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The map label for this gene is yogA [H]

Identifier: 108758045

GI number: 108758045

Start: 2688976

End: 2689989

Strand: Direct

Name: yogA [H]

Synonym: MXAN_2314

Alternate gene names: 108758045

Gene position: 2688976-2689989 (Clockwise)

Preceding gene: 108762588

Following gene: 108761151

Centisome position: 29.42

GC content: 68.24

Gene sequence:

>1014_bases
ATGAGAGCCTATGAAATCCAAGCAGGGTTTGGGTTGGACAAGCTGGTGCAGGTCGAGCGGCCGGACCCGACTCCAGGCCC
CATGCAGGTGCGGGTGCGCGTGAAGGCCACGAGCCTCAACTCCCGTGACTTGATGATGGTGGAGGGTCGTTACAACCCCC
GGCAGAAGCTGCCACTCATTCCCAACTCGGACGCGGCGGGCGTCGTGGATGCGGTAGGCCCGGGTGTGACGCGGGTGAAG
CCTGGTGACCGGGTGATGAGCCTCTTTTCCCAGGCCTGGAGCGCCGGAGAGCCCACGCGGGCGGCGCAGGTGAGCACGCT
GGGAGGACCGTTGGACGGTGCCCTCGCGGACACGGTGCTGTTGCACGAGGACGGCGCGGTGCCTACGCCCGCCTATCTCT
CCGATGAAGAGGCTGCGACGCTGCCGTGCGCGGCCGTGACGGCGTGGAGCGCGCTGGTCACCCATGGGGCACTCAAGGCG
GGGGACACCGTCTTGCTTCAGGGCACCGGTGGCGTGTCCATCTTCGCGTTGCAGATTGCCAGGCTGCTGGGCGCGCGAAT
CATCATCACCTCCAGCAGTGACGCCAAGCTGGCGCGAGCCCGGACGCTCGGCGCGCATGAAGGCATCAACTACGGGACGA
CGCCGGACTGGGACAAGGCGGCGCGCGCGCTGACGGGAGGCGTGGGCGTGGACCACGTGGTGGAAGTGGGTGGGGCGGGG
ACCTTCGAGAAGTCGCTGCGCGCGGTCCGGCCCGGCGGCACGGTGTCTGTGATTGGCGTGCTCAGCGGTGGTGCGGGGAC
GGTGCCGCTGACGCCCATCCTCATGCAGAACCTGCGGGTGCAGGGCATCTTCGTGGGCCACCGGCAGAGCTTCGACGCGC
TCAACCGGGCCTTCGCGTTGCACACCGTTCGCCCGGTGGTGGACCGCGTCTTCGAGTTCTCCGAGGCACGCGCTGCTTTC
GAGCACCTCAAGAGAGGGGCGCACTTCGGGAAGGTGGTCGTCCGGGTGGGGTGA

Upstream 100 bases:

>100_bases
GGGGCTGTGGCCAGCAGCGAACAGGTGAAGAGGACGAGCACGGACACGGTGGCCCGCACTGTAGGCGTGATTGGGAGGGG
CGCGATACAACGCCTCACCT

Downstream 100 bases:

>100_bases
GGCAGTCCCCATCGCCAGACGCGCGCATCCCTGACGCCGCTTCGTCCGGGCACCGGCATTGTCCCGCCGGTGCCATGCAC
GAGGTCATCGAAGTCGGGCC

Product: zinc-binding dehydrogenase family oxidoreductase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MRAYEIQAGFGLDKLVQVERPDPTPGPMQVRVRVKATSLNSRDLMMVEGRYNPRQKLPLIPNSDAAGVVDAVGPGVTRVK
PGDRVMSLFSQAWSAGEPTRAAQVSTLGGPLDGALADTVLLHEDGAVPTPAYLSDEEAATLPCAAVTAWSALVTHGALKA
GDTVLLQGTGGVSIFALQIARLLGARIIITSSSDAKLARARTLGAHEGINYGTTPDWDKAARALTGGVGVDHVVEVGGAG
TFEKSLRAVRPGGTVSVIGVLSGGAGTVPLTPILMQNLRVQGIFVGHRQSFDALNRAFALHTVRPVVDRVFEFSEARAAF
EHLKRGAHFGKVVVRVG

Sequences:

>Translated_337_residues
MRAYEIQAGFGLDKLVQVERPDPTPGPMQVRVRVKATSLNSRDLMMVEGRYNPRQKLPLIPNSDAAGVVDAVGPGVTRVK
PGDRVMSLFSQAWSAGEPTRAAQVSTLGGPLDGALADTVLLHEDGAVPTPAYLSDEEAATLPCAAVTAWSALVTHGALKA
GDTVLLQGTGGVSIFALQIARLLGARIIITSSSDAKLARARTLGAHEGINYGTTPDWDKAARALTGGVGVDHVVEVGGAG
TFEKSLRAVRPGGTVSVIGVLSGGAGTVPLTPILMQNLRVQGIFVGHRQSFDALNRAFALHTVRPVVDRVFEFSEARAAF
EHLKRGAHFGKVVVRVG
>Mature_337_residues
MRAYEIQAGFGLDKLVQVERPDPTPGPMQVRVRVKATSLNSRDLMMVEGRYNPRQKLPLIPNSDAAGVVDAVGPGVTRVK
PGDRVMSLFSQAWSAGEPTRAAQVSTLGGPLDGALADTVLLHEDGAVPTPAYLSDEEAATLPCAAVTAWSALVTHGALKA
GDTVLLQGTGGVSIFALQIARLLGARIIITSSSDAKLARARTLGAHEGINYGTTPDWDKAARALTGGVGVDHVVEVGGAG
TFEKSLRAVRPGGTVSVIGVLSGGAGTVPLTPILMQNLRVQGIFVGHRQSFDALNRAFALHTVRPVVDRVFEFSEARAAF
EHLKRGAHFGKVVVRVG

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=342, Percent_Identity=28.0701754385965, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI22538444, Length=342, Percent_Identity=28.0701754385965, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI194239674, Length=314, Percent_Identity=26.4331210191083, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI13236495, Length=314, Percent_Identity=26.4331210191083, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI18379349, Length=332, Percent_Identity=27.4096385542169, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI194239676, Length=198, Percent_Identity=29.7979797979798, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI47519420, Length=370, Percent_Identity=25.9459459459459, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156627571, Length=326, Percent_Identity=26.0736196319018, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI28557745, Length=283, Percent_Identity=28.9752650176678, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI41872631, Length=316, Percent_Identity=28.1645569620253, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI24308257, Length=371, Percent_Identity=25.3369272237197, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI87081918, Length=317, Percent_Identity=28.7066246056782, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787863, Length=211, Percent_Identity=28.436018957346, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790485, Length=301, Percent_Identity=30.2325581395349, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082125, Length=232, Percent_Identity=27.1551724137931, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790045, Length=328, Percent_Identity=22.5609756097561, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=335, Percent_Identity=25.9701492537313, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=294, Percent_Identity=27.2108843537415, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=279, Percent_Identity=25.4480286738351, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=219, Percent_Identity=26.9406392694064, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=323, Percent_Identity=25.077399380805, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=345, Percent_Identity=29.2753623188406, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=345, Percent_Identity=29.2753623188406, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=335, Percent_Identity=25.6716417910448, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=335, Percent_Identity=25.9701492537313, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=24.251497005988, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=321, Percent_Identity=23.6760124610592, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319520, Length=257, Percent_Identity=28.7937743190661, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24581345, Length=343, Percent_Identity=27.1137026239067, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 35331; Mature: 35331

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAYEIQAGFGLDKLVQVERPDPTPGPMQVRVRVKATSLNSRDLMMVEGRYNPRQKLPLI
CCEEEECCCCCHHHHEEEECCCCCCCCEEEEEEEEEECCCCCCEEEEECCCCCHHCCCCC
PNSDAAGVVDAVGPGVTRVKPGDRVMSLFSQAWSAGEPTRAAQVSTLGGPLDGALADTVL
CCCCCCCCHHHCCCCCEEECCHHHHHHHHHHHHCCCCCCCCEEEHHCCCCCCCHHHCEEE
LHEDGAVPTPAYLSDEEAATLPCAAVTAWSALVTHGALKAGDTVLLQGTGGVSIFALQIA
EECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHH
RLLGARIIITSSSDAKLARARTLGAHEGINYGTTPDWDKAARALTGGVGVDHVVEVGGAG
HHHCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHEEECCCC
TFEKSLRAVRPGGTVSVIGVLSGGAGTVPLTPILMQNLRVQGIFVGHRQSFDALNRAFAL
CHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHCCEEEEEEEECCCCHHHHHHHHHH
HTVRPVVDRVFEFSEARAAFEHLKRGAHFGKVVVRVG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
>Mature Secondary Structure
MRAYEIQAGFGLDKLVQVERPDPTPGPMQVRVRVKATSLNSRDLMMVEGRYNPRQKLPLI
CCEEEECCCCCHHHHEEEECCCCCCCCEEEEEEEEEECCCCCCEEEEECCCCCHHCCCCC
PNSDAAGVVDAVGPGVTRVKPGDRVMSLFSQAWSAGEPTRAAQVSTLGGPLDGALADTVL
CCCCCCCCHHHCCCCCEEECCHHHHHHHHHHHHCCCCCCCCEEEHHCCCCCCCHHHCEEE
LHEDGAVPTPAYLSDEEAATLPCAAVTAWSALVTHGALKAGDTVLLQGTGGVSIFALQIA
EECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHH
RLLGARIIITSSSDAKLARARTLGAHEGINYGTTPDWDKAARALTGGVGVDHVVEVGGAG
HHHCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHEEECCCC
TFEKSLRAVRPGGTVSVIGVLSGGAGTVPLTPILMQNLRVQGIFVGHRQSFDALNRAFAL
CHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHCCEEEEEEEECCCCHHHHHHHHHH
HTVRPVVDRVFEFSEARAAFEHLKRGAHFGKVVVRVG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+; NADH [C]

Metal ions: Co2+ Zn2+-depleted [C]

Kcat value (1/min): 150 [C]

Specific activity: 19

Km value (mM): 0.2 {tryptophol}} 0.0074 {NAD+}} 0.0069 {NAD+}} 13 {ethylene} 6 {methanol}} 27 {pentanol}} 0.44 {1-butanol}} 120 {ethanol}} 0.91 {acetaldehyde}} 0.1 {acetaldehyde}} 0.005 {1-octanol}} 0.004 {benzyl} 0.005 {cyclohe

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: 2, 2'-Bipyridyl; 4-Methyl pyrazole acetaldehyde; 8-Amino-6-methoxyquinoline; 8-Hydroxy quinoline-5-sulfonic acid; Acetaldehyde; Dipicolinic acid; EDTA; Ethanol; GSH; Heptafluorbutanol; Imidazole; Iodoacetamide; Iodoacetate; Isobutyramide EDTA; NAD+; NADH;

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]