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The map label for this gene is phoP [H]

Identifier: 108758042

GI number: 108758042

Start: 5480746

End: 5481741

Strand: Reverse

Name: phoP [H]

Synonym: MXAN_4432

Alternate gene names: 108758042

Gene position: 5481741-5480746 (Counterclockwise)

Preceding gene: 108757858

Following gene: 108763065

Centisome position: 59.98

GC content: 70.78

Gene sequence:

>996_bases
ATGAGTCTCGTCCTGGTCGCGGACGATGAGCCAGCGGTGTTGGAGGTTCTCAGTCAAGTCGTGGAGGACCTGGGCCACGA
CGTCTTGAGAGCGCGGGATGGCGAGGAGGCGCTCGGTCTGGCGCGTGCCCGGCATCCTCAACTGGTGGTGACGGACCACA
TGATGCCGCGGCTGAGCGGCGTGGAGCTCTGCCGCCGGATGAAGCAGGAGGCACAGCTCAAGGACGTGCCCGTCATCCTC
CTCAGCGCGGTGCTGCCCCAGGGCGCGCCGGAGGCGTTCGCCTTCCTCCACAAGCCCTTTGAAATCACCGACTTCGAATC
GGTCATCCACAAATCGCTGGCCGCCTCGCCGGAGCCCCGGATGGCGCACGCGGCGTCCCCCGTGGGCGCGCTGGGGCAGT
GGGTGGCGCAGACGCTCCAGGGCCCGCTCGAAACGGCCCGCGAGCAGCTTCGCCGGCTGGAATGCACGCCCTCCGTGGAC
CGCGCGGCGCTGGACACGCTGGCGGCGCAGCTCCAGTCCATGGAAGCCGTGGGCCGTCACCTGCGCGAGCTGGCGTGGCT
GTCCTCGGGCGAGGCGACGCTGGCGCGAATCGACACGGACGTGGGCCAGCACCTGCGCGACGCGGTGGCGGCGCATGGCG
CACACGTCACGTTGGAAGCACCCGAGGAGCCAGTCCACGCGCAGGTGGACCCGCCGCGCATCCGGCAGGTGTTCGACGTG
CTGCTGGCGAACGCGGTCCGGCAGGGGGACGCGGAGGTGGCGCTCGAAATCTCCCAGACGCAGCTCACGGTGCGCGTGAA
GGACGTGGGGCCGGGGGTGGCCGCGGAGGCGCTGGCCCACCTCTTCACGCCCTTCCGGATGGATGCGAAGGGCGTCCGCG
GACCGGAGCTGTACGTGGCCTCGGAGCTGGTGCGCCTGCAAGGGGGCGCGCTGTCCGTCCAGTCACGACCCGGCGAGGGC
TCCACGTTCAGCCTGATGCTGCCGCGGAGCACCTGA

Upstream 100 bases:

>100_bases
GGATGCACGTCCTCGCGGAGTGTCAGTACACCGTGGGAGTGGATTGTTATCCTGGCGGCGCGCAAGCAGTCGCGGCGTGC
CGAGGCGAGGGAGTGGAAGC

Downstream 100 bases:

>100_bases
CACGCGATGGCATCCCTTCACGGGCGCTTCGCGTGACGAGACGTCAGGCCTGCTGCGACTTCAGCATCCAGCCAATCATC
TTGTACAGAAGCCGGGCGCC

Product: putative response regulator/sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSLVLVADDEPAVLEVLSQVVEDLGHDVLRARDGEEALGLARARHPQLVVTDHMMPRLSGVELCRRMKQEAQLKDVPVIL
LSAVLPQGAPEAFAFLHKPFEITDFESVIHKSLAASPEPRMAHAASPVGALGQWVAQTLQGPLETAREQLRRLECTPSVD
RAALDTLAAQLQSMEAVGRHLRELAWLSSGEATLARIDTDVGQHLRDAVAAHGAHVTLEAPEEPVHAQVDPPRIRQVFDV
LLANAVRQGDAEVALEISQTQLTVRVKDVGPGVAAEALAHLFTPFRMDAKGVRGPELYVASELVRLQGGALSVQSRPGEG
STFSLMLPRST

Sequences:

>Translated_331_residues
MSLVLVADDEPAVLEVLSQVVEDLGHDVLRARDGEEALGLARARHPQLVVTDHMMPRLSGVELCRRMKQEAQLKDVPVIL
LSAVLPQGAPEAFAFLHKPFEITDFESVIHKSLAASPEPRMAHAASPVGALGQWVAQTLQGPLETAREQLRRLECTPSVD
RAALDTLAAQLQSMEAVGRHLRELAWLSSGEATLARIDTDVGQHLRDAVAAHGAHVTLEAPEEPVHAQVDPPRIRQVFDV
LLANAVRQGDAEVALEISQTQLTVRVKDVGPGVAAEALAHLFTPFRMDAKGVRGPELYVASELVRLQGGALSVQSRPGEG
STFSLMLPRST
>Mature_330_residues
SLVLVADDEPAVLEVLSQVVEDLGHDVLRARDGEEALGLARARHPQLVVTDHMMPRLSGVELCRRMKQEAQLKDVPVILL
SAVLPQGAPEAFAFLHKPFEITDFESVIHKSLAASPEPRMAHAASPVGALGQWVAQTLQGPLETAREQLRRLECTPSVDR
AALDTLAAQLQSMEAVGRHLRELAWLSSGEATLARIDTDVGQHLRDAVAAHGAHVTLEAPEEPVHAQVDPPRIRQVFDVL
LANAVRQGDAEVALEISQTQLTVRVKDVGPGVAAEALAHLFTPFRMDAKGVRGPELYVASELVRLQGGALSVQSRPGEGS
TFSLMLPRST

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=125, Percent_Identity=33.6, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081816, Length=115, Percent_Identity=40, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: 2.7.3.- [C]

Molecular weight: Translated: 35733; Mature: 35602

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVLVADDEPAVLEVLSQVVEDLGHDVLRARDGEEALGLARARHPQLVVTDHMMPRLSG
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECHHHHHHHH
VELCRRMKQEAQLKDVPVILLSAVLPQGAPEAFAFLHKPFEITDFESVIHKSLAASPEPR
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC
MAHAASPVGALGQWVAQTLQGPLETAREQLRRLECTPSVDRAALDTLAAQLQSMEAVGRH
HHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRELAWLSSGEATLARIDTDVGQHLRDAVAAHGAHVTLEAPEEPVHAQVDPPRIRQVFDV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHH
LLANAVRQGDAEVALEISQTQLTVRVKDVGPGVAAEALAHLFTPFRMDAKGVRGPELYVA
HHHHHHHCCCCCEEEEEECEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHH
SELVRLQGGALSVQSRPGEGSTFSLMLPRST
HHHHHHCCCEEEECCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
SLVLVADDEPAVLEVLSQVVEDLGHDVLRARDGEEALGLARARHPQLVVTDHMMPRLSG
EEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECHHHHHHHH
VELCRRMKQEAQLKDVPVILLSAVLPQGAPEAFAFLHKPFEITDFESVIHKSLAASPEPR
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC
MAHAASPVGALGQWVAQTLQGPLETAREQLRRLECTPSVDRAALDTLAAQLQSMEAVGRH
HHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRELAWLSSGEATLARIDTDVGQHLRDAVAAHGAHVTLEAPEEPVHAQVDPPRIRQVFDV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHH
LLANAVRQGDAEVALEISQTQLTVRVKDVGPGVAAEALAHLFTPFRMDAKGVRGPELYVA
HHHHHHHCCCCCEEEEEECEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHH
SELVRLQGGALSVQSRPGEGSTFSLMLPRST
HHHHHHCCCEEEECCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Phosphotransferases with a nitrogenous group as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]