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The map label for this gene is dhaT [H]

Identifier: 108758582

GI number: 108758582

Start: 3364629

End: 3365807

Strand: Reverse

Name: dhaT [H]

Synonym: MXAN_2881

Alternate gene names: 108758582

Gene position: 3365807-3364629 (Counterclockwise)

Preceding gene: 108759163

Following gene: 108761410

Centisome position: 36.83

GC content: 72.69

Gene sequence:

>1179_bases
GTGACGGACGTGAGCGCTTCTTCCTCGTTCGAGTTCGCCACCGCCACCCGCGTCGTCTTCGGCCCGGGCCGCCTGGCCGA
GGCACCCGAAATCATTCGCGGCCTCGGGGGCTCCCGGGTGCTGCTCGTCACCGGCGCGAATCCCTCCCGCGCACGGCCCC
TCCACGACGCATTGGAGCGCCTGGGCCTGGGGGTGACTGTCTTCTCCGTGGACGGCGAGCCCACCGTGGAGCGTGCTCGT
GAAGGCACCGCGCGCGTCGCGGAAGCGGGCTGTGATGTGGTGGTGGCCCTGGGCGGAGGCAGCGCGTTGGACGCGGGCAA
GGCCATTGCAGCGCTCGCCGCCAACGGGGGCGACCCGCTGGACTACCTGGAAGTCATTGGCCGGGGCCAGCCGCTCACCC
GCCCGTCCCTGCCCTTCATGGCCATCCCCACCACGGCCGGCACGGGCTCCGAGGTGACGCGCAACGCGGTGCTGGGCTCG
AAGGACGCGAAGGCGAAGGCCAGCCTGCGCAGTCCACACATGCTGCCGCGCGTGGCGCTGGTGGACCCGGACCTGCTCAC
GGGGGCACCGGCCGCCGTGCTTGCATCCAGTGGCATGGACGCGCTGTCGCAGCTCATCGAGCCCTACCTCTCCGCGCGCG
CCAACCCGCTGACGGACGCGCTGGCACGCGAGGGCCTGCGAAGGTCGGCCCGCTCGCTGCGGCGCGCGGTGCTGGACGGT
CCGGATGCGCCCGCCCGCGAGGACCTGGCCCTGGCCAGTCTCTTCGGCGGTCTGTGTCTGGCCAATGCGGGCCTGGGCGC
GGTGCACGGCTTCGCCGCGCCCCTGGGTGGCATGTTCGACGCGCCCCACGGCGCGGTGTGCGCGGCATTGCTGCCAGCGG
TGTTGGACGTCAACCTGCGCGCGCTGCGGGCCCGTGCGCCAACGCATCCATCACTGCCCCGGGTGCAGGAGTTGGCGGCG
CTGCTGACGGGGCGGGTGGATGCAAGGGCCGAGGACGCCGTCACGTGGGTGGACGAACTTCGCGCGGCGCTGGGCGTACC
GGGGCTGGGACGCTACGGGCTGACGGAGGCCCAGGTACCAGCGCTGGTGGCGAAGGCCAAGGAGGCCAGCAGCATGAAGG
CCAACCCCCTGGTGCTCACCGACGCAGAGCTGGCGGAAATCGCCAGCCGGTCGCTGTAG

Upstream 100 bases:

>100_bases
CGGCGCACTACCTCACATGGCGCGACACCGTGGCTCCGATGATGTCAGAGCCCCGCACCAGCCGGAAGTTCGTCAACCGC
TTCCCTGAAGACGCCGGGTG

Downstream 100 bases:

>100_bases
GACCCGCGCCGTTACACCTTGTAGAGCAGGTCCATGTACTTCTTGAGCAGGTCGCTCACCAGACCGCGGAAGGGCACGGA
GGCCGCCATGCCGTACACGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTDVSASSSFEFATATRVVFGPGRLAEAPEIIRGLGGSRVLLVTGANPSRARPLHDALERLGLGVTVFSVDGEPTVERAR
EGTARVAEAGCDVVVALGGGSALDAGKAIAALAANGGDPLDYLEVIGRGQPLTRPSLPFMAIPTTAGTGSEVTRNAVLGS
KDAKAKASLRSPHMLPRVALVDPDLLTGAPAAVLASSGMDALSQLIEPYLSARANPLTDALAREGLRRSARSLRRAVLDG
PDAPAREDLALASLFGGLCLANAGLGAVHGFAAPLGGMFDAPHGAVCAALLPAVLDVNLRALRARAPTHPSLPRVQELAA
LLTGRVDARAEDAVTWVDELRAALGVPGLGRYGLTEAQVPALVAKAKEASSMKANPLVLTDAELAEIASRSL

Sequences:

>Translated_392_residues
MTDVSASSSFEFATATRVVFGPGRLAEAPEIIRGLGGSRVLLVTGANPSRARPLHDALERLGLGVTVFSVDGEPTVERAR
EGTARVAEAGCDVVVALGGGSALDAGKAIAALAANGGDPLDYLEVIGRGQPLTRPSLPFMAIPTTAGTGSEVTRNAVLGS
KDAKAKASLRSPHMLPRVALVDPDLLTGAPAAVLASSGMDALSQLIEPYLSARANPLTDALAREGLRRSARSLRRAVLDG
PDAPAREDLALASLFGGLCLANAGLGAVHGFAAPLGGMFDAPHGAVCAALLPAVLDVNLRALRARAPTHPSLPRVQELAA
LLTGRVDARAEDAVTWVDELRAALGVPGLGRYGLTEAQVPALVAKAKEASSMKANPLVLTDAELAEIASRSL
>Mature_391_residues
TDVSASSSFEFATATRVVFGPGRLAEAPEIIRGLGGSRVLLVTGANPSRARPLHDALERLGLGVTVFSVDGEPTVERARE
GTARVAEAGCDVVVALGGGSALDAGKAIAALAANGGDPLDYLEVIGRGQPLTRPSLPFMAIPTTAGTGSEVTRNAVLGSK
DAKAKASLRSPHMLPRVALVDPDLLTGAPAAVLASSGMDALSQLIEPYLSARANPLTDALAREGLRRSARSLRRAVLDGP
DAPAREDLALASLFGGLCLANAGLGAVHGFAAPLGGMFDAPHGAVCAALLPAVLDVNLRALRARAPTHPSLPRVQELAAL
LTGRVDARAEDAVTWVDELRAALGVPGLGRYGLTEAQVPALVAKAKEASSMKANPLVLTDAELAEIASRSL

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=394, Percent_Identity=32.2335025380711, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI48994951, Length=394, Percent_Identity=35.0253807106599, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87082107, Length=311, Percent_Identity=39.5498392282958, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1789163, Length=373, Percent_Identity=32.4396782841823, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI1787493, Length=401, Percent_Identity=29.426433915212, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789386, Length=375, Percent_Identity=27.2, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17537053, Length=299, Percent_Identity=31.438127090301, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321181, Length=378, Percent_Identity=32.5396825396825, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24657991, Length=426, Percent_Identity=29.3427230046948, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 40039; Mature: 39908

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVSASSSFEFATATRVVFGPGRLAEAPEIIRGLGGSRVLLVTGANPSRARPLHDALER
CCCCCCCCCCCHHHEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHH
LGLGVTVFSVDGEPTVERAREGTARVAEAGCDVVVALGGGSALDAGKAIAALAANGGDPL
HCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCHH
DYLEVIGRGQPLTRPSLPFMAIPTTAGTGSEVTRNAVLGSKDAKAKASLRSPHMLPRVAL
HHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCCEEEE
VDPDLLTGAPAAVLASSGMDALSQLIEPYLSARANPLTDALAREGLRRSARSLRRAVLDG
ECCHHHCCCCHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PDAPAREDLALASLFGGLCLANAGLGAVHGFAAPLGGMFDAPHGAVCAALLPAVLDVNLR
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCHHH
ALRARAPTHPSLPRVQELAALLTGRVDARAEDAVTWVDELRAALGVPGLGRYGLTEAQVP
HHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
ALVAKAKEASSMKANPLVLTDAELAEIASRSL
HHHHHHHHHCCCCCCCEEEECHHHHHHHHCCC
>Mature Secondary Structure 
TDVSASSSFEFATATRVVFGPGRLAEAPEIIRGLGGSRVLLVTGANPSRARPLHDALER
CCCCCCCCCCHHHEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHH
LGLGVTVFSVDGEPTVERAREGTARVAEAGCDVVVALGGGSALDAGKAIAALAANGGDPL
HCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCHH
DYLEVIGRGQPLTRPSLPFMAIPTTAGTGSEVTRNAVLGSKDAKAKASLRSPHMLPRVAL
HHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCCEEEE
VDPDLLTGAPAAVLASSGMDALSQLIEPYLSARANPLTDALAREGLRRSARSLRRAVLDG
ECCHHHCCCCHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PDAPAREDLALASLFGGLCLANAGLGAVHGFAAPLGGMFDAPHGAVCAALLPAVLDVNLR
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCHHH
ALRARAPTHPSLPRVQELAALLTGRVDARAEDAVTWVDELRAALGVPGLGRYGLTEAQVP
HHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
ALVAKAKEASSMKANPLVLTDAELAEIASRSL
HHHHHHHHHCCCCCCCEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]