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The map label for this gene is groEL

Identifier: 108758906

GI number: 108758906

Start: 5530482

End: 5532125

Strand: Reverse

Name: groEL

Synonym: MXAN_4467

Alternate gene names: 108758906

Gene position: 5532125-5530482 (Counterclockwise)

Preceding gene: 108759817

Following gene: 108763633

Centisome position: 60.53

GC content: 67.82

Gene sequence:

>1644_bases
ATGGCAGCGAAGGAAATTTTCTTCCATCAGTCCGCGCGTGAGGCCATCCTGCGCGGCGTCCGCACCCTGTCGGACGCGGT
CGCGGTGACCCTCGGCCCCAAGGGCCGTAACGTGGTCATCGAGAAGAGCTTCGGCTCCCCCACGATCACCAAGGACGGCG
TCACCGTCGCCAAGGAGATCGACCTCGAGAACAAGTTCGAGAACATGGGCGCGCAGATGGTGAAGGAGGTCGCGTCCAAG
ACCTCCGACAAGGCCGGCGACGGCACCACCACCGCCACGGTGCTGGCGCGCGCCATCTATGAGGAGGGCCTCAAGCTGGT
GGCCGCCGGCCACAGCCCGATGGACCTCAAGCGCGGCATCGACAAGGCCGTCGAGGTCGTCGTGGGCGAGCTGAAGAGCC
TGTCCAAGCCCACCGCCGACAAGAAGGCCATCACCCAGGTGGGGACCATCTCCGCCAACGGGGATGAGACCATCGGCGCC
ATCATCGCGGACGCGATGGAGAAGGTCGGCAAGGAGGGCGTCATCACCGTCGAGGAGGCGAAGGGCCTCGAGACGACGCT
CGACGTGGTCGAGGGCATGCAGTTCGACCGCGGCTACGTGTCCCCGTACTTCGTGACCAACCGCGAGCGGATGGAGGCCG
TCCTGGAGGACCCCTACATCCTCATCAGCGAGAAGAAGGTCTCGTCGATGCAGGACATGATTCCGCTGCTCGAGCAGGTG
GCCCGCTCCGGCAAGCCGTTGATCATCATCGCCGACGACATCGAGGGCGAGGCCCTGGCCACCCTGGTGGTCAACAAGAT
CCGCGGCGTGCTGAACGTGTGCGCGGTGAAGGCCCCCGGCTTTGGTGACCGCCGCAAGGAGATGCTGCAGGACATCGCCG
TCCTCACCGGCGGCACGGTGGTCAGCGAGGACCTGGGCCACAAGTTCGAGACGCTGACGCTGACCGACCTGGGCCGCGCC
AAGCGCGTCACGGTGGACAAGGACAACACCACCGTCGTGGACGGCGTGGGCACGAAGGCGGCCATCGAGGGCCGCATCAA
GCTCATCCGCACGCAGATTGACTCCGTCACCAGCGACTACGACCGCGAGAAGCTCCAGGAGCGTCTGGCGAAGCTGGTGG
GCGGCGTGGCCGTCATCAACGTCGGCGCGGCCACCGAGACGGAGATGAAGGAGAAGAAGGCCCGCGTCGAGGACGCGCTG
CACGCGACCCGCGCGGCCGTCGAAGAGGGCATCGTCCCTGGCGGCGGCGTGGCCTACCTCCGCGCGCTGCCCGCGCTGGA
GAAGCTGAAGCCGGGCGGTGAGCAGGACTTCGGCGTGGCCATCATCCGCCGTGCGCTCCAGGAGCCGCTGCGGAAGATCG
CCAGCAACGCCGGCGTCGAGGGCGCCGTGGTCATCAACAAGGTCCGCGAGGGCACCGGCGCGTTCGGCTACAACGCCCGC
ACGGAGGTCTACGAGGACCTGGAGAAGGCCGGCGTCATCGACCCGACGAAGGTGGAGCGCACCGCGCTGCAGAACGCCGC
CTCCGTCGCCTCGCTGCTGCTGACCACCGAGGCCATGGTCGCCGAGCGCCCGAAGGGCAAGGCCAAGGGCGGCGGCGCTG
GTGCCGGCATGCCGGACTACGGCGGCGACGACATGGACTACTGA

Upstream 100 bases:

>100_bases
GACATCGTTCAGGCGGCCCTTATGTTGGCGCTCGCCATGGCCGAGTGCTAACGGCCCGTGTCGTACTAGTAAAATCCCCC
AGTGAATTCAGGAGGTTGCG

Downstream 100 bases:

>100_bases
GCCGCTCCGGAGGGCTCGGGACGTGAGTCCCGGGCCGTCTGGGCCTCGGCAGTCAACGGCCCCGGATGCCTCGTCAGGAG
GCGCCGGGGCCGTTGTCGTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKEIFFHQSAREAILRGVRTLSDAVAVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIDLENKFENMGAQMVKEVASK
TSDKAGDGTTTATVLARAIYEEGLKLVAAGHSPMDLKRGIDKAVEVVVGELKSLSKPTADKKAITQVGTISANGDETIGA
IIADAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYVSPYFVTNRERMEAVLEDPYILISEKKVSSMQDMIPLLEQV
ARSGKPLIIIADDIEGEALATLVVNKIRGVLNVCAVKAPGFGDRRKEMLQDIAVLTGGTVVSEDLGHKFETLTLTDLGRA
KRVTVDKDNTTVVDGVGTKAAIEGRIKLIRTQIDSVTSDYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDAL
HATRAAVEEGIVPGGGVAYLRALPALEKLKPGGEQDFGVAIIRRALQEPLRKIASNAGVEGAVVINKVREGTGAFGYNAR
TEVYEDLEKAGVIDPTKVERTALQNAASVASLLLTTEAMVAERPKGKAKGGGAGAGMPDYGGDDMDY

Sequences:

>Translated_547_residues
MAAKEIFFHQSAREAILRGVRTLSDAVAVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIDLENKFENMGAQMVKEVASK
TSDKAGDGTTTATVLARAIYEEGLKLVAAGHSPMDLKRGIDKAVEVVVGELKSLSKPTADKKAITQVGTISANGDETIGA
IIADAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYVSPYFVTNRERMEAVLEDPYILISEKKVSSMQDMIPLLEQV
ARSGKPLIIIADDIEGEALATLVVNKIRGVLNVCAVKAPGFGDRRKEMLQDIAVLTGGTVVSEDLGHKFETLTLTDLGRA
KRVTVDKDNTTVVDGVGTKAAIEGRIKLIRTQIDSVTSDYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDAL
HATRAAVEEGIVPGGGVAYLRALPALEKLKPGGEQDFGVAIIRRALQEPLRKIASNAGVEGAVVINKVREGTGAFGYNAR
TEVYEDLEKAGVIDPTKVERTALQNAASVASLLLTTEAMVAERPKGKAKGGGAGAGMPDYGGDDMDY
>Mature_546_residues
AAKEIFFHQSAREAILRGVRTLSDAVAVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIDLENKFENMGAQMVKEVASKT
SDKAGDGTTTATVLARAIYEEGLKLVAAGHSPMDLKRGIDKAVEVVVGELKSLSKPTADKKAITQVGTISANGDETIGAI
IADAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYVSPYFVTNRERMEAVLEDPYILISEKKVSSMQDMIPLLEQVA
RSGKPLIIIADDIEGEALATLVVNKIRGVLNVCAVKAPGFGDRRKEMLQDIAVLTGGTVVSEDLGHKFETLTLTDLGRAK
RVTVDKDNTTVVDGVGTKAAIEGRIKLIRTQIDSVTSDYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALH
ATRAAVEEGIVPGGGVAYLRALPALEKLKPGGEQDFGVAIIRRALQEPLRKIASNAGVEGAVVINKVREGTGAFGYNART
EVYEDLEKAGVIDPTKVERTALQNAASVASLLLTTEAMVAERPKGKAKGGGAGAGMPDYGGDDMDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=525, Percent_Identity=52.9523809523809, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI31542947, Length=525, Percent_Identity=52.9523809523809, Blast_Score=538, Evalue=1e-153,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=66.351606805293, Blast_Score=694, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=52.1739130434783, Blast_Score=530, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=52.60663507109, Blast_Score=200, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=54.5801526717557, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322524, Length=145, Percent_Identity=28.2758620689655, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641193, Length=525, Percent_Identity=53.1428571428571, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24641191, Length=525, Percent_Identity=53.1428571428571, Blast_Score=536, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=52.2900763358779, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=52.2900763358779, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=52.2900763358779, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=45.5535390199637, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24584129, Length=526, Percent_Identity=37.8326996197719, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI19921262, Length=526, Percent_Identity=37.8326996197719, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24583944, Length=203, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_MYXXD (Q1D3Y5)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_632638.1
- ProteinModelPortal:   Q1D3Y5
- SMR:   Q1D3Y5
- STRING:   Q1D3Y5
- GeneID:   4103745
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4467
- TIGR:   MXAN_4467
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   CELENAY
- PhylomeDB:   Q1D3Y5
- ProtClustDB:   PRK12849
- BioCyc:   MXAN246197:MXAN_4467-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58146; Mature: 58015

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEIFFHQSAREAILRGVRTLSDAVAVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEI
CCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHC
DLENKFENMGAQMVKEVASKTSDKAGDGTTTATVLARAIYEEGLKLVAAGHSPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
DKAVEVVVGELKSLSKPTADKKAITQVGTISANGDETIGAIIADAMEKVGKEGVITVEEA
HHHHHHHHHHHHHCCCCCCCHHHHHHHCEEECCCCHHHHHHHHHHHHHHCCCCEEEECCC
KGLETTLDVVEGMQFDRGYVSPYFVTNRERMEAVLEDPYILISEKKVSSMQDMIPLLEQV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHH
ARSGKPLIIIADDIEGEALATLVVNKIRGVLNVCAVKAPGFGDRRKEMLQDIAVLTGGTV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCH
VSEDLGHKFETLTLTDLGRAKRVTVDKDNTTVVDGVGTKAAIEGRIKLIRTQIDSVTSDY
HHHHHCCCEEEEEEECCCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALHATRAAVEEGIVPGGGVAYL
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RALPALEKLKPGGEQDFGVAIIRRALQEPLRKIASNAGVEGAVVINKVREGTGAFGYNAR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCH
TEVYEDLEKAGVIDPTKVERTALQNAASVASLLLTTEAMVAERPKGKAKGGGAGAGMPDY
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGDDMDY
CCCCCCC
>Mature Secondary Structure 
AAKEIFFHQSAREAILRGVRTLSDAVAVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEI
CCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHC
DLENKFENMGAQMVKEVASKTSDKAGDGTTTATVLARAIYEEGLKLVAAGHSPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
DKAVEVVVGELKSLSKPTADKKAITQVGTISANGDETIGAIIADAMEKVGKEGVITVEEA
HHHHHHHHHHHHHCCCCCCCHHHHHHHCEEECCCCHHHHHHHHHHHHHHCCCCEEEECCC
KGLETTLDVVEGMQFDRGYVSPYFVTNRERMEAVLEDPYILISEKKVSSMQDMIPLLEQV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHH
ARSGKPLIIIADDIEGEALATLVVNKIRGVLNVCAVKAPGFGDRRKEMLQDIAVLTGGTV
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCH
VSEDLGHKFETLTLTDLGRAKRVTVDKDNTTVVDGVGTKAAIEGRIKLIRTQIDSVTSDY
HHHHHCCCEEEEEEECCCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALHATRAAVEEGIVPGGGVAYL
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RALPALEKLKPGGEQDFGVAIIRRALQEPLRKIASNAGVEGAVVINKVREGTGAFGYNAR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCH
TEVYEDLEKAGVIDPTKVERTALQNAASVASLLLTTEAMVAERPKGKAKGGGAGAGMPDY
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GGDDMDY
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA