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The map label for this gene is atoC [H]

Identifier: 108758047

GI number: 108758047

Start: 7034115

End: 7035728

Strand: Direct

Name: atoC [H]

Synonym: MXAN_5672

Alternate gene names: 108758047

Gene position: 7034115-7035728 (Clockwise)

Preceding gene: 108759130

Following gene: 108756861

Centisome position: 76.96

GC content: 70.07

Gene sequence:

>1614_bases
GTGCCTTGCCATTCAAGGCAAGACATCGCGGGTGGGCGGCTCGGTGGTGTCGTTCTCGAAGTGGATCCAGGCCATTGCAG
TGGGTGTGCCAGGGCGCTCCAGCACCTCCGGAGCCGAGGCGAGGCGCGCGCTCCAGAGGAGGACGCCCGGAGAGGCGCTC
CGACGGGCCTGGTAACCGCGGTTGTCAGGTGGCAACAACAGTTGTCACCCCCTCCCCCGCCTGGGTGGGGTGGTAGCCTG
CCCGCCGTGGCGGACCCAGGCGACATGGACACGGAGGTGGACGCGCTGGTCCAGACGGCGCCCGTCCCGGTGGCGCGACG
CGGCCCCTTGCGGTTGAAGCTGCTGATGCTCTCCGGGGAACAGGCGGGACACAGCCACGTCCTGCGCCCGGGGGTGGTCC
GGCTCGGCACGTCCTCGACGTGCGACATCGTATTGACGGACCGCGTCGTGTCCCGGCAGCACCTCCAGTTGGAGGTGACG
GACGAACGGGTGGTGGCCACCGACCTGGGCTCGCGCAACGGCTCCTTCCATGAAGGGGTGCGCTTCACCGAGTTGGAGGT
GCGGCCCGGGGCGTCGCTGACGCTGGGCACCGTCGTCCTCAAGGTGGTGCCCGAGGACTCACGGGAGCGGCCGATGCCCC
TGTCCTCGCGGCGTAACTTCGGCGCGCTCGTGGGCGCCAGCGTGAGGATGCGCGAGCTGTTCACCGTCCTGGAGCGGGTG
GCCGCGGGCGGTGGGGACGTGCTCGTCCAGGGCGAGACGGGGACGGGCAAGGAGCTGTGCGCGGAGGCGATTCACCAGGA
AAGCCCGCGGGCCGGTGGGCCCTTCATCATCGTGGACATCGCCGGGATTCCGCCCTCCTTGATGGAGTCCGAGCTCTTCG
GGCACGTGAAGGGTGCCTTCACGGGCGCGCAGACGGAGCGCGCCGGGGCCTTCGAGCGTGCCCAGGGAGGCACCGTCTTC
CTGGATGAGGTCGGCGAACTGCCCCTGGAGCTGCAACCCCGGCTCCTGCGCGCGCTTGAGCGCCGGCAGCTGAAGCGCGT
GGGCGCCAACGACTACCGCACGGTGGACATGCGCGTCGTCGCAGCCACACACGTCGACCTGGAGCAGGCCGTGCAACAGG
GCCGGTTCCGCAAGGACCTCTATCACCGGCTCGCGGTGCTCAAGGTCGTCCCGCCCCCACTGCGGGAGCGGGTGGAGGAC
CTGCCCCTGCTCATCGACGCCATGCTGGAGCGGCTGGGCCGTCCACCCAGCGCCCTGTCGGAACAGACGCGCGCCCTGCT
GGCCCAGTATCCCTGGCCCGGCAACGTGCGCGAGCTGCGCAACGTGGTGGAGCAGGCCATCCATCTGGGCGAGGACACTC
TGCCGCCCATGGACGCCCCCTCCGGTTCGGTCCGGTCGCCCCAAGGCACGCTCGACGCGGAGCTGCCCTTCAAGGAGGCC
AAGGAGCGGCTCATCGAGGTCTTCGAGCGGGACTACCTCCAGGGCCTCATCGCACGCTGCGACCGGAACATCTCCCGCGC
GGCCCGCGAGGCAGGTATCGCCCGGGTGTACCTGCGCAAGCTGCTCACGAAGCACGGGATGATGCTCGTGGACGACGACG
ATTCACGGGATTGA

Upstream 100 bases:

>100_bases
GTCGGATACGCGCGGTGTTTCGTGCGGTGTTTTCATTTACTTTTCGCGCGCTTCCGAGGGGAGCGAGTACAAATCAAAGA
CAAACAAGCCCACCCGCAGA

Downstream 100 bases:

>100_bases
GGGAGACGACGCATGCGACCGCCCGTCCGCGCATGACCGCTCACGAAAGCGTGCGCGTCAGTCCTTCAGGTCGTTCATGA
AGTGGAGGGGCTCACCAGGA

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MPCHSRQDIAGGRLGGVVLEVDPGHCSGCARALQHLRSRGEARAPEEDARRGAPTGLVTAVVRWQQQLSPPPPPGWGGSL
PAVADPGDMDTEVDALVQTAPVPVARRGPLRLKLLMLSGEQAGHSHVLRPGVVRLGTSSTCDIVLTDRVVSRQHLQLEVT
DERVVATDLGSRNGSFHEGVRFTELEVRPGASLTLGTVVLKVVPEDSRERPMPLSSRRNFGALVGASVRMRELFTVLERV
AAGGGDVLVQGETGTGKELCAEAIHQESPRAGGPFIIVDIAGIPPSLMESELFGHVKGAFTGAQTERAGAFERAQGGTVF
LDEVGELPLELQPRLLRALERRQLKRVGANDYRTVDMRVVAATHVDLEQAVQQGRFRKDLYHRLAVLKVVPPPLRERVED
LPLLIDAMLERLGRPPSALSEQTRALLAQYPWPGNVRELRNVVEQAIHLGEDTLPPMDAPSGSVRSPQGTLDAELPFKEA
KERLIEVFERDYLQGLIARCDRNISRAAREAGIARVYLRKLLTKHGMMLVDDDDSRD

Sequences:

>Translated_537_residues
MPCHSRQDIAGGRLGGVVLEVDPGHCSGCARALQHLRSRGEARAPEEDARRGAPTGLVTAVVRWQQQLSPPPPPGWGGSL
PAVADPGDMDTEVDALVQTAPVPVARRGPLRLKLLMLSGEQAGHSHVLRPGVVRLGTSSTCDIVLTDRVVSRQHLQLEVT
DERVVATDLGSRNGSFHEGVRFTELEVRPGASLTLGTVVLKVVPEDSRERPMPLSSRRNFGALVGASVRMRELFTVLERV
AAGGGDVLVQGETGTGKELCAEAIHQESPRAGGPFIIVDIAGIPPSLMESELFGHVKGAFTGAQTERAGAFERAQGGTVF
LDEVGELPLELQPRLLRALERRQLKRVGANDYRTVDMRVVAATHVDLEQAVQQGRFRKDLYHRLAVLKVVPPPLRERVED
LPLLIDAMLERLGRPPSALSEQTRALLAQYPWPGNVRELRNVVEQAIHLGEDTLPPMDAPSGSVRSPQGTLDAELPFKEA
KERLIEVFERDYLQGLIARCDRNISRAAREAGIARVYLRKLLTKHGMMLVDDDDSRD
>Mature_536_residues
PCHSRQDIAGGRLGGVVLEVDPGHCSGCARALQHLRSRGEARAPEEDARRGAPTGLVTAVVRWQQQLSPPPPPGWGGSLP
AVADPGDMDTEVDALVQTAPVPVARRGPLRLKLLMLSGEQAGHSHVLRPGVVRLGTSSTCDIVLTDRVVSRQHLQLEVTD
ERVVATDLGSRNGSFHEGVRFTELEVRPGASLTLGTVVLKVVPEDSRERPMPLSSRRNFGALVGASVRMRELFTVLERVA
AGGGDVLVQGETGTGKELCAEAIHQESPRAGGPFIIVDIAGIPPSLMESELFGHVKGAFTGAQTERAGAFERAQGGTVFL
DEVGELPLELQPRLLRALERRQLKRVGANDYRTVDMRVVAATHVDLEQAVQQGRFRKDLYHRLAVLKVVPPPLRERVEDL
PLLIDAMLERLGRPPSALSEQTRALLAQYPWPGNVRELRNVVEQAIHLGEDTLPPMDAPSGSVRSPQGTLDAELPFKEAK
ERLIEVFERDYLQGLIARCDRNISRAAREAGIARVYLRKLLTKHGMMLVDDDDSRD

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG3604

COG function: function code KT; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=344, Percent_Identity=40.406976744186, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1788905, Length=402, Percent_Identity=36.0696517412935, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1790299, Length=224, Percent_Identity=51.3392857142857, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1790437, Length=320, Percent_Identity=40.9375, Blast_Score=222, Evalue=6e-59,
Organism=Escherichia coli, GI87082117, Length=240, Percent_Identity=48.3333333333333, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87082152, Length=316, Percent_Identity=42.0886075949367, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1789087, Length=253, Percent_Identity=44.6640316205534, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=37.8125, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1786524, Length=262, Percent_Identity=45.4198473282443, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=37.4213836477987, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1787583, Length=322, Percent_Identity=35.4037267080745, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI1789828, Length=310, Percent_Identity=32.9032258064516, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI87081858, Length=202, Percent_Identity=35.6435643564356, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 58567; Mature: 58436

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50006 FHA_DOMAIN ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCHSRQDIAGGRLGGVVLEVDPGHCSGCARALQHLRSRGEARAPEEDARRGAPTGLVTA
CCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHH
VVRWQQQLSPPPPPGWGGSLPAVADPGDMDTEVDALVQTAPVPVARRGPLRLKLLMLSGE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEECC
QAGHSHVLRPGVVRLGTSSTCDIVLTDRVVSRQHLQLEVTDERVVATDLGSRNGSFHEGV
CCCCCCCCCCCEEEECCCCCCEEEEECHHHCCCCEEEEECCCEEEEECCCCCCCCHHCCC
RFTELEVRPGASLTLGTVVLKVVPEDSRERPMPLSSRRNFGALVGASVRMRELFTVLERV
EEEEEEECCCCCEEHHHEEEEECCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHH
AAGGGDVLVQGETGTGKELCAEAIHQESPRAGGPFIIVDIAGIPPSLMESELFGHVKGAF
HCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHC
TGAQTERAGAFERAQGGTVFLDEVGELPLELQPRLLRALERRQLKRVGANDYRTVDMRVV
CCCCHHHCCCHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEE
AATHVDLEQAVQQGRFRKDLYHRLAVLKVVPPPLRERVEDLPLLIDAMLERLGRPPSALS
EHHHCCHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
EQTRALLAQYPWPGNVRELRNVVEQAIHLGEDTLPPMDAPSGSVRSPQGTLDAELPFKEA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
KERLIEVFERDYLQGLIARCDRNISRAAREAGIARVYLRKLLTKHGMMLVDDDDSRD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure 
PCHSRQDIAGGRLGGVVLEVDPGHCSGCARALQHLRSRGEARAPEEDARRGAPTGLVTA
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHH
VVRWQQQLSPPPPPGWGGSLPAVADPGDMDTEVDALVQTAPVPVARRGPLRLKLLMLSGE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEECC
QAGHSHVLRPGVVRLGTSSTCDIVLTDRVVSRQHLQLEVTDERVVATDLGSRNGSFHEGV
CCCCCCCCCCCEEEECCCCCCEEEEECHHHCCCCEEEEECCCEEEEECCCCCCCCHHCCC
RFTELEVRPGASLTLGTVVLKVVPEDSRERPMPLSSRRNFGALVGASVRMRELFTVLERV
EEEEEEECCCCCEEHHHEEEEECCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHH
AAGGGDVLVQGETGTGKELCAEAIHQESPRAGGPFIIVDIAGIPPSLMESELFGHVKGAF
HCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHC
TGAQTERAGAFERAQGGTVFLDEVGELPLELQPRLLRALERRQLKRVGANDYRTVDMRVV
CCCCHHHCCCHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEE
AATHVDLEQAVQQGRFRKDLYHRLAVLKVVPPPLRERVEDLPLLIDAMLERLGRPPSALS
EHHHCCHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
EQTRALLAQYPWPGNVRELRNVVEQAIHLGEDTLPPMDAPSGSVRSPQGTLDAELPFKEA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
KERLIEVFERDYLQGLIARCDRNISRAAREAGIARVYLRKLLTKHGMMLVDDDDSRD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]