Click here to switch to the map view.

The map label for this gene is folD

Identifier: 108758766

GI number: 108758766

Start: 3559312

End: 3560178

Strand: Direct

Name: folD

Synonym: MXAN_3032

Alternate gene names: 108758766

Gene position: 3559312-3560178 (Clockwise)

Preceding gene: 108759184

Following gene: 108760493

Centisome position: 38.94

GC content: 68.74

Gene sequence:

>867_bases
GTGAACGCCCAGTTGATTGATGGCAAGGCAGTTGCGGCGCGCGTGCGAGCGGAGGTCAAGGCGGAGGTCGACCGGCTCAA
GCTCGAGCATGGCCTGACGCCGGGGCTGGCCGTGGTGCGCGTGGGGGAGGACCCCGCCTCCAAGGTCTACGTCAATGGGA
AGAAGAAGGCCGCGGAGGAGGTGGGCTTCCGCTCCTGGGAGCTCCACCCGGACGAGGGCATCACCCAGGCGGCGCTGCTG
GAGGTCATCCACCAGCTCAACGCGGACCCGGCGGTGCACGGCATCCTGGTTCAGTTGCCGTTGCCCAGGCACATCGACCC
GGACGTCATCATCTCCGCCGTGAAGCCGGAGAAGGACGTGGACGGCTTCCACCCGCTCAACGCCGGCAACCTGCTGCTGG
GCCGGTCCACCACCCGGGCGTGTACGCCCTACGGGGTGATGCGGCTGCTGGAGGAGATTGGCTGCGACCCCGCGGGCAAG
CGGGCGGTGGTGGTGGGGCGCAGCAACATCGTGGGCAAGCCCATGGCGCTGATGCTGCTCCAGAAGAACGCCACGGTGAC
CATCTGCCACAGCAAGAGCGACCTGCGCCGGGAAGTGGAGGGCGCGGACATCCTGGTGGTGGCGGTGGGGGCGGCCGAGC
TGGTGAAGGGCGCGTGGATAAAGCCCGGCGCGGTGGTGATTGACGTGGGGATGAATCGCAAGCCGGACGGCAAGCTCGTG
GGCGACGTGGAATTCGCCGCTGCCGCCGAGCGCGCGTCATTCATCACCCCCGTGCCCGGTGGCGTGGGGCCCATGACCAT
CGCCATGCTGATGCGCAACACGCTCGACGCGGCCGTCCGCTACGGCCTGGTGCCTGTCGTCAGGTAG

Upstream 100 bases:

>100_bases
CCCGCCATCAACCCCAGCATTGCTCCCAGAACTGTTCCTGCGCCCATGGCCGACGTTCCGCTCCCTTTCCGGCGGGGGAG
TTTCGCATAGAGTGGCACGG

Downstream 100 bases:

>100_bases
GCCGTGAGGGTGACGCGCTGGGGCCCCGGTCCCAGCTCCGCCTGCGCGTACTCGTGCATGGACCAGAGCAGCGGCTCCCA
CTGCGGGCCCAGCGCCCTGC

Product: methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNAQLIDGKAVAARVRAEVKAEVDRLKLEHGLTPGLAVVRVGEDPASKVYVNGKKKAAEEVGFRSWELHPDEGITQAALL
EVIHQLNADPAVHGILVQLPLPRHIDPDVIISAVKPEKDVDGFHPLNAGNLLLGRSTTRACTPYGVMRLLEEIGCDPAGK
RAVVVGRSNIVGKPMALMLLQKNATVTICHSKSDLRREVEGADILVVAVGAAELVKGAWIKPGAVVIDVGMNRKPDGKLV
GDVEFAAAAERASFITPVPGGVGPMTIAMLMRNTLDAAVRYGLVPVVR

Sequences:

>Translated_288_residues
MNAQLIDGKAVAARVRAEVKAEVDRLKLEHGLTPGLAVVRVGEDPASKVYVNGKKKAAEEVGFRSWELHPDEGITQAALL
EVIHQLNADPAVHGILVQLPLPRHIDPDVIISAVKPEKDVDGFHPLNAGNLLLGRSTTRACTPYGVMRLLEEIGCDPAGK
RAVVVGRSNIVGKPMALMLLQKNATVTICHSKSDLRREVEGADILVVAVGAAELVKGAWIKPGAVVIDVGMNRKPDGKLV
GDVEFAAAAERASFITPVPGGVGPMTIAMLMRNTLDAAVRYGLVPVVR
>Mature_288_residues
MNAQLIDGKAVAARVRAEVKAEVDRLKLEHGLTPGLAVVRVGEDPASKVYVNGKKKAAEEVGFRSWELHPDEGITQAALL
EVIHQLNADPAVHGILVQLPLPRHIDPDVIISAVKPEKDVDGFHPLNAGNLLLGRSTTRACTPYGVMRLLEEIGCDPAGK
RAVVVGRSNIVGKPMALMLLQKNATVTICHSKSDLRREVEGADILVVAVGAAELVKGAWIKPGAVVIDVGMNRKPDGKLV
GDVEFAAAAERASFITPVPGGVGPMTIAMLMRNTLDAAVRYGLVPVVR

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=291, Percent_Identity=50.1718213058419, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI222418558, Length=292, Percent_Identity=43.1506849315069, Blast_Score=211, Evalue=5e-55,
Organism=Homo sapiens, GI94721354, Length=292, Percent_Identity=44.1780821917808, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI36796743, Length=206, Percent_Identity=28.1553398058252, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1786741, Length=283, Percent_Identity=53.356890459364, Blast_Score=280, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17568735, Length=295, Percent_Identity=43.3898305084746, Blast_Score=212, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321643, Length=298, Percent_Identity=47.986577181208, Blast_Score=249, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6319558, Length=288, Percent_Identity=47.5694444444444, Blast_Score=243, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6322933, Length=311, Percent_Identity=27.6527331189711, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24645718, Length=290, Percent_Identity=50, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17137370, Length=290, Percent_Identity=50, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI62472483, Length=290, Percent_Identity=50, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI45551871, Length=290, Percent_Identity=50, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17136816, Length=292, Percent_Identity=48.2876712328767, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI17136818, Length=292, Percent_Identity=48.2876712328767, Blast_Score=230, Evalue=8e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD2_MYXXD (Q1D7Y2)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631241.1
- ProteinModelPortal:   Q1D7Y2
- SMR:   Q1D7Y2
- STRING:   Q1D7Y2
- GeneID:   4101285
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_3032
- TIGR:   MXAN_3032
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   DVVYETA
- PhylomeDB:   Q1D7Y2
- BioCyc:   MXAN246197:MXAN_3032-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 30599; Mature: 30599

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAQLIDGKAVAARVRAEVKAEVDRLKLEHGLTPGLAVVRVGEDPASKVYVNGKKKAAEE
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCHHHHHH
VGFRSWELHPDEGITQAALLEVIHQLNADPAVHGILVQLPLPRHIDPDVIISAVKPEKDV
CCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHEEEECCCCCCC
DGFHPLNAGNLLLGRSTTRACTPYGVMRLLEEIGCDPAGKRAVVVGRSNIVGKPMALMLL
CCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEE
QKNATVTICHSKSDLRREVEGADILVVAVGAAELVKGAWIKPGAVVIDVGMNRKPDGKLV
ECCCEEEEEECHHHHHHHCCCCCEEEEEECHHHHHHCCCCCCCEEEEECCCCCCCCCCEE
GDVEFAAAAERASFITPVPGGVGPMTIAMLMRNTLDAAVRYGLVPVVR
ECHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNAQLIDGKAVAARVRAEVKAEVDRLKLEHGLTPGLAVVRVGEDPASKVYVNGKKKAAEE
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCHHHHHH
VGFRSWELHPDEGITQAALLEVIHQLNADPAVHGILVQLPLPRHIDPDVIISAVKPEKDV
CCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHEEEECCCCCCC
DGFHPLNAGNLLLGRSTTRACTPYGVMRLLEEIGCDPAGKRAVVVGRSNIVGKPMALMLL
CCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEE
QKNATVTICHSKSDLRREVEGADILVVAVGAAELVKGAWIKPGAVVIDVGMNRKPDGKLV
ECCCEEEEEECHHHHHHHCCCCCEEEEEECHHHHHHCCCCCCCEEEEECCCCCCCCCCEE
GDVEFAAAAERASFITPVPGGVGPMTIAMLMRNTLDAAVRYGLVPVVR
ECHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA