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The map label for this gene is moeA [H]

Identifier: 108758916

GI number: 108758916

Start: 5171110

End: 5172342

Strand: Direct

Name: moeA [H]

Synonym: MXAN_4212

Alternate gene names: 108758916

Gene position: 5171110-5172342 (Clockwise)

Preceding gene: 108758001

Following gene: 108762929

Centisome position: 56.58

GC content: 69.75

Gene sequence:

>1233_bases
ATGAACGACTCCGCCACATTGCTGCCGGAAGAAGAAGCCCGGTCGCAGATCCTGGCCCTGTGCGCGCCCCTTCCCTCCGA
GTGGCTGCCCCTGGATGACGCACTGGGACGCGTGCTCGCCGAGGATGTGACGGCGCAGCGGACACTCCCTCCCTGGGACA
ACTCGGCCATGGACGGCTACGCGGTGCGCAGCGCGGATCTGGCGGGTCCCCTACCCGTCCGGCTCATCGTCGGAGAGACC
ATCTACGCCGGCGCGGTGGGCCACCAGGCGCTGGCCTCCGGGGTATGCGCCCGCATCATGACGGGCGCTCCCCTCCCCGC
GGGTGCGGATGCGGTGGTGATGCGAGAGCGGACACGGCCCGTGGTCCAGAGCGGCGCGGATCAGGTCGACATGCTCGAAG
CGGTGGCCCCGGGCCAGTTCGTGCGGCCCCGGGGCGAGGACGCTCGGGAGGGACAGGTGTTGCTGGCACGCTGCACGCCG
CTGGGCATCCCCGAACTGGGCCTCCTCTGGGCCCAGGGCCGACAAGCCGTGCCAGTGTCGCGCGCACCACGAGTGGCCAT
CCTCTCCACGGGCGACGAGTTGTGCCACGCGGACGAGCCACCCAACGGCCGCATCGTGGACACCAATGCTCCGTCCCTGG
CGCTGGCGGTCCGCCGCGCGGGCGGCATTCCCACGCAATTGGGCATCGCTCGGGATACGCGCGACGCCGTACTGGCCGCG
CTTTCCCGGCTGGACGGGTTCGACGTGGTGCTCACCAGCGCGGGGGTGTCCGTGGGCGAGCGCGACTACGTGAAGGAAGT
GCTGGCCGAGTTGGGCGTGGAGCAACACTTCTGGCGCGTCGCCATCAAGCCGGGAAAGCCGCTGGTGGTGGGCCGTCGTG
GCGCCACGCTGTTCTTTGGACTTCCGGGTAACCCCACCTCCTCCCTGGTGACGTTCGAGCTCTTCGTGCGCCCAGCCCTC
CGCAAGCTGCTGGGGCATGCGCAGGTGGGGCCTGGGCGCGTAGCCGGACGCCTGGAAGGCAAGCTTTCCAAGCCCTCCGG
CCTGGCGCATTTCGTCCGCGTCACGGCTGCTTGGAGAGAAGGCAACCTGTGGGCCCGTCCGCTGGCGACACAAACGTCTG
GTGCCCTGCGTTCTGCGGCGGCGGCCACCCACCTGCTGCATTTCCCTCGGGAAGCCAGCAGTTTGACGGAGGGGGACGCG
GTAGAACTGCTTCCGCTCTCATGGGTGGCCTGA

Upstream 100 bases:

>100_bases
GATGATCAGGTAGGCTGTCAAACTAACACTTGATTATCTCACGGACTTTGTTCGTGAACGGGTTCAAGCCACAAAGCCAC
GGCATGGCTATAAGCCGGGC

Downstream 100 bases:

>100_bases
GGAACGAAGGACGCCGTGGAGCATCCTCTTGGGGGCTCGTGCTCGAAAGCACGAGCCGCCTTGACTTGAGAACCTGAGGA
CTCCAAACAGGGGCCCGCAT

Product: molybdopterin biosynthesis MoeA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MNDSATLLPEEEARSQILALCAPLPSEWLPLDDALGRVLAEDVTAQRTLPPWDNSAMDGYAVRSADLAGPLPVRLIVGET
IYAGAVGHQALASGVCARIMTGAPLPAGADAVVMRERTRPVVQSGADQVDMLEAVAPGQFVRPRGEDAREGQVLLARCTP
LGIPELGLLWAQGRQAVPVSRAPRVAILSTGDELCHADEPPNGRIVDTNAPSLALAVRRAGGIPTQLGIARDTRDAVLAA
LSRLDGFDVVLTSAGVSVGERDYVKEVLAELGVEQHFWRVAIKPGKPLVVGRRGATLFFGLPGNPTSSLVTFELFVRPAL
RKLLGHAQVGPGRVAGRLEGKLSKPSGLAHFVRVTAAWREGNLWARPLATQTSGALRSAAAATHLLHFPREASSLTEGDA
VELLPLSWVA

Sequences:

>Translated_410_residues
MNDSATLLPEEEARSQILALCAPLPSEWLPLDDALGRVLAEDVTAQRTLPPWDNSAMDGYAVRSADLAGPLPVRLIVGET
IYAGAVGHQALASGVCARIMTGAPLPAGADAVVMRERTRPVVQSGADQVDMLEAVAPGQFVRPRGEDAREGQVLLARCTP
LGIPELGLLWAQGRQAVPVSRAPRVAILSTGDELCHADEPPNGRIVDTNAPSLALAVRRAGGIPTQLGIARDTRDAVLAA
LSRLDGFDVVLTSAGVSVGERDYVKEVLAELGVEQHFWRVAIKPGKPLVVGRRGATLFFGLPGNPTSSLVTFELFVRPAL
RKLLGHAQVGPGRVAGRLEGKLSKPSGLAHFVRVTAAWREGNLWARPLATQTSGALRSAAAATHLLHFPREASSLTEGDA
VELLPLSWVA
>Mature_410_residues
MNDSATLLPEEEARSQILALCAPLPSEWLPLDDALGRVLAEDVTAQRTLPPWDNSAMDGYAVRSADLAGPLPVRLIVGET
IYAGAVGHQALASGVCARIMTGAPLPAGADAVVMRERTRPVVQSGADQVDMLEAVAPGQFVRPRGEDAREGQVLLARCTP
LGIPELGLLWAQGRQAVPVSRAPRVAILSTGDELCHADEPPNGRIVDTNAPSLALAVRRAGGIPTQLGIARDTRDAVLAA
LSRLDGFDVVLTSAGVSVGERDYVKEVLAELGVEQHFWRVAIKPGKPLVVGRRGATLFFGLPGNPTSSLVTFELFVRPAL
RKLLGHAQVGPGRVAGRLEGKLSKPSGLAHFVRVTAAWREGNLWARPLATQTSGALRSAAAATHLLHFPREASSLTEGDA
VELLPLSWVA

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=409, Percent_Identity=37.6528117359413, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI10880983, Length=409, Percent_Identity=37.6528117359413, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1787049, Length=359, Percent_Identity=43.1754874651811, Blast_Score=228, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI25147659, Length=395, Percent_Identity=32.4050632911392, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17562606, Length=372, Percent_Identity=26.8817204301075, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136978, Length=380, Percent_Identity=33.1578947368421, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24638841, Length=380, Percent_Identity=33.1578947368421, Blast_Score=161, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43313; Mature: 43313

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSATLLPEEEARSQILALCAPLPSEWLPLDDALGRVLAEDVTAQRTLPPWDNSAMDGY
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
AVRSADLAGPLPVRLIVGETIYAGAVGHQALASGVCARIMTGAPLPAGADAVVMRERTRP
EEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHCCH
VVQSGADQVDMLEAVAPGQFVRPRGEDAREGQVLLARCTPLGIPELGLLWAQGRQAVPVS
HHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCC
RAPRVAILSTGDELCHADEPPNGRIVDTNAPSLALAVRRAGGIPTQLGIARDTRDAVLAA
CCCCEEEEECCHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LSRLDGFDVVLTSAGVSVGERDYVKEVLAELGVEQHFWRVAIKPGKPLVVGRRGATLFFG
HHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCEEEEE
LPGNPTSSLVTFELFVRPALRKLLGHAQVGPGRVAGRLEGKLSKPSGLAHFVRVTAAWRE
CCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHHEEEHEEC
GNLWARPLATQTSGALRSAAAATHLLHFPREASSLTEGDAVELLPLSWVA
CCEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MNDSATLLPEEEARSQILALCAPLPSEWLPLDDALGRVLAEDVTAQRTLPPWDNSAMDGY
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCE
AVRSADLAGPLPVRLIVGETIYAGAVGHQALASGVCARIMTGAPLPAGADAVVMRERTRP
EEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHCCH
VVQSGADQVDMLEAVAPGQFVRPRGEDAREGQVLLARCTPLGIPELGLLWAQGRQAVPVS
HHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCC
RAPRVAILSTGDELCHADEPPNGRIVDTNAPSLALAVRRAGGIPTQLGIARDTRDAVLAA
CCCCEEEEECCHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LSRLDGFDVVLTSAGVSVGERDYVKEVLAELGVEQHFWRVAIKPGKPLVVGRRGATLFFG
HHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCEEEEE
LPGNPTSSLVTFELFVRPALRKLLGHAQVGPGRVAGRLEGKLSKPSGLAHFVRVTAAWRE
CCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHHEEEHEEC
GNLWARPLATQTSGALRSAAAATHLLHFPREASSLTEGDAVELLPLSWVA
CCEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]