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The map label for this gene is bioF

Identifier: 108759040

GI number: 108759040

Start: 1470251

End: 1471426

Strand: Direct

Name: bioF

Synonym: MXAN_1258

Alternate gene names: 108759040

Gene position: 1470251-1471426 (Clockwise)

Preceding gene: 108760442

Following gene: 108759849

Centisome position: 16.09

GC content: 74.06

Gene sequence:

>1176_bases
GTGAGTGATGAAGCCGTCGCGGCGGCGTGGGCCCGGGAGGACCTGGAGGCCCTGTCCGAGCGCGGCCTGCGCCGCTACCT
GGAGCCCCTGGACTCTCCCCAGGGGCCCGTGGTGCGCGTGGGGGGCGAGACGCTCGTCAACTTCTCGTCCAATGACTACC
TGGGGCTGGCCGCGTCACCCACCGTGCGTGCCGCGGCGCTGGCCGCCGTGGAGCGCTACGGCGTGGGCACCGGTGCCAGC
CGGTTGGTGGTGGGCGACACCGCCGCGCATCACCGGTTGGAAACGCGGCTGGCCGCCTTCGAGCGCGCGGAGGCCGTGCG
CCTGTTCAACAGCGGCTACGCCGCCAACACCGGCATCATCCCCGCGCTGGTGGGGTCGGAGGACGCCGTCTTCTCCGATG
CCCTCAACCACGCCTCGCTCGTGGATGGCTGCCGGCTGTCACGCGCCCGCGTCTGCGTCTATCCGCACGCGGACGTGGAG
GCGCTCACGCGCGCCCTGGCGGAGACGCCCGCGCGCCGCAAGCTGGTGGTGACGGACACCGTCTTCTCCATGGACGGAGA
CGTGGCCCCGCTGCGCGACATCGTCGCCGCGTGCCGGGCCCACGGCGCCGCGCTGATGGTGGACGAAGCGCATGCCACCG
GCGTGCTAGGCGCACGTGGAGCGGGCCTCTGCGATGAGCTGGGGTTGGAAAGCGAGGTGGACCTGCGCATGGGCACGCTG
AGCAAGGCGCTGGGCGTCATGGGCGCGTACGTGGCGACCTCACGCGAGGTGGCGGACCTGCTGGTATCCCGCGCGCGGCC
CTTCGTCTTCTCCACCGCGCTGCCCGCGCACCTGTGCGCCGCCGCCGAGGCCGCCGTGGACGCCGTGGAGGGCGACCCGG
ACCTGCGCGAGCGGCTGTGGCGCAACATCCGTCGCTTCGCGGACGGCCTGCGCGGCTTGGGCGTGCGCGCCGAGCCTCGC
AGCGCCGTGTTCCCCCTCATCCTCGGCGAGCCCGAGCGGGCGCTGGACGCCGCGCGCCGTCTGCGCGAGGCGGGCGTGCT
GGTGAAGGCCATCCGCCCGCCCACCGTTCCCGAGGGCACCAGCCGCCTGCGCTTCTGCCTGTCCGCTTCCCACACCGTGG
GCCACGTGGACCTGGCGCTGGAGGCGCTGCGCAGCGTGGGAGTCCGCCGTGGCTGA

Upstream 100 bases:

>100_bases
CTGCTCACCACCGGCAACCCCGAGTACACCCAGGACATGGCCCTGCTGGAGAAGGCGGGAATCCGCCCCCTGGAGCCGCG
TCAGGAAGGCTGAGCCCACC

Downstream 100 bases:

>100_bases
GCGTGGCAAGCCGTTCCAGATTTTCGTGACGGGCACGGACACCGGCGTGGGGAAGACGCAGGCGTCGTGCGCGCTCCTGT
CGCTGCTGGCGGACGCGGGG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSDEAVAAAWAREDLEALSERGLRRYLEPLDSPQGPVVRVGGETLVNFSSNDYLGLAASPTVRAAALAAVERYGVGTGAS
RLVVGDTAAHHRLETRLAAFERAEAVRLFNSGYAANTGIIPALVGSEDAVFSDALNHASLVDGCRLSRARVCVYPHADVE
ALTRALAETPARRKLVVTDTVFSMDGDVAPLRDIVAACRAHGAALMVDEAHATGVLGARGAGLCDELGLESEVDLRMGTL
SKALGVMGAYVATSREVADLLVSRARPFVFSTALPAHLCAAAEAAVDAVEGDPDLRERLWRNIRRFADGLRGLGVRAEPR
SAVFPLILGEPERALDAARRLREAGVLVKAIRPPTVPEGTSRLRFCLSASHTVGHVDLALEALRSVGVRRG

Sequences:

>Translated_391_residues
MSDEAVAAAWAREDLEALSERGLRRYLEPLDSPQGPVVRVGGETLVNFSSNDYLGLAASPTVRAAALAAVERYGVGTGAS
RLVVGDTAAHHRLETRLAAFERAEAVRLFNSGYAANTGIIPALVGSEDAVFSDALNHASLVDGCRLSRARVCVYPHADVE
ALTRALAETPARRKLVVTDTVFSMDGDVAPLRDIVAACRAHGAALMVDEAHATGVLGARGAGLCDELGLESEVDLRMGTL
SKALGVMGAYVATSREVADLLVSRARPFVFSTALPAHLCAAAEAAVDAVEGDPDLRERLWRNIRRFADGLRGLGVRAEPR
SAVFPLILGEPERALDAARRLREAGVLVKAIRPPTVPEGTSRLRFCLSASHTVGHVDLALEALRSVGVRRG
>Mature_390_residues
SDEAVAAAWAREDLEALSERGLRRYLEPLDSPQGPVVRVGGETLVNFSSNDYLGLAASPTVRAAALAAVERYGVGTGASR
LVVGDTAAHHRLETRLAAFERAEAVRLFNSGYAANTGIIPALVGSEDAVFSDALNHASLVDGCRLSRARVCVYPHADVEA
LTRALAETPARRKLVVTDTVFSMDGDVAPLRDIVAACRAHGAALMVDEAHATGVLGARGAGLCDELGLESEVDLRMGTLS
KALGVMGAYVATSREVADLLVSRARPFVFSTALPAHLCAAAEAAVDAVEGDPDLRERLWRNIRRFADGLRGLGVRAEPRS
AVFPLILGEPERALDAARRLREAGVLVKAIRPPTVPEGTSRLRFCLSASHTVGHVDLALEALRSVGVRRG

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily

Homologues:

Organism=Homo sapiens, GI7657118, Length=383, Percent_Identity=36.8146214099217, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI284448556, Length=350, Percent_Identity=37.4285714285714, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI83977442, Length=348, Percent_Identity=35.0574712643678, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI83977444, Length=348, Percent_Identity=35.0574712643678, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI83977440, Length=348, Percent_Identity=35.0574712643678, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI4758668, Length=363, Percent_Identity=31.6804407713499, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI119220554, Length=363, Percent_Identity=31.9559228650138, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI4502025, Length=353, Percent_Identity=34.8441926345609, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI40316939, Length=353, Percent_Identity=34.8441926345609, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI5454084, Length=307, Percent_Identity=30.9446254071661, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI1790046, Length=388, Percent_Identity=38.1443298969072, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1786993, Length=363, Percent_Identity=41.8732782369146, Blast_Score=225, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI71994529, Length=387, Percent_Identity=35.6589147286822, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI32566772, Length=367, Percent_Identity=32.425068119891, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17560914, Length=420, Percent_Identity=28.3333333333333, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17560912, Length=420, Percent_Identity=28.3333333333333, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71982617, Length=268, Percent_Identity=27.2388059701493, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71982625, Length=268, Percent_Identity=27.2388059701493, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320438, Length=367, Percent_Identity=31.6076294277929, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6320267, Length=362, Percent_Identity=31.4917127071823, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6323954, Length=310, Percent_Identity=26.4516129032258, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24662918, Length=391, Percent_Identity=36.0613810741688, Blast_Score=235, Evalue=3e-62,
Organism=Drosophila melanogaster, GI17137420, Length=349, Percent_Identity=35.243553008596, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=29.4594594594595, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24653280, Length=326, Percent_Identity=26.9938650306748, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24653276, Length=326, Percent_Identity=26.9938650306748, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24653278, Length=326, Percent_Identity=26.9938650306748, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOF_MYXXD (Q1DCV8)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_629515.1
- ProteinModelPortal:   Q1DCV8
- STRING:   Q1DCV8
- GeneID:   4103979
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_1258
- TIGR:   MXAN_1258
- eggNOG:   COG0156
- HOGENOM:   HBG649839
- OMA:   CASAPVV
- PhylomeDB:   Q1DCV8
- ProtClustDB:   CLSK946683
- BioCyc:   MXAN246197:MXAN_1258-MONOMER
- HAMAP:   MF_01693
- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.47

Molecular weight: Translated: 41406; Mature: 41274

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 25-25 BINDING 137-137 BINDING 183-183 BINDING 355-355

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEAVAAAWAREDLEALSERGLRRYLEPLDSPQGPVVRVGGETLVNFSSNDYLGLAASP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCEEEEECCC
TVRAAALAAVERYGVGTGASRLVVGDTAAHHRLETRLAAFERAEAVRLFNSGYAANTGII
HHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PALVGSEDAVFSDALNHASLVDGCRLSRARVCVYPHADVEALTRALAETPARRKLVVTDT
EEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEEE
VFSMDGDVAPLRDIVAACRAHGAALMVDEAHATGVLGARGAGLCDELGLESEVDLRMGTL
EECCCCCCHHHHHHHHHHHHCCCEEEEECCHHCCCCCCCCCCCHHHHCCCCCCHHHHHHH
SKALGVMGAYVATSREVADLLVSRARPFVFSTALPAHLCAAAEAAVDAVEGDPDLRERLW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RNIRRFADGLRGLGVRAEPRSAVFPLILGEPERALDAARRLREAGVLVKAIRPPTVPEGT
HHHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCEEEECCCCCCCCCH
SRLRFCLSASHTVGHVDLALEALRSVGVRRG
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDEAVAAAWAREDLEALSERGLRRYLEPLDSPQGPVVRVGGETLVNFSSNDYLGLAASP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCEEEEECCC
TVRAAALAAVERYGVGTGASRLVVGDTAAHHRLETRLAAFERAEAVRLFNSGYAANTGII
HHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PALVGSEDAVFSDALNHASLVDGCRLSRARVCVYPHADVEALTRALAETPARRKLVVTDT
EEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEEE
VFSMDGDVAPLRDIVAACRAHGAALMVDEAHATGVLGARGAGLCDELGLESEVDLRMGTL
EECCCCCCHHHHHHHHHHHHCCCEEEEECCHHCCCCCCCCCCCHHHHCCCCCCHHHHHHH
SKALGVMGAYVATSREVADLLVSRARPFVFSTALPAHLCAAAEAAVDAVEGDPDLRERLW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RNIRRFADGLRGLGVRAEPRSAVFPLILGEPERALDAARRLREAGVLVKAIRPPTVPEGT
HHHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCEEEECCCCCCCCCH
SRLRFCLSASHTVGHVDLALEALRSVGVRRG
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA