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The map label for this gene is bioI [H]

Identifier: 108759169

GI number: 108759169

Start: 5067899

End: 5069143

Strand: Direct

Name: bioI [H]

Synonym: MXAN_4127

Alternate gene names: 108759169

Gene position: 5067899-5069143 (Clockwise)

Preceding gene: 108761058

Following gene: 108759053

Centisome position: 55.45

GC content: 68.43

Gene sequence:

>1245_bases
ATGGCACAGGCCAGCATCTTCGAGCAGATCCTCGACCCGGCCAACCGGGCCAACCCCTACCCGCTCTACGCCGAGTTGCG
GAAGACTCCCGTGGCGCGCGAGGCCGACGGCACGTACATCGTCAGCACCTACGATGAGATTGTCGCGTTGCTCCACGACC
CACGGGTCAGCTCCGACATACGCAACCTCGTCCGGCAGGCCGGTGCCACGCCCTCCCCCCAGGAGGGCCCTCCAGGGCTG
CCAGAGCCCTTCATCCGGCGCGACCCTCCCGACCACGACCGGCTCCGGAAGCTGGCGATGAGGCCCTTCGGGCCGCCGCA
CACCCCCGGACGCATTGATGCCCTTCGTCCCTGGCTGGTCGAGACCACGACGGGCCTGCTTGACGCGCTCGCGGGCAAGA
ACCAAGTCGACATCGTCGGCGACGTGGCCTACCCATTCCCTGTGACTGTCATCTGCAAGCTGCTGGGAGTCCCTCGCGAG
GACGAAGCGCGCTTTCACGAGTTGGCCGACGCGGGCGTCGAGACCCTTGACCCCACCACAGGGACGATCGAGCAGCGAAA
GGCCAAGCGCGACCGGACGAAAGCGGAGCTGGGGCAGTACCTCGCTGCGCTCGCCGATGCCCACCTGCGCCAGCCGGGCG
GCGACCTGCTCTCCGGGTTCCTGACGGATAACGGCCCCGACGGGCGGATGTCGCGGGAAGAGGTGTTGAGCACCGCCGCG
TTGCTGCTCGTCGCTGGCCATGAGACCACCGTCAACCTCATCGCCAATGGCATGCTCACCCTGCTGCGCCACCCCGGCGT
GTTCGAGCGGCTGCGCCGCGAGCCCGAGCTGAGCATCCCGCTGGTCGAGGAGCTGCTGCGCTATGAACCACCGGTGCAGT
TCCTGCCTGACCGAGTCACTCTGGCCGACATCGACATTGCCGGCACCACCATTCCCCAGGGCTCGCCGCTCGTGCTGATG
CTCGCTGCGGGCAGCCGCGACCCAGAGCGCTTCGACGACCCCGACCGCTTCATGCCCGACCGGCCCAACAACTCGCACCT
GGGCTTCGGCAGTGGCATTCACTACTGCTTTGGTGCACCGCTTGCCCGGTTGGAGGCACAGATCGCCTTGACCGAACTCG
CCTGCCGCCTTGAGCACCCCAGGCTCGTTGCCGACCCGCCCCCCTACCGGCCCAACCCGGCCTTGCGAGGTCCCCTCCAC
CTCCTCGTCGAGGTCGACGGCATCCGGGCGGCGGGCGTGCGATAG

Upstream 100 bases:

>100_bases
CCCTACGAGCGGCGGGTCCGGTGGGTGTACCGGCACCTTTGAGCCGAATGTCGGCAGCCGCGTCACCCCACCCCTCCAAC
GGACTCAAGGAGACCGCTTC

Downstream 100 bases:

>100_bases
CGTCTGCCCCGGCTCGCTGACCAGGCGACGGGCTTCGCCATGTTGCACGTATGTCGCAGGAACGTGCGGAATGGGCTGGA
ACAGGACGGGACGCGGCGGG

Product: cytochrome P450 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MAQASIFEQILDPANRANPYPLYAELRKTPVAREADGTYIVSTYDEIVALLHDPRVSSDIRNLVRQAGATPSPQEGPPGL
PEPFIRRDPPDHDRLRKLAMRPFGPPHTPGRIDALRPWLVETTTGLLDALAGKNQVDIVGDVAYPFPVTVICKLLGVPRE
DEARFHELADAGVETLDPTTGTIEQRKAKRDRTKAELGQYLAALADAHLRQPGGDLLSGFLTDNGPDGRMSREEVLSTAA
LLLVAGHETTVNLIANGMLTLLRHPGVFERLRREPELSIPLVEELLRYEPPVQFLPDRVTLADIDIAGTTIPQGSPLVLM
LAAGSRDPERFDDPDRFMPDRPNNSHLGFGSGIHYCFGAPLARLEAQIALTELACRLEHPRLVADPPPYRPNPALRGPLH
LLVEVDGIRAAGVR

Sequences:

>Translated_414_residues
MAQASIFEQILDPANRANPYPLYAELRKTPVAREADGTYIVSTYDEIVALLHDPRVSSDIRNLVRQAGATPSPQEGPPGL
PEPFIRRDPPDHDRLRKLAMRPFGPPHTPGRIDALRPWLVETTTGLLDALAGKNQVDIVGDVAYPFPVTVICKLLGVPRE
DEARFHELADAGVETLDPTTGTIEQRKAKRDRTKAELGQYLAALADAHLRQPGGDLLSGFLTDNGPDGRMSREEVLSTAA
LLLVAGHETTVNLIANGMLTLLRHPGVFERLRREPELSIPLVEELLRYEPPVQFLPDRVTLADIDIAGTTIPQGSPLVLM
LAAGSRDPERFDDPDRFMPDRPNNSHLGFGSGIHYCFGAPLARLEAQIALTELACRLEHPRLVADPPPYRPNPALRGPLH
LLVEVDGIRAAGVR
>Mature_413_residues
AQASIFEQILDPANRANPYPLYAELRKTPVAREADGTYIVSTYDEIVALLHDPRVSSDIRNLVRQAGATPSPQEGPPGLP
EPFIRRDPPDHDRLRKLAMRPFGPPHTPGRIDALRPWLVETTTGLLDALAGKNQVDIVGDVAYPFPVTVICKLLGVPRED
EARFHELADAGVETLDPTTGTIEQRKAKRDRTKAELGQYLAALADAHLRQPGGDLLSGFLTDNGPDGRMSREEVLSTAAL
LLVAGHETTVNLIANGMLTLLRHPGVFERLRREPELSIPLVEELLRYEPPVQFLPDRVTLADIDIAGTTIPQGSPLVLML
AAGSRDPERFDDPDRFMPDRPNNSHLGFGSGIHYCFGAPLARLEAQIALTELACRLEHPRLVADPPPYRPNPALRGPLHL
LVEVDGIRAAGVR

Specific function: Catalyzes the C-C bond cleavage of fatty acid linked to acyl carrier protein (ACP) to generate pimelic acid for biotin biosynthesis. It has high affinity for long-chain fatty acids with the greatest affinity for myristic acid [H]

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Homo sapiens, GI310125128, Length=227, Percent_Identity=30.3964757709251, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI14550409, Length=227, Percent_Identity=30.3964757709251, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI310125130, Length=227, Percent_Identity=30.3964757709251, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI190570174, Length=227, Percent_Identity=30.3964757709251, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI40805836, Length=225, Percent_Identity=27.1111111111111, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI68509921, Length=225, Percent_Identity=27.1111111111111, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115532670, Length=215, Percent_Identity=28.3720930232558, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540354, Length=185, Percent_Identity=27.5675675675676, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17552522, Length=185, Percent_Identity=27.027027027027, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71982977, Length=205, Percent_Identity=26.8292682926829, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24642101, Length=181, Percent_Identity=32.5966850828729, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17933518, Length=192, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: NA

Molecular weight: Translated: 45405; Mature: 45274

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQASIFEQILDPANRANPYPLYAELRKTPVAREADGTYIVSTYDEIVALLHDPRVSSDI
CCHHHHHHHHHCHHHCCCCCCHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHCCCCHHHH
RNLVRQAGATPSPQEGPPGLPEPFIRRDPPDHDRLRKLAMRPFGPPHTPGRIDALRPWLV
HHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCHHH
ETTTGLLDALAGKNQVDIVGDVAYPFPVTVICKLLGVPREDEARFHELADAGVETLDPTT
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCC
GTIEQRKAKRDRTKAELGQYLAALADAHLRQPGGDLLSGFLTDNGPDGRMSREEVLSTAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
LLLVAGHETTVNLIANGMLTLLRHPGVFERLRREPELSIPLVEELLRYEPPVQFLPDRVT
HHHEECCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHCCCCCHHHCCCCEE
LADIDIAGTTIPQGSPLVLMLAAGSRDPERFDDPDRFMPDRPNNSHLGFGSGIHYCFGAP
EEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCC
LARLEAQIALTELACRLEHPRLVADPPPYRPNPALRGPLHLLVEVDGIRAAGVR
HHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
AQASIFEQILDPANRANPYPLYAELRKTPVAREADGTYIVSTYDEIVALLHDPRVSSDI
CHHHHHHHHHCHHHCCCCCCHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHCCCCHHHH
RNLVRQAGATPSPQEGPPGLPEPFIRRDPPDHDRLRKLAMRPFGPPHTPGRIDALRPWLV
HHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCHHH
ETTTGLLDALAGKNQVDIVGDVAYPFPVTVICKLLGVPREDEARFHELADAGVETLDPTT
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCC
GTIEQRKAKRDRTKAELGQYLAALADAHLRQPGGDLLSGFLTDNGPDGRMSREEVLSTAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
LLLVAGHETTVNLIANGMLTLLRHPGVFERLRREPELSIPLVEELLRYEPPVQFLPDRVT
HHHEECCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHCCCCCHHHCCCCEE
LADIDIAGTTIPQGSPLVLMLAAGSRDPERFDDPDRFMPDRPNNSHLGFGSGIHYCFGAP
EEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCC
LARLEAQIALTELACRLEHPRLVADPPPYRPNPALRGPLHLLVEVDGIRAAGVR
HHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377 [H]