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The map label for this gene is atoC [H]

Identifier: 108758279

GI number: 108758279

Start: 1385311

End: 1386663

Strand: Reverse

Name: atoC [H]

Synonym: MXAN_1189

Alternate gene names: 108758279

Gene position: 1386663-1385311 (Counterclockwise)

Preceding gene: 108760457

Following gene: 108758749

Centisome position: 15.17

GC content: 72.88

Gene sequence:

>1353_bases
ATGAAGCCCGGTCCTCGCATCCTCATCGTCGATGACGACTCTGGCGTCCTCAGGGCCCTGCGCGGACTGCTGAGTGATGA
GGGCTTCACGCCCGTGGAGGCCCGCTCCGCGGCGGAGGCCTCCCAGTTGCTCGACGCGCCCGAAGGTCCCCCGGCGATGA
TGCTGCTCGACCTGCGCATGCCGGGCGAGACGGGCCTGGAGCTGCTCGCGCGCCTGCCCCGGCCCTTCCCCGCGCCCGTG
GTGGTGCTGTCCGGAGAGGCGTCGCCCGCCGAGGCCGTGCAGGCGCTGCGGCTGGGCGCGACGGACTTCGTGGAGAAGCC
GCCCTCCCCCGAGCGGCTGCTCACCGCCGTGCGAAACGCACTGGCACTGGGCTCGCTCCAGGAAGAGCGCGAGCGGCTGC
TGGACGCACTGGCCCGCCCCGGGCACCTGGTGGGTGACAGCGCTGGCATGGCGTCACTGCGCCAACTCATCGCGCGCGTG
GGCCCCAGCGACACCGCCATCCTCATCACCGGCGAGACGGGCACGGGCAAGGAACGCGTGGCGCGAGCGCTGCACCTCGC
TTCGGGACGCAAGGGCCGGCTCGTCGCCGTCAACTGCGCGGCCATTCCCTCCACCCTGCTGGAGAGCGAGCTGTTCGGCC
ACGAGAAGGGCGCGTTCTCCGGTGCGCTGTCGCGGCGCGCGGGCCGCATCGAACAGGCGCACGGCGGCACGCTGTTCCTC
GACGAACTGGGCGACATGCCCCTGGAGCTCCAGGCCAAGCTGCTGCGCGTCCTGGAGACGAAGGAAGTGGAGCGGCTGGG
CGGCAGCCTGCCCGTGCCGGTGGATGCGCGCGTCGTCACGGCCACGCACCAGGACCTCGCCCGCGCGGTGAAGGAGGGCC
GCTTCCGGCAGGACCTCTACTTCCGCCTCAACGTGATGCCTCTCCAGGTGCCGCCCCTGCGCGAGCGGCCGGAGGACCTG
CTCCCCCTGGCCCGCGCCTTCGCGGCGGAGTTCGCGGGGCCGCAGGTGCCACTGGTGCTCGCGCCCGGCGCGGAGACCTC
GCTGCGCGCCTATGCGTGGCCGGGCAACGTGCGCGAACTGCGCAACCTCATCGAGCGCCTCAACCTGCTCCGGGGTGAGG
GCCCGCTCACCCTGGGCCCGGAGCTCGTCTCCGCGCCCCAGGCCACCGCCGCGGCCAGCCGCCCCTCCCTGGGACAAAAG
AGCTACCGAGAGCACGTGGAGGACTTCGAGCGCGAGCTCATCCGCGCGGCGCTCCAGGAAGGCGAAAGCATCGCCGGGGC
CGCGCGGCTGCTGCAGGTCGACCGGGGCAACCTCTACCGGCGCATCAAGGCGCTCGGACTCCCTGTCACCTGA

Upstream 100 bases:

>100_bases
AAATCGTCCACGAGCACGGCGGCAGCCTGCGCCTGGAGCCCGCGCCCGGAGGCGGTACGCTCGCGCGTGTGGAACTGCCC
CTCACCCCGCCTCCGTCCCC

Downstream 100 bases:

>100_bases
AGCCCCGCGGGAGTGCAGCTGCTCTGCCCCCGATTTTCGGACCGGCCGCAACCACGGCCCCAGTACCGAAAGCGCCCCCA
TGCCTCCAGGTGGATGCCGG

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MKPGPRILIVDDDSGVLRALRGLLSDEGFTPVEARSAAEASQLLDAPEGPPAMMLLDLRMPGETGLELLARLPRPFPAPV
VVLSGEASPAEAVQALRLGATDFVEKPPSPERLLTAVRNALALGSLQEERERLLDALARPGHLVGDSAGMASLRQLIARV
GPSDTAILITGETGTGKERVARALHLASGRKGRLVAVNCAAIPSTLLESELFGHEKGAFSGALSRRAGRIEQAHGGTLFL
DELGDMPLELQAKLLRVLETKEVERLGGSLPVPVDARVVTATHQDLARAVKEGRFRQDLYFRLNVMPLQVPPLRERPEDL
LPLARAFAAEFAGPQVPLVLAPGAETSLRAYAWPGNVRELRNLIERLNLLRGEGPLTLGPELVSAPQATAAASRPSLGQK
SYREHVEDFERELIRAALQEGESIAGAARLLQVDRGNLYRRIKALGLPVT

Sequences:

>Translated_450_residues
MKPGPRILIVDDDSGVLRALRGLLSDEGFTPVEARSAAEASQLLDAPEGPPAMMLLDLRMPGETGLELLARLPRPFPAPV
VVLSGEASPAEAVQALRLGATDFVEKPPSPERLLTAVRNALALGSLQEERERLLDALARPGHLVGDSAGMASLRQLIARV
GPSDTAILITGETGTGKERVARALHLASGRKGRLVAVNCAAIPSTLLESELFGHEKGAFSGALSRRAGRIEQAHGGTLFL
DELGDMPLELQAKLLRVLETKEVERLGGSLPVPVDARVVTATHQDLARAVKEGRFRQDLYFRLNVMPLQVPPLRERPEDL
LPLARAFAAEFAGPQVPLVLAPGAETSLRAYAWPGNVRELRNLIERLNLLRGEGPLTLGPELVSAPQATAAASRPSLGQK
SYREHVEDFERELIRAALQEGESIAGAARLLQVDRGNLYRRIKALGLPVT
>Mature_450_residues
MKPGPRILIVDDDSGVLRALRGLLSDEGFTPVEARSAAEASQLLDAPEGPPAMMLLDLRMPGETGLELLARLPRPFPAPV
VVLSGEASPAEAVQALRLGATDFVEKPPSPERLLTAVRNALALGSLQEERERLLDALARPGHLVGDSAGMASLRQLIARV
GPSDTAILITGETGTGKERVARALHLASGRKGRLVAVNCAAIPSTLLESELFGHEKGAFSGALSRRAGRIEQAHGGTLFL
DELGDMPLELQAKLLRVLETKEVERLGGSLPVPVDARVVTATHQDLARAVKEGRFRQDLYFRLNVMPLQVPPLRERPEDL
LPLARAFAAEFAGPQVPLVLAPGAETSLRAYAWPGNVRELRNLIERLNLLRGEGPLTLGPELVSAPQATAAASRPSLGQK
SYREHVEDFERELIRAALQEGESIAGAARLLQVDRGNLYRRIKALGLPVT

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=459, Percent_Identity=39.8692810457516, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=38.8888888888889, Blast_Score=281, Evalue=8e-77,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=41.5730337078652, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI87082117, Length=362, Percent_Identity=44.7513812154696, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1789087, Length=361, Percent_Identity=44.5983379501385, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1788905, Length=444, Percent_Identity=38.2882882882883, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI87082152, Length=321, Percent_Identity=46.417445482866, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=43.8871473354232, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1786524, Length=326, Percent_Identity=45.398773006135, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=41.3793103448276, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI1787583, Length=288, Percent_Identity=42.0138888888889, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1789828, Length=341, Percent_Identity=33.4310850439883, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081858, Length=288, Percent_Identity=32.6388888888889, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790863, Length=130, Percent_Identity=31.5384615384615, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786599, Length=119, Percent_Identity=31.9327731092437, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789809, Length=124, Percent_Identity=33.8709677419355, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790552, Length=134, Percent_Identity=32.089552238806, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48335; Mature: 48335

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPGPRILIVDDDSGVLRALRGLLSDEGFTPVEARSAAEASQLLDAPEGPPAMMLLDLRM
CCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEC
PGETGLELLARLPRPFPAPVVVLSGEASPAEAVQALRLGATDFVEKPPSPERLLTAVRNA
CCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHH
LALGSLQEERERLLDALARPGHLVGDSAGMASLRQLIARVGPSDTAILITGETGTGKERV
HHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHH
ARALHLASGRKGRLVAVNCAAIPSTLLESELFGHEKGAFSGALSRRAGRIEQAHGGTLFL
HHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCEEEH
DELGDMPLELQAKLLRVLETKEVERLGGSLPVPVDARVVTATHQDLARAVKEGRFRQDLY
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHCCCHHEEE
FRLNVMPLQVPPLRERPEDLLPLARAFAAEFAGPQVPLVLAPGAETSLRAYAWPGNVREL
EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEECCCCHHHH
RNLIERLNLLRGEGPLTLGPELVSAPQATAAASRPSLGQKSYREHVEDFERELIRAALQE
HHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GESIAGAARLLQVDRGNLYRRIKALGLPVT
CCHHHHHHHHHHHHCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKPGPRILIVDDDSGVLRALRGLLSDEGFTPVEARSAAEASQLLDAPEGPPAMMLLDLRM
CCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEC
PGETGLELLARLPRPFPAPVVVLSGEASPAEAVQALRLGATDFVEKPPSPERLLTAVRNA
CCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHH
LALGSLQEERERLLDALARPGHLVGDSAGMASLRQLIARVGPSDTAILITGETGTGKERV
HHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHH
ARALHLASGRKGRLVAVNCAAIPSTLLESELFGHEKGAFSGALSRRAGRIEQAHGGTLFL
HHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCEEEH
DELGDMPLELQAKLLRVLETKEVERLGGSLPVPVDARVVTATHQDLARAVKEGRFRQDLY
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHCCCHHEEE
FRLNVMPLQVPPLRERPEDLLPLARAFAAEFAGPQVPLVLAPGAETSLRAYAWPGNVREL
EEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEECCCCHHHH
RNLIERLNLLRGEGPLTLGPELVSAPQATAAASRPSLGQKSYREHVEDFERELIRAALQE
HHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GESIAGAARLLQVDRGNLYRRIKALGLPVT
CCHHHHHHHHHHHHCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]