVGAYLGNPNVHNLGNMLFGPELLRT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCHHHHHH
LRSRNRFSATSVDQLPHQLTAYLMFGHQLMVPIPDIDHTGYMLVLGANPLASNGSLMTAP
HHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCCCCEEECC
DVRARLRAIQQRGGRIVVMDPRRTETAAIADTHVFIRPGTDALALLALLHVAVVEHAPRL
HHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCC
GPLDAFTDGLETVCALARDFPPEKVSPHTGVPAHTLRRIARDFLSARAAVCYGRMGVSTQ
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
SFGALCQWLITVLNVVSGNLDRRGGAMFTLPAFDVVGGPRALAVGRGGFGRWKSRVRGLP
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHCCCCCEEEECCCCHHHHHHHHCCCH
EFAGELPTAAMAEEMLTPGPGRIRALLTVAGNPALSTPDGARMEQALAGLDFMVSIDPYL
HHHHCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEECCHHH
NETTRHAHLILPPVSPLERSHYDIAFHALAVRNTAKYSPALFEPGPGSRQDWQILLALQH
CCCCCCEEEEECCCCCHHCCCCHHHEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RLLTLRKGRPSVRATLKYQALSRLGPERVLDLGLRLGPYGARFHPAKQGLTLEKLRQSPH
HHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHCCCCHHHHHCCCC
GIDLGPLQSCLPQRLQTKDRRIHLAPELLVADVRRLQAAFPQDTVPEQHSGELLLIGRRH
CCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHH
LRDNNSWMHNVPGLLKGKPRCTLMMHPEDAARRALADGMEATVTSRVGTVTVPIHVTDEV
CCCCCCHHHCCCHHHCCCCCEEEEECCCHHHHHHHHCCHHHHHHHCCCEEEEEEEECCCC
MPGVVSLPHGYGHGRQGTRLAVATAHAGASHNDLTDAQAVDALCGNAAFSGTPVRVLRAA
CCCCEECCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHC
APESATPAG
CCCCCCCCC
>Mature Secondary Structure
MRRTASGWEPVSWDDALDETARRLHAIQREHGRDAVGAYLGNPNVHNLGNMLFGPELLRT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCHHHHHH
LRSRNRFSATSVDQLPHQLTAYLMFGHQLMVPIPDIDHTGYMLVLGANPLASNGSLMTAP
HHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCCCCEEECC
DVRARLRAIQQRGGRIVVMDPRRTETAAIADTHVFIRPGTDALALLALLHVAVVEHAPRL
HHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCC
GPLDAFTDGLETVCALARDFPPEKVSPHTGVPAHTLRRIARDFLSARAAVCYGRMGVSTQ
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
SFGALCQWLITVLNVVSGNLDRRGGAMFTLPAFDVVGGPRALAVGRGGFGRWKSRVRGLP
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHCCCCCEEEECCCCHHHHHHHHCCCH
EFAGELPTAAMAEEMLTPGPGRIRALLTVAGNPALSTPDGARMEQALAGLDFMVSIDPYL
HHHHCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEECCHHH
NETTRHAHLILPPVSPLERSHYDIAFHALAVRNTAKYSPALFEPGPGSRQDWQILLALQH
CCCCCCEEEEECCCCCHHCCCCHHHEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RLLTLRKGRPSVRATLKYQALSRLGPERVLDLGLRLGPYGARFHPAKQGLTLEKLRQSPH
HHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHCCCCHHHHHCCCC
GIDLGPLQSCLPQRLQTKDRRIHLAPELLVADVRRLQAAFPQDTVPEQHSGELLLIGRRH
CCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHH
LRDNNSWMHNVPGLLKGKPRCTLMMHPEDAARRALADGMEATVTSRVGTVTVPIHVTDEV
CCCCCCHHHCCCHHHCCCCCEEEEECCCHHHHHHHHCCHHHHHHHCCCEEEEEEEECCCC
MPGVVSLPHGYGHGRQGTRLAVATAHAGASHNDLTDAQAVDALCGNAAFSGTPVRVLRAA
CCCCEECCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHC
APESATPAG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2941757; 8265357; 9278503; 2211698; 9036855 [H]