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The map label for this gene is ppsB [H]

Identifier: 108758362

GI number: 108758362

Start: 5291992

End: 5294277

Strand: Reverse

Name: ppsB [H]

Synonym: MXAN_4301

Alternate gene names: 108758362

Gene position: 5294277-5291992 (Counterclockwise)

Preceding gene: 108760156

Following gene: 108758543

Centisome position: 57.93

GC content: 69.16

Gene sequence:

>2286_bases
TTGTTGGTTGAGAATGAAGTTCAAACAGGTGATGAGTCTGAGCGGCTTGCGAGTCGCCAGCGGAGCCGTGCCTTGATGTT
GTGTGAACCCATTGCTGTGATTGGACTGGGCCTGCGTCTGCCCATGTCGGACTGCCCGCGTACGCTCTGGCAAATGCTAT
GTGATGGGATTGATGCGACGGGGGACATCCCGGCCGGGCGCTGGCCTTTGTCTTCGCTCTTCGACGCGGCACCTGATCGC
CCTGGGACGATTCGCAACCGCAAGGCCGGACTGATTGAAGGCGTGGAGCTGGCCGACCCCGCGGCGTTCCGGCTGACGAA
GCGGGAGCTGCGGCAGATGGACCCGCAGCACCGTCTCCTCTTCGAGTGTGCATGGCATGCGCTGGAGGATGCGGGCCTGC
CCTTCGACGCCGTGCGAGGGAGCCGCACGGGCGTCTTCATGGGCGTCAACTTCAGCGACTTCCAGCGGATGCTGGCGAGG
GACTGGTCCTCGCTGGATGGCTATTCCGTCCTGGGAACGACGGCGTCCTTCGCGGCCAACCGGCTCTCCTACGCCTTTGA
TTTCCGGGGACCCAGCACCGTGTCGAGCGTGGGGTGTGCCTCCTCGACGGTGGCCCTCCATGAGGCGTGCCGCAGCTTGA
CGCTGGGCGAGGTGGAGATGGCCCTCGCCGGGGGCGTCGAGCTGATGCTGTCTCCGGACAGCAGCATCATGCTGTCCCAG
GCCGGCGTGTTCTCCGAGCGGGGGCAGTGCCGGACCCTGGATGCGCAGGCGGACGGCTACGTGCGCGGGGAGGGCGCTGG
CGTCGTCGTCCTCAAGCGCCTGTCCAAGGTTGAGCCCGGTGACCGCGTGTACGCGGTGATTCGGGGCAGCGCCGTCAATC
ACAACGGCCGGAACGAGTGGATCATGGCGCCCAGCGCCTCGGCGCAGGCGGACGTCATCCGGCAGGCGTGTGAGCAGGGC
GGGGTGGCTCCGGCGAGCATCGACTACATCGAGATGCACGGCTCGTCGTTCCTCAAGGGCGACGCGGCCGAAGCGGAGGC
CATCGGGGAGGCGCTCGGGACGCAGCGGCCGGTGCCCTGCAGGCTCGGCGCCATCAGCAACAACGTGGGTTACCTGGGCG
CCGCGGCGGGCATCGCGCAGTTCATCAAGGTGTGCCTGTCGCTGCACCACCGGACGTTGGCGCCGACGATTCACGTGGAT
GCGCCCAACCCGCTGGTTTCGTTCGACGCGCTCGGGCTGAGCATCCAGACGGAGCTGGAGCCCTGGGCCGCGCGGGAGCC
TGGCGTGCCGCTGCGAGCGGGCATCGTCTCCACGTCCCTGGGCGGTGCCAACGGCTTCGTGGTCCTGGAGGCAGCTCCGG
CTGCGGTGCTGGAGCGGACGCCCGCGCCGGTCCATTTCCTGGCGCTCTCGGCGCTCTCTCAGGACGCGCTCCGTCAGCGG
GCGCTCCAGCTTCGGGACTTCCTCGCCACGACGCCGGACTCGGTGGCGACGCTGGAGGACGTCTGCTTCACGGCGGCGCT
CAAGCGTCAGCACCACCGGCACCGTGCCGTGGTGATTGCGGGCGACCGGGCTGGGCTCGTGGCGCTCCTGGATTCGCTCG
CGACGTCGAGTGGGACGGCGCTCCTGGTTCAGGAGGGCATGCCGCTGGAGCAGGTGGAGGCCGGGCGTGTCTTCGTCGCG
GATGGGACGGTGCCGCCCGAGGTGTTCCCGGTGCGTGCAGGGCGCTGCGTGAGCCTGCCGGTCTACCCCTTCCAGCGTCA
GCGCCTGTGGCCCGAGTGGCTTTCACCCGATGAAGTCTGCCGCTCACCCAAGGACGCGCGGCCGGACGCCGCCACCCTGC
TTCAGGCCGCCGCGGTGGCCGCCGGGGATGCTTCCCGCGTTCCCGACGTGCATGGGGAGGCCCAGATGCGGGCGTTCCTG
CGGGGGCACCTCGCGGACGTGCTGGAGGTCGAGCCCGCGACGCTCGATGTGCAGGGGCGGACCTTCTTCGAACTGGGCCT
GAACTCCATTGGGGCCACGTTGTTGAAGGAGCGCATCTCGCGGGCGCTCGAGCTCCCGCTGTCGACGACGCTCTTCTTCG
AGCTGCCCCGGCTGGAGTCGCTGGCGAAGCGGCTGCTGTCCCTGCTGGAGGCGCGGCGTGGCCGCCTGCCGTCGGACCCG
GGCGAGGTGAGTACGCCCGAGCAGGAGGAGCAGGGCCTGATGGAACGCATTGCCGGGCTGTCCGAGGACGAAGCGCGCGA
GCAGATCGCCCGGACGTTGGCCGAACTCAGCCTCGAGGTCGCGTGA

Upstream 100 bases:

>100_bases
TTTTGGCGATCTGTCCGTGGTGGAGGACGGAGGCCTCGGGCCGCGTGATGCCACGCCGGCCGCAGTGAAAGACGTTTCGG
ACGTATGTCTTTATTGATTC

Downstream 100 bases:

>100_bases
TGAACCGCAAGGACGGATTCATGGCGGAGTTGTCGCCACTCCAGCAGGCGTTGCTGACCATCGAGAAGCTGCAGAAGAAG
CTGGCCACGGCCTCGAATGG

Product: polyketide synthase type I

Products: [acyl carrier protein]; acetoacetyl-ACP; CO2; [acyl carrier protein]; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 761; Mature: 761

Protein sequence:

>761_residues
MLVENEVQTGDESERLASRQRSRALMLCEPIAVIGLGLRLPMSDCPRTLWQMLCDGIDATGDIPAGRWPLSSLFDAAPDR
PGTIRNRKAGLIEGVELADPAAFRLTKRELRQMDPQHRLLFECAWHALEDAGLPFDAVRGSRTGVFMGVNFSDFQRMLAR
DWSSLDGYSVLGTTASFAANRLSYAFDFRGPSTVSSVGCASSTVALHEACRSLTLGEVEMALAGGVELMLSPDSSIMLSQ
AGVFSERGQCRTLDAQADGYVRGEGAGVVVLKRLSKVEPGDRVYAVIRGSAVNHNGRNEWIMAPSASAQADVIRQACEQG
GVAPASIDYIEMHGSSFLKGDAAEAEAIGEALGTQRPVPCRLGAISNNVGYLGAAAGIAQFIKVCLSLHHRTLAPTIHVD
APNPLVSFDALGLSIQTELEPWAAREPGVPLRAGIVSTSLGGANGFVVLEAAPAAVLERTPAPVHFLALSALSQDALRQR
ALQLRDFLATTPDSVATLEDVCFTAALKRQHHRHRAVVIAGDRAGLVALLDSLATSSGTALLVQEGMPLEQVEAGRVFVA
DGTVPPEVFPVRAGRCVSLPVYPFQRQRLWPEWLSPDEVCRSPKDARPDAATLLQAAAVAAGDASRVPDVHGEAQMRAFL
RGHLADVLEVEPATLDVQGRTFFELGLNSIGATLLKERISRALELPLSTTLFFELPRLESLAKRLLSLLEARRGRLPSDP
GEVSTPEQEEQGLMERIAGLSEDEAREQIARTLAELSLEVA

Sequences:

>Translated_761_residues
MLVENEVQTGDESERLASRQRSRALMLCEPIAVIGLGLRLPMSDCPRTLWQMLCDGIDATGDIPAGRWPLSSLFDAAPDR
PGTIRNRKAGLIEGVELADPAAFRLTKRELRQMDPQHRLLFECAWHALEDAGLPFDAVRGSRTGVFMGVNFSDFQRMLAR
DWSSLDGYSVLGTTASFAANRLSYAFDFRGPSTVSSVGCASSTVALHEACRSLTLGEVEMALAGGVELMLSPDSSIMLSQ
AGVFSERGQCRTLDAQADGYVRGEGAGVVVLKRLSKVEPGDRVYAVIRGSAVNHNGRNEWIMAPSASAQADVIRQACEQG
GVAPASIDYIEMHGSSFLKGDAAEAEAIGEALGTQRPVPCRLGAISNNVGYLGAAAGIAQFIKVCLSLHHRTLAPTIHVD
APNPLVSFDALGLSIQTELEPWAAREPGVPLRAGIVSTSLGGANGFVVLEAAPAAVLERTPAPVHFLALSALSQDALRQR
ALQLRDFLATTPDSVATLEDVCFTAALKRQHHRHRAVVIAGDRAGLVALLDSLATSSGTALLVQEGMPLEQVEAGRVFVA
DGTVPPEVFPVRAGRCVSLPVYPFQRQRLWPEWLSPDEVCRSPKDARPDAATLLQAAAVAAGDASRVPDVHGEAQMRAFL
RGHLADVLEVEPATLDVQGRTFFELGLNSIGATLLKERISRALELPLSTTLFFELPRLESLAKRLLSLLEARRGRLPSDP
GEVSTPEQEEQGLMERIAGLSEDEAREQIARTLAELSLEVA
>Mature_761_residues
MLVENEVQTGDESERLASRQRSRALMLCEPIAVIGLGLRLPMSDCPRTLWQMLCDGIDATGDIPAGRWPLSSLFDAAPDR
PGTIRNRKAGLIEGVELADPAAFRLTKRELRQMDPQHRLLFECAWHALEDAGLPFDAVRGSRTGVFMGVNFSDFQRMLAR
DWSSLDGYSVLGTTASFAANRLSYAFDFRGPSTVSSVGCASSTVALHEACRSLTLGEVEMALAGGVELMLSPDSSIMLSQ
AGVFSERGQCRTLDAQADGYVRGEGAGVVVLKRLSKVEPGDRVYAVIRGSAVNHNGRNEWIMAPSASAQADVIRQACEQG
GVAPASIDYIEMHGSSFLKGDAAEAEAIGEALGTQRPVPCRLGAISNNVGYLGAAAGIAQFIKVCLSLHHRTLAPTIHVD
APNPLVSFDALGLSIQTELEPWAAREPGVPLRAGIVSTSLGGANGFVVLEAAPAAVLERTPAPVHFLALSALSQDALRQR
ALQLRDFLATTPDSVATLEDVCFTAALKRQHHRHRAVVIAGDRAGLVALLDSLATSSGTALLVQEGMPLEQVEAGRVFVA
DGTVPPEVFPVRAGRCVSLPVYPFQRQRLWPEWLSPDEVCRSPKDARPDAATLLQAAAVAAGDASRVPDVHGEAQMRAFL
RGHLADVLEVEPATLDVQGRTFFELGLNSIGATLLKERISRALELPLSTTLFFELPRLESLAKRLLSLLEARRGRLPSDP
GEVSTPEQEEQGLMERIAGLSEDEAREQIARTLAELSLEVA

Specific function: Polyketide synthase involved in phenolpthiocerol synthesis [H]

COG id: COG3321

COG function: function code Q; Polyketide synthase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI41872631, Length=422, Percent_Identity=33.8862559241706, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI8923559, Length=325, Percent_Identity=24.3076923076923, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI239744023, Length=106, Percent_Identity=36.7924528301887, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI310129082, Length=106, Percent_Identity=36.7924528301887, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI310109937, Length=106, Percent_Identity=36.7924528301887, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1787337, Length=433, Percent_Identity=23.3256351039261, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1788663, Length=329, Percent_Identity=28.2674772036474, Blast_Score=83, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI212642053, Length=439, Percent_Identity=31.8906605922551, Blast_Score=230, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17550940, Length=540, Percent_Identity=27.5925925925926, Blast_Score=159, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI71983541, Length=331, Percent_Identity=22.0543806646526, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71983535, Length=240, Percent_Identity=23.75, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320904, Length=398, Percent_Identity=24.1206030150754, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221330659, Length=435, Percent_Identity=32.183908045977, Blast_Score=222, Evalue=8e-58,
Organism=Drosophila melanogaster, GI19920632, Length=435, Percent_Identity=32.183908045977, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24581345, Length=429, Percent_Identity=30.7692307692308, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24644341, Length=320, Percent_Identity=26.875, Blast_Score=90, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR013968
- InterPro:   IPR020806
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF08659 KR; PF00550 PP-binding [H]

EC number: 2.3.1.41 [C]

Molecular weight: Translated: 81651; Mature: 81651

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50075 ACP_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVENEVQTGDESERLASRQRSRALMLCEPIAVIGLGLRLPMSDCPRTLWQMLCDGIDAT
CCCCCCCCCCCHHHHHHHHHHHCEEEEECHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
GDIPAGRWPLSSLFDAAPDRPGTIRNRKAGLIEGVELADPAAFRLTKRELRQMDPQHRLL
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHH
FECAWHALEDAGLPFDAVRGSRTGVFMGVNFSDFQRMLARDWSSLDGYSVLGTTASFAAN
HHHHHHHHHHCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEECCCHHHHHHH
RLSYAFDFRGPSTVSSVGCASSTVALHEACRSLTLGEVEMALAGGVELMLSPDSSIMLSQ
HHCEEEECCCCCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCEEEEECCCCCEEEEC
AGVFSERGQCRTLDAQADGYVRGEGAGVVVLKRLSKVEPGDRVYAVIRGSAVNHNGRNEW
CCCCCCCCCEEEECCCCCCEEECCCCCHHHHHHHHCCCCCCEEEEEEECCEECCCCCCCE
IMAPSASAQADVIRQACEQGGVAPASIDYIEMHGSSFLKGDAAEAEAIGEALGTQRPVPC
EECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCE
RLGAISNNVGYLGAAAGIAQFIKVCLSLHHRTLAPTIHVDAPNPLVSFDALGLSIQTELE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEHHHCCEEEEECCC
PWAAREPGVPLRAGIVSTSLGGANGFVVLEAAPAAVLERTPAPVHFLALSALSQDALRQR
CCCCCCCCCCEEHHHEECCCCCCCCEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHH
ALQLRDFLATTPDSVATLEDVCFTAALKRQHHRHRAVVIAGDRAGLVALLDSLATSSGTA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCE
LLVQEGMPLEQVEAGRVFVADGTVPPEVFPVRAGRCVSLPVYPFQRQRLWPEWLSPDEVC
EEEECCCCHHHHCCCEEEEECCCCCCCEEEECCCCEEECCCCCCHHHCCCCCCCCHHHHH
RSPKDARPDAATLLQAAAVAAGDASRVPDVHGEAQMRAFLRGHLADVLEVEPATLDVQGR
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
TFFELGLNSIGATLLKERISRALELPLSTTLFFELPRLESLAKRLLSLLEARRGRLPSDP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECHHHHHHHHHHHHHHHHHCCCCCCCC
GEVSTPEQEEQGLMERIAGLSEDEAREQIARTLAELSLEVA
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVENEVQTGDESERLASRQRSRALMLCEPIAVIGLGLRLPMSDCPRTLWQMLCDGIDAT
CCCCCCCCCCCHHHHHHHHHHHCEEEEECHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
GDIPAGRWPLSSLFDAAPDRPGTIRNRKAGLIEGVELADPAAFRLTKRELRQMDPQHRLL
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHH
FECAWHALEDAGLPFDAVRGSRTGVFMGVNFSDFQRMLARDWSSLDGYSVLGTTASFAAN
HHHHHHHHHHCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEECCCHHHHHHH
RLSYAFDFRGPSTVSSVGCASSTVALHEACRSLTLGEVEMALAGGVELMLSPDSSIMLSQ
HHCEEEECCCCCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCEEEEECCCCCEEEEC
AGVFSERGQCRTLDAQADGYVRGEGAGVVVLKRLSKVEPGDRVYAVIRGSAVNHNGRNEW
CCCCCCCCCEEEECCCCCCEEECCCCCHHHHHHHHCCCCCCEEEEEEECCEECCCCCCCE
IMAPSASAQADVIRQACEQGGVAPASIDYIEMHGSSFLKGDAAEAEAIGEALGTQRPVPC
EECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCE
RLGAISNNVGYLGAAAGIAQFIKVCLSLHHRTLAPTIHVDAPNPLVSFDALGLSIQTELE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEHHHCCEEEEECCC
PWAAREPGVPLRAGIVSTSLGGANGFVVLEAAPAAVLERTPAPVHFLALSALSQDALRQR
CCCCCCCCCCEEHHHEECCCCCCCCEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHH
ALQLRDFLATTPDSVATLEDVCFTAALKRQHHRHRAVVIAGDRAGLVALLDSLATSSGTA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCE
LLVQEGMPLEQVEAGRVFVADGTVPPEVFPVRAGRCVSLPVYPFQRQRLWPEWLSPDEVC
EEEECCCCHHHHCCCEEEEECCCCCCCEEEECCCCEEECCCCCCHHHCCCCCCCCHHHHH
RSPKDARPDAATLLQAAAVAAGDASRVPDVHGEAQMRAFLRGHLADVLEVEPATLDVQGR
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCC
TFFELGLNSIGATLLKERISRALELPLSTTLFFELPRLESLAKRLLSLLEARRGRLPSDP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECHHHHHHHHHHHHHHHHHCCCCCCCC
GEVSTPEQEEQGLMERIAGLSEDEAREQIARTLAELSLEVA
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: None [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} [C]

Substrates: acetyl-ACP; malonyl-ACP; acyl-ACP [C]

Specific reaction: acetyl-ACP + malonyl-ACP = [acyl carrier protein] + acetoacetyl-ACP + CO2 acyl-ACP + malonyl-ACP = [acyl carrier protein] + beta-ketoacyl-ACP + CO2 [C]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl-ACP-decarboxylation, Cerulenin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]