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The map label for this gene is 108758380

Identifier: 108758380

GI number: 108758380

Start: 1761302

End: 1762609

Strand: Reverse

Name: 108758380

Synonym: MXAN_1501

Alternate gene names: NA

Gene position: 1762609-1761302 (Counterclockwise)

Preceding gene: 108759182

Following gene: 108758696

Centisome position: 19.29

GC content: 65.83

Gene sequence:

>1308_bases
ATGAATCGACACACACTGAAGCTGTTCGTCTCCGTGGGCATGATGTTGCTGATGGGGGCGTGCGCATCGCGGCAGGTGCC
CTGCAAGGACCGCACGGCCAGCAGGCCCACGATGGGCCAGAAGCAGACCGGCAAGTTCATCACTGTCCGAAAGAAGATTC
CGGGTGAATACATTGTCGTCCTGAAGTCGCCCGCACAAAGCCTGGAACAGGTCGAGGTCCAGCAAGCCACGACGAGCCTC
ATCACGGCTTACGGTGGCACCGCATTCGCGATGTATGAGAATGCGTTGCGTGGTTTCGCGGCCAAGATGACGGAAGCCCA
GGCGCGGGCCATGGCGAACGACCCCGCAGTGGACTACGTGCAAGAGAATGGCGTGGTCAAAATCGCCGAAAGCCAGCAGG
GTCCCACGTGGGGCATCGACCGGATGGACCAGCGCAAGCTCCCGCTGGACAAGGTCTACACCTTCACCGCGACGGGCCAG
GGCGTGCACATCTACATCCTGGACACCGGTGTGCGCTTCTCGCACCGGGAGTTCGGTGGCCGGGCCTCCATCGGCTACGA
CGCCATTGGCGACAGCATGCGGGGCAATGACTGCAACGGCCACGGGACACACGTCGCGGGCACGGCGGCGGGCGCCTCCT
ACGGCCTCGCCCGCAACGCGATTGTCCATTCCGTCCGCGTGCTGGGCTGTGACGGCTCCGGAGCCACCTCTGGCGTCATC
GAGGGCATCGACTGGGTGACCCGGAATCACATCTCGCCCGCCGTCGCGAACATGAGTCTGGGCAGCGACGAGGACCCGGC
GCTCGACGACGCGGTCCGCCGCTCCATCGCCGCGGGGGTCACCTACGTCGTCGCCGCGGGCAACGAAGACAACGACGCCT
GCAAGCACTCCCCCGCCCGTGCGCCAGAGGCCATCACCGTTGCCGCCACCGACAACAAGGACAAGCGCGCCACCTTCTCC
AACTGGGGGGACTGCGTGGACGTCTTCGCGCCGGGGAACAAGATCAAGTCCTCCTGGCACTACGGCGACCGCGAGAGCCG
GGAGATGAGCGGCACGTCCATGGCCACCCCTCACGTGACGGGACTGGCCGCGCTGTTCCTCGAGGTGAATCCCACGGCGA
AGCCCGAGACGGTCGCCAATGCGGTGTTCACCAACGCCACCGAGAACACGGTGTCCAACCCGGGCTGGTGCTCGCCCAAC
CTGATGGCGTACTCGGGCTTCATCACCGCGCTCCCGGGGTTGCCCGTCGTGCAACTCAAGGACTTCCTGCCCAAGCCCGC
CGTGGTCAGCAGCAGCGAGCCGCGGTAG

Upstream 100 bases:

>100_bases
TCACGGACCGCCGTCTCATCCCTCCGGGTTGATTCATGAATAAGCCGTTTTTGATGTACACCCGTTTTACCCATCACAAC
CATTTTCCTCTGGGTAAAAC

Downstream 100 bases:

>100_bases
ACGTCTCCCCTGGCAGCCCGGCTTCCCGTGAGGGGAGCCGGGCCCCGGAGGGCAACGCCGCCGGCCGGTATCGTCAGGAG
CCTGCCCCCATCGCCGTCCC

Product: putative aqualysin I

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MNRHTLKLFVSVGMMLLMGACASRQVPCKDRTASRPTMGQKQTGKFITVRKKIPGEYIVVLKSPAQSLEQVEVQQATTSL
ITAYGGTAFAMYENALRGFAAKMTEAQARAMANDPAVDYVQENGVVKIAESQQGPTWGIDRMDQRKLPLDKVYTFTATGQ
GVHIYILDTGVRFSHREFGGRASIGYDAIGDSMRGNDCNGHGTHVAGTAAGASYGLARNAIVHSVRVLGCDGSGATSGVI
EGIDWVTRNHISPAVANMSLGSDEDPALDDAVRRSIAAGVTYVVAAGNEDNDACKHSPARAPEAITVAATDNKDKRATFS
NWGDCVDVFAPGNKIKSSWHYGDRESREMSGTSMATPHVTGLAALFLEVNPTAKPETVANAVFTNATENTVSNPGWCSPN
LMAYSGFITALPGLPVVQLKDFLPKPAVVSSSEPR

Sequences:

>Translated_435_residues
MNRHTLKLFVSVGMMLLMGACASRQVPCKDRTASRPTMGQKQTGKFITVRKKIPGEYIVVLKSPAQSLEQVEVQQATTSL
ITAYGGTAFAMYENALRGFAAKMTEAQARAMANDPAVDYVQENGVVKIAESQQGPTWGIDRMDQRKLPLDKVYTFTATGQ
GVHIYILDTGVRFSHREFGGRASIGYDAIGDSMRGNDCNGHGTHVAGTAAGASYGLARNAIVHSVRVLGCDGSGATSGVI
EGIDWVTRNHISPAVANMSLGSDEDPALDDAVRRSIAAGVTYVVAAGNEDNDACKHSPARAPEAITVAATDNKDKRATFS
NWGDCVDVFAPGNKIKSSWHYGDRESREMSGTSMATPHVTGLAALFLEVNPTAKPETVANAVFTNATENTVSNPGWCSPN
LMAYSGFITALPGLPVVQLKDFLPKPAVVSSSEPR
>Mature_435_residues
MNRHTLKLFVSVGMMLLMGACASRQVPCKDRTASRPTMGQKQTGKFITVRKKIPGEYIVVLKSPAQSLEQVEVQQATTSL
ITAYGGTAFAMYENALRGFAAKMTEAQARAMANDPAVDYVQENGVVKIAESQQGPTWGIDRMDQRKLPLDKVYTFTATGQ
GVHIYILDTGVRFSHREFGGRASIGYDAIGDSMRGNDCNGHGTHVAGTAAGASYGLARNAIVHSVRVLGCDGSGATSGVI
EGIDWVTRNHISPAVANMSLGSDEDPALDDAVRRSIAAGVTYVVAAGNEDNDACKHSPARAPEAITVAATDNKDKRATFS
NWGDCVDVFAPGNKIKSSWHYGDRESREMSGTSMATPHVTGLAALFLEVNPTAKPETVANAVFTNATENTVSNPGWCSPN
LMAYSGFITALPGLPVVQLKDFLPKPAVVSSSEPR

Specific function: Serine proteinase with preferred activity for amino acids with aromatic side groups at the P1' side of the scissible bond [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI31317307, Length=380, Percent_Identity=30.7894736842105, Blast_Score=155, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6324576, Length=345, Percent_Identity=37.3913043478261, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6320775, Length=412, Percent_Identity=35.1941747572816, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6319893, Length=294, Percent_Identity=38.0952380952381, Blast_Score=172, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020
- InterPro:   IPR010259 [H]

Pfam domain/function: PF05922 Inhibitor_I9; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 46305; Mature: 46305

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRHTLKLFVSVGMMLLMGACASRQVPCKDRTASRPTMGQKQTGKFITVRKKIPGEYIVV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
LKSPAQSLEQVEVQQATTSLITAYGGTAFAMYENALRGFAAKMTEAQARAMANDPAVDYV
ECCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEE
QENGVVKIAESQQGPTWGIDRMDQRKLPLDKVYTFTATGQGVHIYILDTGVRFSHREFGG
CCCCEEEEECCCCCCCCCCCCCCCCCCCHHHEEEEEECCCCEEEEEEECCCEECHHHCCC
RASIGYDAIGDSMRGNDCNGHGTHVAGTAAGASYGLARNAIVHSVRVLGCDGSGATSGVI
CCCCCHHHCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHEEEEEEECCCCCCCHHHH
EGIDWVTRNHISPAVANMSLGSDEDPALDDAVRRSIAAGVTYVVAAGNEDNDACKHSPAR
HHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCHHHCCCCCC
APEAITVAATDNKDKRATFSNWGDCVDVFAPGNKIKSSWHYGDRESREMSGTSMATPHVT
CCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCHHCCCCCCCCCCCHHCCCCCCCCCHHH
GLAALFLEVNPTAKPETVANAVFTNATENTVSNPGWCSPNLMAYSGFITALPGLPVVQLK
EEEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCHHHHH
DFLPKPAVVSSSEPR
HHCCCCCCCCCCCCC
>Mature Secondary Structure
MNRHTLKLFVSVGMMLLMGACASRQVPCKDRTASRPTMGQKQTGKFITVRKKIPGEYIVV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
LKSPAQSLEQVEVQQATTSLITAYGGTAFAMYENALRGFAAKMTEAQARAMANDPAVDYV
ECCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEE
QENGVVKIAESQQGPTWGIDRMDQRKLPLDKVYTFTATGQGVHIYILDTGVRFSHREFGG
CCCCEEEEECCCCCCCCCCCCCCCCCCCHHHEEEEEECCCCEEEEEEECCCEECHHHCCC
RASIGYDAIGDSMRGNDCNGHGTHVAGTAAGASYGLARNAIVHSVRVLGCDGSGATSGVI
CCCCCHHHCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHEEEEEEECCCCCCCHHHH
EGIDWVTRNHISPAVANMSLGSDEDPALDDAVRRSIAAGVTYVVAAGNEDNDACKHSPAR
HHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCHHHCCCCCC
APEAITVAATDNKDKRATFSNWGDCVDVFAPGNKIKSSWHYGDRESREMSGTSMATPHVT
CCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCHHCCCCCCCCCCCHHCCCCCCCCCHHH
GLAALFLEVNPTAKPETVANAVFTNATENTVSNPGWCSPNLMAYSGFITALPGLPVVQLK
EEEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCHHHHH
DFLPKPAVVSSSEPR
HHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7551039; 1499549 [H]