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The map label for this gene is fhs

Identifier: 108758771

GI number: 108758771

Start: 210960

End: 212615

Strand: Reverse

Name: fhs

Synonym: MXAN_0175

Alternate gene names: 108758771

Gene position: 212615-210960 (Counterclockwise)

Preceding gene: 108757215

Following gene: 108760019

Centisome position: 2.33

GC content: 72.58

Gene sequence:

>1656_bases
ATGACGCTGAGAGCCATGACCGACGTGGGCGCCGAGCTGGGCCTGTCTCCCGAAGACGTGCTGCCGTGGGGAACCCACCG
CGCCAAGGTGTCGCTGGACGCGCTCGGCAAGCGGGGCGGCCGGCAGGGACGCCTGGTGCTCGTGTCCGCCATCAACCCCA
CGCCGCCGGGCGAAGGGAAGACCACCATGTCCGTGGCGCTGGCCATGGGCTTGCGCAAGCGAGGGCGCCGCGCGGTGGCG
GCCCTGCGCGAGCCGTCACTGGGCCCTGTCTTCGGCGTGAAGGGCGGCGGCACCGGCGGCGGGCAGGCCAGCCTGGAGCC
CGCGGCCGACATCAACCTGCACTTCACCGGTGACTTGCACGCCATCACCAGCGCCAACAACCTGCTGTCCGCGCTGGTGG
ACAACGCCGTCTTCTACGGCCAGCCGGTGGCCCTGGATGCCACGCGCGTGCGCTGGCGGCGCGCGCTGGACATGAATGAC
CGCTTCCTGCGCAACGTCATCGTCGGCCTGGGCGGCAAGGCGCAGGGCGTGCCACGCGAGGACCACTTCGACATCACCGC
CGCCAGCGAGGTCATGGCCATCCTCGCGCTCGCGGAGGGCCTGAAGGACCTGGAGGCGCGGCTGGGACGCGTCATCATCG
GCCACACCCGGGACGGCCAGCCGGTGCGCGCGCGCGACGTGGACGCGGCGGCGTCCATGGTGGCGCTGCTCAAGGACGCG
CTGATGCCCAACCTCGCCCAGACACGCGAGGGCGGCCCCGCGCTGGTGCACGCGGGCCCCTTCGCCAACATCGCGCACGG
GTGCAGCTCCGTGATGGGCACGCGCATGGGGCTGGCCTACGCGGATGAAGTCATCACGGAGGCGGGCTTCGGCTTCGACC
TGGGCGCGGAGAAGTTCCTGGACATCAAGTGCCGCGGCAGCGGGCTGTGGCCCCGGGGCGTGGTGCTGGTGGTGACGCTG
CGCGCGCTGAAGCACCACGGGGGCGCCTCCCCCGCGCGCGTGGCCGAGCCGGACCGCGAGGCCCTGGTTCGCGGCTTCGC
CCACCTGGAGAAGCACCTGGAGTCGGTGGCCGCCTTCGGCCTGCCGGCCGTGCTGTGCGTCAACCGCTTCCCGCAGGACA
CCGAGTCCGAGCTGGAAGAGCTGCGCGCCTTCGGCAAGGCCCGCGGCGTGGAGACGGCCGTGTGTGACGGCTTCTCGCGA
GGGGGTGACGGCTCGCTGGAGCTGGCCGACTGCGTGCTGGAGATGCTGGACGGTACGGACGCCGCGCCGCCCCAGCCGCG
CTTCCTCTACGACGTGGCGCAGACACCCGAGGAGAAGGTGGCCGCCATCGCGCGCACCGTCTACGGCGCGGACGACGTGG
CCTTCACCGCGAGCGCGAAGAAGGACCTGGACGCCATCCGCGAGCTGGGCGGCGCCGGACTGCCCGTGTGCATGGCGAAG
ACGCACCTGTCGCTGTCGGATGACCCCACGAAGCTGGGGCGGCCGCGCGGCTTCACGCTCACCGTGCGCGAGGTGCGGCT
GTCCGCGGGCGCGGGCTTCATGGTGGCGCTCACTGGAGAAATCCTCACCATGCCCGGCCTGCCACGCGAGCCTGCCGCCC
GCCGCGTCACCGTCCACGACGACGGGCGCGTCACCGGGCTGATGCAGGGGGAGTGA

Upstream 100 bases:

>100_bases
GGAATCCAGACACACGAGCGAAGGTCTTCACAGCCCTGAATTGTAGCAGGCATGCGTCTCCGCCGTTGACCGCTGCCAGT
TCCGCACGGAGATTCCCTGC

Downstream 100 bases:

>100_bases
GCCGAGCCCCAAGCCGGGGTGCCACCCAGGACGGTGGCACCCGCGCGGCCCCGAGGCGGCGTCAGACGCGGAAGCCGGTG
GACAGCTCATGGAGCTGTCC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MTLRAMTDVGAELGLSPEDVLPWGTHRAKVSLDALGKRGGRQGRLVLVSAINPTPPGEGKTTMSVALAMGLRKRGRRAVA
ALREPSLGPVFGVKGGGTGGGQASLEPAADINLHFTGDLHAITSANNLLSALVDNAVFYGQPVALDATRVRWRRALDMND
RFLRNVIVGLGGKAQGVPREDHFDITAASEVMAILALAEGLKDLEARLGRVIIGHTRDGQPVRARDVDAAASMVALLKDA
LMPNLAQTREGGPALVHAGPFANIAHGCSSVMGTRMGLAYADEVITEAGFGFDLGAEKFLDIKCRGSGLWPRGVVLVVTL
RALKHHGGASPARVAEPDREALVRGFAHLEKHLESVAAFGLPAVLCVNRFPQDTESELEELRAFGKARGVETAVCDGFSR
GGDGSLELADCVLEMLDGTDAAPPQPRFLYDVAQTPEEKVAAIARTVYGADDVAFTASAKKDLDAIRELGGAGLPVCMAK
THLSLSDDPTKLGRPRGFTLTVREVRLSAGAGFMVALTGEILTMPGLPREPAARRVTVHDDGRVTGLMQGE

Sequences:

>Translated_551_residues
MTLRAMTDVGAELGLSPEDVLPWGTHRAKVSLDALGKRGGRQGRLVLVSAINPTPPGEGKTTMSVALAMGLRKRGRRAVA
ALREPSLGPVFGVKGGGTGGGQASLEPAADINLHFTGDLHAITSANNLLSALVDNAVFYGQPVALDATRVRWRRALDMND
RFLRNVIVGLGGKAQGVPREDHFDITAASEVMAILALAEGLKDLEARLGRVIIGHTRDGQPVRARDVDAAASMVALLKDA
LMPNLAQTREGGPALVHAGPFANIAHGCSSVMGTRMGLAYADEVITEAGFGFDLGAEKFLDIKCRGSGLWPRGVVLVVTL
RALKHHGGASPARVAEPDREALVRGFAHLEKHLESVAAFGLPAVLCVNRFPQDTESELEELRAFGKARGVETAVCDGFSR
GGDGSLELADCVLEMLDGTDAAPPQPRFLYDVAQTPEEKVAAIARTVYGADDVAFTASAKKDLDAIRELGGAGLPVCMAK
THLSLSDDPTKLGRPRGFTLTVREVRLSAGAGFMVALTGEILTMPGLPREPAARRVTVHDDGRVTGLMQGE
>Mature_550_residues
TLRAMTDVGAELGLSPEDVLPWGTHRAKVSLDALGKRGGRQGRLVLVSAINPTPPGEGKTTMSVALAMGLRKRGRRAVAA
LREPSLGPVFGVKGGGTGGGQASLEPAADINLHFTGDLHAITSANNLLSALVDNAVFYGQPVALDATRVRWRRALDMNDR
FLRNVIVGLGGKAQGVPREDHFDITAASEVMAILALAEGLKDLEARLGRVIIGHTRDGQPVRARDVDAAASMVALLKDAL
MPNLAQTREGGPALVHAGPFANIAHGCSSVMGTRMGLAYADEVITEAGFGFDLGAEKFLDIKCRGSGLWPRGVVLVVTLR
ALKHHGGASPARVAEPDREALVRGFAHLEKHLESVAAFGLPAVLCVNRFPQDTESELEELRAFGKARGVETAVCDGFSRG
GDGSLELADCVLEMLDGTDAAPPQPRFLYDVAQTPEEKVAAIARTVYGADDVAFTASAKKDLDAIRELGGAGLPVCMAKT
HLSLSDDPTKLGRPRGFTLTVREVRLSAGAGFMVALTGEILTMPGLPREPAARRVTVHDDGRVTGLMQGE

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=586, Percent_Identity=40.6143344709898, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI36796743, Length=598, Percent_Identity=40.9698996655518, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI310124614, Length=99, Percent_Identity=40.4040404040404, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568737, Length=603, Percent_Identity=40.9618573797678, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17568739, Length=603, Percent_Identity=40.9618573797678, Blast_Score=416, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319558, Length=623, Percent_Identity=38.5232744783307, Blast_Score=395, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6321643, Length=618, Percent_Identity=38.3495145631068, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI62472483, Length=604, Percent_Identity=38.7417218543046, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI45551871, Length=604, Percent_Identity=38.7417218543046, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24645718, Length=604, Percent_Identity=38.7417218543046, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI17137370, Length=604, Percent_Identity=38.7417218543046, Blast_Score=387, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_MYXXD (Q1DFW5)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_628458.1
- ProteinModelPortal:   Q1DFW5
- SMR:   Q1DFW5
- STRING:   Q1DFW5
- GeneID:   4101290
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_0175
- TIGR:   MXAN_0175
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- PhylomeDB:   Q1DFW5
- BioCyc:   MXAN246197:MXAN_0175-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 58072; Mature: 57941

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRAMTDVGAELGLSPEDVLPWGTHRAKVSLDALGKRGGRQGRLVLVSAINPTPPGEGK
CCCCCHHHCCHHCCCCHHHCCCCCCCCEEEEHHHHHCCCCCCCCEEEEEECCCCCCCCCC
TTMSVALAMGLRKRGRRAVAALREPSLGPVFGVKGGGTGGGQASLEPAADINLHFTGDLH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCH
AITSANNLLSALVDNAVFYGQPVALDATRVRWRRALDMNDRFLRNVIVGLGGKAQGVPRE
HHHHHHHHHHHHHHCHHCCCCCEEECHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC
DHFDITAASEVMAILALAEGLKDLEARLGRVIIGHTRDGQPVRARDVDAAASMVALLKDA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
LMPNLAQTREGGPALVHAGPFANIAHGCSSVMGTRMGLAYADEVITEAGFGFDLGAEKFL
HCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
DIKCRGSGLWPRGVVLVVTLRALKHHGGASPARVAEPDREALVRGFAHLEKHLESVAAFG
EEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
LPAVLCVNRFPQDTESELEELRAFGKARGVETAVCDGFSRGGDGSLELADCVLEMLDGTD
CHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCC
AAPPQPRFLYDVAQTPEEKVAAIARTVYGADDVAFTASAKKDLDAIRELGGAGLPVCMAK
CCCCCCCEEEHHHCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCCCEEEHE
THLSLSDDPTKLGRPRGFTLTVREVRLSAGAGFMVALTGEILTMPGLPREPAARRVTVHD
ECCCCCCCHHHCCCCCCCEEEEEEEECCCCCCEEEEEECCEEECCCCCCCCCCCEEEEEC
DGRVTGLMQGE
CCCEEEEECCC
>Mature Secondary Structure 
TLRAMTDVGAELGLSPEDVLPWGTHRAKVSLDALGKRGGRQGRLVLVSAINPTPPGEGK
CCCCHHHCCHHCCCCHHHCCCCCCCCEEEEHHHHHCCCCCCCCEEEEEECCCCCCCCCC
TTMSVALAMGLRKRGRRAVAALREPSLGPVFGVKGGGTGGGQASLEPAADINLHFTGDLH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCH
AITSANNLLSALVDNAVFYGQPVALDATRVRWRRALDMNDRFLRNVIVGLGGKAQGVPRE
HHHHHHHHHHHHHHCHHCCCCCEEECHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC
DHFDITAASEVMAILALAEGLKDLEARLGRVIIGHTRDGQPVRARDVDAAASMVALLKDA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
LMPNLAQTREGGPALVHAGPFANIAHGCSSVMGTRMGLAYADEVITEAGFGFDLGAEKFL
HCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
DIKCRGSGLWPRGVVLVVTLRALKHHGGASPARVAEPDREALVRGFAHLEKHLESVAAFG
EEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
LPAVLCVNRFPQDTESELEELRAFGKARGVETAVCDGFSRGGDGSLELADCVLEMLDGTD
CHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCC
AAPPQPRFLYDVAQTPEEKVAAIARTVYGADDVAFTASAKKDLDAIRELGGAGLPVCMAK
CCCCCCCEEEHHHCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCCCCCEEEHE
THLSLSDDPTKLGRPRGFTLTVREVRLSAGAGFMVALTGEILTMPGLPREPAARRVTVHD
ECCCCCCCHHHCCCCCCCEEEEEEEECCCCCCEEEEEECCEEECCCCCCCCCCCEEEEEC
DGRVTGLMQGE
CCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA