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The map label for this gene is argF [H]

Identifier: 108758773

GI number: 108758773

Start: 6377816

End: 6378823

Strand: Direct

Name: argF [H]

Synonym: MXAN_5104

Alternate gene names: 108758773

Gene position: 6377816-6378823 (Clockwise)

Preceding gene: 108760819

Following gene: 108760106

Centisome position: 69.78

GC content: 69.35

Gene sequence:

>1008_bases
ATGAAGCACGTCACGCACATCAAGGATCTGGGGCCCGAGGGCGTGGAGGCGGTGCTCGCGCAGGCAGCCGCGTGGAAGCA
GAAGGGACCGGAGCACGCGCTCTTCGCCAACACGCTGCTGGGGATGGTGTTCTTCAACCCGTCGCTGCGCACACGCACCT
CGTTCGAGGCCGTCATGCTGCGCGGCGGTGGCAACGCCATCATCCTGGACGTGGGCTCCGGCGTCTGGAAGCTGGAGCAC
CGCGAGGGCGCGGTGATGAACGCGGACCGGGCTGAGCACCTCAAGGAGGCCGCGCCTGTCCTGTCGCGCTTCGTGGACAT
GCTCGGCGTGCGCACCTTCTCGCAAGGCGGCGGTGACGAGGAGGACGAACTCGACCCCGTCATCAACGCGTTCCGCAAGT
GGTCCACCGTGCCGGTGGTGAGCATGGAGTCCGCGCGCGAGCACCCCTGCCAGGGTCTGGCGGACATGCTGACGCTGCGC
GAGACGTTCGGCAACACGAAGAAGCTGCCGGTGACGCTGACGTGGGCGCCGCACATCAAGCCGCTGCCCAAGGCCGTGCC
CAACTCCTTCCTGCTGAGCGCGGCGGCGGCGGGCTGCGAGATTCGCGTAGCCCACCCTCCCGGGTTCGACCTGCACCCGG
CCGTCCGCGCCGAGGCGGAGGCGTACGCCAAGGCCACGGGCGGCAGCGTCACCTATACGCACGACCAGGACGAGGCCCTG
GCCGGCAGCCGCGCCGTCTACGCCAAGTCGTGGGGCCCCACGGCCGCTGCGGCGTTTTCGCCCAATGACGTCTCCGCGCT
GCTCGCGTCCTACTCCGGTTGGATGCCCACCCGCCTGACGATGTCGCGCGCGCAAAAGGACGCAGCCTTCCTCCACTGCC
TGCCCGTGCGCCGCAACGTCGAAGTGGCCGATGAGGTTCTGGACCACCCGAGCAGCCGCGTCGTAGACGAGGCCGGCAAT
CGCTACCACGTCCAGCGGGCGCTGCTGCACTGGATGCGTTCGCGCTGA

Upstream 100 bases:

>100_bases
CTTTCTGCATAATATCCGCCGCCTTTTCGCGGCGATGCACGCATTTTCACGCATATTCATCACGAATATGCAGGTAGCCG
CTGCCGGGGAGGACAGGCCC

Downstream 100 bases:

>100_bases
GCGGCCCCTCCGCATTCTTCCTTTCCTGACTTCGAGGTCTCACGTGCCCCTTTCGCCCGACCCCTACTCCGCGCTTCGCC
ACGCGGCGAAGTACGTGCAG

Product: N-acetylornithine carbamoyltransferase

Products: NA

Alternate protein names: AOTCase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKHVTHIKDLGPEGVEAVLAQAAAWKQKGPEHALFANTLLGMVFFNPSLRTRTSFEAVMLRGGGNAIILDVGSGVWKLEH
REGAVMNADRAEHLKEAAPVLSRFVDMLGVRTFSQGGGDEEDELDPVINAFRKWSTVPVVSMESAREHPCQGLADMLTLR
ETFGNTKKLPVTLTWAPHIKPLPKAVPNSFLLSAAAAGCEIRVAHPPGFDLHPAVRAEAEAYAKATGGSVTYTHDQDEAL
AGSRAVYAKSWGPTAAAAFSPNDVSALLASYSGWMPTRLTMSRAQKDAAFLHCLPVRRNVEVADEVLDHPSSRVVDEAGN
RYHVQRALLHWMRSR

Sequences:

>Translated_335_residues
MKHVTHIKDLGPEGVEAVLAQAAAWKQKGPEHALFANTLLGMVFFNPSLRTRTSFEAVMLRGGGNAIILDVGSGVWKLEH
REGAVMNADRAEHLKEAAPVLSRFVDMLGVRTFSQGGGDEEDELDPVINAFRKWSTVPVVSMESAREHPCQGLADMLTLR
ETFGNTKKLPVTLTWAPHIKPLPKAVPNSFLLSAAAAGCEIRVAHPPGFDLHPAVRAEAEAYAKATGGSVTYTHDQDEAL
AGSRAVYAKSWGPTAAAAFSPNDVSALLASYSGWMPTRLTMSRAQKDAAFLHCLPVRRNVEVADEVLDHPSSRVVDEAGN
RYHVQRALLHWMRSR
>Mature_335_residues
MKHVTHIKDLGPEGVEAVLAQAAAWKQKGPEHALFANTLLGMVFFNPSLRTRTSFEAVMLRGGGNAIILDVGSGVWKLEH
REGAVMNADRAEHLKEAAPVLSRFVDMLGVRTFSQGGGDEEDELDPVINAFRKWSTVPVVSMESAREHPCQGLADMLTLR
ETFGNTKKLPVTLTWAPHIKPLPKAVPNSFLLSAAAAGCEIRVAHPPGFDLHPAVRAEAEAYAKATGGSVTYTHDQDEAL
AGSRAVYAKSWGPTAAAAFSPNDVSALLASYSGWMPTRLTMSRAQKDAAFLHCLPVRRNVEVADEVLDHPSSRVVDEAGN
RYHVQRALLHWMRSR

Specific function: Catalyzes the conversion of N-acetylornithine to N- acetylcitrulline in an alternative arginine biosynthesis pathway. The enzyme has no activity with ornithine [H]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=299, Percent_Identity=31.438127090301, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1790703, Length=349, Percent_Identity=26.3610315186246, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786469, Length=349, Percent_Identity=26.647564469914, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994908, Length=316, Percent_Identity=28.7974683544304, Blast_Score=93, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322373, Length=344, Percent_Identity=25.2906976744186, Blast_Score=86, Evalue=6e-18,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.9 [H]

Molecular weight: Translated: 36457; Mature: 36457

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHVTHIKDLGPEGVEAVLAQAAAWKQKGPEHALFANTLLGMVFFNPSLRTRTSFEAVML
CCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
RGGGNAIILDVGSGVWKLEHREGAVMNADRAEHLKEAAPVLSRFVDMLGVRTFSQGGGDE
ECCCCEEEEECCCCEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EDELDPVINAFRKWSTVPVVSMESAREHPCQGLADMLTLRETFGNTKKLPVTLTWAPHIK
HHHHHHHHHHHHHCCCCCEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
PLPKAVPNSFLLSAAAAGCEIRVAHPPGFDLHPAVRAEAEAYAKATGGSVTYTHDQDEAL
CCHHHCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHH
AGSRAVYAKSWGPTAAAAFSPNDVSALLASYSGWMPTRLTMSRAQKDAAFLHCLPVRRNV
CCCCEEEEECCCCCEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCCCCH
EVADEVLDHPSSRVVDEAGNRYHVQRALLHWMRSR
HHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKHVTHIKDLGPEGVEAVLAQAAAWKQKGPEHALFANTLLGMVFFNPSLRTRTSFEAVML
CCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
RGGGNAIILDVGSGVWKLEHREGAVMNADRAEHLKEAAPVLSRFVDMLGVRTFSQGGGDE
ECCCCEEEEECCCCEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EDELDPVINAFRKWSTVPVVSMESAREHPCQGLADMLTLRETFGNTKKLPVTLTWAPHIK
HHHHHHHHHHHHHCCCCCEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
PLPKAVPNSFLLSAAAAGCEIRVAHPPGFDLHPAVRAEAEAYAKATGGSVTYTHDQDEAL
CCHHHCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHH
AGSRAVYAKSWGPTAAAAFSPNDVSALLASYSGWMPTRLTMSRAQKDAAFLHCLPVRRNV
CCCCEEEEECCCCCEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCCCCH
EVADEVLDHPSSRVVDEAGNRYHVQRALLHWMRSR
HHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]