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The map label for this gene is hemU [H]

Identifier: 108758896

GI number: 108758896

Start: 1544025

End: 1545113

Strand: Direct

Name: hemU [H]

Synonym: MXAN_1320

Alternate gene names: 108758896

Gene position: 1544025-1545113 (Clockwise)

Preceding gene: 108761082

Following gene: 108759867

Centisome position: 16.89

GC content: 73.74

Gene sequence:

>1089_bases
ATGAGTGCGTCGGAGATTGCGCCCGTCTCCGCCACCTACCGCACCCAGGAGCCCATCCAGCCAGCAGCCCCGCGTCCGTG
GCTGTTGCTGACGGCGCTGCTGCTGGGCGTGGTGCTCCTGTCGCTCGCCGTGGGCGCGGTGCCGGTGCCTCTGCTGGCAC
TGGCGGGCAGTCTGCTGGAACGGGTGGGCCTGGACATCGGCCACAAGCTGGAGTCCGTGCAGCAGGCGGTGCTGCTGTCC
ATCCGCCTGCCGCGCGTGACGCTCGGCATCATGGTGGGCGCCGTACTGGCCACCTGTGGTGCCGCGCTGCAGGCGTTGTT
CCGCAACCCGCTGGTGGAGCCCGGCCTGCTGGGCACCTCCAGCGGCGCGGCGCTGGGGGCGGTGGCGGCCATCGTCATGG
ATGTGGCCCTCAGCGCCCACCTGGGCTCGCTGCGGATGCTCGCGGTGCCGGGCGCGGCCTTCCTGGGCGCGCTGGGCGCC
ACGTTGCTCGCGCACCGGCTGGGTGGGGGCGGCGGTCGCACGGAGACGGCGCGCATCCTCCTGGCGGGCGTGGCTGTCAG
CGCGGGGGCGGGCGCGGGCATCGGTCTGCTCACGCAGATGGCCACCGACGCGCAGCTCCGCTCCATCACCTTCTGGACCT
GGGGCAGCCTGGGCGGTGCGTCCTGGGACGTGGTGGGGGCAGCCACGCCGCCGCTGCTCATCGCCCTGGGCCTGCTGCTG
CGTGAAGCGCGCACCCTCAACCTTCTGCTGCTGGGGGAGCGCGAGGCGTGGCACCTGGGCGTGGATGTCGAGCGCCTCAA
GCGCCGGCTCATCCTCGCCGCGGCCCTGGGGGTGGGGGCCGCGGTGTCCGTCACCGGCGTCATCGCCTTCGTGGGCTTGC
TGGTGCCCGCGCTGCTGCGGTTGGCGCTGGGACCTGACCACCGGCGGCTGCTCAGTGCGTCCGCCTTGCTGGGGGCCTCG
CTGCTGGTGGGCGCGGACCTGCTGGCTCGCACGGCGGCCATTCCCGCCGAGTTGCCAGTGGGCGCGCTCACGTCCGTGCT
GGGCGTTCCCGTCTTCATCGGGCTGCTGTCGCGCAAGGGGGCCGCATGA

Upstream 100 bases:

>100_bases
TCACCGTGGACGACGTCCACTTCATGGGGCTGGGGCCTCACCTGGGCAAGGCCGTGAGCCGCTTGCAGGATGGGTACACG
TCCCCGGCTCGGGGCCGCAA

Downstream 100 bases:

>100_bases
GCCTGGAGGTTCGTGGCATCGAGGTGTGGCGTGGCCGTGGGCGGACGCTGGGACCCATGGATTTGACGCTGGAGCCCGGT
GAGGTGCTGGCCGTCGTGGG

Product: hemin ABC transporter permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSASEIAPVSATYRTQEPIQPAAPRPWLLLTALLLGVVLLSLAVGAVPVPLLALAGSLLERVGLDIGHKLESVQQAVLLS
IRLPRVTLGIMVGAVLATCGAALQALFRNPLVEPGLLGTSSGAALGAVAAIVMDVALSAHLGSLRMLAVPGAAFLGALGA
TLLAHRLGGGGGRTETARILLAGVAVSAGAGAGIGLLTQMATDAQLRSITFWTWGSLGGASWDVVGAATPPLLIALGLLL
REARTLNLLLLGEREAWHLGVDVERLKRRLILAAALGVGAAVSVTGVIAFVGLLVPALLRLALGPDHRRLLSASALLGAS
LLVGADLLARTAAIPAELPVGALTSVLGVPVFIGLLSRKGAA

Sequences:

>Translated_362_residues
MSASEIAPVSATYRTQEPIQPAAPRPWLLLTALLLGVVLLSLAVGAVPVPLLALAGSLLERVGLDIGHKLESVQQAVLLS
IRLPRVTLGIMVGAVLATCGAALQALFRNPLVEPGLLGTSSGAALGAVAAIVMDVALSAHLGSLRMLAVPGAAFLGALGA
TLLAHRLGGGGGRTETARILLAGVAVSAGAGAGIGLLTQMATDAQLRSITFWTWGSLGGASWDVVGAATPPLLIALGLLL
REARTLNLLLLGEREAWHLGVDVERLKRRLILAAALGVGAAVSVTGVIAFVGLLVPALLRLALGPDHRRLLSASALLGAS
LLVGADLLARTAAIPAELPVGALTSVLGVPVFIGLLSRKGAA
>Mature_361_residues
SASEIAPVSATYRTQEPIQPAAPRPWLLLTALLLGVVLLSLAVGAVPVPLLALAGSLLERVGLDIGHKLESVQQAVLLSI
RLPRVTLGIMVGAVLATCGAALQALFRNPLVEPGLLGTSSGAALGAVAAIVMDVALSAHLGSLRMLAVPGAAFLGALGAT
LLAHRLGGGGGRTETARILLAGVAVSAGAGAGIGLLTQMATDAQLRSITFWTWGSLGGASWDVVGAATPPLLIALGLLLR
EARTLNLLLLGEREAWHLGVDVERLKRRLILAAALGVGAAVSVTGVIAFVGLLVPALLRLALGPDHRRLLSASALLGASL
LVGADLLARTAAIPAELPVGALTSVLGVPVFIGLLSRKGAA

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=331, Percent_Identity=37.1601208459215, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1788004, Length=284, Percent_Identity=40.8450704225352, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1790741, Length=298, Percent_Identity=37.9194630872483, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786805, Length=293, Percent_Identity=38.5665529010239, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786347, Length=292, Percent_Identity=32.5342465753425, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786804, Length=295, Percent_Identity=35.2542372881356, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36447; Mature: 36316

Theoretical pI: Translated: 11.41; Mature: 11.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASEIAPVSATYRTQEPIQPAAPRPWLLLTALLLGVVLLSLAVGAVPVPLLALAGSLLE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVGLDIGHKLESVQQAVLLSIRLPRVTLGIMVGAVLATCGAALQALFRNPLVEPGLLGTS
HHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SGAALGAVAAIVMDVALSAHLGSLRMLAVPGAAFLGALGATLLAHRLGGGGGRTETARIL
CCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LAGVAVSAGAGAGIGLLTQMATDAQLRSITFWTWGSLGGASWDVVGAATPPLLIALGLLL
HHHHHHHCCCCCCHHHHHHHHCCHHHHEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHH
REARTLNLLLLGEREAWHLGVDVERLKRRLILAAALGVGAAVSVTGVIAFVGLLVPALLR
HHHHHEEEEEEECCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LALGPDHRRLLSASALLGASLLVGADLLARTAAIPAELPVGALTSVLGVPVFIGLLSRKG
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
AA
CC
>Mature Secondary Structure 
SASEIAPVSATYRTQEPIQPAAPRPWLLLTALLLGVVLLSLAVGAVPVPLLALAGSLLE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVGLDIGHKLESVQQAVLLSIRLPRVTLGIMVGAVLATCGAALQALFRNPLVEPGLLGTS
HHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SGAALGAVAAIVMDVALSAHLGSLRMLAVPGAAFLGALGATLLAHRLGGGGGRTETARIL
CCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LAGVAVSAGAGAGIGLLTQMATDAQLRSITFWTWGSLGGASWDVVGAATPPLLIALGLLL
HHHHHHHCCCCCCHHHHHHHHCCHHHHEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHH
REARTLNLLLLGEREAWHLGVDVERLKRRLILAAALGVGAAVSVTGVIAFVGLLVPALLR
HHHHHEEEEEEECCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LALGPDHRRLLSASALLGASLLVGADLLARTAAIPAELPVGALTSVLGVPVFIGLLSRKG
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]